Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions

Journal of Medicinal Chemistry

Volumn 49, Issue 11, 2006, Pages 3185-3203

  Kang, Ji Hye ^a   Benzaria, Samira ^a,d   Sigano, Dina M ^a   Lewin, Nancy E ^b   Pu, Yongmei ^b   Peach, Megan L ^c   Blumberg, Peter M ^b   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

^d Idenix Pharmaceuticals SARL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; DIACYLGLYCEROL LACTONE; PHENYL GROUP; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATION; ENZYME LOCALIZATION; ENZYME REGULATION; PROTEIN DOMAIN;

DIGLYCERIDES; FURANS; LACTONES; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM;

EID: 33744817634     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060011o     Document Type: Article

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