Keratinocyte expression of human β defensin 2 following bacterial infection: Role in cutaneous host defense

Clinical and Diagnostic Laboratory Immunology

Volumn 10, Issue 1, 2003, Pages 161-166

  Dinulos, James G H ^a   Mentele, Laurel ^a   Fredericks, L Page ^a   Dale, Beverly A ^a   Darmstadt, Gary L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN; CYTOKINE; INTERLEUKIN 1BETA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BACTERIAL INFECTION; BACTERIUM ADHERENCE; BACTERIUM CULTURE; CELL CULTURE; COLONY FORMING UNIT; ESCHERICHIA COLI; GENE EXPRESSION; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNITY; KERATINOCYTE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN DISEASE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRATUM CORNEUM; STREPTOCOCCUS PYOGENES;

EID: 0037250369     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/CDLI.10.1.161-166.2003     Document Type: Article

References (25)

1. Ali, R. S., A. Falconer, M. Ikram, C. E. Bissett, R. Cerio, and A. G. Quinn. 2001. Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin. J. Investig. Dermatol. 117:106-111.
2. Bals, R., X. Wang, R. L. Meegalla, S. Wattler, D. J. Weiner, M. C. Nehls, and J. M. Wilson. 1999. Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect. Immun. 67:3542-3547.
3. Chronnell, C. M., L. R. Ghali, R. S. Ali, A. G. Quinn, D. B. Holland, J. J. Bull, W. J. Cunliffe, I. A. McKay, M. P. Philpott, and S. Muller-Rover. 2001. Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions. J. Investig. Dermatol. 117:1120-1125.
4. Dale, B. A., J. R. Kimball, S. Krisanaprakornkit, F. Roberts, M. Robinovitch, R. O'Neal, E. V. Valore, T. Ganz, G. M. Anderson, and A. Weinberg. 2001. Localized antimicrobial peptide expression in human gingiva. J. Periodontal Res. 36:285-294.
5. Darmstadt, G. L., P. Fleckman, M. Jonas, E. Chi, and C. E. Rubens. 1998. Differentiation of cultured keratinocytes promotes the adherence of Streptococcus pyogenes. J. Clin. Investig. 101:128-136.
6. Darmstadt, G. L., P. Fleckman, and C. E. Rubens. 1999. Tumor necrosis factor-alpha and interleukin-1alpha decrease the adherence of Streptococcus pyogenes to cultured keratinocytes. J. Infect. Dis. 180:1718-1721.
7. Darmstadt, G. L., L. Mentele, P. Fleckman, and C. E. Rubens. 1999. Role of keratinocyte injury in adherence of Streptococcus pyogenes. Infect. Immun. 67:6707-6709.
8. Darmstadt, G. L., L. Mentele, A. Podbielski, and C. E. Rubens. 2000. Role of group A streptococcal virulence factors in adherence to keratinocytes. Infect Immun. 68:1215-1221.
9. Diamond, G., D. E. Jones, and C. L. Bevins. 1993. Airway epithelial cells are the site of expression of a mammalian antimicrobial peptide gene. Proc. Natl. Acad. Sci. USA 90:4596-4600.
10. Dorschner, R. A., V. K. Pestonjamasp, S. Tamakuwala, T. Ohtake, J. Rudisill, V. Nizet, B. Agerberth, G. H. Gudmundsson, and R. L. Gallo. 2001. Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A streptococcus. J. Investig. Dermatol. 117:91-97.
11. Haanes, E. J., and P. P. Cleary. 1989. Identification of a divergent M protein gene and an M protein-related gene family in Streptococcus pyogenes serotype 49. J. Bacteriol. 171:6397-6408.
12. Hancock, R. E. 1997. Peptide antibiotics. Lancet 349:418-422.
13. Harder, J., J. Bartels, E. Christophers, and J. M. Schroder. 1997. A peptide antibiotic from human skin. Nature 387:861.
14. Harder, J., U. Meyer-Hoffert, L. M. Teran, L. Schwichtenberg, J. Bartels, S. Maune, and J. M. Schroder. 2000. Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am. J. Respir. Cell Mol. Biol. 22:714-721.
15. Krisanaprakornkit, S., J. R. Kimball, A. Weinberg, R. P. Darveau, B. W. Bainbridge, and B. A. Dale. 2000. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect. Immun. 68:2907-2915.
16. Liu, L., L. Wang, H. P. Jia, C. Zhao, H. H. Heng, B. C. Schutte, P. B. McCray, Jr., and T. Ganz. 1998. Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene 222:237-244.
17. Nizet, V., T. Ohtake, X. Lauth, J. Trowbridge, J. Rudisill, R. A. Dorschner, V. Pestonjamasp, J. Piraino, K. Huttner, and R. L. Gallo. 2001. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414:454-457.
18. Piepkorn, M., P. Hovingh, A. Dillberger, and A. Linker. 1995. Divergent regulation of proteoglycan and glycosaminoglycan free chain expression in human keratinocytes and melanocytes. In Vitro Cell. Dev. Biol. Anim. 31:536-541.
19. Porter, E. M., E. van Dam, E. V. Valore, and T. Ganz. 1997. Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect. Immun. 65:2396-2401.
20. Schmid, P., O. Grenet, J. Medina, S. D. Chibout, C. Osborne, and D. A. Cox. 2001. An intrinsic antibiotic mechanism in wounds and tissue-engineered skin. J. Investig. Dermatol. 116:471-472.
21. Schroder, J. M., and J. Harder. 1999. Human beta-defensin-2. Int. J. Biochem. Cell Biol. 31:645-651.
22. Singh, P. K., H. P. Jia, K. Wiles, J. Hesselberth, L. Liu, B. A. Conway, E. P. Greenberg, E. V. Valore, M. J. Welsh, T. Ganz, B. F. Tack, and P. B. McCray, Jr. 1998. Production of beta-defensins by human airway epithelia. Proc. Natl. Acad. Sci. USA 95:14961-14966.
23. Valore, E. V., C. H. Park, A. J. Quayle, K. R. Wiles, P. B. McCray, Jr., and T. Ganz. 1998. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Investig. 101:1633-1642.
24. Wiedow, O., J. Harder, J. Bartels, V. Streit, and E. Christophers. 1998. Antileukoprotease in human skin: an antibiotic peptide constitutively produced by keratinocytes. Biochem. Biophys. Res. Commun. 248:904-909.
25. Yang, D., O. Chertov, S. N. Bykovskaia, Q. Chen, M. J. Buffo, J. Shogan, M. Anderson, J. M. Schroder, J. M. Wang, O. M. Howard, and J. J. Oppenheim. 1999. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286:525-528.