Cholesterol and Alzheimer's disease;Koleszterin és Alzheimer-kór

Orvosi Hetilap

Volumn 146, Issue 37, 2005, Pages 1903-1911

  Kálmán, János ^a,b   Janka, Zoltán ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b NONE   (Hungary)

Author keywords

Alzheimer's disease; Amyloid protein; Apolipoprotein; Cholesterol; Raft

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; APOLIPOPROTEIN E4; BETA SECRETASE; CHOLESTEROL; CYTOCHROME P450; CYTOCHROME P450 CYP46A1; GAMMA SECRETASE; LIPOPROTEIN; UNCLASSIFIED DRUG; CHOLESTEROL 24 HYDROXYLASE; CHOLESTEROL 24-HYDROXYLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN CHOLESTEROL; STEROID MONOOXYGENASE;

ALLELE; ALZHEIMER DISEASE; BILAYER MEMBRANE; BLOOD BRAIN BARRIER; CELL MEMBRANE; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SPECIFICITY; GENETIC POLYMORPHISM; GLIA CELL; HUMAN; HUNGARY; LIPID COMPOSITION; LIPID RAFT; NERVE CELL; NIEMANN PICK DISEASE; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PROCESSING; REVIEW; BRAIN; GENETICS; METABOLISM; POINT MUTATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; APOLIPOPROTEINS E; BRAIN; CHOLESTEROL; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPOPROTEINS; NEURONS; NIEMANN-PICK DISEASES; POINT MUTATION; STEROID HYDROXYLASES;

EID: 33644662802     PISSN: 00306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (50)

