A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults

European Journal of Neuroscience

Volumn 17, Issue 6, 2003, Pages 1150-1158

  Niikura, Takako ^a   Hashimoto, Yuichi ^a   Tajima, Hirohisa ^a   Ishizaka, Miho ^a   Yamagishi, Yohichi ^a   Kawasumi, Masaoki ^a   Nawa, Mikiro ^a   Terashita, Kenzo ^a   Also, Sadakazu ^a   Nishimoto, Ikuo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Neurodegeneration; Neuroprotective factor; Proteasome; RBCC; RING finger

Indexed keywords

CYSTEINE; GLUTATHIONE TRANSFERASE; HUMANIN; HYBRID PROTEIN; LIGASE; NEUROPROTECTIVE AGENT; PEPTIDE; PROTEASOME INHIBITOR; PROTEIN; TRIPARTITE MOTIF PROTEIN 11; UBIQUITIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL LEVEL; CONSENSUS SEQUENCE; CONTROLLED STUDY; MUTATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; TWO HYBRID SYSTEM; YEAST;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; ANIMALS; CARRIER PROTEINS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; NEUROPROTECTIVE AGENTS; POLYMERASE CHAIN REACTION; PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN; YEASTS;

EID: 0037363692     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02553.x     Document Type: Article

References (38)

