-
1
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
S. Artavanis-Tsakonas, M.D. Rand, and R.J. Lake Notch signaling: cell fate control and signal integration in development Science 284 1999 770 776
-
(1999)
Science
, vol.284
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
3
-
-
0344824688
-
Modulation of Notch Signaling during Somitogenesis
-
G. Weinmaster, and C. Kintner Modulation of Notch Signaling During Somitogenesis Annu Rev Cell Dev Biol 19 2003 367 395
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, pp. 367-395
-
-
Weinmaster, G.1
Kintner, C.2
-
4
-
-
1642382833
-
Notch signaling: Control of cell communication and cell fate
-
E.C. Lai Notch signaling: control of cell communication and cell fate Development 131 2004 965 973
-
(2004)
Development
, vol.131
, pp. 965-973
-
-
Lai, E.C.1
-
5
-
-
0842324623
-
Multiple niches for Notch in cancer: Context is everything
-
A.P. Weng, and J.C. Aster Multiple niches for Notch in cancer: context is everything Curr Opin Genet Dev 14 2004 48 54
-
(2004)
Curr Opin Genet Dev
, vol.14
, pp. 48-54
-
-
Weng, A.P.1
Aster, J.C.2
-
6
-
-
1642344776
-
Anchoring notch genetics and biochemistry; Structural analysis of the ankyrin domain sheds light on existing data
-
O.Y. Lubman, S.V. Korolev, and R. Kopan Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data Mol Cell 13 2004 619 626
-
(2004)
Mol Cell
, vol.13
, pp. 619-626
-
-
Lubman, O.Y.1
Korolev, S.V.2
Kopan, R.3
-
7
-
-
0033868818
-
A Novel Proteolytic Cleavage Involved in Notch Signaling: The Role of the Disintegrin-Metalloprotease TACE
-
C. Brou, F. Logeat, N. Gupta, C. Bessia, O. LeBail, J.R. Doedens, A. Cumano, P. Roux, R.A. Black, and A. Israel A Novel Proteolytic Cleavage Involved in Notch Signaling: The Role of the Disintegrin-Metalloprotease TACE Mol Cell 5 2000 207 216
-
(2000)
Mol Cell
, vol.5
, pp. 207-216
-
-
Brou, C.1
Logeat, F.2
Gupta, N.3
Bessia, C.4
Lebail, O.5
Doedens, J.R.6
Cumano, A.7
Roux, P.8
Black, R.A.9
Israel, A.10
-
8
-
-
0033867521
-
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
-
J.S. Mumm, E.H. Schroeter, M.T. Saxena, A. Griesemer, X. Tian, D.J. Pan, W.J. Ray, and R. Kopan A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1 Mol Cell 5 2000 197 206
-
(2000)
Mol Cell
, vol.5
, pp. 197-206
-
-
Mumm, J.S.1
Schroeter, E.H.2
Saxena, M.T.3
Griesemer, A.4
Tian, X.5
Pan, D.J.6
Ray, W.J.7
Kopan, R.8
-
9
-
-
0029085935
-
Signalling downstream of activated mammalian Notch
-
S. Jarriault, C. Brou, F. Logeat, E.H. Schroeter, R. Kopan, and A. Israel Signalling downstream of activated mammalian Notch Nature 377 1995 355 358
-
(1995)
Nature
, vol.377
, pp. 355-358
-
-
Jarriault, S.1
Brou, C.2
Logeat, F.3
Schroeter, E.H.4
Kopan, R.5
Israel, A.6
-
10
-
-
0032145527
-
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
-
H.Y. Kao, P. Ordentlich, N. Koyano-Nakagawa, Z. Tang, M. Downes, C.R. Kintner, R.M. Evans, and T. Kadesch A histone deacetylase corepressor complex regulates the Notch signal transduction pathway Genes Dev 12 1998 2269 2277
-
(1998)
Genes Dev
, vol.12
, pp. 2269-2277
-
-
Kao, H.Y.1
Ordentlich, P.2
Koyano-Nakagawa, N.3
Tang, Z.4
Downes, M.5
Kintner, C.R.6
Evans, R.M.7
Kadesch, T.8
-
11
-
-
0033524444
-
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
-
J.J. Hsieh, S. Zhou, L. Chen, D.B. Young, and S.D. Hayward CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex Proc Natl Acad Sci USA 96 1999 23 28
