Leptin signalling and leptin-mediated activation of human platelets: Importance of JAK2 and the phospholipases Cγ2 and A2

Thrombosis and Haemostasis

Volumn 98, Issue 5, 2007, Pages 1063-1071

  Dellas, Claudia ^a   Schäfer, Katrin ^a   Rohm, Ilonka K ^a   Lankeit, Mareike ^a   Leifheit, Maren ^a   Loskutoff, David J ^b,c   Hasenfuss, Gerd ^a   Konstantinides, Stavros V ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

Janus kinase; Leptin; Phospholipase; Platelets; Signal transduction

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; JANUS KINASE 2; LEPTIN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE C; STAT3 PROTEIN; THROMBOXANE;

ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; DNA FLANKING REGION; ENZYME BLOOD LEVEL; HUMAN; HYPERLEPTINEMIA; OBESITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RISK; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOSIS;

CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRINOGEN; HUMANS; JANUS KINASE 2; LEPTIN; PHOSPHOLIPASE C GAMMA; PHOSPHOLIPASES A2; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET ADHESIVENESS; SIGNAL TRANSDUCTION;

EID: 36049041393     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH07-03-0213     Document Type: Article

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