메뉴 건너뛰기




Volumn 57, Issue 3, 2000, Pages 429-440

Dysfunctional insulin secretion in type 2 diabetes: Role of metabolic abnormalities

Author keywords

Fatty acids; Hyperglycemia; Insulin secretion; Islets of Langerhans; Type 2 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIAZOXIDE; FATTY ACID; GLUCOSE; INSULIN; PROINSULIN; SOMATOSTATIN;

EID: 0033999680     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000705     Document Type: Review
Times cited : (35)

References (110)
  • 1
    • 0026969347 scopus 로고
    • Genetic and environmental determinants of non-insulin-dependent diabetes mellitus (NIDDM)
    • 1 Hamman R. (1992) Genetic and environmental determinants of non-insulin-dependent diabetes mellitus (NIDDM). Diabetes Metab. Rev 8: 287-338
    • (1992) Diabetes Metab. Rev , vol.8 , pp. 287-338
    • Hamman, R.1
  • 2
    • 0030459185 scopus 로고    scopus 로고
    • Regulation of beta-cell function in vivo. From health to disease
    • 2 Kahn S. (1996) Regulation of beta-cell function in vivo. From health to disease. Diabetes Rev. 4: 372-389
    • (1996) Diabetes Rev. , vol.4 , pp. 372-389
    • Kahn, S.1
  • 3
    • 0028229508 scopus 로고
    • Insulin resistance or insulin deficiency: Which is the primary cause of NIDDM?
    • 3 Taylor S., Accili D. and Inje Y. (1994) Insulin resistance or insulin deficiency: which is the primary cause of NIDDM? Diabetes 43: 735-740
    • (1994) Diabetes , vol.43 , pp. 735-740
    • Taylor, S.1    Accili, D.2    Inje, Y.3
  • 4
    • 0018899699 scopus 로고
    • Increase in insulin response after treatment of overt maturity-onset diabetes independent of the mode of treatment
    • 4 Kosaka K., Kuzuya T., Akanuma Y. and Hagura R. (1980) Increase in insulin response after treatment of overt maturity-onset diabetes independent of the mode of treatment. Diabetologia 18: 23-28
    • (1980) Diabetologia , vol.18 , pp. 23-28
    • Kosaka, K.1    Kuzuya, T.2    Akanuma, Y.3    Hagura, R.4
  • 5
    • 0021990787 scopus 로고
    • The effect of insulin treatment on insulin secretion and insulin action in type 2 diabetes mellitus
    • 5 Garvey W., Olefsky J., Griffin J., Hamman R. and Kolterman O. (1985) The effect of insulin treatment on insulin secretion and insulin action in type 2 diabetes mellitus. Diabetes 34: 222-234
    • (1985) Diabetes , vol.34 , pp. 222-234
    • Garvey, W.1    Olefsky, J.2    Griffin, J.3    Hamman, R.4    Kolterman, O.5
  • 6
    • 0030751382 scopus 로고    scopus 로고
    • Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient insulin treatment
    • 6 Ilkova H., Glaser B., Tunckale A., Bagriacik N. and Cerasi E. (1997) Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient insulin treatment. Diabetes Care 20: 1356-1356
    • (1997) Diabetes Care , vol.20 , pp. 1356-1356
    • Ilkova, H.1    Glaser, B.2    Tunckale, A.3    Bagriacik, N.4    Cerasi, E.5
  • 7
    • 0030038249 scopus 로고    scopus 로고
    • Annotated questions and answers about glucose metabolism and insulin secretion of beta cells
    • 7 Matschinsky F. and Sweet I. (1996) Annotated questions and answers about glucose metabolism and insulin secretion of beta cells. Diabetes Rev 4: 130-144
    • (1996) Diabetes Rev , vol.4 , pp. 130-144
    • Matschinsky, F.1    Sweet, I.2
  • 8
    • 0028068288 scopus 로고
    • Mechanisms of action of nonglucose insulin secretagogues
    • 8 Liang Y. and Matschinsky F. (1994) Mechanisms of action of nonglucose insulin secretagogues. Ann. Review Nutrit. 14: 59-81
    • (1994) Ann. Review Nutrit. , vol.14 , pp. 59-81
    • Liang, Y.1    Matschinsky, F.2
  • 9
    • 0033556082 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
    • 9 Lang J. (1999) Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur. J. Biochem. 259: 3-17
    • (1999) Eur. J. Biochem. , vol.259 , pp. 3-17
    • Lang, J.1
  • 10
    • 0032787462 scopus 로고    scopus 로고
    • ATP sensitive K + channels and insulin secretion: Their role in health and disease
    • 10 Ashcroft F. and Gribble F. (1999) ATP sensitive K + channels and insulin secretion: their role in health and disease. Diabetologia 42: 203-920
    • (1999) Diabetologia , vol.42 , pp. 203-920
    • Ashcroft, F.1    Gribble, F.2
  • 11
    • 0029914927 scopus 로고    scopus 로고
    • Maternally inherited diabetes and deafness: A new diabetic subtype
    • 11 Maasen J. and Kadowaki T. (1996) Maternally inherited diabetes and deafness: a new diabetic subtype. Diabetologia 39: 375-382
    • (1996) Diabetologia , vol.39 , pp. 375-382
    • Maasen, J.1    Kadowaki, T.2
  • 12
    • 17344370411 scopus 로고    scopus 로고
    • Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line betaHC9
    • 12 Hayakawa T., Noda M., Yasuda K., Yorifuji H., Taniguchi S., Miwa I. et al. (1998) Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line betaHC9. J. Biol. Chem. 273: 20300-20307
    • (1998) J. Biol. Chem. , vol.273 , pp. 20300-20307
    • Hayakawa, T.1    Noda, M.2    Yasuda, K.3    Yorifuji, H.4    Taniguchi, S.5    Miwa, I.6
  • 13
    • 0033548138 scopus 로고    scopus 로고
    • Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion
    • 13 Eto K., Tsubamoto Y., Terauchi Y., Sugiyama T., Kishimoto T., Takahashi N. et al. (1999) Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283: 981-985
    • (1999) Science , vol.283 , pp. 981-985
    • Eto, K.1    Tsubamoto, Y.2    Terauchi, Y.3    Sugiyama, T.4    Kishimoto, T.5    Takahashi, N.6
  • 16
    • 0031712798 scopus 로고    scopus 로고
    • The K + -ATP channel-independent pathway of regulation of insulin secretion by glucose: In search of the underlying mechanism
    • 16 Sato Y. and Henquin J.-C. (1998) The K + -ATP channel-independent pathway of regulation of insulin secretion by glucose: in search of the underlying mechanism. Diabetes 47: 1713-1722
    • (1998) Diabetes , vol.47 , pp. 1713-1722
    • Sato, Y.1    Henquin, J.-C.2
  • 17
    • 0030926003 scopus 로고    scopus 로고
    • Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta cells
    • 17 Maechler P., Kennedy E., Pozzan T. and Wollheim C. (1997) Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta cells. EMBO J. 16: 3833-3841
    • (1997) EMBO J. , vol.16 , pp. 3833-3841
    • Maechler, P.1    Kennedy, E.2    Pozzan, T.3    Wollheim, C.4
  • 19
    • 0002084588 scopus 로고
    • An update on implications of phasic insulin secretion
    • Flatt P. and Lenzen S. (eds), Smith-Gordon, London
    • 19 Grodsky G. (1994) An update on implications of phasic insulin secretion. In: Frontiers of Insulin Secretion and Pancreatic Beta-Cell Research, pp. 421-430, Flatt P. and Lenzen S. (eds), Smith-Gordon, London
    • (1994) Frontiers of Insulin Secretion and Pancreatic Beta-cell Research , pp. 421-430
    • Grodsky, G.1
  • 20
    • 0031758346 scopus 로고    scopus 로고
    • Glucagon-like peptide I (GLP-I): A potent gut hormone with a possible therapeutic perspective
    • 20 Nauck M. A. (1998) Glucagon-like peptide I (GLP-I): a potent gut hormone with a possible therapeutic perspective. Acta Diabetol. 35: 117-129
    • (1998) Acta Diabetol. , vol.35 , pp. 117-129
    • Nauck, M.A.1
  • 21
    • 0001582609 scopus 로고
    • Neural regulation of islet hormones and its role in energy balance and stress hyperglycemia
    • Rifkin H. and Porte D. Jr (eds), Elsevier, New York
    • th edn, pp. 175-197, Rifkin H. and Porte D. Jr (eds), Elsevier, New York
    • (1990) th Edn , pp. 175-197
    • Porte, D.1    Woods, S.2
  • 22
    • 0030036874 scopus 로고    scopus 로고
    • Regulation of insulin secretion by phosphinositide-specific phospholipase C and protein kinase C activation
    • 22 Zawalich W. (1996) Regulation of insulin secretion by phosphinositide-specific phospholipase C and protein kinase C activation. Diabetes Rev. 4: 160-176
    • (1996) Diabetes Rev. , vol.4 , pp. 160-176
    • Zawalich, W.1
  • 24
    • 0002119846 scopus 로고    scopus 로고
    • The biosynthesis and secretion of insulin
    • Pickup J. and Williams G. (eds), Blackwell Science London
    • 24 Howell S. (1997) The biosynthesis and secretion of insulin. In: Textbook of Diabetes, vol. 1, pp. 8.1-8.14, Pickup J. and Williams G. (eds), Blackwell Science London
    • (1997) Textbook of Diabetes , vol.1 , pp. 81-814
    • Howell, S.1
  • 25
    • 0030001136 scopus 로고    scopus 로고
    • Insulin gene: Organization, expression and regulation
    • 25 Dumonteil E. and Philippe J. (1996) Insulin gene: organization, expression and regulation. Diabetes and Metabolism 22: 164-173
    • (1996) Diabetes and Metabolism , vol.22 , pp. 164-173
    • Dumonteil, E.1    Philippe, J.2
  • 26
    • 0031738115 scopus 로고    scopus 로고
    • Transcribing pancreas
    • 26 Edlund H. (1998) Transcribing pancreas. Diabetes 47: 1817-1823
    • (1998) Diabetes , vol.47 , pp. 1817-1823
    • Edlund, H.1
  • 27
    • 0028330976 scopus 로고
    • Islet cell growth and the growth factors involved
    • 27 Bonner-Weir S. and Smith F. (1994) Islet cell growth and the growth factors involved. Trends Endocrinol. Metabol. 5: 60-64
    • (1994) Trends Endocrinol. Metabol. , vol.5 , pp. 60-64
    • Bonner-Weir, S.1    Smith, F.2
  • 28
    • 0029944459 scopus 로고    scopus 로고
    • Islet cell neogenesis in the pancreas
    • 28 Bouwens L. and Klöppel G. (1996) Islet cell neogenesis in the pancreas. Virshow Arch 427: 553-560
    • (1996) Virshow Arch , vol.427 , pp. 553-560
    • Bouwens, L.1    Klöppel, G.2
  • 29
    • 0028845665 scopus 로고
    • Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas
    • 29 Scaglia L., Smith F. and Bonner-Weir S. (1995) Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas. Endocrinology 136: 5461-5468
    • (1995) Endocrinology , vol.136 , pp. 5461-5468
    • Scaglia, L.1    Smith, F.2    Bonner-Weir, S.3
  • 30
    • 0026110135 scopus 로고
    • Beta cells in type 2 diabetes mellitus
    • 30 Porte D. (1991) Beta cells in type 2 diabetes mellitus. Diabetes 40: 166-180
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte, D.1
  • 31
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS-33)
    • 31 UK Prospective Diabetes Study Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS-33). Lancet 352: 837-853