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 23-28
-
-
Hsieh, J.J.1
Zhou, S.2
Chen, L.3
Young, D.B.4
Hayward, S.D.5
-
12
-
-
0034073379
-
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function
-
S. Zhou, M. Fujimuro, J.J. Hsieh, L. Chen, A. Miyamoto, G. Weinmaster, and S.D. Hayward SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function Mol Cell Biol 20 2000 2400 2410
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2400-2410
-
-
Zhou, S.1
Fujimuro, M.2
Hsieh, J.J.3
Chen, L.4
Miyamoto, A.5
Weinmaster, G.6
Hayward, S.D.7
-
13
-
-
0033662392
-
MAML1, a human homologue of drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
-
L. Wu, J.C. Aster, S.C. Blacklow, R. Lake, S. Artavanis-Tsakonas, and J.D. Griffin MAML1, a human homologue of drosophila mastermind, is a transcriptional co-activator for NOTCH receptors Nat Genet 26 2000 484 489
-
(2000)
Nat Genet
, vol.26
, pp. 484-489
-
-
Wu, L.1
Aster, J.C.2
Blacklow, S.C.3
Lake, R.4
Artavanis-Tsakonas, S.5
Griffin, J.D.6
-
14
-
-
0036606776
-
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
-
C.J. Fryer, E. Lamar, I. Turbachova, C. Kintner, and K.A. Jones Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex Genes Dev 16 2002 1397 1411
-
(2002)
Genes Dev
, vol.16
, pp. 1397-1411
-
-
Fryer, C.J.1
Lamar, E.2
Turbachova, I.3
Kintner, C.4
Jones, K.A.5
-
15
-
-
0036096912
-
Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line
-
S. Jeffries, D.J. Robbins, and A.J. Capobianco Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line Mol Cell Biol 22 2002 3927 3941
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3927-3941
-
-
Jeffries, S.1
Robbins, D.J.2
Capobianco, A.J.3
-
16
-
-
0036840497
-
P300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro
-
A.E. Wallberg, K. Pedersen, U. Lendahl, and R.G. Roeder p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro Mol Cell Biol 22 2002 7812 7819
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7812-7819
-
-
Wallberg, A.E.1
Pedersen, K.2
Lendahl, U.3
Roeder, R.G.4
-
17
-
-
0038079817
-
Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex
-
Y. Nam, A.P. Weng, J.C. Aster, and S.C. Blacklow Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex J Biol Chem 278 2003 21232 21239
-
(2003)
J Biol Chem
, vol.278
, pp. 21232-21239
-
-
Nam, Y.1
Weng, A.P.2
Aster, J.C.3
Blacklow, S.C.4
-
18
-
-
0033577768
-
Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors
-
J. Bash, W.X. Zong, S. Banga, A. Rivera, D.W. Ballard, Y. Ron, and C. Gelinas Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors EMBO J 18 1999 2803 2811
-
(1999)
EMBO J
, vol.18
, pp. 2803-2811
-
-
Bash, J.1
Zong, W.X.2
Banga, S.3
Rivera, A.4
Ballard, D.W.5
Ron, Y.6
Gelinas, C.7
-
19
-
-
18544384874
-
The p53 family member genes are involved in the Notch signal pathway
-
Y. Sasaki, S. Ishida, I. Morimoto, T. Yamashita, T. Kojima, C. Kihara, T. Tanaka, K. Imai, Y. Nakamura, and T. Tokino The p53 family member genes are involved in the Notch signal pathway J Biol Chem 277 2002 719 724
-
(2002)
J Biol Chem
, vol.277
, pp. 719-724
-
-
Sasaki, Y.1
Ishida, S.2
Morimoto, I.3
Yamashita, T.4
Kojima, T.5
Kihara, C.6
Tanaka, T.7
Imai, K.8
Nakamura, Y.9
Tokino, T.10
-
20
-
-
0035651380
-
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. [see comments]
-
