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Volumn 29, Issue 11, 2008, Pages 1666-1679

The length of hippocampal cholinergic fibers is reduced in the aging brain

Author keywords

Aging; Brain derived neurotrophic factor; Choline acetyltransferase; Cholinergic axons; Cholinergic neurons; Hippocampus; Medial septal nucleus; Nerve growth factor; Optical fractionator probe; p75 neurotrophin receptor; Septohippocampal pathway; Spherical probe; Stereology; Synaptophysin; Tropomyosin related kinase receptor A; Tropomyosin related kinase receptor B

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CHOLINE ACETYLTRANSFERASE; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR P75; SYNAPTOPHYSIN; TROPOMYOSIN; TROPOMYOSIN RELATED KINASE RECEPTOR; UNCLASSIFIED DRUG;

EID: 51449106987     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.04.001     Document Type: Article
Times cited : (40)

References (126)
  • 1
    • 0025168085 scopus 로고
    • Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture
    • Alderson R.F., Alterman A.L., Barde Y.A., and Lindsay R.M. Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron 5 (1990) 297-306
    • (1990) Neuron , vol.5 , pp. 297-306
    • Alderson, R.F.1    Alterman, A.L.2    Barde, Y.A.3    Lindsay, R.M.4
  • 2
    • 0028902107 scopus 로고
    • Cholinergic innervation of the primate hippocampal formation. I. Distribution of choline acetyltransferase immunoreactivity in the Macaca fascicularis and Macaca mulatta monkeys
    • Alonso J.R., and Amaral D.G. Cholinergic innervation of the primate hippocampal formation. I. Distribution of choline acetyltransferase immunoreactivity in the Macaca fascicularis and Macaca mulatta monkeys. J. Comp. Neurol. 355 (1995) 135-170
    • (1995) J. Comp. Neurol. , vol.355 , pp. 135-170
    • Alonso, J.R.1    Amaral, D.G.2
  • 3
  • 4
    • 0024842108 scopus 로고
    • The three-dimensional organization of the hippocampal formation: a review of anatomical data
    • Amaral D.G., and Witter M.P. The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 31 (1989) 571-591
    • (1989) Neuroscience , vol.31 , pp. 571-591
    • Amaral, D.G.1    Witter, M.P.2
  • 5
    • 0027295385 scopus 로고
    • Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats
    • Armstrong D.M., Sheffield R., Buzsaki G., Chen K.S., Hersh L.B., Nearing B., and Gage F.H. Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats. Neurobiol. Aging 14 (1993) 457-470
    • (1993) Neurobiol. Aging , vol.14 , pp. 457-470
    • Armstrong, D.M.1    Sheffield, R.2    Buzsaki, G.3    Chen, K.S.4    Hersh, L.B.5    Nearing, B.6    Gage, F.H.7
  • 6
    • 0032517150 scopus 로고    scopus 로고
    • Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation
    • Aubert I., Ridet J.L., Schachner M., Rougon G., and Gage F.H. Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation. J. Comp. Neurol. 399 (1998) 1-19
    • (1998) J. Comp. Neurol. , vol.399 , pp. 1-19
    • Aubert, I.1    Ridet, J.L.2    Schachner, M.3    Rougon, G.4    Gage, F.H.5
  • 7
    • 0029003781 scopus 로고
    • Cholinergic markers in aged cognitively impaired Long-Evans rats
    • Aubert I., Rowe W., Meaney M.J., Gauthier S., and Quirion R. Cholinergic markers in aged cognitively impaired Long-Evans rats. Neuroscience 67 (1995) 277-292
    • (1995) Neuroscience , vol.67 , pp. 277-292
    • Aubert, I.1    Rowe, W.2    Meaney, M.J.3    Gauthier, S.4    Quirion, R.5
  • 8
    • 15044357074 scopus 로고    scopus 로고
    • Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease
    • Aucoin J.S., Jiang P., Aznavour N., Tong X.K., Buttini M., Descarries L., and Hamel E. Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease. Neuroscience 132 (2005) 73-86
    • (2005) Neuroscience , vol.132 , pp. 73-86
    • Aucoin, J.S.1    Jiang, P.2    Aznavour, N.3    Tong, X.K.4    Buttini, M.5    Descarries, L.6    Hamel, E.7
  • 9
    • 0036810329 scopus 로고    scopus 로고
    • Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies
    • Auld D.S., Kornecook T.J., Bastianetto S., and Quirion R. Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies. Prog. Neurobiol. 68 (2002) 209-245
    • (2002) Prog. Neurobiol. , vol.68 , pp. 209-245
    • Auld, D.S.1    Kornecook, T.J.2    Bastianetto, S.3    Quirion, R.4
  • 10
    • 0035873718 scopus 로고    scopus 로고
    • Nerve growth factor rapidly induces prolonged acetylcholine release from cultured basal forebrain neurons: differentiation between neuromodulatory and neurotrophic influences
    • Auld D.S., Mennicken F., and Quirion R. Nerve growth factor rapidly induces prolonged acetylcholine release from cultured basal forebrain neurons: differentiation between neuromodulatory and neurotrophic influences. J. Neurosci. 21 (2001) 3375-3382
    • (2001) J. Neurosci. , vol.21 , pp. 3375-3382
    • Auld, D.S.1    Mennicken, F.2    Quirion, R.3
  • 11
    • 0036227727 scopus 로고    scopus 로고
    • Comparative analysis of cholinergic innervation in the dorsal hippocampus of adult mouse and rat: a quantitative immunocytochemical study
    • Aznavour N., Mechawar N., and Descarries L. Comparative analysis of cholinergic innervation in the dorsal hippocampus of adult mouse and rat: a quantitative immunocytochemical study. Hippocampus 12 (2002) 206-217
    • (2002) Hippocampus , vol.12 , pp. 206-217
    • Aznavour, N.1    Mechawar, N.2    Descarries, L.3
  • 12
    • 17644417076 scopus 로고    scopus 로고
    • Postnatal development of the cholinergic innervation in the dorsal hippocampus of rat: quantitative light and electron microscopic immunocytochemical study