    • (1998) Lancet , vol.352 , pp. 837-853
  • 32
    • 0028135578 scopus 로고
    • Relationships between diabetes duration, metabolic control and B-cell function in a representative population of type 2 diabetic patients in Sweden
    • 32 Clausson P., Linnarsson R., Sundqvist G., Gottsäter A. and Grill V. (1994) Relationships between diabetes duration, metabolic control and B-cell function in a representative population of type 2 diabetic patients in Sweden. Diabetic Medicine 11: 794-801
    • (1994) Diabetic Medicine , vol.11 , pp. 794-801
    • Clausson, P.1    Linnarsson, R.2    Sundqvist, G.3    Gottsäter, A.4    Grill, V.5
  • 33
    • 0032969276 scopus 로고    scopus 로고
    • Islet amyloid. A long-recognized but under-appreciated pathological feature of type 2 diabetes
    • 33 Kahn S., Andrikopoulos S. and Verchere C. (1999) Islet amyloid. A long-recognized but under-appreciated pathological feature of type 2 diabetes. Diabetes 48: 241-253
    • (1999) Diabetes , vol.48 , pp. 241-253
    • Kahn, S.1    Andrikopoulos, S.2    Verchere, C.3
  • 34
    • 0031914679 scopus 로고    scopus 로고
    • Maturity-onset diabetes of the young: Clinical heterogeneity explained by genetic heterogeneity
    • 34 Hattersley A. (1998) Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity. Diabetic Medicine 15: 15-24
    • (1998) Diabetic Medicine , vol.15 , pp. 15-24
    • Hattersley, A.1
  • 35
    • 0026772772 scopus 로고
    • Type 2 (non-insulin dependent) diabetes mellitus: The thrifty phenotype hypothesis
    • 35 Hales C. and Barker D. (1992) Type 2 (non-insulin dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35: 595-601
    • (1992) Diabetologia , vol.35 , pp. 595-601
    • Hales, C.1    Barker, D.2
  • 36
    • 0030980023 scopus 로고    scopus 로고
    • Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs
    • 36 Poulsen P., Vaag A., Möller Jensen D. and Beck-Nielsen H. (1997) Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia 40: 439-446
    • (1997) Diabetologia , vol.40 , pp. 439-446
    • Poulsen, P.1    Vaag, A.2    Möller Jensen, D.3    Beck-Nielsen, H.4
  • 37
    • 0032976938 scopus 로고    scopus 로고
    • Low birth weight, family history of diabetes and glucose intolerance in Swedish middle-aged men
    • 37 Carlsson S., Persson P.-G., Alvarsson A., Efendic S., Norman A., Svanström L. et al. (1999) Low birth weight, family history of diabetes and glucose intolerance in Swedish middle-aged men. Diabetes Care 22: 1043-1047
    • (1999) Diabetes Care , vol.22 , pp. 1043-1047
    • Carlsson, S.1    Persson, P.-G.2    Alvarsson, A.3    Efendic, S.4    Norman, A.5    Svanström, L.6
  • 38
    • 0027476081 scopus 로고
    • Association of low birth weight with beta cell function in the adult first degree relatives of non-insulin dependent diabetic subjects
    • 38 Cook J., Levy J., Page R., Shaw J., Hattersley A. and Turner R. (1993) Association of low birth weight with beta cell function in the adult first degree relatives of non-insulin dependent diabetic subjects. Br. Med. J. 306: 302-3066
    • (1993) Br. Med. J. , vol.306 , pp. 302-3066
    • Cook, J.1    Levy, J.2    Page, R.3    Shaw, J.4    Hattersley, A.5    Turner, R.6
  • 39
  • 40
    • 0030743847 scopus 로고    scopus 로고
    • Relationship between birth weight and the insulin sensitivity index in a population sample of 3311 young healthy Caucasians
    • 40 Clausen J., Borch-Johnsen K. and Pedersen O. (1997) Relationship between birth weight and the insulin sensitivity index in a population sample of 3311 young healthy Caucasians. Am. J. Epidemiol. 146: 23-31
    • (1997) Am. J. Epidemiol. , vol.146 , pp. 23-31
    • Clausen, J.1    Borch-Johnsen, K.2    Pedersen, O.3
  • 41
    • 0021997016 scopus 로고
    • Frequency of diabetes mellitus in probands with gestational diabetes: Possible maternal influence on the predisposition to maternal diabetes
    • 41 Martin A., Simpsin J. and Freinkel N. (1985) Frequency of diabetes mellitus in probands with gestational diabetes: possible maternal influence on the predisposition to maternal diabetes. Am. J. Obstet. Gynecol. 151: 471-473
    • (1985) Am. J. Obstet. Gynecol. , vol.151 , pp. 471-473
    • Martin, A.1    Simpsin, J.2    Freinkel, N.3
  • 42
    • 0023929665 scopus 로고
    • Congenital suceptibility to NIDDM: Role of intrauterine environment
    • 42 Pettitt D., Aleck K., Belre R., Carraher M., Bennett P. and Knowler W. (1988) Congenital suceptibility to NIDDM: role of intrauterine environment. Diabetes 37: 622-628
    • (1988) Diabetes , vol.37 , pp. 622-628
    • Pettitt, D.1    Aleck, K.2    Belre, R.3    Carraher, M.4    Bennett, P.5    Knowler, W.6
  • 43
    • 0022468017 scopus 로고
    • Impaired glucose homestasis in adult rats from hyper-glycemic mothers
    • 43 Bihoreau M., Ktorza A., Kinebayan M. and Pican L. (1986) Impaired glucose homestasis in adult rats from hyper-glycemic mothers. Diabetes 35: 979-984
    • (1986) Diabetes , vol.35 , pp. 979-984