E.C. Lai, G.A. Deblandre, C. Kintner, and G.M. Rubin Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. [see comments] Dev Cell 1 2001 783 794
-
(2001)
Dev Cell
, vol.1
, pp. 783-794
-
-
Lai, E.C.1
Deblandre, G.A.2
Kintner, C.3
Rubin, G.M.4
-
21
-
-
0035650895
-
Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signalling. [see comments]
-
G.A. Deblandre, E.C. Lai, and C. Kintner Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signalling. [see comments] Dev Cell 1 2001 795 806
-
(2001)
Dev Cell
, vol.1
, pp. 795-806
-
-
Deblandre, G.A.1
Lai, E.C.2
Kintner, C.3
-
22
-
-
0035975961
-
Neuralized functions as an E3 ubiquitin ligase during Drosophila development
-
E. Yeh, M. Dermer, C. Commisso, L. Zhou, C.J. McGlade, and G.L. Boulianne Neuralized functions as an E3 ubiquitin ligase during Drosophila development Curr Biol 11 2001 1675 1679
-
(2001)
Curr Biol
, vol.11
, pp. 1675-1679
-
-
Yeh, E.1
Dermer, M.2
Commisso, C.3
Zhou, L.4
McGlade, C.J.5
Boulianne, G.L.6
-
23
-
-
0037238008
-
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
-
M. Itoh, C.H. Kim, G. Palardy, T. Oda, Y.J. Jiang, D. Maust, S.Y. Yeo, K. Lorick, G.J. Wright, and L. Ariza-McNaughton Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta Dev Cell 4 2003 67 82
-
(2003)
Dev Cell
, vol.4
, pp. 67-82
-
-
Itoh, M.1
Kim, C.H.2
Palardy, G.3
Oda, T.4
Jiang, Y.J.5
Maust, D.6
Yeo, S.Y.7
Lorick, K.8
Wright, G.J.9
Ariza-Mcnaughton, L.10
-
24
-
-
0031573944
-
Requirement for dynamin during Notch signaling in Drosophila neurogenesis
-
L. Seugnet, P. Simpson, and M. Haenlin Requirement for dynamin during Notch signaling in Drosophila neurogenesis Dev Biol 192 1997 585 598
-
(1997)
Dev Biol
, vol.192
, pp. 585-598
-
-
Seugnet, L.1
Simpson, P.2
Haenlin, M.3
-
25
-
-
0034051852
-
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
-
A.L. Parks, K.M. Klueg, J.R. Stout, and M.A. Muskavitch Ligand endocytosis drives receptor dissociation and activation in the Notch pathway Development 127 2000 1373 1385
-
(2000)
Development
, vol.127
, pp. 1373-1385
-
-
Parks, A.L.1
Klueg, K.M.2
Stout, J.R.3
Muskavitch, M.A.4
-
26
-
-
0038686503
-
Unequal segregation of Neuralized biases Notch activation during asymmetric cell division
-
R. Le Borgne, and F. Schweisguth Unequal segregation of Neuralized biases Notch activation during asymmetric cell division Dev Cell 5 2003 139 148
-
(2003)
Dev Cell
, vol.5
, pp. 139-148
-
-
Le Borgne, R.1
Schweisguth, F.2
-
27
-
-
0141995063
-
Glycosylation regulates Notch signalling
-
N. Haines, and K.D. Irvine Glycosylation regulates Notch signalling Nat Rev Mol Cell Biol 4 2003 786 797
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 786-797
-
-
Haines, N.1
Irvine, K.D.2
-
28
-
-
0001395691
-
Fringe is a glycosyltransferase that modifies Notch
-
D.J. Moloney, V.M. Panin, S.H. Johnston, J. Chen, L. Shao, R. Wilson, Y. Wang, P. Stanley, K.D. Irvine, and R.S. Haltiwanger Fringe is a glycosyltransferase that modifies Notch Nature 406 2000 369 375
-
(2000)
Nature
, vol.406
, pp. 369-375
-
-
Moloney, D.J.1
Panin, V.M.2
Johnston, S.H.3
Chen, J.4
Shao, L.5
Wilson, R.6
Wang, Y.7
Stanley, P.8
Irvine, K.D.9
Haltiwanger, R.S.10
-
29
-
-
0034253589
-
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
-
C. Hicks, S.H. Johnston, G. diSibio, A. Collazo, T.F. Vogt, and G. Weinmaster Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2 Nat Cell Biol 2 2000 515 520
-
(2000)
Nat Cell Biol
, vol.2
, pp. 515-520
-
-