    • Aznavour N., Watkins K.C., and Descarries L. Postnatal development of the cholinergic innervation in the dorsal hippocampus of rat: quantitative light and electron microscopic immunocytochemical study. J. Comp. Neurol. 486 (2005) 61-75
    • (2005) J. Comp. Neurol. , vol.486 , pp. 61-75
    • Aznavour, N.1    Watkins, K.C.2    Descarries, L.3
  • 13
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis
    • Bartus R.T. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp. Neurol. 163 (2000) 495-529
    • (2000) Exp. Neurol. , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 14
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus R.T., Dean R.L.I., Beer B., and Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217 (1982) 408-417
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.I.2    Beer, B.3    Lippa, A.S.4
  • 15
    • 0037111111 scopus 로고    scopus 로고
    • Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout
    • Beck Jr. R.D., King M.A., Huang Z., and Petitto J.M. Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout. Brain Res. 955 (2002) 16-23
    • (2002) Brain Res. , vol.955 , pp. 16-23
    • Beck Jr., R.D.1    King, M.A.2    Huang, Z.3    Petitto, J.M.4
  • 16
    • 32644469698 scopus 로고    scopus 로고
    • Long-term continuous, but not daily, environmental enrichment reduces spatial memory decline in aged male mice
    • Bennett J.C., McRae P.A., Levy L.J., and Frick K.M. Long-term continuous, but not daily, environmental enrichment reduces spatial memory decline in aged male mice. Neurobiol. Learn. Mem. 85 (2006) 139-152
    • (2006) Neurobiol. Learn. Mem. , vol.85 , pp. 139-152
    • Bennett, J.C.1    McRae, P.A.2    Levy, L.J.3    Frick, K.M.4
  • 18
    • 0033635904 scopus 로고    scopus 로고
    • Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system
    • Bibel M., and Barde Y.A. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14 (2000) 2919-2937
    • (2000) Genes Dev. , vol.14 , pp. 2919-2937
    • Bibel, M.1    Barde, Y.A.2
  • 20
    • 0034210750 scopus 로고    scopus 로고
    • Acetylcholinesterase-positive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein london mutant transgenic mice
    • Bronfman F.C., Moechars D., and Van Leuven F. Acetylcholinesterase-positive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein london mutant transgenic mice. Neurobiol. Dis. 7 (2000) 152-168
    • (2000) Neurobiol. Dis. , vol.7 , pp. 152-168
    • Bronfman, F.C.1    Moechars, D.2    Van Leuven, F.3
  • 21
    • 33750054664 scopus 로고    scopus 로고
    • Polysialic acid limits choline acetyltransferase activity induced by brain-derived neurotrophic factor
    • Burgess A., and Aubert I. Polysialic acid limits choline acetyltransferase activity induced by brain-derived neurotrophic factor. J. Neurochem. 99 (2006) 797-806
    • (2006) J. Neurochem. , vol.99 , pp. 797-806
    • Burgess, A.1    Aubert, I.2
  • 22
    • 29244439038 scopus 로고    scopus 로고
    • Neural plasticity in the ageing brain
    • Burke S.N., and Barnes C.A. Neural plasticity in the ageing brain. Nat. Rev. Neurosci. 7 (2006) 30-40
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 30-40
    • Burke, S.N.1    Barnes, C.A.2
  • 23
    • 0037756819 scopus 로고    scopus 로고
    • Nerve growth factor prevents cell death and induces hypertrophy of basal forebrain cholinergic neurons in rats withdrawn from prolonged ethanol intake
    • Cadete-Leite A., Pereira P.A., Madeira M.D., and Paula-Barbosa M.M. Nerve growth factor prevents cell death and induces hypertrophy of basal forebrain cholinergic neurons in rats withdrawn from prolonged ethanol intake. Neuroscience 119 (2003) 1055-1069
    • (2003) Neuroscience , vol.119 , pp. 1055-1069
    • Cadete-Leite, A.1    Pereira, P.A.2    Madeira, M.D.3    Paula-Barbosa, M.M.4
  • 26
    • 3042769201 scopus 로고    scopus 로고
    • Reduction in hippocampal cholinergic innervation is unrelated to recognition memory impairment in aged rhesus monkeys
    • Calhoun M.E., Mao Y., Roberts J.A., and Rapp P.R. Reduction in hippocampal cholinergic innervation is unrelated to recognition memory impairment in aged rhesus monkeys. J. Comp. Neurol. 475 (2004) 238-246
    • (2004) J. Comp. Neurol. , vol.475 , pp. 238-246
    • Calhoun, M.E.1    Mao, Y.2    Roberts, J.A.3    Rapp, P.R.4
  • 27
    • 0035346369 scopus 로고    scopus 로고
    • Length measurement: new developments in neurostereology and 3D imagery
    • Calhoun M.E., and Mouton P.R. Length measurement: new developments in neurostereology and 3D imagery. J. Chem. Neuroanat. 21 (2001) 257-265
    • (2001) J. Chem. Neuroanat. , vol.21 , pp. 257-265
    • Calhoun, M.E.1    Mouton, P.R.2
  • 28
    • 0030958684 scopus 로고    scopus 로고
    • The fimbria-fornix/cingular bundle pathways: a review of neurochemical and behavioural approaches using lesions and transplantation techniques
    • Cassel J.C., Duconseille E., Jeltsch H., and Will B. The fimbria-fornix/cingular bundle pathways: a review of neurochemical and behavioural approaches using lesions and transplantation techniques. Prog. Neurobiol. 51 (1997) 663-716
    • (1997) Prog. Neurobiol. , vol.51 , pp. 663-716
    • Cassel, J.C.1    Duconseille, E.2    Jeltsch, H.3    Will, B.4
  • 29
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: a convergence point for many signalling pathways
    • Chao M.V. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 4 (2003) 299-309
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 30
    • 0029033909 scopus 로고
    • Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion
    • Chen K.S., Masliah E., Mallory M., and Gage F.H. Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion. Neuroscience 68 (1995) 19-27
