Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: Atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction

Biochemistry

Volumn 47, Issue 41, 2008, Pages 10881-10891

  Inaoka, Daniel Ken ^a   Sakamoto, Kimitoshi ^a   Shimizu, Hironari ^a   Shiba, Tomoo ^b   Kurisu, Genji ^b   Nara, Takeshi ^c   Aoki, Takashi ^c   Kita, Kiyoshi ^a,e   Harada, Shigeharu ^d,e  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

^d KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^e NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CHEMICAL OXYGEN DEMAND; CONFORMATIONS; DYES; ENZYMES; LIGANDS; MECHANISMS; OFFSHORE OIL WELL PRODUCTION; OXIDATION; SEPARATION;

ACTIVE SITES; ATOMIC RESOLUTIONS; COFACTOR; COFACTORS; ENZYMATIC REACTIONS; FUMARATE; HALF REACTIONS; KINETIC ISOTOPE EFFECTS; KINETIC STUDIES; LACTOCOCCUS LACTIS; LIGAND-FREE; PARTIAL CHARGES; PHYSIOLOGICAL SUBSTRATES; PING-PONG BI-BI MECHANISM; PLANAR CONFORMATIONS; PYRIMIDINE BIOSYNTHESIS; STRUCTURAL CHANGES; SURVIVAL AND GROWTH; T. CRUZI; TRYPANOSOMA CRUZI; TWISTED CONFORMATION; WATER MOLECULES; X-RAY STRUCTURES;

CRYSTAL ATOMIC STRUCTURE;

DIHYDROOROTATE DEHYDROGENASE; FUMARIC ACID;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; LACTOCOCCUS LACTIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; PRIORITY JOURNAL; REACTION ANALYSIS; REDUCTION; THERMODYNAMICS; TRYPANOSOMA CRUZI;

AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; FUMARATES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OROTIC ACID; OXIDATION-REDUCTION; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TRYPANOSOMA CRUZI;

LACTOCOCCUS LACTIS; TRYPANOSOMA CRUZI;

EID: 53749085717     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800413r     Document Type: Article

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