Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities

Journal of Medicinal Chemistry

Volumn 51, Issue 17, 2008, Pages 5198-5220

  Duan, Dehui ^a,i   Sigano, Dina M ^a   Kelley, James A ^a   Lai, Christopher C ^a   Lewin, Nancy E ^b   Kedei, Noemi ^b   Peach, Megan L ^c   Lee, Jeewoo ^d   Abeyweera, Thushara P ^e,g   Rotenberg, Susan A ^e   Kim, Hee ^f   Young, Ho Kim ^f   El Kazzouli, Saïd ^a   Chung, Jae Uk ^d,j   Young, Howard A ^a   Young, Matthew R ^a   Baker, Alyson ^a   Colburn, Nancy H ^a   Haimovitz Friedman, Adriana ^g   Truman, Jean Philip ^g   Parrish, Damon A ^h   Deschamps, Jeffrey R ^h   Perry, Nicholas A ^b   Surawski, Robert J ^b   Blumberg, Peter M ^b   Marquez, Victor E ^a   more..

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

^d Seoul National University   (South Korea)

^e CITY UNIVERSITY OF NEW YORK   (United States)

^f Digital Biotech   (South Korea)

^g MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^h NAVAL RESEARCH LABORATORY   (United States)

ⁱ Sequoia Pharmaceuticals Inc   (United States)

^j Choongwae Pharma Co   (South Korea)

more..

Author keywords

[No Author keywords available]

Indexed keywords

[2 (HYDROXYMETHYL) 5 OXO 4 [[4 (TRIFLUOROMETHYL)PHENYL]METHYLENE] 2 2,3 DIHYDROFURYL]METHYL 2 PROPYLPENTANOATE; [4 [(4 FLUOROPHENYL)METHYLENE] 2 (HYDROXYMETHYL) 5 OXO 2 2,3 DIHYDROFURYL]METHYL 2 PROPYLPENTANOATE; DIACYLGLYCEROL; DIACYLGLYCEROL DERIVATIVE; ISOENZYME; LACTONE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CELL MEMBRANE; CELL ORGANELLE; CELLULAR DISTRIBUTION; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION;

BINDING SITES; CHEMISTRY; COMBINATORIAL CHEMISTRY TECHNIQUES; DIGLYCERIDES; HUMANS; LACTONES; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN KINASE C-ALPHA; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51849101594     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8001907     Document Type: Article

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