    • (1995) Neuroscience , vol.68 , pp. 19-27
    • Chen, K.S.1    Masliah, E.2    Mallory, M.3    Gage, F.H.4
  • 31
    • 0032077897 scopus 로고    scopus 로고
    • Effect of physical training on the age-related changes of acetylcholinesterase-positive fibers in the hippocampal formation and parietal cortex in the C57BL/6J mouse
    • Chen Y.C., Lei J.L., Chen Q.S., and Wang S.L. Effect of physical training on the age-related changes of acetylcholinesterase-positive fibers in the hippocampal formation and parietal cortex in the C57BL/6J mouse. Mech. Ageing Dev. 102 (1998) 81-93
    • (1998) Mech. Ageing Dev. , vol.102 , pp. 81-93
    • Chen, Y.C.1    Lei, J.L.2    Chen, Q.S.3    Wang, S.L.4
  • 32
    • 27644591304 scopus 로고    scopus 로고
    • Axon degeneration mechanisms: commonality amid diversity
    • Coleman M. Axon degeneration mechanisms: commonality amid diversity. Nat. Rev. Neurosci. 6 (2005) 889-898
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 889-898
    • Coleman, M.1
  • 33
    • 33645105539 scopus 로고    scopus 로고
    • Septal networks: relevance to theta rhythm, epilepsy and Alzheimer's disease
    • Colom L.V. Septal networks: relevance to theta rhythm, epilepsy and Alzheimer's disease. J. Neurochem. 96 (2006) 609-623
    • (2006) J. Neurochem. , vol.96 , pp. 609-623
    • Colom, L.V.1
  • 34
    • 33645323789 scopus 로고    scopus 로고
    • Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases
    • Contestabile A., Fila T., Bartesaghi R., Contestabile A., and Ciani E. Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. J. Neurochem. 97 (2006) 515-526
    • (2006) J. Neurochem. , vol.97 , pp. 515-526
    • Contestabile, A.1    Fila, T.2    Bartesaghi, R.3    Contestabile, A.4    Ciani, E.5
  • 35
    • 26844507790 scopus 로고    scopus 로고
    • A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging
    • Costantini C., Weindruch R., Della V.G., and Puglielli L. A TrkA-to-p75NTR molecular switch activates amyloid beta-peptide generation during aging. Biochem. J. 391 (2005) 59-67
    • (2005) Biochem. J. , vol.391 , pp. 59-67
    • Costantini, C.1    Weindruch, R.2    Della, V.G.3    Puglielli, L.4
  • 36
    • 0001153788 scopus 로고
    • Analysis of epitopes on choline acetyltransferase (ChAT) using monoclonal antibodies (mabs) [abstract]
    • Cozzari C., Howard J., and Hartman B.K. Analysis of epitopes on choline acetyltransferase (ChAT) using monoclonal antibodies (mabs) [abstract]. Soc. Neurosci. Abstr. 16 (1990) 200
    • (1990) Soc. Neurosci. Abstr. , vol.16 , pp. 200
    • Cozzari, C.1    Howard, J.2    Hartman, B.K.3
  • 37
    • 13544260852 scopus 로고    scopus 로고
    • Intracellular and extracellular Abeta, a tale of two neuropathologies
    • Cuello A.C. Intracellular and extracellular Abeta, a tale of two neuropathologies. Brain Pathol. 15 (2005) 66-71
    • (2005) Brain Pathol. , vol.15 , pp. 66-71
    • Cuello, A.C.1
  • 38
    • 33646857906 scopus 로고    scopus 로고
    • Actions of neurotrophic factors and their signaling pathways in neuronal survival and axonal regeneration
    • Cui Q. Actions of neurotrophic factors and their signaling pathways in neuronal survival and axonal regeneration. Mol. Neurobiol. 33 (2006) 155-179
    • (2006) Mol. Neurobiol. , vol.33 , pp. 155-179
    • Cui, Q.1
  • 39
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies P., and Maloney A.J.F. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 25 (1976) 1403
    • (1976) Lancet , vol.25 , pp. 1403
    • Davies, P.1    Maloney, A.J.F.2
  • 40
    • 0030572744 scopus 로고    scopus 로고
    • Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats
    • De Lacalle S., Cooper J.D., Svendsen C.N., Dunnett S.B., and Sofroniew M.V. Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats. Neuroscience 75 (1996) 19-27
    • (1996) Neuroscience , vol.75 , pp. 19-27
    • De Lacalle, S.1    Cooper, J.D.2    Svendsen, C.N.3    Dunnett, S.B.4    Sofroniew, M.V.5
  • 41
    • 0032562162 scopus 로고    scopus 로고
    • Hippocampal grafts of acetylcholine-producing cells are sufficient to improve behavioural performance following a unilateral fimbria-fornix lesion
    • Dickinson-Anson H., Aubert I., Gage F.H., and Fisher L.J. Hippocampal grafts of acetylcholine-producing cells are sufficient to improve behavioural performance following a unilateral fimbria-fornix lesion. Neuroscience 84 (1998) 771-781
    • (1998) Neuroscience , vol.84 , pp. 771-781
    • Dickinson-Anson, H.1    Aubert, I.2    Gage, F.H.3    Fisher, L.J.4
  • 42
    • 26844474356 scopus 로고    scopus 로고
    • A model for dynamic regulation of choline acetyltransferase by phosphorylation
    • Dobransky T., and Rylett R.J. A model for dynamic regulation of choline acetyltransferase by phosphorylation. J. Neurochem. 95 (2005) 305-313
    • (2005) J. Neurochem. , vol.95 , pp. 305-313
    • Dobransky, T.1    Rylett, R.J.2
  • 43
    • 0031745813 scopus 로고    scopus 로고
    • The cholinergic gene locus
    • Eiden L.E. The cholinergic gene locus. J. Neurochem. 70 (1998) 2227-2240
    • (1998) J. Neurochem. , vol.70 , pp. 2227-2240
    • Eiden, L.E.1
  • 44
    • 0032101868 scopus 로고    scopus 로고
    • Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury
    • Fagan A.M., Murphy B.A., Patel S.N., Kilbridge J.F., Mobley W.C., Bu G., and Holtzman D.M. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Exp. Neurol. 151 (1998) 314-325
    • (1998) Exp. Neurol. , vol.151 , pp. 314-325
    • Fagan, A.M.1    Murphy, B.A.2    Patel, S.N.3    Kilbridge, J.F.4    Mobley, W.C.5    Bu, G.6    Holtzman, D.M.7
  • 45
    • 0036047652 scopus 로고    scopus 로고
    • Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule?
