Leptin enhances human β-defensin-2 production in human keratinocytes

Endocrinology

Volumn 149, Issue 10, 2008, Pages 5189-5198

  Kanda, Naoko ^a   Watanabe, Shinichi ^a  

^a TEIKYO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BETA DEFENSIN 2; INTERLEUKIN 1BETA; JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT1 PROTEIN; STAT3 PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BETA-DEFENSINS; CELLS, CULTURED; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; INTERLEUKIN-1BETA; JANUS KINASE 2; KERATINOCYTES; LEPTIN; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RECEPTORS, LEPTIN; RNA, MESSENGER; SERINE; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION; TYROSINE; WOUND HEALING;

EID: 53249151930     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0343     Document Type: Article

References (53)

1. La Cava A, Matarese G 2004 The weight of leptin in immunity. Nat Rev Immunol 4:371-379
2. Otero M, Lago R, Lago F, Casanueva FF, Dieguez C, Gómez-Reino JJ, Gualillo O 2005 Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 579:295-301
3. Myers Jr MG 2004 Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res 59:287-304
4. Mancuso P, Huffnagle GB, Olszewski MA, Phipps J, Peters-Golden M 2006 Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia. Am J Respir Crit Care Med 173:212-218
5. Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB 2002 Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol 168:4018-4024
6. Hsu A, Aronoff DM, Phipps J, Goel D, Mancuso P 2007 Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia. Clin Exp Immunol 150:332-339
7. Iguchi M, Aiba S, Yoshino Y, Tagami H 2001 Human follicular papilla cells carry out nonadipose tissue production of leptin. J Invest Dermatol 117:1349-1356
8. Stallmeyer B, Kämpfer H, Podda M, Kaufmann R, Pfeilschifter J, Frank S 2001 A novel keratinocyte mitogen: regulation of leptin and its functional receptor in skin repair. J Invest Dermatol 117:98-105
9. De Jongh GJ, Zeeuwen PL, Kucharekova M, Pfundt R, Van Der Valk PG, Blokx W, Dogan A, Hiemstra PS, Van De Kerkhof PC, Schalkwijk J 2005 High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis. J Invest Dermatol 125:1163-1173
10. Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H 2007 Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol 127:594-604
11. Dinulos JG, Mentele L, Fredericks LP, Dale BA, Darmstadt GL 2003 Keratinocyte expression of human β defensin 2 following bacterial infection: role in cutaneous host defense. Clin Diagn Lab Immunol 10:161-166
12. Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schröder JM, Wang JM, Howard OM, Oppenheim JJ 1999 β-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286:525-528
13. Nomura I, Goleva E, Howell MD, Hamid QA, Ong PY, Hall CF, Darst MA, Gao B, Boguniewicz M, Travers JB, Leung DY 2003 Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 171:3262-3269
14. Bondeson J, Browne KA, Brennan FM, Foxwell BM, Feldmann M 1999 Selective regulation of cytokine induction by adenoviral gene transfer of IκBα into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-κB independent. J Immunol 162:2939-2945
15. Amigó M, Payá M, De Rosa S, Terencio MC 2007 Antipsoriatic effects of avarol-3′-thiosalicylate are mediated by inhibition of TNF-α generation and NF-κB activation in mouse skin. Br J Pharmacol 152:353-365
16. Kanda N, Watanabe S 2007 Histamine enhances the production of human β-defensin-2 in human keratinocytes. Am J Physiol Cell Physiol 293:C1916-C1923
17. Kanda N, Watanabe S 2007 Prolactin enhances interferon-γ- induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes. Endocrinology 148:2317-2325
18. 2-terminal kinase activation. Endocrinology 147:4505-4516
19. Schlee M, Harder J, Köten B, Stange EF, Wehkamp J, Fellermann K 2008 Probiotic lactobacilli and VSL#3 induce enterocyte β-defensin 2. Clin Exp Immunol 151:528-535
20. Kanda N, Shimizu T, Tada Y, Watanabe S 2007 IL-18 enhances IFN-γ-induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes. Eur J Immunol 37:338-350
21. Kanda N, Watanabe S 2005 17β-estradiol enhances heparin-binding epidermal growth factor-like growth factor production in human keratinocytes. Am J Physiol Cell Physiol 288:C813-C823
22. Kanda N, Watanabe S 2008 IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes. Eur J Immunol 38:1287-1296
23. Eickelberg O, Pansky A, Koehler E, Bihl M, Tamm M, Hildebrand P, Perruchoud AP, Kashgarian M, Roth M 2001 Molecular mechanisms of TGF-β antagonism by interferon-γ and cyclosporine A in lung fibroblasts. FASEB J 15:797-806
24. Rocchi P, Beraldi E, Ettinger S, Fazli L, Vessella RL, Nelson C, Gleave M 2005 Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis. Cancer Res 65:11083-11093
25. Mineshiba J, Myokai F, Mineshiba F, Matsuura K, Nishimura F, Takashiba S 2005 Transcriptional regulation of β-defensin-2 by lipopolysaccharide in cultured human cervical carcinoma (HeLa) cells. FEMS Immunol Med Microbiol 45:37-44
