Salivary leptin induces increased expression of growth factors in oral keratinocytes

Journal of Molecular Endocrinology

Volumn 34, Issue 2, 2005, Pages 353-366

  Gröschl, Michael ^b,c   Topf, H G ^b   Kratzsch, J ^a   Dotsch J ^b   Rascher, W ^b   Rauh, M ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR; LEPTIN; LEPTIN RECEPTOR; RECOMBINANT LEPTIN; RNA; STAT1 PROTEIN; STAT3 PROTEIN;

AFFINITY CHROMATOGRAPHY; ANTIBODY SPECIFICITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FILTRATION; HUMAN; HUMAN CELL; INCUBATION TIME; KERATINOCYTE; MOUTH CAVITY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; SALIVA LEVEL; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; WOUND HEALING;

CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; LEPTIN; MOUTH MUCOSA; SALIVA; SIGNAL TRANSDUCTION;

EID: 17844363986     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.01658     Document Type: Article

References (68)

1. Alison MR & Sarraf CE 1994 The role of growth factors in gastrointestinal cell proliferation. Cell Biology International 18 1-10.
2. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre Millo M, Le-Marchand Brustel Y et al. 1998 The stomach is a source of leptin. Nature 394 790-793.
3. Banks AS, Davis SM, Bates SH & Myers MGJ 2000 Activation of downstream signals by the long form of the leptin receptor. Journal of Biological Chemistry 275 14563-14572.
4. Bendinelli P, Maroni P, Pecori-Girakli F & Piccoletti R 2000 Leptin activates Stat3, Stat1 and AP-1 in mouse adipose tissue. Molecular and Cellular Endocrinology 168 11-20.
5. Bodner L 1991 Effect of parotid submandibular and sublingual saliva on wound healing in rats. Comparative Biochemistry and Physiology 100 887-890.
6. Bodner L, Dayan D, Oberman M, Hirshberg A & Tal H 1992 Healing of experimental wounds in sialadenectomized rat. Journal of Clinical Periadontology 19 345-347.
7. Bodner L, Dayan D, Pinto Y & Hammel I 1993 Characteristics of palatal wound healing in desalivated rats. Archives of Oral Biology 38 17-21.
8. Bohlender J, Rauh M, Zenk J & Gröschl M 2003. Differential distribution and expression of leptin and the functional leptin-receptor in major salivary glands of humans. Journal of Endocrinology 178 217-223.
9. Breidert M, Miehlke S, Glasow A, Orban Z, Stolte M, Ehninger G, Bayerdorffer E, Nettesheim O, Halm U, Haidan A et al. 1999 Leptin and its receptor in normal human gastric mucosa and in Helicobacter pylori-associated gastritis. Scandinavian Journal of Gastroenterology 34 954-961.
10. Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Duda A, Pierzchalski P, Bielanski W & Hahn EG 1999 Leptin in gastroprotection induced by cholecystokinin or by a meal. Role of vagal and sensory nerves and nitric oxide. European Journal of Pharmacology 374 263-276.
11. Cinti S, De Matteis R, Pico C, Ceresi E, Obrador A, Maffei C, Oliver J & Pulou A 2000 Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin. International Journal of Obesity 24 789-793.
12. De Matteis R, Puxeddu R, Riva A & Cinti S 2002 Intralobular ducts of human major salivary glands contain leptin and its receptor. Journal of Anatomy 201 363-370.
13. Dörr W, Spekl K & Farrell CL 2002 The effect of keratinocyte growth factor on healing of manifest radiation ulcers in mouse tongue epithelium. Cell Proliferation 35 (Suppl 1) 86-92.
14. Drugan CS, Stone A, Game SM & Prime SS 1997 The mitogenic effect of KGF and the expression of its cell surface receptor on cultured normal and malignant human oral keratinocytes and on contiguous fibroblasts. Journal of Oral Pathology and Medicine 26 327-333.
15. Ducroc R, Guilmeau S, Akashi K, Devaud H, Buyse M & Bado A 2005 Luminal leptin induces inhibition of active intestinal absorption of glucose mediated by sodium-glucose co-transporter, SGLT-1. Diabetes 54 348-354.
16. Elmquist JK, Ahima RS, Maratos-Flier E, Flier JS & Saper CB 1997 Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138 839-842.
17. Elmquist JK, Maratos-Flier E, Saper CB & Flier JS 1998 Unraveling the central nervous system pathways underlying responses to leptin. Nature Neuroscience 1 445-450.
18. Formanek M, Knerer B & Kornfehl J 1999 Cytokine expression of human oral keratinocytes. Journal of Oto-Rhino-Larygology and its Related Specialties 61 103-107.
19. Frank S, Stallmeyer B, Kampfer H, Kolb N & Pfeilschifter J 2000 Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. Journal of Clinical Investigation 106 501-509.
20. Goren I, Pfeilschifter J & Frank S 2003 Determination of leptin signaling pathways in human and murine keratinocytes. Biochemical and Biophysical Research Communications 303 1080-1085.