    • Fahnestock M., Garzon D., Holsinger R.M., and Michalski B. Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule?. J. Neural. Transm. Suppl. Suppl. (2002) 241-252
    • (2002) J. Neural. Transm. Suppl. , Issue.SUPPL , pp. 241-252
    • Fahnestock, M.1    Garzon, D.2    Holsinger, R.M.3    Michalski, B.4
  • 46
    • 0026567917 scopus 로고
    • Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging
    • Fischer W., Chen K.S., Gage F.H., and Björklund A. Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol. Aging 13 (1991) 9-23
    • (1991) Neurobiol. Aging , vol.13 , pp. 9-23
    • Fischer, W.1    Chen, K.S.2    Gage, F.H.3    Björklund, A.4
  • 47
    • 0023643241 scopus 로고
    • Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
    • Fischer W., Wictorin K., Björklund A., Williams L.R., Varon S., and Gage F.H. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329 (1987) 65-68
    • (1987) Nature , vol.329 , pp. 65-68
    • Fischer, W.1    Wictorin, K.2    Björklund, A.3    Williams, L.R.4    Varon, S.5    Gage, F.H.6
  • 48
    • 0014602871 scopus 로고
    • Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities
    • Fonnum F. Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. Biochem. J. 115 (1969) 465-472
    • (1969) Biochem. J. , vol.115 , pp. 465-472
    • Fonnum, F.1
  • 49
    • 33646554798 scopus 로고    scopus 로고
    • Seeking long-term relationship: axon and target communicate to organize synaptic differentiation
    • Fox M.A., and Umemori H. Seeking long-term relationship: axon and target communicate to organize synaptic differentiation. J. Neurochem. 97 (2006) 1215-1231
    • (2006) J. Neurochem. , vol.97 , pp. 1215-1231
    • Fox, M.A.1    Umemori, H.2
  • 50
    • 0037411533 scopus 로고    scopus 로고
    • Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice
    • Frick K.M., and Fernandez S.M. Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice. Neurobiol. Aging 24 (2003) 615-626
    • (2003) Neurobiol. Aging , vol.24 , pp. 615-626
    • Frick, K.M.1    Fernandez, S.M.2
  • 51
    • 0033953377 scopus 로고    scopus 로고
    • Evidence for the existence of non-GABAergic, cholinergic interneurons in the rodent hippocampus
    • Frotscher M., Vida I., and Bender R. Evidence for the existence of non-GABAergic, cholinergic interneurons in the rodent hippocampus. Neuroscience 96 (2000) 27-31
    • (2000) Neuroscience , vol.96 , pp. 27-31
    • Frotscher, M.1    Vida, I.2    Bender, R.3
  • 52
    • 0020598320 scopus 로고
    • Reinnervation of the partially deafferented hippocampus by compensatory collateral sprouting from spared cholinergic and noradrenergic afferents
    • Gage F.H., Björklund A., and Stenevi U. Reinnervation of the partially deafferented hippocampus by compensatory collateral sprouting from spared cholinergic and noradrenergic afferents. Brain Res. 268 (1983) 27-37
    • (1983) Brain Res. , vol.268 , pp. 27-37
    • Gage, F.H.1    Björklund, A.2    Stenevi, U.3
  • 55
    • 0037420952 scopus 로고    scopus 로고
    • Loss of calbindin-D28k from aging human cholinergic basal forebrain: relation to neuronal loss
    • Geula C., Bu J., Nagykery N., Scinto L.F., Chan J., Joseph J., Parker R., and Wu C.K. Loss of calbindin-D28k from aging human cholinergic basal forebrain: relation to neuronal loss. J. Comp. Neurol. 455 (2003) 249-259
    • (2003) J. Comp. Neurol. , vol.455 , pp. 249-259
    • Geula, C.1    Bu, J.2    Nagykery, N.3    Scinto, L.F.4    Chan, J.5    Joseph, J.6    Parker, R.7    Wu, C.K.8
  • 56
    • 0023473444 scopus 로고
    • Age-dependent loss and compensatory changes of septohippocampal cholinergic neurons in two strains differing in longevity and response to stress
    • Gilad G.M., Rabey J.M., Tizabi Y., and Gilad V.H. Age-dependent loss and compensatory changes of septohippocampal cholinergic neurons in two strains differing in longevity and response to stress. Brain Res. 436 (1987) 311-322
    • (1987) Brain Res. , vol.436 , pp. 311-322
    • Gilad, G.M.1    Rabey, J.M.2    Tizabi, Y.3    Gilad, V.H.4
  • 57
    • 33745416559 scopus 로고    scopus 로고
    • Single cell gene expression profiling in Alzheimer's disease
    • Ginsberg S.D., Che S., Counts S.E., and Mufson E.J. Single cell gene expression profiling in Alzheimer's disease. NeuroRx 3 (2006) 302-318
    • (2006) NeuroRx , vol.3 , pp. 302-318
    • Ginsberg, S.D.1    Che, S.2    Counts, S.E.3    Mufson, E.J.4
  • 60
    • 0024207353 scopus 로고
    • A method for parallel determination of choline acetyltransferase and muscarinic cholinergic receptors: application in aged-rat brain
    • Haba K., Ogawa N., Kawata M., and Mori A. A method for parallel determination of choline acetyltransferase and muscarinic cholinergic receptors: application in aged-rat brain. Neurochem. Res. 13 (1988) 951-955
    • (1988) Neurochem. Res. , vol.13 , pp. 951-955
    • Haba, K.1    Ogawa, N.2    Kawata, M.3    Mori, A.4
  • 61
    • 0024394332 scopus 로고
    • Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases
    • Hefti F., Hartikka J., and Knüsel B. Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases. Neurobiol. Aging 10 (1989) 515-533
    • (1989) Neurobiol. Aging , vol.10 , pp. 515-533
    • Hefti, F.1    Hartikka, J.2    Knüsel, B.3
  • 62
    • 0035947141 scopus 로고    scopus 로고
    • Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes
    • Hernandez D., Sugaya K., Qu T., McGowan E., Duff K., and McKinney M. Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes. NeuroReport 12 (2001) 1377-1384
    • (2001) NeuroReport , vol.12 , pp. 1377-1384
    • Hernandez, D.1    Sugaya, K.2    Qu, T.3    McGowan, E.4    Duff, K.5    McKinney, M.6
