Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1

Pharmacogenetics and Genomics

Volumn 18, Issue 7, 2008, Pages 559-568

  Oswald, Stefan ^a   König, Jörg ^a   Lütjohann, Dieter ^a   Giessmann, Thomas ^a   Kroemer, Heyo K ^a   Rimmbach, Christian ^a   Rosskopf, Dieter ^a   Fromm, Martin F ^a   Siegmund, Werner ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Ezetimibe; Genetic polymorphisms; Hepatic uptake; Organic anion transporting polypeptide1B1

Indexed keywords

BROMSULFOPHTHALEIN; CARRIER PROTEINS AND BINDING PROTEINS; EZETIMIBE; GLUCURONIDE; ORGANIC ANION TRANSPORTER 2; STEROL; AZETIDINE DERIVATIVE; ORGANIC ANION TRANSPORTER; SLCO1B1 PROTEIN, HUMAN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN HEK293; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DISPOSITION; DRUG EFFECT; DRUG EXCRETION; DRUG FECES LEVEL; DRUG UPTAKE; DRUG URINE LEVEL; EMBRYO; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IC 50; LIVER MICROSOME METABOLISM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; CELL CULTURE; CLINICAL TRIAL; DRUG DETOXIFICATION; GENETICS; LIVER; METABOLISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AZETIDINES; CELLS, CULTURED; FEMALE; GENOTYPE; HUMANS; LIVER; MALE; METABOLIC DETOXICATION, DRUG; ORGANIC ANION TRANSPORTERS; POLYMORPHISM, SINGLE NUCLEOTIDE; STEROLS; SULFOBROMOPHTHALEIN;

EID: 53049109106     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3282fe9a2c     Document Type: Article

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