1. Bauskin, A.R., Zhang, H.P., Fairlie, W.D., He, X.Y., Russell, P.K., Moore, A.G., Brown, D.A., Stanley, K.K. & Breit, S.N. (2000) The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1. EMBO J., 19, 2212-2220.
2. Bonifacino, J.S. & Weissman, A.M. (1998) Ubiquitination and the control of protein fate in the secretory and endocytic pathway. Annu. Rev. Cell Dev. Biol., 14, 19-57.
3. Borden, K.L. (1998) RING fingers and B-boxes: zinc-binding protein-protein interaction domains. Biochem. Cell Biol., 76, 351-358.
4. Borden, K.L. (2000) RING domains: master builders of molecular scaffolds? J. Mol. Biol., 295, 1103-1112.
5. Brodsky, J.L. & McCracken, A.A. (1997) ER-associated and proteasome mediated protein degradation: how two topologically restricted events came together. Trends Cell Biol., 7, 151-156.
6. Cao, T., Borden, K.L., Freemont, P.S. & Etkin, L.D. (1997) Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution. J. Cell Sci., 110, 1563-1571.
7. Cao, T., Duprez, E., Borden, K.L., Freemont, P.S. & Etkin, L.D. (1998) Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. J. Cell Sci., 111, 1319-1329.
8. Caricasole, A., Bruno, V., Cappuccio, I., Melchiorri, D., Copani, A. & Nicoletti, F. (2002) A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity. FASEB J., 16, 1331-1333.
9. Diamonti, J.A., Guy, P.M., Ivanof, C., Wong, K., Sweeney, C. & Carraway, K.L. III (2002) An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels. Proc. Natl Acad. Sci. USA, 99, 2866-2871.
10. Etkin, L.D., el-Hodiri, H.M., Nakamura, H., Wu, C.F., Shou, W. & Gong, S.G. (1997) Characterization and function of Xnf7 during early development of Xenopus. J. Cell. Physiol., 153, 144-146.
11. Fenteany, G., Standaert, R.F., Lane, W.S., Choi, S., Corey, E.J. & Schreiber, S.L. (1995) Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science, 268, 726-731.
12. Fisher, E.A., Zhou, M., Mitchell, D.M., Wu, X., Onuma, S., Wang, H., Goldberg, A.L. & Ginsberg, H.N. (1997) The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J. Biol. Chem., 272, 20427-20434.
13. Hashimoto, Y., Ito, Y., Niikura, T., Shao, Z., Hata, M., Oyama, F. & Nishimoto, I. (2001a) Mechanisms of neuroprotection by a novel rescue factor Humanin from Swedish mutant amyloid precursor protein. Biochem. Biophys. Res. Commun., 283, 460-468.
14. Hashimoto, Y., Niikura, T., Ito, Y., Sudo, H., Hata, M., Arakawa, E., Abe, Y., Kita, Y. & Nishimoto, I. (2001b) Detailed characterization of neuroprotection by a rescue factor Humanin against various Alzheimer's disease-relevant insults. J. Neurosci., 21, 9235-9245.
15. Hashimoto, Y., Niikura, T., Tajima, H., Yasukawa, T., Sudo, H., Ito, Y., Kita, Y., Kawasumi, M., Kouyama, K., Doyu, M., Sobue, G., Koide, T., Tsuji, S., Lang, J., Kurokawa, K. & Nishimoto, I. (2001c) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. Proc. Natl. Acad. Sci. USA, 98, 6336-6341. [Erratum in: Proc. Natl. Acad. Sci. USA, 98, 12854.]
16. Honda, T., Yasutake, K., Nihonmatsu, N., Mercken, M., Takahashi, H., Murayama, O., Murayama, M., Sato, K., Omori, A., Tsubuki, S., Saido, T.C. & Takashima, A. (1999) Dual roles of proteasome in the metabolism of presenilin 1. J. Neurochem., 72, 255-261.
17. Jensen, K., Shiels, C. & Freemont, P.S. (2001) PML protein isoforms and the RBCC/TRIM motif. Oncogene, 20, 7223-7233.
18. Joazeiro, C.A. & Weissman, A.M. (2000) RING finger proteins: mediators of ubiquitin ligase activity. Cell, 102, 549-552.
19. Joazeiro, C.A., Wing, S.S., Huang, H., Leverson, J.D., Hunter, T. & Liu, Y.C. (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin protein ligase. Science, 286, 309-312.
20. Kariya, S., Takahashi, N., Ooba, N., Kawahara, M., Nakayama, H. & Ueno, S. (2002) Humanin inhibits cell death of serum-deprived PC12h cells. Neuroreport, 13, 903-907.
21. Keller, J.N., Hanni, K.B. & Markesbery, W.R. (2000) Impaired proteasome function in Alzheimer's disease. J. Neurochem., 75, 436-439.
22. Lopez-Salon, M., Morelli, L., Castano, E.M., Soto, E.F. & Pasquini, J.M. (2000) Defective ubiquitination of cerebral proteins in Alzheimer's disease. J. Neurosci. Res., 62, 302-310.
23. Lorick, K.L., Jensen, J.P., Fang, S., Ong, A.M., Hatakeyama, S. & Weissman, A.M. (1999) RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl Acad. Sci. USA, 96, 11364-11369.
24. Mamiya, T. & Ukai, M. (2001) [Gly (14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo. Br. J. Pharmacol., 134, 1597-1599.
25. Marambaud, P., Chevallier, N., Barelli, H., Wilk, S. & Checler, F. (1997) Proteasome contributes to the alpha-secretase pathway of amyloid precursor protein in human cells. J. Neurochem., 68, 698-703.
26. Meerovitch, K., Wing, S. & Goltzman, D. (1998) Proparathyroid hormone-related protein is associated with the chaperone protein BiP and undergoes proteasome mediated degradation. J. Biol. Chem., 273, 21025-21030.
27. Perez, A., Kastner, P., Sethi, S., Lutz, Y., Reibel, C. & Chambon, P. (1993) PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR. EMBO J., 12, 3171-3182.
28. Pickart, C.M. (2001) Mechanisms underlying ubiquitination. Annu. Rev. Biochem., 70, 503-533.
29. Platika, D., Boulos, M.H., Baizer, L. & Fishman, M.C. (1985) Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells. Proc. Natl Acad. Sci. USA, 82, 3499-3503.
30. Reymond, A., Meroni, G., Fantozzi, A., Merla, G., Cairo, S., Luzi, L., Riganelli, D., Zanaria, E., Messali, S., Cainarca, S., Guffanti, A., Minucci, S., Pelicci, P.G. & Ballabio, A. (2001) The tripartite motif family identifies cell compartments. EMBO J., 20, 2140-2151.
31. Sakwe, A.M., Engstrom, A., Larsson, M. & Rask, L. (2002) Biosynthesis and secretion of parathyroid hormone are sensitive to proteasome inhibitors in dispersed bovine parathyroid cells. J. Biol. Chem., 277, 17687-17695.
32. Saurin, A.J., Borden, K.L., Boddy, M.N. & Freemont, P.S. (1996) Does this have a familiar RING? Trends Biochem. Sci., 21, 208-214.
33. Shou, W., Li, X., Wu, C., Cao, T., Kuang, J., Che, S. & Etkin, L.D. (1996) Finely tuned regulation of cytoplasmic retention of Xenopus nuclear factor 7 by phosphorylation of individual threonine residues. Mol. Cell. Biol., 16, 990-997.
34. Tajima, H., Niikura, T., Hashimoto, Y., Ito, Y., Kita, Y., Terashita, K., Yamazaki, K., Koto, A., Aiso, S. & Nishimoto, I. (2002) Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. Neurosci. Lett., 324, 227-231.
35. Trockenbacher, A., Suckow, V., Foerster, J., Winter, J., Krauss, S., Ropers, H.H., Schneider, R. & Schweiger, S. (2001) MID1, mutated in OpitZ. syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation. Nature Genet., 29, 287-294.
36. Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y. & Inoue, S. (2002) Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Nature, 417, 871-875.
37. Waterman, H., Levkowitz, G., Alroy, I. & Yarden, Y. (1999) The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J. Biol. Chem., 274, 22151-22154.
38. Yamagishi, Y., Hashimoto, Y., Niikura, T. & Nishimoto, I. (2003) Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease relevant insults. Peptides, In press.