    • Bihoreau, M.1    Ktorza, A.2    Kinebayan, M.3    Pican, L.4
  • 44
    • 0024262646 scopus 로고
    • The diabetic intrauterine milieu has a long-lasting effect on insulin secretion by B-cells and on insulin uptake in target tissues
    • 44 Aerts L., Sodoyez-Goffaux F., Sodoyez J., Malaisse W. and van Assche F. (1988) The diabetic intrauterine milieu has a long-lasting effect on insulin secretion by B-cells and on insulin uptake in target tissues. Am. J. Obstet. Gynecol. 159: 1287-1292
    • (1988) Am. J. Obstet. Gynecol. , vol.159 , pp. 1287-1292
    • Aerts, L.1    Sodoyez-Goffaux, F.2    Sodoyez, J.3    Malaisse, W.4    Van Assche, F.5
  • 45
    • 0031054031 scopus 로고    scopus 로고
    • An early intervention accelerates pancreatic beta-cell dysfunction in young Goto-Kakizaki rats, a model of naturally occurring non-insulin dependent diabetes
    • 45 Suzuki N., Aizawa T., Asanuma N., Sato Y., Komatsu M., Hidaka H. et al. (1997) An early intervention accelerates pancreatic beta-cell dysfunction in young Goto-Kakizaki rats, a model of naturally occurring non-insulin dependent diabetes. Endocrinology 138: 1106-1110
    • (1997) Endocrinology , vol.138 , pp. 1106-1110
    • Suzuki, N.1    Aizawa, T.2    Asanuma, N.3    Sato, Y.4    Komatsu, M.5    Hidaka, H.6
  • 46
    • 0030749043 scopus 로고    scopus 로고
    • Insulin administration enhances growth of the beta cell mass in streptozotocin-treated newborn rat
    • 46 Movassat J., Saulnier C. and Portha B. (1997) Insulin administration enhances growth of the beta cell mass in streptozotocin-treated newborn rat. Diabetes 46: 1445-1452
    • (1997) Diabetes , vol.46 , pp. 1445-1452
    • Movassat, J.1    Saulnier, C.2    Portha, B.3
  • 47
    • 0026536790 scopus 로고
    • Duration of obesity increases the incidence of NIDDM
    • 47 Everhart J., Pettitt J., Bennett P. and Knowler W. (1992) Duration of obesity increases the incidence of NIDDM. Diabetes 41: 235-240
    • (1992) Diabetes , vol.41 , pp. 235-240
    • Everhart, J.1    Pettitt, J.2    Bennett, P.3    Knowler, W.4
  • 49
    • 0022522943 scopus 로고
    • Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions
    • 49 Leahy J., Cooper H., Deal D. and Weir G. (1986) Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions. J. Clin. Invest. 77: 908-915
    • (1986) J. Clin. Invest. , vol.77 , pp. 908-915
    • Leahy, J.1    Cooper, H.2    Deal, D.3    Weir, G.4
  • 50
    • 0028147826 scopus 로고
    • Involvement of the autonomic nervous system in the in vivo memory to glucose of pancreatic beta-cell in rats
    • 50 N'Guyen J.-M., Magnan C., Laury M.-C., Thibault C., Leveteau J., Penicaud L. et al. (1994) Involvement of the autonomic nervous system in the in vivo memory to glucose of pancreatic beta-cell in rats. J. Clin. Invest. 94: 1456-1462
    • (1994) J. Clin. Invest. , vol.94 , pp. 1456-1462
    • N'Guyen, J.-M.1    Magnan, C.2    Laury, M.-C.3    Thibault, C.4    Leveteau, J.5    Penicaud, L.6
  • 51
    • 0025677462 scopus 로고
    • Coupling of B-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats
    • 51 Sako Y. and Grill V. (1990) Coupling of B-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats. Diabetes 39: 1580-1583
    • (1990) Diabetes , vol.39 , pp. 1580-1583
    • Sako, Y.1    Grill, V.2
  • 52
    • 0027450505 scopus 로고
    • B-cell insensitivity in vitro: Reversal by diazoxide entails more than one event in stimulus-secretion coupling
    • 52 Björklund A. and Grill V. (1993) B-cell insensitivity in vitro: reversal by diazoxide entails more than one event in stimulus-secretion coupling. Endocrinology 132: 1319-1328
    • (1993) Endocrinology , vol.132 , pp. 1319-1328
    • Björklund, A.1    Grill, V.2
  • 53
    • 0022621813 scopus 로고
    • The third phase of in vitro insulin secretion. Evidence for glucose insensitivity
    • 53 Bolaffi J., Heldt A., Lewis L. and Grodsky G. (1986) The third phase of in vitro insulin secretion. Evidence for glucose insensitivity. Diabetes 35: 370-373
    • (1986) Diabetes , vol.35 , pp. 370-373
    • Bolaffi, J.1    Heldt, A.2    Lewis, L.3    Grodsky, G.4
  • 54
    • 0029783411 scopus 로고    scopus 로고
    • Beta-cell dysfunction with chronic hyper-glycemia: 'Overworked betacell' hypothesis
    • 54 Leahy J. (1996) Beta-cell dysfunction with chronic hyper-glycemia: 'overworked betacell' hypothesis. Diabetes Rev. 4: 298-319
    • (1996) Diabetes Rev. , vol.4 , pp. 298-319
    • Leahy, J.1
  • 55
    • 0021287365 scopus 로고
    • Cooling dissociates glucose-induced insulin release from electrical activity and cation fluxes in rodent pancreatic islets
    • 55 Atwater I., Goncalues A., Herchuelz A., Jebran P., Malaisse W., Rojas E. et al. (1984) Cooling dissociates glucose-induced insulin release from electrical activity and cation fluxes in rodent pancreatic islets. J. Physiol. 348: 615-627
    • (1984) J. Physiol. , vol.348 , pp. 615-627
    • Atwater, I.1    Goncalues, A.2    Herchuelz, A.3    Jebran, P.4    Malaisse, W.5    Rojas, E.6
  • 56
    • 0030004317 scopus 로고    scopus 로고
    • Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization
    • 56 Renström E., Eliason L., Bokvist K. and Rorsman P. (1996) Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization. J. Physiol. 494: 41-52
    • (1996) J. Physiol. , vol.494 , pp. 41-52
    • Renström, E.1    Eliason, L.2    Bokvist, K.3    Rorsman, P.4
  • 57
    • 0017103668 scopus 로고
    • 2O of glucose-induced cyclic AMP accumulation in rat islets of Langerhans
    • 2O of glucose-induced cyclic AMP accumulation in rat islets of Langerhans. FEBS Lett. 68: 165-169
    • (1976) FEBS Lett. , vol.68 , pp. 165-169
    • Grill, V.1    Cerasi, E.2
  • 58
    • 85038046588 scopus 로고    scopus 로고
    • Association but not linkage of impaired insulin-and Ca2 + responses to glucose in human pancreatic islets
    • abstract
    • 58 Björklund A. and Grill V. (1999) Association but not linkage of impaired insulin-and Ca2 + responses to glucose in human pancreatic islets. Diabetologia 42 (Suppl 1): A137 (abstract)
    • (1999) Diabetologia , vol.42 , Issue.SUPPL. 1
    • Björklund, A.1    Grill, V.2
  • 59
    • 0344258475 scopus 로고    scopus 로고
    • Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose
    • 59 Marshak S., Leibowitz G., Bertuzzi F., Socci C., Kaiser N., Gross D. et al. (1999) Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose. Diabetes 48: 1230-1237
    • (1999) Diabetes , vol.48 , pp. 1230-1237
    • Marshak, S.1    Leibowitz, G.2    Bertuzzi, F.3    Socci, C.4    Kaiser, N.5    Gross, D.6
  • 60
    • 0026451942 scopus 로고
    • Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function
    • 60 Eizirik D., Korbutt G. and Hellerström C. (1992) Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. J. Clin. Invest. 90: 1263-1268
    • (1992) J. Clin. Invest. , vol.90 , pp. 1263-1268
    • Eizirik, D.1    Korbutt, G.2    Hellerström, C.3
  • 61
    • 0040503709 scopus 로고    scopus 로고
    • Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets
    • 61 Björklund A. and Grill V. (1999) Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets. Diabetes 48: 1409-1415
    • (1999) Diabetes , vol.48 , pp. 1409-1415
    • Björklund, A.1    Grill, V.2
  • 62
    • 17144458294 scopus 로고    scopus 로고
    • Long-term in vitro exposure to high glucose increases proinsulin-like molecules released by isolated human islets
    • 62 Bertuzzi F., Saccomanno K., Socci C., Davalli A., Taglietti M., Berra C. et al. (1998) Long-term in vitro exposure to high glucose increases proinsulin-like molecules released by isolated human islets. J. Endocrinol. 158: 205-211
    • (1998) J. Endocrinol. , vol.158 , pp. 205-211
    • Bertuzzi, F.1    Saccomanno, K.2    Socci, C.3    Davalli, A.4    Taglietti, M.5    Berra, C.6
  • 63
    • 0033347050 scopus 로고    scopus 로고
    • Prolonged exposure of human beta cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine
    • 63 Hostens K., Ling Z., van Schravendijk C. and Pipeleers D. (1999) Prolonged exposure of human beta cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine. J. Clin. Endocrinol. Metabol. 84: 1386-1390
    • (1999) J. Clin. Endocrinol. Metabol. , vol.84 , pp. 1386-1390
    • Hostens, K.1    Ling, Z.2    Van Schravendijk, C.3    Pipeleers, D.4
  • 64
    • 0027389774 scopus 로고
    • Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats
    • 64 Leahy J. (1993) Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats. Diabetes 42: 22-27
    • (1993) Diabetes , vol.42 , pp. 22-27
    • Leahy, J.1
  • 65
    • 0032740992 scopus 로고    scopus 로고
    • Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release
    • 65 Hostens K., Pavlovic D., Zambre Y., Ling Z., Van Schravendijk C., Eizirik D. et al. (1999) Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release. J. Clin. Invest. 104: 67-72
    • (1999) J. Clin. Invest. , vol.104 , pp. 67-72
    • Hostens, K.1    Pavlovic, D.2    Zambre, Y.3    Ling, Z.4    Van Schravendijk, C.5    Eizirik, D.6
  • 66
    • 85038044245 scopus 로고    scopus 로고
    • Treatment with diazoxide causes prolonged improvement of B-cell functions of rat islets transplanted to a diabetic environment
    • in press
    • 66 Hiramatsu S. and Grill V. Treatment with diazoxide causes prolonged improvement of B-cell functions of rat islets transplanted to a diabetic environment. Metabolism, in press
    • Metabolism
    • Hiramatsu, S.1    Grill, V.2
  • 68
    • 0031581060 scopus 로고    scopus 로고
    • The role of calcium in the regulation of apoptosis
    • 68 McConkey D. and Orrenius S. (1997) The role of calcium in the regulation of apoptosis. Biochem. Biophys. Res. Commun. 239: 357-366
    • (1997) Biochem. Biophys. Res. Commun. , vol.239 , pp. 357-366
    • McConkey, D.1    Orrenius, S.2
  • 69
    • 0032055459 scopus 로고    scopus 로고
    • Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial
    • 69 DCCT Study (1998) Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. Annals Int. Med. 128: 517-523
    • (1998) Annals Int. Med. , vol.128 , pp. 517-523
  • 70
    • 0029784458 scopus 로고    scopus 로고
    • Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmunne diabetes
    • 70 Björk E., Berne C., Kämpe O., Wibell L., Oskarsson P. and Karlsson F. A. (1996) Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmunne diabetes. Diabetes 45: 1427-1430
    • (1996) Diabetes , vol.45 , pp. 1427-1430
    • Björk, E.1    Berne, C.2    Kämpe, O.3    Wibell, L.4    Oskarsson, P.5    Karlsson, F.A.6
  • 71
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group
    • 71 DCCT Study (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N. Engl. J. Med. 329: 977-986
    • (1993) N. Engl. J. Med. , vol.329 , pp. 977-986
  • 72
    • 0028453652 scopus 로고
    • Glycation and diabetic complications
    • 72 Brownlee M. (1994) Glycation and diabetic complications. Diabetes 43: 836-841
    • (1994) Diabetes , vol.43 , pp. 836-841
    • Brownlee, M.1
  • 73
    • 0031025828 scopus 로고    scopus 로고
    • Long term effects of aminoguanidine on insulin release and biosynthesis. Evidence that the formation of advanced glycosylation end products inhibits B-cell function
    • 73 Tajiri Y., Möller C. and Grill V. (1997) Long term effects of aminoguanidine on insulin release and biosynthesis. Evidence that the formation of advanced glycosylation end products inhibits B-cell function. Endocrinology 138: 273-280
    • (1997) Endocrinology , vol.138 , pp. 273-280
    • Tajiri, Y.1    Möller, C.2    Grill, V.3
  • 74
    • 0031020374 scopus 로고    scopus 로고
    • Glycation-dependent reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells
    • 74 Matsuoka T., Kajimoto Y., Watada H., Kaneto H., Kishimoto M., Umayahara Y. et al. (1997) Glycation-dependent reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J. Clin. Invest. 99: 144-150
    • (1997) J. Clin. Invest. , vol.99 , pp. 144-150
    • Matsuoka, T.1    Kajimoto, Y.2    Watada, H.3    Kaneto, H.4    Kishimoto, M.5    Umayahara, Y.6
  • 76
    • 0032863183 scopus 로고    scopus 로고
    • Prevention of glucose toxicity in HIR-T15 cells and Zucker diabetic fatty rats by antioxidants
    • 76 Tanaka Y., Gleason C., Tran P., Harmon J. and Robertson P. (1999) Prevention of glucose toxicity in HIR-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc. Natl. Acad. Sci. USA 96: 10857-10862
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10857-10862
    • Tanaka, Y.1    Gleason, C.2    Tran, P.3    Harmon, J.4    Robertson, P.5
  • 77
    • 0032980829 scopus 로고    scopus 로고
    • Interactions between vitamin E and glucose on B-cell functions in the rat: An in vivo and in vitro study
    • 77 Tajiri Y. and Grill V. (1999) Interactions between vitamin E and glucose on B-cell functions in the rat: an in vivo and in vitro study. Pancreas 18: 274-281
    • (1999) Pancreas , vol.18 , pp. 274-281
    • Tajiri, Y.1    Grill, V.2
  • 78
    • 0014594153 scopus 로고
    • Stimulation of insulin secretion by infusion of free fatty acids
    • 78 Crespin S., Greenough W. and Steinberg D. (1969) Stimulation of insulin secretion by infusion of free fatty acids. J. Clin. Invest. 48: 1934-1943
    • (1969) J. Clin. Invest. , vol.48 , pp. 1934-1943
    • Crespin, S.1    Greenough, W.2    Steinberg, D.3
  • 79
    • 0014333141 scopus 로고
    • Stimulation of insulin secretion by non-carbohydrate metabolites
    • 79 Malaisse W. J. and Malaisse-Lagae F. (1968) Stimulation of insulin secretion by non-carbohydrate metabolites. J. Lab. Clin. Med. 72: 438-448
    • (1968) J. Lab. Clin. Med. , vol.72 , pp. 438-448
    • Malaisse, W.J.1    Malaisse-Lagae, F.2
  • 80
    • 0024995157 scopus 로고
    • A 48 h lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B-cell oxidation through a process likely coupled to fatty acid oxidation
    • 80 Sako Y. and Grill V. (1990) A 48 h lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B-cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127: 1580-1589
    • (1990) Endocrinology , vol.127 , pp. 1580-1589
    • Sako, Y.1    Grill, V.2
  • 81
    • 0027008279 scopus 로고
    • Possible new therapeutic approach in diabetes mellitus by inhibition of carnithine palmitoyl transferase 1 (CPT1)
    • 81 Wolf H. (1992) Possible new therapeutic approach in diabetes mellitus by inhibition of carnithine palmitoyl transferase 1 (CPT1). Horm. Metabol. Res. Suppl. 26: 62-67
    • (1992) Horm. Metabol. Res. Suppl. , vol.26 , pp. 62-67
    • Wolf, H.1
  • 82
    • 0028268936 scopus 로고
    • Long term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • 82 Zhou Y.-P. and Grill V. (1994) Long term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J. Clin. Invest. 93: 870-876
    • (1994) J. Clin. Invest. , vol.93 , pp. 870-876
    • Zhou, Y.-P.1    Grill, V.2
  • 83
    • 0027994544 scopus 로고
    • Mechanisms modifying glucose oxidation in diabetes mellitus
    • 83 Randle P. J., Priestman D., Mistry S. and Halsall A. (1994) Mechanisms modifying glucose oxidation in diabetes mellitus. Diabetologia 37(Suppl. 2): S155-S161
    • (1994) Diabetologia , vol.37 , Issue.SUPPL. 2
    • Randle, P.J.1    Priestman, D.2    Mistry, S.3    Halsall, A.4