26. Schouten GJ, Vertegaal AC, Whiteside ST, Israel A, Toebes M, Dorsman JC, Van Der Eb AJ, Zantema A 1997 IκB α is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. EMBO J 16:3133-3144
27. Goh KC, Haque SJ, Williams BR 1999 p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. EMBO J 18:5601-5608
28. Morel JC, Park CC, Zhu K, Kumar P, Ruth JH, Koch AE 2002 Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression. J Biol Chem 277:34679-34691
29. Tsutsumi-Ishii Y, Nagaoka I 2003 Modulation of human β-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production. J Immunol 170:4226-4236
30. Sauer F, Hansen SK, Tjian R 1995 Multiple TAFIIs directing synergistic activation of transcription. Science 270:1783-1788
31. Thanos D, Maniatis T 1995 Virus induction of human IFN β gene expression requires the assembly of an enhanceosome. Cell 83:1091-1100
32. Hiroi M, Ohmori Y 2003 The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-κB for synergistic transcriptional activation of the CXC ligand9/monokine induced by interferon-γ gene. J Biol Chem 278:651-660
33. Ohmori Y, Schreiber RD, Hamilton TA 1997 Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κB. J Biol Chem 272:14899-14907
34. Bendinelli P, Maroni P, Pecori Giraldi F, Piccoletti R 2000 Leptin activates Stat3, Stat1 and AP-1 in mouse adipose tissue. Mol Cell Endocrinol 168:11-20
35. Gröschl M, Topf HG, Kratzsch J, Dötsch J, Rascher W, Rauh M 2005 Salivary leptin induces increased expression of growth factors in oral keratinocytes. J Mol Endocrinol 34:353-366
36. Zeidan A, Javadov S, Chakrabarti S, Karmazyn M 2008 Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei. Cardiovasc Res 77:64-72
37. Nguyen H, Ramana CV, Bayes J, Stark GR 2001 Roles of phosphatidylinositol 3-kinase in interferon-γ-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression. J Biol Chem 276:33361-33368
38. Gartsbein M, Alt A, Hashimoto K, Nakajima K, Kuroki T, Tennenbaum T 2006 The role of protein kinase C - activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation. J Cell Sci 119(Pt 3):470-481
39. Eiras S, Camiña JP, Diaz-Rodriguez E, Gualillo O, Casanueva FF 2004 Leptin inhibits lysophosphatidic acid-induced intracellular calcium rise by a protein kinase C-dependent mechanism. J Cell Physiol 201:214-226
40. Dellas C, Schäfer K, Rohm IK, Lankeit M, Leifheit M, Loskutoff DJ, Hasenfuss G, Konstantinides SV 2007 Leptin signalling and leptin-mediated activation of human platelets: importance of JAK2 and the phospholipases Cγ2 and A2. Thromb Haemost 98:1063-1071
41. Bowie A, O'Neill LA 2000 The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. J Leukoc Biol 67:508-514
42. Carter AB, Knudtson KL, Monick MM, Hunninghake GW 1999 The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression. The role of TATA-binding protein (TBP). J Biol Chem 274:30858-30863
43. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G 2003 Transcriptional activation of the NF-κB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J 22:1313-1324
44. Nguyen H, Chatterjee Kishore M, Jiang Z, Qing Y, Ramana CV, Bayes J, Commane M, Li X, Stark GR 2003 IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression. J Interferon Cytokine Res 23:183-192
45. Samanta AK, Lin H, Sun T, Kantarjian H, Arlinghaus RB 2006 Janus kinase 2: a critical target in chronic myelogenous leukemia. Cancer Res 66:6468-6472
46. Rouet-Benzineb P, Aparicio T, Guilmeau S, Pouzet C, Descatoire V, Buyse M, Bado A 2004 Leptin counteracts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-κB signaling. J Biol Chem 279:16495-16502
47. Kisich KO, Howel MD, Boguniewiczm M, Heizerm HR, Watson NU, Leung DY 2007 The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on β-defensin 3. J Invest Dermatol 127:2368-2380
48. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155-1161
49. Cohen AD, Sherf M, Vidavsky L, Vardy DA, Shapiro J, Meyerovitch J 2008 Association between psoriasis and the metabolic syndrome. A cross-sectional study. Dermatology 216:152-155
50. Hamminga EA, Van Der Lely AJ, Neumann HA, Thio HB 2006 Chronic inflammation in psoriasis and obesity: implications for therapy. Med Hypotheses 67:768-773
51. Buyukoglan H, Gulmez I, Kelestimur F, Kart L, Oymak FS, Demir R, Ozesmi M 2007 Leptin levels in various manifestations of pulmonary tuberculosis. Mediators Inflamm 2007:64859
52. Mantovani G, Macciò A, Madeddu C, Mura L, Massa E, Mudu MC, Mulas C, Lusso MR, Gramignano G, Piras MB 2001 Serum values of proinflammatory cytokines are inversely correlated with serum leptin levels in patients with advanced stage cancer at different sites. J Mol Med 79:406-414
53. Schols AM, Creutzberg EC, Buurman WA, Campfield LA, Saris WH, Wouters EF 1999 Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160:1220-1226