  • 63
    • 0030800975 scopus 로고    scopus 로고
    • Localization of two cholinergic markers, choline acetyltransferase and vesicular acetylcholine transporter in the central nervous system of the rat: in situ hybridization histochemistry and immunohistochemistry
    • Ichikawa T., Ajiki K., Matsuura J., and Misawa H. Localization of two cholinergic markers, choline acetyltransferase and vesicular acetylcholine transporter in the central nervous system of the rat: in situ hybridization histochemistry and immunohistochemistry. J. Chem. Neuroanat. 13 (1997) 23-39
    • (1997) J. Chem. Neuroanat. , vol.13 , pp. 23-39
    • Ichikawa, T.1    Ajiki, K.2    Matsuura, J.3    Misawa, H.4
  • 64
    • 0019795577 scopus 로고
    • Age and neurochemical correlates of radial maze performance in rats
    • Ingram D.K., London E.D., and Goodrick C.L. Age and neurochemical correlates of radial maze performance in rats. Neurobiol. Aging 2 (1981) 41-47
    • (1981) Neurobiol. Aging , vol.2 , pp. 41-47
    • Ingram, D.K.1    London, E.D.2    Goodrick, C.L.3
  • 65
    • 0034870817 scopus 로고    scopus 로고
    • Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway
    • Jaffar S., Counts S.E., Ma S.Y., Dadko E., Gordon M.N., Morgan D., and Mufson E.J. Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway. Exp. Neurol. 170 (2001) 227-243
    • (2001) Exp. Neurol. , vol.170 , pp. 227-243
    • Jaffar, S.1    Counts, S.E.2    Ma, S.Y.3    Dadko, E.4    Gordon, M.N.5    Morgan, D.6    Mufson, E.J.7
  • 66
    • 0033659772 scopus 로고    scopus 로고
    • Structural brain aging in inbred mice: potential for genetic linkage
    • Jucker M., Bondolfi L., Calhoun M.E., Long J.M., and Ingram D.K. Structural brain aging in inbred mice: potential for genetic linkage. Exp. Gerontol. 35 (2000) 1383-1388
    • (2000) Exp. Gerontol. , vol.35 , pp. 1383-1388
    • Jucker, M.1    Bondolfi, L.2    Calhoun, M.E.3    Long, J.M.4    Ingram, D.K.5
  • 67
    • 11144279290 scopus 로고    scopus 로고
    • The protean actions of neurotrophins and their receptors on the life and death of neurons
    • Kalb R. The protean actions of neurotrophins and their receptors on the life and death of neurons. Trends Neurosci. 28 (2005) 5-11
    • (2005) Trends Neurosci. , vol.28 , pp. 5-11
    • Kalb, R.1
  • 68
    • 4444253462 scopus 로고    scopus 로고
    • Cholinergic neurons in the basal forebrain of aged female mice
    • Kalesnykas G., Puolivali J., Sirvio J., and Miettinen R. Cholinergic neurons in the basal forebrain of aged female mice. Brain Res. 1022 (2004) 148-156
    • (2004) Brain Res. , vol.1022 , pp. 148-156
    • Kalesnykas, G.1    Puolivali, J.2    Sirvio, J.3    Miettinen, R.4
  • 69
    • 17144409347 scopus 로고    scopus 로고
    • The effect of aging on the subcellular distribution of estrogen receptor-alpha in the cholinergic neurons of transgenic and wild-type mice
    • Kalesnykas G., Roschier U., Puolivali J., Wang J., and Miettinen R. The effect of aging on the subcellular distribution of estrogen receptor-alpha in the cholinergic neurons of transgenic and wild-type mice. Eur. J. Neurosci. 21 (2005) 1437-1442
    • (2005) Eur. J. Neurosci. , vol.21 , pp. 1437-1442
    • Kalesnykas, G.1    Roschier, U.2    Puolivali, J.3    Wang, J.4    Miettinen, R.5
  • 70
    • 0031709896 scopus 로고    scopus 로고
    • Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3
    • Katoh-Semba R., Semba R., Takeuchi I.K., and Kato K. Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3. Neurosci. Res. 31 (1998) 227-234
    • (1998) Neurosci. Res. , vol.31 , pp. 227-234
    • Katoh-Semba, R.1    Semba, R.2    Takeuchi, I.K.3    Kato, K.4
  • 71
    • 0038472369 scopus 로고    scopus 로고
    • Role of the medial septum diagonal band of Broca cholinergic neurons in oestrogen-induced spine synapse formation on hippocampal CA1 pyramidal cells of female rats
    • Lam T.T., and Leranth C. Role of the medial septum diagonal band of Broca cholinergic neurons in oestrogen-induced spine synapse formation on hippocampal CA1 pyramidal cells of female rats. Eur. J. Neurosci. 17 (2003) 1997-2005
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 1997-2005
    • Lam, T.T.1    Leranth, C.2
  • 73
    • 0022922249 scopus 로고
    • Age and sex-dependent decreases in ChAT in basal forebrain nuclei
    • Luine V.N., Renner K.J., Heady S., and Jones K.J. Age and sex-dependent decreases in ChAT in basal forebrain nuclei. Neurobiol. Aging 7 (1986) 193-198
    • (1986) Neurobiol. Aging , vol.7 , pp. 193-198
    • Luine, V.N.1    Renner, K.J.2    Heady, S.3    Jones, K.J.4
  • 74
    • 0033575467 scopus 로고    scopus 로고
    • Effects of age and sex on the water maze performance and hippocampal cholinergic fibers in rats
    • Lukoyanov N.V., Andrade J.P., Dulce M.M., and Paula-Barbosa M.M. Effects of age and sex on the water maze performance and hippocampal cholinergic fibers in rats. Neurosci. Lett. 269 (1999) 141-144
    • (1999) Neurosci. Lett. , vol.269 , pp. 141-144
    • Lukoyanov, N.V.1    Andrade, J.P.2    Dulce, M.M.3    Paula-Barbosa, M.M.4
  • 75
    • 23244436227 scopus 로고    scopus 로고
    • Axon retraction and degeneration in development and disease
    • Luo L., and O'Leary D.D. Axon retraction and degeneration in development and disease. Annu. Rev. Neurosci. 28 (2005) 127-156
    • (2005) Annu. Rev. Neurosci. , vol.28 , pp. 127-156
    • Luo, L.1    O'Leary, D.D.2
  • 76
    • 33644848964 scopus 로고    scopus 로고
    • Involvement of neurotrophic factors in aging of noradrenergic innervations in hippocampus and frontal cortex
