Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung

European Journal of Pharmacology

Volumn 402, Issue 1-2, 2000, Pages 171-179

  Corboz, Michel R ^a   Rivelli, Maria A ^a   Egan, Robert W ^a   Tulshian, Deen ^a   Matasi, Julius ^a   Fawzi, Ahmad B ^a   Benbow, Lawrence ^a   Smith Torhan, April ^a   Zhang, Hongtao ^a   Hey, John A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Isolated lung, guinea pig; Nociceptin orphanin FQ; ORL1 receptor antagonist; ORL1 receptors

Indexed keywords

1 (1 CYCLOOCTYLMETHYL 3 HYDROXYMETHYL 4 PIPERIDYL) 3 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; CAPSAICIN; NALOXONE; NEUROKININ A; NOCICEPTIN; OPIATE ANTAGONIST; OPIATE RECEPTOR; TACHYKININ; TACHYKININ RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; DOSE RESPONSE; GUINEA PIG; ISOLATED LUNG; NONHUMAN; PERFUSION; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN SECRETION; RECEPTOR UPREGULATION; SENSORY NERVE;

ANIMALS; BENZIMIDAZOLES; BRONCHOCONSTRICTION; CAPSAICIN; CHO CELLS; CRICETINAE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUINEA PIGS; LUNG; NALOXONE; NARCOTIC ANTAGONISTS; OPIOID PEPTIDES; PIPERIDINES; RECEPTORS, OPIOID; SULFUR RADIOISOTOPES;

EID: 13744265513     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00505-7     Document Type: Article

References (53)