Hicks, C.1
Johnston, S.H.2
Disibio, G.3
Collazo, A.4
Vogt, T.F.5
Weinmaster, G.6
-
30
-
-
0035955684
-
Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase
-
Y. Wang, L. Shao, S. Shi, R.J. Harris, M.W. Spellman, P. Stanley, and R.S. Haltiwanger Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase J Biol Chem 276 2001 40338 40345
-
(2001)
J Biol Chem
, vol.276
, pp. 40338-40345
-
-
Wang, Y.1
Shao, L.2
Shi, S.3
Harris, R.J.4
Spellman, M.W.5
Stanley, P.6
Haltiwanger, R.S.7
-
31
-
-
0141991292
-
Neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions
-
T. Sasamura, N. Sasaki, F. Miyashita, S. Nakao, H.O. Ishikawa, M. Ito, M. Kitagawa, K. Harigaya, E. Spana, and D. Bilder neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions Development 130 2003 4785 4795
-
(2003)
Development
, vol.130
, pp. 4785-4795
-
-
Sasamura, T.1
Sasaki, N.2
Miyashita, F.3
Nakao, S.4
Ishikawa, H.O.5
Ito, M.6
Kitagawa, M.7
Harigaya, K.8
Spana, E.9
Bilder, D.10
-
32
-
-
0141922141
-
Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe
-
T. Okajima, A. Xu, and K.D. Irvine Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe J Biol Chem 278 2003 42340 42345
-
(2003)
J Biol Chem
, vol.278
, pp. 42340-42345
-
-
Okajima, T.1
Xu, A.2
Irvine, K.D.3
-
33
-
-
0346505185
-
An O-fucose site in the ligand binding domain inhibits Notch activation
-
L. Lei, A. Xu, V.M. Panin, and K.D. Irvine An O-fucose site in the ligand binding domain inhibits Notch activation Development 130 2003 6411 6421
-
(2003)
Development
, vol.130
, pp. 6411-6421
-
-
Lei, L.1
Xu, A.2
Panin, V.M.3
Irvine, K.D.4
-
34
-
-
0033974972
-
Calcium depletion dissociates and activates heterodimeric notch receptors
-
M.D. Rand, L.M. Grimm, S. Artavanis-Tsakonas, V. Patriub, S.C. Blacklow, J. Sklar, and J.C. Aster Calcium depletion dissociates and activates heterodimeric notch receptors Mol Cell Biol 20 2000 1825 1835
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1825-1835
-
-
Rand, M.D.1
Grimm, L.M.2
Artavanis-Tsakonas, S.3
Patriub, V.4
Blacklow, S.C.5
Sklar, J.6
Aster, J.C.7
-
35
-
-
0347192982
-
Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination
-
+-ATPase generated a gradient of calcium ions and that this gradient was ultimately responsible for the asymmetric activation of Notch. Co-culture experiments confirmed that Notch's ability to signal in response to Delta is proportional to the concentration of calcium ions.
-
(2004)
Nature
, vol.427
, pp. 121-128
-
-
Raya, A.1
Kawakami, Y.2
Rodriguez-Esteban, C.3
Ibanes, M.4
Rasskin-Gutman, D.5
Rodriguez-Leon, J.6
Buscher, D.7
Feijo, J.A.8
Izpisua Belmonte, J.C.9
-
36
-
-
10744233414
-
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
-
Q.D. Hu, B.T. Ang, M. Karsak, W.P. Hu, X.Y. Cui, T. Duka, Y. Takeda, W. Chia, N. Sankar, and Y.K. Ng F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation Cell 115 2003 163 175 Here, it is demonstrated that F3/contactin can bind to Notch on oligodendrocyte precursor cells and this leads to the generation of NICD. Whereas Notch signaling from Jagged leads to an inhibition of oligodendrocyte differentiation, signaling from F3/contactin promoted differentiation, suggesting the existence of two distinct pathways. In support of this, the group showed that dominant-negative forms of CSL did not block the effects of F3/contactin, and NICD alone could not recapitulate the effects of F3/contactin.