    • Matsunaga W., Isobe K., and Shirokawa T. Involvement of neurotrophic factors in aging of noradrenergic innervations in hippocampus and frontal cortex. Neurosci. Res. 54 (2006) 313-318
    • (2006) Neurosci. Res. , vol.54 , pp. 313-318
    • Matsunaga, W.1    Isobe, K.2    Shirokawa, T.3
  • 77
    • 33645299025 scopus 로고    scopus 로고
    • Ageing and neuronal vulnerability
    • Mattson M.P., and Magnus T. Ageing and neuronal vulnerability. Nat. Rev. Neurosci. 7 (2006) 278-294
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 278-294
    • Mattson, M.P.1    Magnus, T.2
  • 79
    • 0024333162 scopus 로고
    • Age-related differences in brain choline acetyltransferase, cholinesterases and muscarinic receptor sites in two strains of rats
    • Michalek H., Fortuna S., and Pintor A. Age-related differences in brain choline acetyltransferase, cholinesterases and muscarinic receptor sites in two strains of rats. Neurobiol. Aging 10 (1989) 143-148
    • (1989) Neurobiol. Aging , vol.10 , pp. 143-148
    • Michalek, H.1    Fortuna, S.2    Pintor, A.3
  • 80
    • 0027200693 scopus 로고
    • Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions
    • Moser E., Moser M.B., and Andersen P. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J. Neurosci. 13 (1993) 3916-3925
    • (1993) J. Neurosci. , vol.13 , pp. 3916-3925
    • Moser, E.1    Moser, M.B.2    Andersen, P.3
  • 82
    • 0035239020 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
    • Murer M.G., Yan Q., and Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog. Neurobiol. 63 (2001) 71-124
    • (2001) Prog. Neurobiol. , vol.63 , pp. 71-124
    • Murer, M.G.1    Yan, Q.2    Raisman-Vozari, R.3
  • 83
    • 0036249987 scopus 로고    scopus 로고
    • Amelioration of cholinergic neurons dysfunction in aged rats depends on the continuous supply of NGF
    • Niewiadomska G., Komorowski S., and Baksalerska-Pazera M. Amelioration of cholinergic neurons dysfunction in aged rats depends on the continuous supply of NGF. Neurobiol. Aging 23 (2002) 601-613
    • (2002) Neurobiol. Aging , vol.23 , pp. 601-613
    • Niewiadomska, G.1    Komorowski, S.2    Baksalerska-Pazera, M.3
  • 84
    • 0033953960 scopus 로고    scopus 로고
    • Brief exposure to neurotrophins produces a calcium-dependent increase in choline acetyltransferase activity in cultured rat septal neurons
    • Nonner D., Barrett E.F., and Barrett J.N. Brief exposure to neurotrophins produces a calcium-dependent increase in choline acetyltransferase activity in cultured rat septal neurons. J. Neurochem. 74 (2000) 988-999
    • (2000) J. Neurochem. , vol.74 , pp. 988-999
    • Nonner, D.1    Barrett, E.F.2    Barrett, J.N.3
  • 85
    • 0028120409 scopus 로고
    • Reduced choline acetyltransferase activity and muscarinic M1 receptor levels in aged Fisher 344 rat brains did not parallel their respective mRNA levels
    • Ogawa N., Asanuma M., Kondo Y., Nishibayashi S., and Mori A. Reduced choline acetyltransferase activity and muscarinic M1 receptor levels in aged Fisher 344 rat brains did not parallel their respective mRNA levels. Brain Res. 658 (1994) 87-92
    • (1994) Brain Res. , vol.658 , pp. 87-92
    • Ogawa, N.1    Asanuma, M.2    Kondo, Y.3    Nishibayashi, S.4    Mori, A.5
  • 86
    • 0026672792 scopus 로고
    • Effects of dihydroergotoxine on central cholinergic neuronal systems and discrimination learning test in aged rats
    • Ogawa N., Nomura M., Haba K., Asanuma M., Tanaka K., Hori K., and Mori A. Effects of dihydroergotoxine on central cholinergic neuronal systems and discrimination learning test in aged rats. Brain Res. 586 (1992) 229-234
    • (1992) Brain Res. , vol.586 , pp. 229-234
    • Ogawa, N.1    Nomura, M.2    Haba, K.3    Asanuma, M.4    Tanaka, K.5    Hori, K.6    Mori, A.7
  • 88
    • 20744434559 scopus 로고    scopus 로고
    • Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease
    • Peng S., Wuu J., Mufson E.J., and Fahnestock M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J. Neurochem. 93 (2005) 1412-1421
    • (2005) J. Neurochem. , vol.93 , pp. 1412-1421
    • Peng, S.1    Wuu, J.2    Mufson, E.J.3    Fahnestock, M.4
  • 89
  • 90
    • 0025259796 scopus 로고
    • Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system-I. Forebrain
    • Pioro E.P., and Cuello A.C. Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system-I. Forebrain. Neuroscience 34 (1990) 57-87
    • (1990) Neuroscience , vol.34 , pp. 57-87
    • Pioro, E.P.1    Cuello, A.C.2
  • 91
    • 0029821150 scopus 로고    scopus 로고
    • Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
    • Rapp P.R., and Gallagher M. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 9926-9930
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 9926-9930
    • Rapp, P.R.1    Gallagher, M.2
  • 92
    • 0030053883 scopus 로고    scopus 로고
    • Memory impaired aged rats: no loss of principal hippocampal and subicular neurons
    • Rasmussen T., Schliemann T., Sorensen J.C., Zimmer J., and West M.J. Memory impaired aged rats: no loss of principal hippocampal and subicular neurons. Neurobiol. Aging 17 (1996) 143-147
    • (1996) Neurobiol. Aging , vol.17 , pp. 143-147
    • Rasmussen, T.1    Schliemann, T.2    Sorensen, J.C.3    Zimmer, J.4    West, M.J.5
  • 93
    • 0028019154 scopus 로고
    • Role of neurotrophins in cholinergic-neurone function in the adult and aged CNS
    • Rylett R.J., and Williams L.R. Role of neurotrophins in cholinergic-neurone function in the adult and aged CNS. Trends Neurosci. 17 (1994) 486-490
    • (1994) Trends Neurosci. , vol.17 , pp. 486-490
    • Rylett, R.J.1    Williams, L.R.2
  • 94
    • 0037303935 scopus 로고    scopus 로고
    • Traffic at the intersection of neurotrophic factor signaling and neurodegeneration
