Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain

Journal of Medicinal Chemistry

Volumn 46, Issue 13, 2003, Pages 2790-2793

  Choi, Yongseok ^a   Kang, Ji Hye ^a   Lewin, Nancy E ^b   Blumberg, Peter M ^b   Lee, Jeewoo ^c   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

6 [[2 [[2 (2 CYANO 1 PYRROLIDINYL) 2 OXOETHYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; DIACYLGLYCEROL DERIVATIVE; HYDROXYLAMINE; LACTONE DERIVATIVE; N HYDROXY N [[2 (HYDROXYMETHYL) 4 [5 METHYL 3 (2 METHYLPROPYL)HEXYLIDENE] 5 OXO (2,3 DIHYDROFURYL)]METHYL] 2,2 DIMETHYLPROPANAMIDE; PROTEIN KINASE C; UNCLASSIFIED DRUG; VILDAGLIPTIN;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING;

4-BUTYROLACTONE; DIGLYCERIDES; LACTONES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN KINASE C; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038115296     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030082c     Document Type: Article

References (5)

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2. Lee, J.; Han, K.-C.; Kang, J.-H.; Pearce, L. L.; Lewin, N. E.; Yan, S.; Benzaria, S.; Nicklaus, M. C.; Blumberg, P. M.; Marquez, V. E. J. Med. Chem. 2003, 46, 2794.
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4. 5: C, 70.16; H, 6.48. Found: C, 70.13; H, 6.49.
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