-
(2003)
Cell
, vol.115
, pp. 163-175
-
-
Hu, Q.D.1
Ang, B.T.2
Karsak, M.3
Hu, W.P.4
Cui, X.Y.5
Duka, T.6
Takeda, Y.7
Chia, W.8
Sankar, N.9
Ng, Y.K.10
-
37
-
-
2942554826
-
NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes
-
X.Y. Cui, Q.D. Hu, M. Tekaya, Y. Shimoda, B.T. Ang, D.Y. Nie, L. Sun, W.P. Hu, M. Karsak, and T. Duka NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes J Biol Chem 2004
-
(2004)
J Biol Chem
-
-
Cui, X.Y.1
Hu, Q.D.2
Tekaya, M.3
Shimoda, Y.4
Ang, B.T.5
Nie, D.Y.6
Sun, L.7
Hu, W.P.8
Karsak, M.9
Duka, T.10
-
38
-
-
0032915458
-
Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts
-
D. Nofziger, A. Miyamoto, K.M. Lyons, and G. Weinmaster Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts Development 126 1999 1689 1702
-
(1999)
Development
, vol.126
, pp. 1689-1702
-
-
Nofziger, D.1
Miyamoto, A.2
Lyons, K.M.3
Weinmaster, G.4
-
39
-
-
0035862738
-
Ligand-induced signaling in the absence of furin processing of Notch1
-
G. Bush, G. diSibio, A. Miyamoto, J.B. Denault, R. Leduc, and G. Weinmaster Ligand-induced signaling in the absence of furin processing of Notch1 Dev Biol 229 2001 494 502
-
(2001)
Dev Biol
, vol.229
, pp. 494-502
-
-
Bush, G.1
Disibio, G.2
Miyamoto, A.3
Denault, J.B.4
Leduc, R.5
Weinmaster, G.6
-
40
-
-
0032923759
-
Processing of the notch ligand delta by the metalloprotease Kuzbanian
-
H. Qi, M.D. Rand, X. Wu, N. Sestan, W. Wang, P. Rakic, T. Xu, and S. Artavanis-Tsakonas Processing of the notch ligand delta by the metalloprotease Kuzbanian Science 283 1999 91 94
-
(1999)
Science
, vol.283
, pp. 91-94
-
-
Qi, H.1
Rand, M.D.2
Wu, X.3
Sestan, N.4
Wang, W.5
Rakic, P.6
Xu, T.7
Artavanis-Tsakonas, S.8
-
42
-
-
0442294193
-
The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins
-
N. Chen, and I. Greenwald The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins Dev Cell 6 2004 183 192 In an attempt to identify the source of the lateral signal that specifies vulval precursor cells, Chen and Greenwald computationally identified several DSL proteins encoded by the C. elegans genome. One of these, encoded by dsl-1, lacks a transmembrane domain, yet meets the genetic criteria of a bona fide Notch ligand.
-
(2004)
Dev Cell
, vol.6
, pp. 183-192
-
-
Chen, N.1
Greenwald, I.2
-
43
-
-
0035943685
-
Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype
-
D. Small, D. Kovalenko, D. Kacer, L. Liaw, M. Landriscina, C. Di Serio, I. Prudovsky, and T. Maciag Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype J Biol Chem 276 2001 32022 32030
-
(2001)
J Biol Chem
, vol.276
, pp. 32022-32030
-
-
Small, D.1
Kovalenko, D.2
Kacer, D.3
Liaw, L.4
Landriscina, M.5
Di Serio, C.6
Prudovsky, I.7
MacIag, T.8
-
44
-
-
0141817915
-
The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments
-
M.J. LaVoie, and D.J. Selkoe The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments J Biol Chem 278 2003 34427 34437 LaVoie and Selkoe show that Delta and Jagged can each be proteolyzed sequentially to generate a C-terminal fragment, in a manner similar to that observed for the Notch receptor. Interestingly, these C-terminal fragments can enter the nucleus where they may affect transcription.
-
(2003)
J Biol Chem
, vol.278
, pp. 34427-34437
-
-
Lavoie, M.J.1
Selkoe, D.J.2
-
45
-
-
0037648484
-
Notch-induced proteolysis and nuclear localization of the Delta ligand
-
C.E. Bland, P. Kimberly, and M.D. Rand Notch-induced proteolysis and nuclear localization of the Delta ligand J Biol Chem 278 2003 13607 13610
-
(2003)
J Biol Chem
, vol.278
, pp. 13607-13610
-
-
Bland, C.E.1
Kimberly, P.2
Rand, M.D.3
-
46
-
-
0037468759
-
The role of presenilin cofactors in the gamma-secretase complex
-
N. Takasugi, T. Tomita, I. Hayashi, M. Tsuruoka, M. Niimura, Y. Takahashi, G. Thinakaran, and T. Iwatsubo The role of presenilin cofactors in the gamma-secretase complex Nature 422 2003 438 441
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
Tsuruoka, M.4
Niimura, M.5
Takahashi, Y.6
Thinakaran, G.7
Iwatsubo, T.8
-
47
-
-
0038360879
-
Different cofactor activities in gamma-secretase assembly: Evidence for a nicastrin-Aph-1 subcomplex
-
Y. Hu, and M.E. Fortini Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex J Cell Biol 161 2003 685 690
-
(2003)
J Cell Biol
, vol.161
, pp. 685-690
-
-
Hu, Y.1
Fortini, M.E.2
-
48
-
-
0037332254
-
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway
-
-/- cells. Given the known effect of Notch on these cells, this is the result expected if MINT acts as an inhibitor of Notch signaling in vivo.
