A rescue factor for Alzheimer's diseases: Discovery activity structure, and mechanism

Current Medicinal Chemistry

Volumn 15, Issue 21, 2008, Pages 2086-2098

  Arakawa, T ^a   Kita, Y ^b   Niikura, T ^c  

^a ALLIANCE PROTEIN LABORATORIES   (United States)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ADNF; Alzheimer's disease; Circular dichroism; Colivelin; Humanin; Neuroprotection; Sedimentation analysis; Structure and function

Indexed keywords

AMYLOID BETA PROTEIN; BINDING PROTEIN; COLIVELIN; G PROTEIN COUPLED RECEPTOR; HUMANIN; HUMANIN BINDING PROTEIN; HUMANIN DERIVATIVE; NEUROPROTECTIVE AGENT; PROLYLALANYLGLYCYLALANYLSERYLCYSTEINYLLEUCYLLEUCYLLEUCYLLEUCYLTHREONYLGLYCYLGLUTAMYLISOLEUCYLASPARTYLLEUCYLPROLINE; UNCLASSIFIED DRUG; LIGAND; SIGNAL PEPTIDE;

ALZHEIMER DISEASE; BINDING AFFINITY; CELL DEATH; CELL STIMULATION; CHEMICAL MODIFICATION; COGNITIVE DEFECT; CONFORMATIONAL TRANSITION; DIMERIZATION; DRUG CLASSIFICATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; HUMAN; LIGAND BINDING; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; BINDING SITE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; GENETICS; NERVE CELL; PATHOLOGY; PROTEIN CONFORMATION;

ALZHEIMER DISEASE; ANIMALS; BINDING SITES; CELL DEATH; DRUG DESIGN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 54849164100     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986708785747616     Document Type: Review

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