Quality control in combinatorial chemistry: Determination of the quantity, purity, and quantitative purity of compounds in combinatorial libraries

Journal of Combinatorial Chemistry

Volumn 5, Issue 5, 2003, Pages 547-559

  Yan, Bing ^a   Fang, Liling ^a   Irving, Mark ^a   Zhang, Sue ^a   Boldi, Armen M ^a   Woolard, Frank ^a   Johnson, Charles R ^a   Kshirsagar, Tushar ^a   Figliozzi, Gianine M ^a   Krueger, Clinton A ^a   Collins, Nathan ^a  

^a Discovery Partners International   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMBINATORIAL CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; MEASUREMENT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PURIFICATION; QUALITY CONTROL; QUANTITATIVE ASSAY; SAMPLING; SCREENING TEST; ULTRAVIOLET RADIATION; ULTRAVIOLET SPECTROSCOPY;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG CONTAMINATION; PHARMACEUTICAL PREPARATIONS; QUALITY CONTROL;

EID: 0141795499     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc030008f     Document Type: Article

References (37)

1. (a) Gordon, E. M.; Barrett, R. W.; Dower, W. J.; Fodor, S. P.; Gallop, M. A. J. Med. Chem. 1994, 37, 1385.
2. (b) Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555.
3. (c) DeWitt, D. H.; Czarnik, A. W. Acc. Chem. Res. 1996, 29, 114.
4. (d) Balkenhohl, F.; Bussche-Hunnefeld, C.; Lansky, A.; Zechel, C. Angew. Chem., Int. Ed. Engl. 1996, 35, 2288.
5. (e) Lam, K. S.; Lebl, M.; Krchnak, V. Chem. Rev. 1997, 97, 411.
6. (a) Leznoff, C. C. Chem. Soc. Rev. 1974, 3, 65.
7. (b) James, I. W. Mol. Diversity 1996, 2, 175.
8. (c) Hermkens, P. H. H.; Ottenheijm, H. C. J.; Rees, D. Tetrahedron 1996, 52, 4527.
9. (d) Brown, R. Contemp. Org. Synth. 1997, 4, 216.
10. (e) Czarnik, A. W.; DeWitt, S. H. A Practical Guide to Combinatorial Chemistry; American Chemical Society: Washington, DC, 1997.
11. (a) Keifer, P. A. Drug Discovery Today, 1997, 2, 468.
12. (b) Keifer, P. A. Drugs Future 1998, 23, 301.
13. (a) Weller, H. N. Mol. Diversity 1999, 4, 47.
14. (b) Kyranos, J. N.; Cai, H.; Zhang, B.; Goetzinger, W. K. Curr. Opin. Drug Discovery Dev. 2001, 4, 719.
15. (c) Edwards, C.; Hunter, D. J. J. Comb. Chem. 2002, in press.
16. (d) Isbell, J.; Xu, R.; Cai, Z.; Kassel, D. B. J. Comb. Chem. 2002, 4, 600.
17. Fang, L.; Demee, M.; Cournoyer, J.; Sierra, T.; Young, C.; Yan, B. Rapid Commun. Mass Spectrom. 2003, in press.
18. (a) Hsu, B. H.; Orton, E., Tang, S.Y.; Carlton, R.A. J. Chromatogr., B 1999, 725, 103.
19. (b) Kibbey, C.E.; Mol. Diversity 1995, 1, 247.
20. (c) Fang, L.; Wan, M.; Pennacchio, M.; Pan, J. J. Comb. Chem. 2000, 2, 254.
21. Fang, L.; Pan, J.; Yan, B. Bioeng. Biotechnol. Comb. Chem. 2001, 71, 162.
22. Fang, L.; Demee, M.; Sierra, T.; Zhao, J.; Tokushige, D.; Yan, B. Rapid Commun. Mass Spectrom. 2002, 16, 1440.
23. (a) Rabenstein, D. L.; Keire, D. A. Marcel Dekker: New York, 1991, pp 323-369.
24. (b) Maniara, G.; Rajamoorthi, K.; Rajan, S.; Stockton, G. W. Anal. Chem. 1998, 70, 4921.
25. (c) Godejohann, M.; Preiss, A. Anal. Chem. 1998, 70, 590.
26. (d) Drew, M.; Orton, E.; Krolokowski, P.; Salvino, J.; Kumar, V. J. Comb. Chem. 2000, 2, 8.
27. (e) Ellis, D. A.; Martin, J. W.; Muir, D. C. G.; Mabury, S. A. Anal. Chem. 2000, 72, 726.
28. (f) Gerritz, S.; Sefler A. J. Comb. Chem. 2000, 2, 39.
29. (g) Pinciroli, V.; Biancardi, R.; Colombo, N.; Colombo, M.; Rizzo, V. J. Comb. Chem. 2001, 3, 434.
30. (h) Silvestre, V.; Goupry, S.; Trierweiler, M.; Robins, R.; Akoka, S. Anal. Chem. 2001, 73, 1862.
31. (i) Hany, R.; Rentsch, D.; Dhanapal, B.; Obrecht, D. J. Comb. Chem. 2001, 3, 85.
32. (a) Fitch, W. L.; Szardenings, A. K.; Fujinari, E. M. Tetrahedron Lett. 1997, 38, 1689.
33. (b) Fujinari, E. M.; Manes, J. D.; Bizanek, R. J. Chromatogr., A. 1996, 743, 85.
34. (c) Fujinari, E. M.; Manes, J. D. J. Chromatogr., A, 1994, 676, 113.
35. (d) Taylor, E. W.; Qian, M. G.; Dollinger, G. D. Anal. Chem. 1998, 70, 3339.
36. (e) Yurek, D. A.; Branch, D. L.; Kuo, M. J. Comb. Chem. 2002, 4, 138.
37. MacDonald, A. A.; DeWitt, S. H.; Ghosh, S.; Hogan, E. M.; Kieras, L.; Czarnik, A. W.; Ramage, R. Mol. Diversity 1995, 1, 183.