-
(2003)
Immunity
, vol.18
, pp. 301-312
-
-
Kuroda, K.1
Han, H.2
Tani, S.3
Tanigaki, K.4
Tun, T.5
Furukawa, T.6
Taniguchi, Y.7
Kurooka, H.8
Hamada, Y.9
Toyokuni, S.10
-
49
-
-
0036682974
-
Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
-
S. Barolo, T. Stone, A.G. Bang, and J.W. Posakony Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless Genes Dev 16 2002 964 976
-
(2002)
Genes Dev
, vol.16
, pp. 964-976
-
-
Barolo, S.1
Stone, T.2
Bang, A.G.3
Posakony, J.W.4
-
50
-
-
0035425232
-
Nrarp is a novel intracellular component of the Notch signaling pathway
-
E. Lamar, G. Deblandre, D. Wettstein, V. Gawantka, N. Pollet, C. Niehrs, and C. Kintner Nrarp is a novel intracellular component of the Notch signaling pathway Genes Dev 15 2001 1885 1899
-
(2001)
Genes Dev
, vol.15
, pp. 1885-1899
-
-
Lamar, E.1
Deblandre, G.2
Wettstein, D.3
Gawantka, V.4
Pollet, N.5
Niehrs, C.6
Kintner, C.7
-
51
-
-
0035476460
-
The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway
-
L.T. Krebs, M.L. Deftos, M.J. Bevan, and T. Gridley The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway Dev Biol 238 2001 110 119
-
(2001)
Dev Biol
, vol.238
, pp. 110-119
-
-
Krebs, L.T.1
Deftos, M.L.2
Bevan, M.J.3
Gridley, T.4
-
52
-
-
0037606092
-
Notch-regulated ankyrin-repeat protein inhibits notch1 signaling: Multiple notch1 signaling pathways involved in T cell development
-
T.J. Yun, and M.J. Bevan Notch-regulated ankyrin-repeat protein inhibits notch1 signaling: multiple notch1 signaling pathways involved in T cell development J Immunol 170 2003 5834 5841
-
(2003)
J Immunol
, vol.170
, pp. 5834-5841
-
-
Yun, T.J.1
Bevan, M.J.2
-
53
-
-
0030200217
-
Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis
-
W. Zhong, J.N. Feder, M.M. Jiang, L.Y. Jan, and Y.N. Jan Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis Neuron 17 1996 43 53
-
(1996)
Neuron
, vol.17
, pp. 43-53
-
-
Zhong, W.1
Feder, J.N.2
Jiang, M.M.3
Jan, L.Y.4
Jan, Y.N.5
-
54
-
-
0030199973
-
Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch
-
M. Guo, L.Y. Jan, and Y.N. Jan Control of daughter cell fates during asymmetric division: interaction of Numb and Notch Neuron 17 1996 27 41
-
(1996)
Neuron
, vol.17
, pp. 27-41
-
-
Guo, M.1
Jan, L.Y.2
Jan, Y.N.3
-
55
-
-
0030199995
-
Numb antagonizes Notch signaling to specify sibling neuron cell fates
-
E.P. Spana, and C.Q. Doe Numb antagonizes Notch signaling to specify sibling neuron cell fates Neuron 17 1996 21 26
-
(1996)
Neuron
, vol.17
, pp. 21-26
-
-
Spana, E.P.1
Doe, C.Q.2
-
56
-
-
0036696444
-
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila
-
D. Berdnik, T. Torok, M. Gonzalez-Gaitan, and J.A. Knoblich The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila Dev Cell 3 2002 221 231
-
(2002)
Dev Cell
, vol.3
, pp. 221-231
-
-
Berdnik, D.1
Torok, T.2
Gonzalez-Gaitan, M.3
Knoblich, J.A.4
-
57
-
-
0037663379
-
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
-
M.A. McGill, and C.J. McGlade Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain J Biol Chem 278 2003 23196 23203
-
(2003)
J Biol Chem
, vol.278
, pp. 23196-23203
-
-
McGill, M.A.1
McGlade, C.J.2
-
58
-
-
0037155232
-
HERP1 is a cell type-specific primary target of Notch
-
T. Iso, G. Chung, Y. Hamamori, and L. Kedes HERP1 is a cell type-specific primary target of Notch J Biol Chem 277 2002 6598 6607
-
(2002)
J Biol Chem
, vol.277
, pp. 6598-6607
-
-
Iso, T.1
Chung, G.2
Hamamori, Y.3
Kedes, L.4
-
59
-
-
0034791336
-
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
-
G. Wu, S. Lyapina, I. Das, J. Li, M. Gurney, A. Pauley, I. Chui, R.J. Deshaies, and J. Kitajewski SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation Mol Cell Biol 21 2001 7403 7415
