Mechanisms of neuroprotection by a novel rescue factor humanin from swedish mutant amyloid precursor protein

Biochemical and Biophysical Research Communications

Volumn 283, Issue 2, 2001, Pages 460-468

  Hashimoto, Yuichi ^a   Ito, Yuko ^a   Niikura, Takako ^a   Shao, Zongjun ^a   Hata, Michihiro ^a   Oyama, Fumitaka ^b   Nishimoto, Ikuo ^a  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; COMPLEMENTARY DNA; POLYPEPTIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

EID: 0034805623     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4765     Document Type: Article

References (33)

1. Alzheimer's disease: Etiologies, pathophysiology, cognitive reserve, and treatment opportunities
2. Genes and susceptible loci of Alzheimer's disease
3. G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP
4. Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells
5. Death of PC12 cells and hippocampal neurons induced by adenoviral-mediated FAD human amyloid precursor protein gene expression
6. Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
7. Regulation of apoptosis by presenilin 1
8. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide
9. Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB
10. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
11. Characterization of human presenilin 1 transgenic rats: Increased sensitivity to apoptosis in primary neuronal cultures
12. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation
13. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis
14. Multiple mechanisms underlie neurotoxicity by different type Alzheimer's disease mutations of amyloid precursor protein
15. Functional cloning of genes involved in T-cell receptor-induced programmed cell death
16. A novel rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ
17. Antibody-regulated neurotoxic function of cell-surface β-amyloid precursor protein
18. Apoptotic cell death induced by β-amyloid 1-42 peptide is cell type dependent
19. Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells
20. Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachykinin neuropeptides
21. Suppression of mitochondrial succinate dehydrogenase, a primary target of β-amyloid, and its derivative racemized at Ser residue
22. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
23. Apoptosis is induced by β-amyloid in cultured central nervous system neurons
24. Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F·DP, in β-amyloid-induced neuronal death
25. A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor
26. +-ATPase activity in hippocampal neurons
27. Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity
28. Activity-dependent neurotrophic factor: Structure-activity relationships of femtomolar-acting peptides
29. 2+ accumulation
30. Alzheimer's disease: A central role for amyloid
31. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
32. Production of amyloid β protein from normal amyloid β-protein precursor (βAPP) and the mutated βAPPS linked to familial Alzheimer's disease
33. Prospects for pharmacological intervention in Alzheimer disease