    • Salehi A., Delcroix J.D., and Mobley W.C. Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci. 26 (2003) 73-80
    • (2003) Trends Neurosci. , vol.26 , pp. 73-80
    • Salehi, A.1    Delcroix, J.D.2    Mobley, W.C.3
  • 95
    • 28844454312 scopus 로고    scopus 로고
    • Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex
    • Saragovi H.U. Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex. J. Neurochem. 95 (2005) 1472-1480
    • (2005) J. Neurochem. , vol.95 , pp. 1472-1480
    • Saragovi, H.U.1
  • 96
    • 11144243802 scopus 로고    scopus 로고
    • Choline transporters, cholinergic transmission and cognition
    • Sarter M., and Parikh V. Choline transporters, cholinergic transmission and cognition. Nat. Rev. Neurosci. 6 (2005) 48-56
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 48-56
    • Sarter, M.1    Parikh, V.2
  • 97
    • 27744556554 scopus 로고    scopus 로고
    • Neurogenesis of the cholinergic medial septum in female and male C57BL/6J mice
    • Schaevitz L.R., and Berger-Sweeney J. Neurogenesis of the cholinergic medial septum in female and male C57BL/6J mice. J. Neurobiol. 65 (2005) 294-303
    • (2005) J. Neurobiol. , vol.65 , pp. 294-303
    • Schaevitz, L.R.1    Berger-Sweeney, J.2
  • 98
    • 26244437738 scopus 로고    scopus 로고
    • Basal forebrain cholinergic dysfunction in Alzheimer's disease-interrelationship with beta-amyloid, inflammation and neurotrophin signaling
    • Schliebs R. Basal forebrain cholinergic dysfunction in Alzheimer's disease-interrelationship with beta-amyloid, inflammation and neurotrophin signaling. Neurochem. Res. 30 (2005) 895-908
    • (2005) Neurochem. Res. , vol.30 , pp. 895-908
    • Schliebs, R.1
  • 99
    • 11844300345 scopus 로고    scopus 로고
    • Design-based stereology in neuroscience
    • Schmitz C., and Hof P.R. Design-based stereology in neuroscience. Neuroscience 130 (2005) 813-831
    • (2005) Neuroscience , vol.130 , pp. 813-831
    • Schmitz, C.1    Hof, P.R.2
  • 100
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 298 (2002) 789-791
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 101
    • 0019845096 scopus 로고
    • Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments
    • Sherman K.A., Kuster J.E., Dean R.L., Bartus R.T., and Friedman E. Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments. Neurobiol. Aging 2 (1981) 99-104
    • (1981) Neurobiol. Aging , vol.2 , pp. 99-104
    • Sherman, K.A.1    Kuster, J.E.2    Dean, R.L.3    Bartus, R.T.4    Friedman, E.5
  • 102
    • 0024245015 scopus 로고
    • Pre- and postsynaptic markers of cholinergic neurons in the cerebral cortex of rats of different ages
    • Sirvio J., Hervonen A., Valjakka A., and Riekkinen P.J. Pre- and postsynaptic markers of cholinergic neurons in the cerebral cortex of rats of different ages. Exp. Gerontol. 23 (1988) 473-479
    • (1988) Exp. Gerontol. , vol.23 , pp. 473-479
    • Sirvio, J.1    Hervonen, A.2    Valjakka, A.3    Riekkinen, P.J.4
  • 103
    • 0023883347 scopus 로고
    • Cholinergic enzyme activities and muscarinic binding in the cerebral cortex of rats of different age and sex
    • Sirvio J., Valjakka A., Jolkkonen J., Hervonen A., and Riekkinen P.J. Cholinergic enzyme activities and muscarinic binding in the cerebral cortex of rats of different age and sex. Comp. Biochem. Physiol. C 90 (1988) 245-248
    • (1988) Comp. Biochem. Physiol. C , vol.90 , pp. 245-248
    • Sirvio, J.1    Valjakka, A.2    Jolkkonen, J.3    Hervonen, A.4    Riekkinen, P.J.5
  • 104
    • 2342612629 scopus 로고    scopus 로고
    • Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons
    • Smith D.E., Rapp P.R., McKay H.M., Roberts J.A., and Tuszynski M.H. Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J. Neurosci. 24 (2004) 4373-4381
    • (2004) J. Neurosci. , vol.24 , pp. 4373-4381
    • Smith, D.E.1    Rapp, P.R.2    McKay, H.M.3    Roberts, J.A.4    Tuszynski, M.H.5
  • 105
    • 0032845156 scopus 로고    scopus 로고
    • Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy
    • Smith D.E., Roberts J., Gage F.H., and Tuszynski M.H. Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 10893-10898
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 10893-10898
    • Smith, D.E.1    Roberts, J.2    Gage, F.H.3    Tuszynski, M.H.4
  • 106
    • 0027279403 scopus 로고
    • 3-D reconstruction of the cholinergic basal forebrain system in young and aged rats
    • Smith M.L., Deadwyler S.A., and Booze R.M. 3-D reconstruction of the cholinergic basal forebrain system in young and aged rats. Neurobiol. Aging 14 (1993) 389-392
    • (1993) Neurobiol. Aging , vol.14 , pp. 389-392
    • Smith, M.L.1    Deadwyler, S.A.2    Booze, R.M.3
  • 107
    • 5444238860 scopus 로고    scopus 로고
    • Histological changes of the dopaminergic nigrostriatal system in aging
    • Stark A.K., and Pakkenberg B. Histological changes of the dopaminergic nigrostriatal system in aging. Cell Tissue Res. 318 (2004) 81-92
    • (2004) Cell Tissue Res. , vol.318 , pp. 81-92
    • Stark, A.K.1    Pakkenberg, B.2
  • 108
    • 24644441051 scopus 로고    scopus 로고
    • Measuring morphological and cellular changes in Alzheimer's dementia: a review emphasizing stereology
    • Stark A.K., Pelvig D.P., Jorgensen A.M., Andersen B.B., and Pakkenberg B. Measuring morphological and cellular changes in Alzheimer's dementia: a review emphasizing stereology. Curr. Alzheimer Res. 2 (2005) 449-481
    • (2005) Curr. Alzheimer Res. , vol.2 , pp. 449-481
    • Stark, A.K.1    Pelvig, D.P.2    Jorgensen, A.M.3    Andersen, B.B.4    Pakkenberg, B.5
  • 109
    • 0033975658 scopus 로고    scopus 로고