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7403-7415
-
-
Wu, G.1
Lyapina, S.2
Das, I.3
Li, J.4
Gurney, M.5
Pauley, A.6
Chui, I.7
Deshaies, R.J.8
Kitajewski, J.9
-
60
-
-
0033561365
-
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation
-
T. Ohtsuka, M. Ishibashi, G. Gradwohl, S. Nakanishi, F. Guillemot, and R. Kageyama Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation EMBO J 18 1999 2196 2207
-
(1999)
EMBO J
, vol.18
, pp. 2196-2207
-
-
Ohtsuka, T.1
Ishibashi, M.2
Gradwohl, G.3
Nakanishi, S.4
Guillemot, F.5
Kageyama, R.6
-
61
-
-
18544404101
-
Control of endodermal endocrine development by Hes-1
-
J. Jensen, E.E. Pedersen, P. Galante, J. Hald, R.S. Heller, M. Ishibashi, R. Kageyama, F. Guillemot, P. Serup, and O.D. Madsen Control of endodermal endocrine development by Hes-1 Nat Genet 24 2000 36 44
-
(2000)
Nat Genet
, vol.24
, pp. 36-44
-
-
Jensen, J.1
Pedersen, E.E.2
Galante, P.3
Hald, J.4
Heller, R.S.5
Ishibashi, M.6
Kageyama, R.7
Guillemot, F.8
Serup, P.9
Madsen, O.D.10
-
62
-
-
0346727348
-
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
-
R. Sumazaki, N. Shiojiri, S. Isoyama, M. Masu, K. Keino-Masu, M. Osawa, H. Nakauchi, R. Kageyama, and A. Matsui Conversion of biliary system to pancreatic tissue in Hes1-deficient mice Nat Genet 36 2004 83 87
-
(2004)
Nat Genet
, vol.36
, pp. 83-87
-
-
Sumazaki, R.1
Shiojiri, N.2
Isoyama, S.3
Masu, M.4
Keino-Masu, K.5
Osawa, M.6
Nakauchi, H.7
Kageyama, R.8
Matsui, A.9
-
64
-
-
0037058935
-
Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2
-
Y. Sakata, C.N. Kamei, H. Nakagami, R. Bronson, J.K. Liao, and M.T. Chin Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2 Proc Natl Acad Sci USA 99 2002 16197 16202
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16197-16202
-
-
Sakata, Y.1
Kamei, C.N.2
Nakagami, H.3
Bronson, R.4
Liao, J.K.5
Chin, M.T.6
-
65
-
-
0037125957
-
Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice
-
J. Donovan, A. Kordylewska, Y.N. Jan, and M.F. Utset Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice Curr Biol 12 2002 1605 1610
-
(2002)
Curr Biol
, vol.12
, pp. 1605-1610
-
-
Donovan, J.1
Kordylewska, A.2
Jan, Y.N.3
Utset, M.F.4
-
66
-
-
0037125916
-
-/- Mice
-
-/- Mice Curr Biol 12 2002 1601 1604
-
(2002)
Curr Biol
, vol.12
, pp. 1601-1604
-
-
Gessler, M.1
Knobeloch, K.2
Helisch, A.3
Amann, K.4
Schumacher, N.5
Rohde, E.6
Fischer, A.7
Leimeister, C.8
-
67
-
-
1942498907
-
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
-
A. Fischer, N. Schumacher, M. Maier, M. Sendtner, and M. Gessler The Notch target genes Hey1 and Hey2 are required for embryonic vascular development Genes Dev 18 2004 901 911
-
(2004)
Genes Dev
, vol.18
, pp. 901-911
-
-
Fischer, A.1
Schumacher, N.2
Maier, M.3
Sendtner, M.4
Gessler, M.5
-
68
-
-
1842452938
-
Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes
-
D.A. Ross, P.K. Rao, and T. Kadesch Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes Mol Cell Biol 24 2004 3505 3513
-
(2004)
Mol Cell Biol
, vol.24
, pp. 3505-3513
-
-
Ross, D.A.1
Rao, P.K.2
Kadesch, T.3
-
69
-
-
2342496710
-
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
-
D. Amsen, J.M. Blander, G.R. Lee, K. Tanigaki, T. Honjo, and R.A. Flavell Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells Cell 117 2004 515 526 This study conclusively demonstrates that Notch signaling promotes the development of TH2 helper T cells, probably through the direct induction of IL-4 gene transcription. They also provide indirect evidence that supports the idea that development of the TH1 and TH2 subsets is induced by Delta and Jagged, respectively.