  • 84
    • 0028988135 scopus 로고
    • Palmitale-induced B-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets
    • 84 Zhou Y.-P. and Grill V. (1995) Palmitale-induced B-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets. Diabetes 44: 394-399
    • (1995) Diabetes , vol.44 , pp. 394-399
    • Zhou, Y.-P.1    Grill, V.2
  • 85
    • 0028333838 scopus 로고
    • Role of protein synthesis and of fatty acid metabolism in the longer term regulation of pyruvate dehydrogenase kinase
    • 85 Priestman D., Mistry A., Halsall A. and Randle P. (1994) Role of protein synthesis and of fatty acid metabolism in the longer term regulation of pyruvate dehydrogenase kinase. Biochem. J. 300: 659-664
    • (1994) Biochem. J. , vol.300 , pp. 659-664
    • Priestman, D.1    Mistry, A.2    Halsall, A.3    Randle, P.4
  • 86
    • 0010991077 scopus 로고    scopus 로고
    • Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets
    • 86 Liu Y., Tornheim K. and Leahy J. (1999) Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets. Diabetes 48: 1747-1753
    • (1999) Diabetes , vol.48 , pp. 1747-1753
    • Liu, Y.1    Tornheim, K.2    Leahy, J.3
  • 87
    • 0032861252 scopus 로고    scopus 로고
    • Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells
    • 87 Segall L., Lameloise N., Assimacopoulos-Jeannet F., Roche E., Corkey P., Thumelin S. et al. (1999) Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells. Am. J. Physiol. 277: E521-E528
    • (1999) Am. J. Physiol. , vol.277
    • Segall, L.1    Lameloise, N.2    Assimacopoulos-Jeannet, F.3    Roche, E.4    Corkey, P.5    Thumelin, S.6
  • 88
    • 0030823179 scopus 로고    scopus 로고
    • Chronic effects of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic B-cell line (BHC9)
    • 88 Liang Y., Buetteger C., Berner D. and Matschinsky F. (1997) Chronic effects of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic B-cell line (BHC9). Diabetologia 40: 1018-1027
    • (1997) Diabetologia , vol.40 , pp. 1018-1027
    • Liang, Y.1    Buetteger, C.2    Berner, D.3    Matschinsky, F.4
  • 89
    • 0033305516 scopus 로고    scopus 로고
    • Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro
    • 89 Carlsson C., Borg L. and Welsh N. (1999) Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 140: 3422-3428
    • (1999) Endocrinology , vol.140 , pp. 3422-3428
    • Carlsson, C.1    Borg, L.2    Welsh, N.3
  • 90
    • 0027947379 scopus 로고
    • Beta cell lipotoxicity in the pathogenesis of non-insulin dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
    • 90 Lee Y., Hiroshi H., Ohneda M., Johnson J., McGarry D. and Unger R. (1994) Beta cell lipotoxicity in the pathogenesis of non-insulin dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc. Natl. Acad. Sci. USA 91: 10878-10882
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10878-10882
    • Lee, Y.1    Hiroshi, H.2    Ohneda, M.3    Johnson, J.4    McGarry, D.5    Unger, R.6
  • 91
    • 0029787332 scopus 로고    scopus 로고
    • Inhibitory effects of fatty acids on glucose-regulated B-cell function: Association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism
    • 91 Zhou Y.-P., Ling Z.-C. and Grill V. (1996) Inhibitory effects of fatty acids on glucose-regulated B-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism. Metabolism 8: 981-986
    • (1996) Metabolism , vol.8 , pp. 981-986
    • Zhou, Y.-P.1    Ling, Z.-C.2    Grill, V.3
  • 93
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced apoptosis: A link between obesity and diabetes
    • 93 Shimabukuro M., Zhou Y.-T., Levi M. and Unger R. (1998) Fatty acid-induced apoptosis: a link between obesity and diabetes. Proc. Natl. Acad. Sci. USA 95: 2498-3202
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2498-3202
    • Shimabukuro, M.1    Zhou, Y.-T.2    Levi, M.3    Unger, R.4
  • 95
  • 96
    • 0029036835 scopus 로고
    • Long-term exposure to fatty acids and kelones inhibits B-cell functions in human pancreatic islets of Langerhans
    • 96 Zhou Y.-P. and Grill V. (1995) Long-term exposure to fatty acids and kelones inhibits B-cell functions in human pancreatic islets of Langerhans. J. Clin. Endocrinol. Metabol. 80: 1584-1590
    • (1995) J. Clin. Endocrinol. Metabol. , vol.80 , pp. 1584-1590
    • Zhou, Y.-P.1    Grill, V.2
  • 97
    • 0032030866 scopus 로고    scopus 로고
    • Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increased basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
    • 97 Bollheimer C., Skelly R., Chester M., McGarry D. and Rhodes C. (1998) Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increased basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J. Clin. Invest. 101: 1094-1101
    • (1998) J. Clin. Invest. , vol.101 , pp. 1094-1101
    • Bollheimer, C.1    Skelly, R.2    Chester, M.3    McGarry, D.4    Rhodes, C.5
  • 98
    • 0033059201 scopus 로고    scopus 로고
    • Long term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta cell line MIN6