1. Beffert, U., Poirier, J.: Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease. Ann. N. Y. Acad. Sci., 1996, 777, 166-174.
2. Bjorkhem, I., Lutjohann, D., Breuer, O. és mtsai: Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro. J. Biol. Chem., 1997, 272, 30178-30184.
3. Bogdanovic, N., Bretillon, L., Lund, E. G. és mtsai: On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. Neurosci. Lett., 2001, 13, 45-48.
4. Bouillot, C., A. Prochiantz, G. Rougon, B.: Allinquant. Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties. J. Biol. Chem., 1996, 271, 7640-7644.
5. Boyles, J. K., Pitas, R. E., Wilson, E. és mtsai: Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J. Clin. Invest., 1985, 76, 1501-1513.
6. Brugger, B., Sandhoff, R., Wegehingel, S. és mtsai: Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J. Cell. Biol., 2000, 30, 507-518.
7. Caselli, R. J., Reiman, E. M., Osborne, D. és mtsai: Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele. Neurology, 2004, 62, 1990-1995.
8. Császár A.: Az apolipoprotein E genetikai polimorfizmus klinikai jenetosége, és kapcsolata az atherogenezissel. Lege Artis Med., 1993, 3, 704-714.
9. Császár, A., Kálmán, J., Szalai, Cs. és mtsai: Association of the apolipoprotein A-IV codon 360 mutation with Alzheimer's disease. Neurosci. Lett., 1997, 230, 1-4.
10. Dietschy, J. M., Turley, S. D.: Cholesterol metabolism in the brain. Curr. Opin. Lipidol., 2001, 12, 105-112.
11. Edidin, M.: The state of lipid rafts: from model membranes to cells. Annu. Rev. Biophys. Biomol. Struct., 2003, 32, 257-283.
12. Fassbender, K. M., Simons, C., Bergmann, M. és mtsai: Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc. Natl. Acad. Sci. USA. 2001, 98, 5856-5861.
13. Haass, C., Selkoe, D. J.: Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell. 1993, 17, 1039-1042.
14. Han, S. H., Hulette, C., Saunders, A. M. és mtsai: Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Exp. Neurol., 1994, 128, 13-26.
15. Hardy, J. A., Higgins, G. A.: Alzheimer's disease: the amyloid cascade hypothesis. Science., 1992, 10, 184-185.
16. Hofman, A., Ott, A., Breteler, M. M. és mtsai: Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study. Lancet., 1997, 18, 151-154.
17. Hewlett, D. R., Simmons, D. L, Dingwall, C. és mtsai: In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase. Trends Neurosci., 2000, 23, 565-570.
18. Kabara, J. J.: A critical review of brain cholesterol metabolism. Prog. Brain Res., 1973, 40, 363-382.
19. Kálmán, J., Dey, I., Varga, I. és mtsai: Platelet membrane fluidity and plasma malondialdehyde levels in Alzheimer's demented patients with and without family history of dementia. Biol. Psychiat., 1994, 35, 190-194.
20. Kálmán, J., Juhász, A., Császár, A. és mtsai: Apolipoprotein E allele frequencies in patients with late-onset Alzheimer's disease in Hungary. Acta Neurol. Scand., 1997, 95, 56-59.
21. Kálmán, J., Juhász, A., Császár, A. és mtsai: Increased apolipoprotein E4 allele frequency is associated with vascular dementia in the Hungarian population. Acta Neurol. Scand., 1998, 98, 166-168.
22. Kálmán, J., Kudchodkar, B. J., Murray, K. és mtsai: Evaluation of serum lipid related cardiovascular risk factors in Alzheimer's disease. Dement. Geriatr. Cogn. Disord., 1999, 10, 488-493.
23. Kálmán, J., Juhász, A., Rimanóczy, A. és mtsai: Increased apolipoprotein E4 allele frequency is associated with Pick's dementia, but not with Huntington's disease. Neurobiol. Aging., 2000, 21, 555-558.
24. Kálmán, J., Kudchodkar, B. J., Krishnamoorthy, R. és mtsai: High cholesterol diet down regulates the activity of activator protein-1 but not nuclear factor-kappa B in rabbit brain. Life Sci., 2001, 68, 495-503.
25. Kálmán, J., Juhász, A., Rimanóczy, Á. és mtsai: Lack of influence of the apolipoprotein E genotype on the outcome of selegiline treatment in Alzheimer's disease. Dement. Geriatr. Cogn. Disord., 2003, 16, 31-34.
26. Kolsch, H., Lutjohann, D., Ludwig, M. és mtsai: Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. Mol. Psychiatry., 2002, 7, 899-902.
27. Liscum, L., Klansek, J. J.: Niemann-Pick disease type C. Curr. Opin. Lipidol., 1998, 9, 131-135.
28. Mahley, R. W.: Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science, 1988, 240, 622-630.
29. Nathan, B. P., Bellasta, S., Sanan, D. A. és mtsai: Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science., 1994, 264, 850-852.
30. Németh A., Urbanics K., Tariska P. és mtsai: Az Alzheimer-dementia molekuláris genetikai markerei. Orv. Hetil., 1995, 36, 1931-1935.
31. Papassotiropoulos, A., Lutjohann, D., Bagli, M. és mtsai: Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease. Neuroreport., 2000, 26, 1959-1962.
32. Papassotiropoulos, A., Lutjohann, D., Bagli, M. és mtsai: 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. J Psychiat. Res., 2002, 36, 27-32.
33. Racchi, M., Baetta, R., Salvietti, N. és mtsai: Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content. Biochem. J., 1997, 322, 893-898.
34. Roheim, P. S., Carey, M., Forte, T. és mtsai: Apolipoproteins in human cerebrospinal fluid. Proc. Natl. Acad. Sci. USA. 1979, 76, 4646-4649.
35. Roses, A. D., Saunders, A. M., Corder, E. H. és mtsai: Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease. Arzneimittelforschung, 1995, 45, 413-417.
36. Sankaram, M. B., Thompson, T. E.: Modulation of phospholipid acyl chain order by cholesterol. A solid-state 2H nuclear magnetic resonance study. Biochemistry, 1990, 29, 10676-10684.
37. Schmechel, D. E., Saunders, A. M., Strittmatter, W. J. és mtsai: Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA. 1993, 90, 9649-9653.
38. Selkoe, D. J.: Normal and abnormal biology of the beta-amyloid precursor protein. Annu. Rev. Neurosci., 1994, 17, 489-517.
39. Simons, K., Ikonen, E.: Functional rafts in cell membranes. Nature, 1997, 387, 569-572.
40. Simons, M., Keller, P., Strooper, B. D. és mtsai: Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc. Natl. Acad. Sci. USA. 1998, 95, 6460-6464.
41. Simons, K., Toomre, D.: Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol., 2000, 1, 31-39.
42. Sing, C. F., Davignon, J.: Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am. J. Hum. Genet., 1985, 37, 268-285.
43. Smart, E., Graf, J. G. A., McNiven, M. A., és mtsai: Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell Biol., 1999, 19, 7289-7304.
44. Smith, J. D.: Apolipoprotein E4: an allele associated with many diseases. Ann. Med., 2000, 32, 118-127.
45. Sparks, D. L.: Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease? Ann. N. Y. Acad. Sci., 1997, 826, 128-146.
46. Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y. és mtsai: Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA. 1993, 90, 8098-8102.
47. Vanier, M. T., Duthel, S., Rodriguez-Lafrasse, C. és mtsai: Genetic heterogeneity in Niemann-Pick C disease: a study using somatic cell hybridization and linkage analysis. Am. J. Hum. Genet., 1996, 58, 118-125.
48. Weisgraber, K. H., Mahley, R. W.: Human apolipoprotein E: the Alzheimer's disease connection. FASEB J. 1996, 10, 1485-1494.
49. Yao, Z. X., Papadopoulos, V.: Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity. FASEB J., 2002, 16, 1677-1679.
50. Zannis, V. I., Breslow, J. L.: Human very low density lipoprotein apolipoprotcein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. Biochemistry, 1981, 20, 1033-1041.