-
(2004)
Cell
, vol.117
, pp. 515-526
-
-
Amsen, D.1
Blander, J.M.2
Lee, G.R.3
Tanigaki, K.4
Honjo, T.5
Flavell, R.A.6
-
70
-
-
2442522357
-
Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
-
K. Tanigaki, M. Tsuji, N. Yamamoto, H. Han, J. Tsukada, H. Inoue, M. Kubo, and T. Honjo Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling Immunity 20 2004 611 622 Although not a central conclusion of the paper, Tanigaki and colleagues provide evidence that CSL does not appreciably repress Notch target genes in the absence of Notch activation.
-
(2004)
Immunity
, vol.20
, pp. 611-622
-
-
Tanigaki, K.1
Tsuji, M.2
Yamamoto, N.3
Han, H.4
Tsukada, J.5
Inoue, H.6
Kubo, M.7
Honjo, T.8
-
71
-
-
0043178993
-
A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos
-
I. Stancheva, A.L. Collins, I.B. Van den Veyver, H. Zoghbi, and R.R. Meehan A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos Mol Cell 12 2003 425 435 The authors show that the xHairy2a promoter, a direct target of Notch, is also bound by MeCP2. Paradoxically, a mutant form of MeCP2 that cannot bind the co-repressor SMRT is not displaced from the xHairy2a promoter by Notch. This leads to an overall decrease in the activation of this promoter by Notch and demonstrates that promoter architecture can influence the ability of Notch to activate target genes.
-
(2003)
Mol Cell
, vol.12
, pp. 425-435
-
-
Stancheva, I.1
Collins, A.L.2
Van Den Veyver, I.B.3
Zoghbi, H.4
Meehan, R.R.5
-
72
-
-
0347519180
-
Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation
-
C. Dahlqvist, A. Blokzijl, G. Chapman, A. Falk, K. Dannaeus, C.F. Ibanez, and U. Lendahl Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation Development 130 2003 6089 6099 A molecular explanation is provided for the crosstalk between the Notch and BMP signaling pathways in muscle development. Although Notch signaling can inhibit muscle differentiation on its own, inhibition by BMP requires sub-inhibitory levels of Notch signaling. This appears to be due to the recruitment of activated SMAD proteins by the NICD-CSL complex.
-
(2003)
Development
, vol.130
, pp. 6089-6099
-
-
Dahlqvist, C.1
Blokzijl, A.2
Chapman, G.3
Falk, A.4
Dannaeus, K.5
Ibanez, C.F.6
Lendahl, U.7
-
73
-
-
0345166971
-
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
-
A. Blokzijl, C. Dahlqvist, E. Reissmann, A. Falk, A. Moliner, U. Lendahl, and C.F. Ibanez Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3 J Cell Biol 163 2003 723 728
-
(2003)
J Cell Biol
, vol.163
, pp. 723-728
-
-
Blokzijl, A.1
Dahlqvist, C.2
Reissmann, E.3
Falk, A.4
Moliner, A.5
Lendahl, U.6
Ibanez, C.F.7
-
74
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
E.H. Schroeter, J.A. Kisslinger, and R. Kopan Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain Nature 393 1998 382 386
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
Kisslinger, J.A.2
Kopan, R.3
-
75
-
-
0032524325
-
Nuclear access and action of notch in vivo
-
G. Struhl, and A. Adachi Nuclear access and action of notch in vivo Cell 93 1998 649 660
-
(1998)
Cell
, vol.93
, pp. 649-660
-
-
Struhl, G.1
Adachi, A.2
-
76
-
-
0032417174
-
Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
-
S. Kidd, T. Lieber, and M.W. Young Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos Genes Dev 12 1998 3728 3740
-
(1998)
Genes Dev
, vol.12
, pp. 3728-3740
-
-
Kidd, S.1
Lieber, T.2
Young, M.W.3
-
77
-
-
0037363922
-
HES and HERP families: Multiple effectors of the Notch signaling pathway
-
T. Iso, L. Kedes, and Y. Hamamori HES and HERP families: multiple effectors of the Notch signaling pathway J Cell Physiol 194 2003 237 255
-
(2003)
J Cell Physiol
, vol.194
, pp. 237-255
-
-
Iso, T.1
Kedes, L.2
Hamamori, Y.3
|