    • Immunohistochemical and neurochemical correlates of learning deficits in aged rats
    • Stemmelin J., Lazarus C., Cassel S., Kelche C., and Cassel J.-C. Immunohistochemical and neurochemical correlates of learning deficits in aged rats. Neuroscience 96 (2000) 275-289
    • (2000) Neuroscience , vol.96 , pp. 275-289
    • Stemmelin, J.1    Lazarus, C.2    Cassel, S.3    Kelche, C.4    Cassel, J.-C.5
  • 110
    • 33746355958 scopus 로고    scopus 로고
    • Axonal transport and Alzheimer's disease
    • Stokin G.B., and Goldstein L.S. Axonal transport and Alzheimer's disease. Annu. Rev. Biochem. 75 (2006) 607-627
    • (2006) Annu. Rev. Biochem. , vol.75 , pp. 607-627
    • Stokin, G.B.1    Goldstein, L.S.2
  • 111
    • 33644793597 scopus 로고    scopus 로고
    • Axonal regeneration in adult CNS neurons-signaling molecules and pathways
    • Teng F.Y., and Tang B.L. Axonal regeneration in adult CNS neurons-signaling molecules and pathways. J. Neurochem. 96 (2006) 1501-1508
    • (2006) J. Neurochem. , vol.96 , pp. 1501-1508
    • Teng, F.Y.1    Tang, B.L.2
  • 112
    • 0344691730 scopus 로고
    • Choline acetyltransferase
    • Chapman and Hall, London pp. 1-258
    • Tucek S. Choline acetyltransferase. Acetylcholine Synthesis in Neurons (1978), Chapman and Hall, London pp. 1-258
    • (1978) Acetylcholine Synthesis in Neurons
    • Tucek, S.1
  • 113
    • 0025119804 scopus 로고
    • The synthesis of acetylcholine: twenty years of progress
    • Tucek S. The synthesis of acetylcholine: twenty years of progress. Prog. Brain Res. 84 (1990) 467-477
    • (1990) Prog. Brain Res. , vol.84 , pp. 467-477
    • Tucek, S.1
  • 115
    • 0029552754 scopus 로고
    • Relational features of acetylcholine, noradrenaline, serotonin and GABA axon terminals in the stratum radiatum of adult rat hippocampus (CA1)
    • Umbriaco D., Garcia S., Beaulieu C., and Descarries L. Relational features of acetylcholine, noradrenaline, serotonin and GABA axon terminals in the stratum radiatum of adult rat hippocampus (CA1). Hippocampus 5 (1995) 605-620
    • (1995) Hippocampus , vol.5 , pp. 605-620
    • Umbriaco, D.1    Garcia, S.2    Beaulieu, C.3    Descarries, L.4
  • 116
    • 0021083265 scopus 로고
    • Age-differences in choline acetyltransferase activities and muscarinic receptor binding in brain regions of C57BL/6J mice
    • Waller S.B., and London E.D. Age-differences in choline acetyltransferase activities and muscarinic receptor binding in brain regions of C57BL/6J mice. Exp. Gerontol. 18 (1983) 419-425
    • (1983) Exp. Gerontol. , vol.18 , pp. 419-425
    • Waller, S.B.1    London, E.D.2
  • 117
    • 0024347957 scopus 로고
    • Choline acetyltransferase activity and muscarinic binding in brain regions of aging Fischer-344 rats
    • Waller S.B., and London E.D. Choline acetyltransferase activity and muscarinic binding in brain regions of aging Fischer-344 rats. Neurochem. Int. 14 (1989) 483-490
    • (1989) Neurochem. Int. , vol.14 , pp. 483-490
    • Waller, S.B.1    London, E.D.2
  • 118
    • 0027194462 scopus 로고
    • New stereological methods for counting neurons
    • West M.J. New stereological methods for counting neurons. Neurobiol. Aging 14 (1993) 275-285
    • (1993) Neurobiol. Aging , vol.14 , pp. 275-285
    • West, M.J.1
  • 119
    • 0027164617 scopus 로고
    • Regionally specific loss of neurons in the aging human hippocampus
    • West M.J. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol. Aging 14 (1993) 287-293
    • (1993) Neurobiol. Aging , vol.14 , pp. 287-293
    • West, M.J.1
  • 120
    • 0033083082 scopus 로고    scopus 로고
    • Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias
    • West M.J. Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias. Trends Neurosci. 22 (1999) 51-61
    • (1999) Trends Neurosci. , vol.22 , pp. 51-61
    • West, M.J.1
  • 121
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
    • West M.J., Coleman P.D., Flood D.G., and Troncoso J.C. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344 (1994) 769-772
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1    Coleman, P.D.2    Flood, D.G.3    Troncoso, J.C.4
  • 123
    • 0022391791 scopus 로고
    • Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles
    • Wiedenmann B., and Franke W.W. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell 41 (1985) 1017-1028
    • (1985) Cell , vol.41 , pp. 1017-1028
    • Wiedenmann, B.1    Franke, W.W.2
  • 124
    • 0024995462 scopus 로고
    • Exogenous nerve growth factor increases the activity of high-affinity choline uptake and choline acetyltransferase in brain of Fisher 344 male rats
    • Williams L.R., and Rylett R.J. Exogenous nerve growth factor increases the activity of high-affinity choline uptake and choline acetyltransferase in brain of Fisher 344 male rats. J. Neurochem. 55 (1990) 1042-1049
    • (1990) J. Neurochem. , vol.55 , pp. 1042-1049
    • Williams, L.R.1    Rylett, R.J.2
  • 125
    • 0025941928 scopus 로고
    • Cholinergic systems in mammalian brain and spinal cord
    • Woolf N.J. Cholinergic systems in mammalian brain and spinal cord. Prog. Neurobiol. 37 (1991) 475-524
    • (1991) Prog. Neurobiol. , vol.37 , pp. 475-524
    • Woolf, N.J.1
  • 126
    • 23044515099 scopus 로고    scopus 로고
    • Functions and mechanisms of retrograde neurotrophin signalling
    • Zweifel L.S., Kuruvilla R., and Ginty D.D. Functions and mechanisms of retrograde neurotrophin signalling. Nat. Rev. Neurosci. 6 (2005) 615-625
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 615-625
    • Zweifel, L.S.1    Kuruvilla, R.2    Ginty, D.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.