Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis

Biochemistry

Volumn 46, Issue 19, 2007, Pages 5741-5753

  Wolfe, Abigail E ^a   Thymark, Majbritt ^b,c   Gattis, Samuel G ^a   Fagan, Rebecca L ^a   Hu, Yu Chen ^a   Johansson, Eva ^b,d   Arent, Susan ^b   Larsen, Sine ^b,d   Palfey, Bruce A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Mental Health Center Glostrup   (Denmark)

^d EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOSYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; HYDROGEN BONDS; MOLECULAR INTERACTIONS; OXIDATION;

BENZOATE PYRIMIDINE ANALOGUES; DIHYDROOROTATE DEHYDROGENASES (DHOD); LACTOCOCCUS LACTIS; PYRIMIDINE BIOSYNTHESIS;

NITROGEN COMPOUNDS;

ALPHA RESORCYLIC ACID; ASPARAGINE; BENZOIC ACID; DIHYDROOROTATE DEHYDROGENASE; FLUOROOROTIC ACID; OROTIC ACID; OXONIC ACID; PROTOCATECHUIC ACID; PYRIMIDINE DERIVATIVE; QUERCETIN;

ACIDITY; ALKALINITY; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DRUG BINDING; DRUG STRUCTURE; HYDROGEN BOND; ISOMERIZATION; LACTOCOCCUS LACTIS; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; BINDING SITES; CALORIMETRY; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYDROXYBENZOIC ACIDS; KINETICS; LACTOCOCCUS LACTIS; MODELS, MOLECULAR; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS;

LACTOCOCCUS LACTIS;

EID: 34248577146     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7001554     Document Type: Article

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