21. Gröschl M, Wagner R, Dörr HG, Blum WF, Rascher W & Dötsch J 2000 Variability of leptin values measured from different sample matrices. Hormone Research 54 26-31.
22. Gröschl M, Rauh M, Wagner R, Neuhuber W, Metzler M, Tamgüney G, Zenk J, Schoof E, Dörr HG, Blum WF et al. 2001 Identification of leptin in human saliva. Journal of Clinical Endocrinology and Metabolism 86 5234-5239.
23. Gröschl M, Rauh M, Dörr HG, Blum WF, Rascher W & Dötsch J 2002 Salivary leptin during the menstrual cycle and its relation to progesterone. Fertility and Sterility 77 1306-1307.
24. Gröschl M, Topf HG, Bohlender J, Zenk J, Klussmann S, Dötsch J, Rascher W & Rauh M 2005 Identification of ghrelin in human saliva: expression by the salivary glands and potential role on the proliferation of oral keratinocytes. Clinical Chemistry (In Press).
25. Hackel P, Zwick E, Prenzel N & Ullrich A 1999 Epidermal growth factor receptors: critical mediators of multiple receptor pathways. Current Opinion in Cell Biology 11 184-189.
26. Hakansson ML & Meister B 1998 Transcription factor STAT3 in leptin target neurons of the rat hypothalamus. Neuroendocrinology 68 420-427.
27. Halaas JL & Friedman JM 1997 Leptin and its receptor. Journal of Endocrinology 155 215-216.
28. Hart BL & Powell KL 1990 Antibacterial properties of saliva: role in maternal periparturient grooming and in licking wounds. Physiology and Behavior 48 383-386.
29. Hart BL, Korinek E & Brennan P 1987 Postcopulatory genital grooming in male rats: prevention of sexually transmitted infections. Physiology and Behavior 41 321-325.
30. Higa M, Shimabukurro M, Fukuchi M, Komiya I & Takasu N 2002 Atrophic change of rat salivary gland during adenovirus-induced hyperleptinemia. Biochemical and Biophysical Research Communications 291 675-679.
31. Hu X, Juneja SC, Maihle NJ & Cleary MP 2002 Leptin - a growth factor in normal and malignant breast cells and for normal mammary gland development. Journal of the National Cancer Institute 94 1704-1711.
32. Iversen PO, Drevon CA & Reseland JE 2002 Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. Blood 100 4123-4128.
33. Jahovic N, Güzel E, Arbak S & Yegen BC 2004 The healing-promoting effect of saliva on skin burn is mediated by epidermal growth factor (EGF): role of the neutrophils. Burns 30 531-538.
34. Jurukovski V & Simon M 2000 Epidermal growth factor signaling pathway influences retinoid metabolism by reduction of retinyl ester hydrolase activities in normal and malignant keratinocytes. Journal of Cellular Physiology 183 265-272.
35. Kondo S 1999 The roles of keratinocyte-derived cytokines in the epidermis and their possible responses to UVA-irradiation. Journal of Investigative Dermatology. Symposium Proceedings 4 177-183.
36. Konturek PC, Brzozowski T, Sulekova Z, Brzozowska I, Duda A, Meixner H, Hahn EG & Konturek SJ 2001 Role of leptin in ulcer healing. European Journal of Pharmacology 414 87-97.
37. Lammert A, Kiess W, Bottner A, Glasow A & Kratzsch J 2001 Soluble leptin receptor represents the main leptin binding activity in human blood. Biochemical and Biophysical Research Communications 283 982-988.
38. Lauer G, Schimming R & Frankenschmidt A 2001 Intraoral wound closure with tissue-engineered mucosa: new perspectives for urethra reconstruction with buccal mucosa grafts. Plastic and Reconstructive Surgery 107 25-33.
39. Loftus TM 1999 An adipocyte-central nervous system regulatory loop in the control of adipose homeostasis. Seminars in Cell and Developmental Biology 10 11-18.
40. Marchese C, Chedid M, Dirsch O, Csasky K, Santanelli F, Latini C, LaRocelle W, Torrisi M & Aaronson S 1995 Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin. Journal of Experimental Medicine 182 1369-1376.
41. Martin Romero C, Santos Alvarez J, Goberna R & Sanchez Margalet V 2000 Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cellular Immunology 199 15-24.
42. Morash B, Li A, Murphy PR, Wilkinson M & Ur E 1999 Leptin gene expression in the brain and pituitary gland. Endocrinology 140 5995-5998.
43. Morton NM, Emilsson V, Liu YL & Cawthorne MA 1998 Leptin action in intestinal cells. Journal of Biological Chemistry 273 26194-26201.
44. Muoio DM & Dohm GL 2002 Peripheral metabolic actions of leptin. Best Practice and Research. Clinical Endocrinology and Metabolism 16 653-666.
45. Olsen PS, Poulsen SS, Kirkegaard P & Nexo E 1984 Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Gastroenterology 87 103-108.