1. Belvisi M.G., Chung K.F., Jackson D.M., Barnes P.J. Opioid modulation of non-cholinergic neural bronchoconstriction in guinea pig in vivo. Br. J. Pharmacol. 95:1988;413-418.
2. Berzetei-Gurske I.P., Schwartz R.W., Toll L. Determination of activity for nociceptin in the mouse vas deferens. Eur. J. Pharmacol. 302:1996;R1-R2.
3. Bigoni R., Guiliani S., Calo G., Rizzi A., Guerrini R., Salvadori S., Regoli D., Maggi C.A. Characterization of nociceptin receptors in the periphery: in vitro and in vivo studies. Naunyn-Schmiedeberg's Arch. Pharmacol. 359:1999;160-167.
4. Bucher B. ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery. Naunyn-Schmiedeberg's Arch. Pharmacol. 358:1998;682-685.
5. Bunzow J.R., Saez C., Mortrud M., Bouvier C., Williams J.T., Low M., Grandy D.K. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type. FEBS Lett. 347:1994;284-288.
6. Calo G., Rizzi A., Bogoni G., Neugebauer V., Salvadori S., Guerrini R., Bianchi C., Regoli D. The mouse vas deferens: a pharmacological preparation sensitive to nociceptin. Eur. J. Pharmacol. 311:1996;R3-R5.
7. Calo G., Rizzi A., Bodin M., Neugebauer V., Salvadori S., Guerrini R., Bianchi C., Regoli D. Pharmacological characterization of nociceptin receptor: an in vitro study. Can. J. Physiol. Pharmacol. 75:1997;713-718.
8. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:1973;3099-3108.
9. 2+ in the SH-SY5Y human neuroblastoma cell line. Br. J. Pharmacol. 118:1996;205-207.
10. Connor M., Vaughan C.W., Chieng B., Christie M.J. Nociceptin receptor coupling to a potassium conductance in locus coeruleus neurons in vitro. Br. J. Pharmacol. 119:1996;1614-1618.
11. Corbett A.D., Menzies J.R.W., Davies M.R.P., Paterson S.J. The pharmacological actions of nociceptin in the isolated colon of rat, mouse and man. Naunyn-Schmiedeberg's Arch. Pharmacol. 358(Suppl. 1):1998;. 40.47.
12. Fawzi A.B., Zhang H., Weig B., Hawes B., Graziano M.P. Nociceptin activation of the human ORL1 receptor expressed in Chinese hamster ovary cells: functional homology with opioid receptors. Eur. J. Pharmacol. 336:1997;233-242.
13. Feuerstein N., Ramwell P.W. In vivo and in vitro effects of endotoxin on prostaglandin release from rat lung. Br. J. Pharmacol. 73:1981;511-516.
14. Fisher A., Forssman W.G., Undem B.J. Nociceptin-induced inhibition of tachykinergic neurotransmission in guinea pig bronchus. J. Pharmacol. Exp. Ther. 268:1998;85-89.
15. Frossard N., Barnes P.J. μ-Opioid receptors modulate non-cholinergic constrictor nerves in guinea pig airways. Eur. J. Pharmacol. 141:1987;519-522.
16. Garssen J., Van Loveren H., Van der Vliet H., Nijkamp F.P. An isometric method to study respiratory smooth muscle responses in mice. J. Pharmacol. Methods. 24:1990;209-217.
17. Giuliani S., Maggi C.A. Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide. Br. J. Pharmacol. 118:1996;1567-1569.
18. Giuliani S., Maggi C.A. Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea pig left atrium. Eur. J. Pharmacol. 332:1997;231-236.
19. Guerrini R., Calo G., Rizzi A., Bigoni R., Bianca C., Salvadori S., Regoli D. A new selective antagonist of the nociceptin receptor. Br. J. Pharmacol. 123:1998;163-165.
20. Held H.-D., Martin C., Uhlig S. Characterization of airway and vascular responses in murine lungs. Br. J. Pharmacol. 126:1999;1191-1199.
21. Helyes Z., Nemeth J., Pinter E., Szolcsanyl J. Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals. Br. J. Pharmacol. 121:1997;613-615.
22. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience. 24:1988;739-768.
23. Kanazawa H., Kurihara N., Hirata K., Kudoh S., Kawaguchi T., Takeda T. Adrenomedullin, a newly discovered hypotensive peptide, is a potent bronchodilator. Biochem. Biophys. Res. Commun. 205:1994;251-254.
24. Kawamoto H., Ozaki S., Itoh Y., Miyaji M., Arai S., Nakashima H., Kato T., Ohta H., Iwasawa Y. Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R, 4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihidro-2H- benzimidazol-2-one (J-113397). J. Med. Chem. 42:1999;5061-5063.
25. Knoflach F., Reinscheid R.K., Civelli O., Kemp J. Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons. J. Neurosci. 16:1996;6657-6664.
26. + channel in Xenopus oocytes. Br. J. Pharmacol. 120:1997;986-987.
27. Lundberg J.M., Saria A., Theodorsson-Norheim E., Brodin E., Hua X., Martling C.-R., Gamse R., Hokfelt T. Multiple tachykinins in capsaicin-sensitive afferents: occurrence, release and biological effects with special reference to irritation of the airways. Fernstrom Foundation Series. Tachykinin Antagonists. vol. 6:1985;159-169 Elsevier, Amsterdam.