    • 98 Furukawa H., Carroll R., Swift H. and Steiner D. (1999) Long term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta cell line MIN6. Diabetes 48: 1395-1401
    • (1999) Diabetes , vol.48 , pp. 1395-1401
    • Furukawa, H.1    Carroll, R.2    Swift, H.3    Steiner, D.4
  • 99
    • 0033042342 scopus 로고    scopus 로고
    • Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats
    • 99 Mason T., Goh T., Tchipasvili V., Sandhu H., Gupta N., Lewis G. et al. (1999) Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats. Diabetes 48: 524-530
    • (1999) Diabetes , vol.48 , pp. 524-530
    • Mason, T.1    Goh, T.2    Tchipasvili, V.3    Sandhu, H.4    Gupta, N.5    Lewis, G.6
  • 100
    • 0032960430 scopus 로고    scopus 로고
    • Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose
    • 100 Magnan C., Collins S., Berthault M.-F., Kassis N., Vincent M., Gilbert M. et al. (1999) Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose. J. Clin. Invest. 102: 413-419
    • (1999) J. Clin. Invest. , vol.102 , pp. 413-419
    • Magnan, C.1    Collins, S.2    Berthault, M.-F.3    Kassis, N.4    Vincent, M.5    Gilbert, M.6
  • 102
    • 0029046673 scopus 로고
    • Effects of a 48-fat infusion on insulin secretion and glucose utilization
    • 102 Boden G., Chen X., Rosner J. and Barton M. (1995) Effects of a 48-fat infusion on insulin secretion and glucose utilization. Diabetes 44: 1239-1242
    • (1995) Diabetes , vol.44 , pp. 1239-1242
    • Boden, G.1    Chen, X.2    Rosner, J.3    Barton, M.4
  • 103
    • 0032999260 scopus 로고    scopus 로고
    • Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation
    • 103 Carpentier A., Mittelman S., Lamarche B., Bergman R., Giacca A. and Lewis G. (1999) Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am. J. Physiol. 276: E1055-E1066
    • (1999) Am. J. Physiol. , vol.276
    • Carpentier, A.1    Mittelman, S.2    Lamarche, B.3    Bergman, R.4    Giacca, A.5    Lewis, G.6
  • 104
    • 0018575289 scopus 로고
    • Direct effect of corticosterone upon insulin secretion studied by three different techniques
    • 104 Billaudel B. and Suttter B. (1979) Direct effect of corticosterone upon insulin secretion studied by three different techniques. Horm. Metabol. Res. 11: 555-560
    • (1979) Horm. Metabol. Res. , vol.11 , pp. 555-560
    • Billaudel, B.1    Suttter, B.2
  • 105
    • 0030866606 scopus 로고    scopus 로고
    • Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets
    • 105 Lambilotte C., Gilon P. and Henquin J.-C. (1997) Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. J. Clin. Invest. 99: 414-423
    • (1997) J. Clin. Invest. , vol.99 , pp. 414-423
    • Lambilotte, C.1    Gilon, P.2    Henquin, J.-C.3
  • 106
    • 0017843135 scopus 로고
    • Development of the insulin secretory defect in genetically (db/db) mouse
    • 106 Berglund O., Frankel B. and Hellman B. (1978) Development of the insulin secretory defect in genetically (db/db) mouse. Acta Endocrinol. 87: 543-551
    • (1978) Acta Endocrinol. , vol.87 , pp. 543-551
    • Berglund, O.1    Frankel, B.2    Hellman, B.3
  • 107
    • 0029983884 scopus 로고    scopus 로고
    • A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of B-cell dysfunction in the obese diabetic db/db mouse
    • 107 Zhou Y.-P., Berggren P.-O. and Grill V. (1996) A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of B-cell dysfunction in the obese diabetic db/db mouse. Diabetes 45: 580-586
    • (1996) Diabetes , vol.45 , pp. 580-586
    • Zhou, Y.-P.1    Berggren, P.-O.2    Grill, V.3
  • 108
    • 0026493330 scopus 로고
    • Fat-induced changes in mouse pancreatic islet secretion, insulin biosynthesis and glucose metabolism
    • 108 Capito K., Hansen S., Hedeskov C. and Thams P. (1992) Fat-induced changes in mouse pancreatic islet secretion, insulin biosynthesis and glucose metabolism. Acta Diabetol. 28: 193-198
    • (1992) Acta Diabetol. , vol.28 , pp. 193-198
    • Capito, K.1    Hansen, S.2    Hedeskov, C.3    Thams, P.4
  • 109
    • 85038040100 scopus 로고    scopus 로고
    • Difference in the effect of prolonged FFA elevation on glucose-stimulated insulin secretion (GSIS) between non-diabetic subjects and patients with type 2 diabetes
    • abstract
    • 109 Carpentier A., Lamarche B., Giacca A. and Lewis G. (1998) Difference in the effect of prolonged FFA elevation on glucose-stimulated insulin secretion (GSIS) between non-diabetic subjects and patients with type 2 diabetes. Diabetes 47 (Suppl. 1): A255 (abstract)
    • (1998) Diabetes , vol.47 , Issue.SUPPL. 1
    • Carpentier, A.1    Lamarche, B.2    Giacca, A.3    Lewis, G.4
  • 110
    • 4243801618 scopus 로고    scopus 로고
    • Acute reduction of fatty acids increases insulin secretion in type 2 diabetes
    • abstract
    • 110 Qvigstad E., Mostad I., Bjerve K. and Grill V. (1999) Acute reduction of fatty acids increases insulin secretion in type 2 diabetes. Diabetologia 42 (Suppl. 1): A153 (abstract)
    • (1999) Diabetologia , vol.42 , Issue.SUPPL. 1
    • Qvigstad, E.1    Mostad, I.2    Bjerve, K.3    Grill, V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.