46. Partridge M, Kiguwa S, Luqmani Y & Langdon JD 1996 Expression of bFGF, KGF and FGF receptors on normal oral mucosa and SCC. European Journal of Cancer. Part B Oral Oncology 32B 76-82.
47. Randeva H, Karteris E, Sailesh S, O'Hare P & Hillhouse EW 2003 Circadian rhythmicity of salivary leptin in healthy subjects. Molecular Genetics and Metabolism 78 229-235.
48. Rosenblum CI, Tota M, Cully D, Smith T, Collum R, Qureshi S, Hess JF, Phillips MS, Hey PJ, Vongs A et al. 1996 Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells. Endocrinology 137 5178-5181.
49. Sanaie AR, Firth JD, Uitto VJ & Putnins EE 2002 Keratinocyte growth factor (KGF)-1 and -2 protein and gene expression in human gingival fibroblasts. Journal of Periodontal Research 37 66-74.
50. Seeley RJ, van Dijk G, Campfield LA, Smith FJ, Burn P, Nelligan JA, Bell SM, Baskin DG, Woods SC & Schwartz MW 1996 Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Hormone and Metabolic Research 28 664-668.
51. Shintani S, Matsuo K, Crohin C, McBride J, Tsuji T, Donoff B, Posner M, Todd M & Wong D 1999 Intergenic mutation analysis of human epidermal growth factor receptor (EGFR) gene in malignant human oral keratinocytes. Cancer Research 59 4142-4147.
52. Slomiany B & Slomiany A 2003 Leptin suppresses Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis. Biochemical and Biophysical Research Communications 312 1099-1103.
53. Slonina D, Hoinkis C & Dörr W 2001 Effect of keratinocyte growth factor on radiation survival and colony size of human epidermal keratinocytes in vitro. Radiation Research 156 761-766.
54. Sobhani I, Buyse M, Goiot H, Weber N, Laigneau JP, Henin D, Soul JC & Bado A 2002 Vagal stimulation rapidly increases leptin secretion in human stomach. Gastroenterology 122 259-263.
55. Stallmeyer B, Kämpfer H, Podda M, Kaufmann R, Pfeilschifter J & Frank S 2001 A novel keratinocyte mitogen: regulation of leptin and its functional receptor in skin repair. Journal of Investigative Dermatology 117 98-105.
56. Sweeney G 2002 Leptin signalling. Cellular Signalling 14 655-663.
57. Tebar F, Grau M, Mena MP, Arnau A, Soley M & Ramirez I 2000 Epidermal growth factor secreted from submandibular salivary glands interferes with the lipolytic effect of adrenaline in mice. Endocrinology 141 876-882.
58. Thomas SA, Preston JE, Wilson MR, Farrell CL & Segal MB 2001 Leptin transport at the blood-cerebrospinal fluid barrier using the perfused sheep choroid plexus model. Brain Research 895 283-290.
59. Thulesen J, Bor MV, Thulesen S, Nexo E, Poulsen SS & Jorgensen PE 2002 Altered secretion and processing of epidermal growth factor in adrenergic-induced growth of the rat submandibular gland. Regulatory Peptides 106 105-114.
60. Tsuchiya T, Shimizu H, Horie T & Mori M 1999 Expression of leptin receptor in lung: leptin as a growth factor. European Journal of Pharmacology 365 273-279.
61. Visco V, Belleudi F, Marchese C, Leone L, Aimati L, Cardinali G, Kovacs D, Frati L & Torrisi M 2004 Differential response to keratinocyte growth factor receptor and epidermal growth factor receptor ligands of proliferating and differentiating intestinal epithelial cells. Journal of Cell Physiology 200 31-44.
62. Wang MY, Zhou YT, Newgard CB & Unger RH 1996 A novel leptin receptor isoform in rat. FEBS Letters 392 87-90.
63. Wolf G, Hamann A, Han DC, Helmchen U, Thaiss F, Ziyadeh FN & Stahl RA 1999 Leptin stimulates proliferation and TGF-beta expression in renal glomerular endothelial cells: potential role in glomerulosclerosis. Kidney International 56 860-872.
64. Wu MH, Chuang PC, Chen HM, Lin CC & Tsai SJ 2002 Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation. Molecular Human Reproduction 8 456-464.
65. Yoshizawa T, Watanabe S, Hirose M, Yamamoto J, Osada T, Sato K, Oide H, Kitamura T, Takei Y, Ogihara T et al. 2000 Effects of growth factors on aspirin-induced inhibition of wound repair in a rabbit gastric epithelial cell model. Alimentary Pharmacology and Therapeutics 14 (Suppl 1) 176-182.
66. Zhang HH, Kumar S, Barnett AH & Eggo MC 2000 Ceiling culture of mature human adipocytes: use in studies of adipocyte functions. Journal of Endocrinology 164 119-128.
67. Zhao J, Kunz TH, Tumba N, Schulz LC, Li C, Reeves M & Widmaier EP 2003 Comparative analysis of expression and secretion of placental leptin in mammals. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 285 R438-R446.
68. Zwick E, Hackel P, Prenzel N & Ullrich A 1999 The EGF receptor as signal transducer of heterologous signalling systems. Trends in Pharmacological Sciences 20 408-412.