28. 2-adrenoceptor and opiate receptors. Eur. J. Pharmacol. 163:1989;15-23.
29. Meunier J.C., Mollereau C., Toll L., Suaudeau C., Moisand C., Alvinerie P., Butour J.L., Guillemot J.C., Ferrara P., Monsarrat B., Mazarguil H., Vassart G., Parmentier M., Costentin J. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature. 377:1995;532-535.
30. Mogil J.S., Grisel J.E., Reinscheid R.K., Civelli O., Belknap J.K., Grandy D.K. Orphanin FQ is a functional anti-opioid peptide. Neuroscience. 75:1996;333-337.
31. Mollereau G., Parmentier M., Mailleux P., Butour J.L., Moisand C., Chalon P., Caput D., Vassart G., Meunier J.C. ORL1, a novel member of the opioid receptor family: Cloning, functional expression and localization. FEBS Lett. 341:1994;33-38.
32. Nicholson J.R., Paterson S.J., Menzies J.R.W., Corbett A.D., McKnight A.T. Pharmacological studies on the "orphan" opioid receptor in central and peripheral sites. Can. J. Physiol. Pharmacol. 76:1998;304-313.
33. + evoked glutamate release from rat cerebrocortical slices. Br. J. Pharmacol. 119:1996;1081-1083.
34. Noda Y., Mamiya Y., Nabeshima T., Nishi T., Higashioka M., Takeshima M. Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice. J. Biol. Chem. 273:1998;18047-18051.
35. Patel H.J., Giembycz M.A., Spicuzza L., Barnes P.J., Belvisi M.G. Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea pig trachea by the novel opioid, nociceptin. Br. J. Pharmacol. 120:1997;735-736.
36. Pinto A., Sekizawa K., Yamaya M., Ohrui T., Jia Y.X., Sasaki H. Effect of adrenomedullin and calcitonin gene-related peptide on airway and pulmonary vascular smooth muscle in guinea pigs. Br. J. Pharmacol. 119:1996;1477-1483.
37. Pomonis J.D., Billington C.J., Levine A.S. Orphanin FQ, agonist of orphan opioid receptor ORL1, stimulates feeding in rats. NeuroReport. 8:1996;369-371.
38. Reinscheid R.K., Nothacker H.P., Bourson A., Ardati A., Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsma F.J., Civelli O. Orphanin FQ: a neuropeptide that activates an opioid like G-protein-coupled receptor. Science. 270:1995;792-794.
39. Rivelli M.A., Corboz M.R., Fernandez X., Hey J.A. Increased activity of combined NK1/NK2 blockade on tachykinin-induced bronchoconstriction in isolated lung and in vivo in the guinea pigs. Am. J. Respir. Crit. Care Med. 159:1999;A281.
40. Rizzi A., Calo G., Trevisani M., Tognetto M., Fabbri L., Mapp C., Guerrini R., Salvadori S., Regoli D., Geppetti P. Nociceptin receptor activation inhibits tachykinergic non-adrenergic non-cholinergic contraction of guinea pig isolated bronchus. Life Sci. 64:1998;157-163.
41. 2 antagonizes nociceptin effects in the mouse colon. Eur. J. Pharmacol. 285:1999;R3-R5.
42. Sandin J., Georgieva J., Schott P.A., Ogren S.O., Terenius L. Nociceptin/Orphanin FQ microinjected into hyppocampus impairs spatial learning in rats. Eur. J. Neurosci. 9:1997;194-197.
43. Shah S., Page C.P., Spina D. Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea pig airway. Br. J. Pharmacol. 125:1998;510-516.
44. Stanfa L.C., Chapman V., Kerr N., Dickenson A.H. Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo. Br. J. Pharmacol. 118:1996;1875-1877.
45. Stretton D., Miura M., Belvisi M.G., Barnes P.J. Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves. Proc. Natl. Acad. Sci. U. S. A. 89:1992;1325-1329.
46. Tozzi S., Monahan M.E., Hey J.A. Synergistic blockade of combined NK1 and NK2 antagonists on tachykinin induced-bronchoconstriction in isolated guinea pig lung. Am. J. Respir. Crit. Care Med. 153:1996;A848.
47. Uhlig S., Nusing R., von Bethmann A., Featherstone R.L., Klein T., Brasch F., Muller K.-M., Ullrich V., Wendel A. Mol. Med. 2:1996;373-383.
48. 1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones. Br. J. Pharmacol. 117:1996;1609-1611.
49. 1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro. J. Neurosci. 17:1997;996-1003.
50. Vemulapalli S., Rivelli M., Chiu P.J.S., del Prado M., Hey J.A. Phosphoramidon abolishes the increases in endothelin-1 release induced by ischemia-hypoxia in isolated perfused guinea pig lungs. J. Pharmacol. Exp. Ther. 262:1992;1062-1068.
51. Xu X.J., Hao J.X., Wiesenfeld-Hllin Z. Nociceptin or anti-nociceptin: potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat. NeuroReport. 7:1996;2092-2094.
52. Zhang G., Murray T.F., Grandy D.K. Orphanin FQ has an inhibitory effect on the guinea pig ileum and the mouse vas deferens. Brain Res. 772:1997;102-106.
53. Wang J.B., Johnson P.S., Imai Y., Persico A.M., Ozenberger B.A., Eppler C.M., Uhl G.R. cDNA cloning of an orphan opiate receptor gene family member and its splice variant. FEBS Lett. 348:1994;75-79.