Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients

Diabetes/Metabolism Research and Reviews

Volumn 20, Issue 3, 2004, Pages 246-251

  Lupi, Roberto ^a   Marselli, Lorella ^a   Dionisi, Sabrina ^a   Del Guerra, Silvia ^a   Boggi, Ugo ^a   Del Chiaro, Marco ^a   Lencioni, Cristina ^a   Bugliani, Marco ^a   Mosca, Franco ^a   Di Mario, Umberto ^b   Del Prato, Stefano ^a   Dotta, Francesco ^b   Marchetti, Piero ^a  

^a UNIVERSITY OF PISA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Chemotactic properties; Cytokines; glucose oxidation; Insulin secretion; Pancreatic islets; Type 1 diabetes

Indexed keywords

ARGININE; CYTOKINE; FRUCTOSE BISPHOSPHATE ALDOLASE; GAMMA INTERFERON; GLIBENCLAMIDE; GLUCOKINASE; GLUCOSE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; INSULIN; INTERLEUKIN 10; MESSENGER RNA; MITOCHONDRIAL ENZYME; PYRUVATE KINASE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CASE REPORT; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; GLUCOSE OXIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE CULTURE; TISSUE LEVEL;

ADOLESCENT; ADULT; CHEMOTAXIS; CHILD; CYTOKINES; DIABETES MELLITUS, TYPE 1; FEMALE; FRUCTOSE-BISPHOSPHATE ALDOLASE; GLUCOKINASE; GLUCOSE; GLYCEROLPHOSPHATE DEHYDROGENASE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; PYRUVATE KINASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE CULTURE TECHNIQUES;

EID: 2642525150     PISSN: 15207552     EISSN: None     Source Type: Journal    
DOI: 10.1002/dmrr.460     Document Type: Article

References (23)

1. Wucherpfennig KW, Eisenbarth GS. Type 1 diabetes. Nat Immunol 2001; 2(9): 767-768.
2. Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H. Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 2003; 52 (3): 581-587.
3. Leibowitz G, Yuh M, Donath MY, et al. Beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes. Diabetes 2001; 50(Suppl. 1): S113-S117.
4. Lupi R, Del Guerra S, Tellini C, et al. The biguanide compound metformin prevents desensitization of human pancreatic islets induced by high glucose. Eur J Pharmacol 1999; 364(2-3): 205-209.
5. Purrello F, Buscema M, Rabuazzo AM, et al. Glucose modulates glucose transporter affinity, glucokinase activity, and secretory response in rat pancreatic beta-cells. Diabetes 1993; 42(1): 199-205.
6. Marchetti P, Dotta F, Ling Z, et al. Function of pancreatic islets isolated from a type 1 diabetic patient. Diabetes Care 2000; 23(5): 701-703.
7. Marchetti P, Lupi R, Federici M, et al. Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-> Arg IRS-1 polymorphism. Diabetes 2002; 51(5): 1419-1424.
8. Marselli L, Marchetti P, Tellini C, et al. Lymphokine release from human lymphomononuclear cells after co-culture with isolated pancreatic islets: effects of islet species, long-term culture, and monocyte-macrophage cell removal. Cytokine 2000; 12(5): 503-505.
9. Kessler L, Jesser C, Lombard Y, et al. Cytotoxicity of peritoneal murine macrophages against encapsulated pancreatic rat islets: in vivo and in vitro studies. J Leukoc Biol 1996; 60(6): 729-736.
10. Lupi R, Del Guerra S, Fierabracci V, et al. Lipotoxicity in human pancreatic islets and the protective effect of metformin. Diabetes 2002; 51(Suppl. 1): S134-S137.
11. De Vos A, Heimberg H, Quartier E, et al. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest 1995; 96(5): 2489-2495.
12. Strandell E, Eizirik DL, Sandler S. Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus. J Clin Invest 1990; 85(6): 1944-1950.
13. Marselli L, Dotta F, Piro S, et al. Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines. J Clin Endocrinol Metab 2001; 86(10): 4974-4978.
14. Eizirik DL, Darville MI. Beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes. Diabetes 2001; 50(Suppl. 1): S64-S69.
15. Andersson AK, Flodstrom M, Sandler S. Cytokine-induced inhibition of insulin release from mouse pancreatic beta-cells deficient in inducible nitric oxide synthase. Biochem Biophys Res Commun 2001; 281(2): 396-403.
16. Ma Z, Landt M, Bohrer A, Ramanadham S, Kipnis DM, Turk J. Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism. J Biol Chem 1997; 272(28): 17 827-17 835.
17. Kuttler B, Hartmann A, Wanka H. Long-term culture of islets abrogates cytokine-induced or lymphocyte-induced increase of antigen expression on beta-cells. Transplantation 2002; 74(4): 440-445.
18. Stiller CR, Dupre J, Gent M, et al. Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 1984; 30;223(4643): 1362-1367.
19. Dupre J, Jenner MR, Mahon JL, Purdon C, Rodger NW, Stiller CR. Endocrine-metabolic function in remission-phase IDDM during administration of cyclosporine. Diabetes 1991; 40(5): 598-604.
20. Robertson RP, Olson LK, Zhang HJ. Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene. Diabetes 1994; 43(9): 1085-1089.
21. Purrello F, Rahuazzo AM. Metabolic factors that affect beta-cell function and survival. Diabetes Nutr Metab 2000; 13(2): 84-91.
22. LeRoith D. Beta-cell dysfunction and insulin resistance in Type 2 diabetes: role of metabolic and genetic abnormalities. Am J Med 2002; 113: 3S-11S.
23. Maedler K, Sergeev P, Ris F, et al. Glucose-induced beta-cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002; 110(6): 851-860.