Increased prevalence of mitochondrial DNA deletions in skeletal muscle of older individuals with impaired glucose tolerance: Possible marker of glycemic stress

Diabetes

Volumn 46, Issue 5, 1997, Pages 920-923

  Liang, Ping ^a   Hughes, Virginia ^b   Fukagawa, Naomi K ^a,c  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b TUFTS UNIVERSITY   (United States)

^c UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DIABETES MELLITUS; FEMALE; GENE DELETION; GENETIC LINKAGE; GLUCOSE TOLERANCE TEST; HUMAN; MALE; OXIDATIVE STRESS; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0031004167     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.46.5.920     Document Type: Article

References (16)

1. Ballinger SW, Shoffner JM, Hedaya EV, Trounce I, Polak MA, Koontz DA, Wallace DC: Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion. Nature Genet 1:11-15, 1992
2. Barnett Y, King C: An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans. Mutat Res 338:115-128, 1995
3. Boveris A: Mitochondrial production of Superoxide radical and hydrogen peroxide. Adv Exp Med Biol 78:67-82, 1977
4. Corral-Debrinski M, Shoffner J, Lott M, Wallace D: Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat Res 275:169-180, 1992
5. Corral-Debrinski M, Stepien G, Shoffner J, Lott M, Kanter K, Wallace D: Hypoxemia is associated with mitochondrial DNA damage and gene induction: implications for cardiac disease. JAMA 266:1812-1816, 1991
6. DeFronzo R: Glucose intolerance and aging: evidence for tissue insensitivity to insulin. Diabetes 28:1095-1101, 1979
7. Evans D, Burbach J, Van Leeuwen F: Somatic mutations in the brain: relationship to aging? Mutat Res 338:173-182, 1995
8. 2 in human umbilical vein endothelial cells cultured in high glucose medium. Diabetologia 37:264-269, 1994
9. Linnane A, Baumer A, Maxwell R, Preston H, Zhang C, Marzuki S: Mitochondrial gene mutation: the ageing process and degenerative diseases. Biochem Int 22:1067-1076, 1990
10. Luft R: The development of mitochondrial medicine. Proc Natl Acad Sci USA 91:8731-8738, 1994
11. Melov S, Shoffner J, Kaufman A, Wallace D: Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acids Res 23:4122-4126, 1995
12. National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057, 1979
13. Richter C, Park J, Ames B: Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 85:6465-6467, 1988
14. van den Ouweland JMW, Lemkes HHPJ, Ruitenbeek W, Sandkuijl LA, de Vijlder MF, Struyvenberg PAA, van de Kamp JJP, Maasen JA: Mutation in mitochondrial tRNALeu(UUR)gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nature Genet 1:368-371, 1992
15. Wolff S, Dean R: Glucose autoxidation and protein modification. Biochem J 245:243-250, 1987
16. Zhang C, Baumer A, Maxwell R, Linnane A, Nagley P: Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett 297:34-38, 1992