The fimbria-fornix/cingular bundle pathways: A review of neurochemical and behavioural approaches using lesions and transplantation techniques

Progress in Neurobiology

Volumn 51, Issue 6, 1997, Pages 663-716

  Cassel, Jean Christophe ^a   Duconseille, Elee ^a   Jeltsch, Hélène ^a   Will, Bruno ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN FORNIX; BRAIN INJURY; BRAIN TRANSPLANTATION; CHOLINERGIC SYSTEM; CINGULATE GYRUS; DENERVATION; HIPPOCAMPUS; LEARNING; MEMORY; NEUROANATOMY; NEUROCHEMISTRY; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM;

AFFERENT PATHWAYS; ANIMALS; BEHAVIOR, ANIMAL; BRAIN TISSUE TRANSPLANTATION; GYRUS CINGULI; HIPPOCAMPUS;

EID: 0030958684     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(97)00009-9     Document Type: Article

References (463)

1. Abe, E., Murai, S., Saito, H., Masuda, Y., Takasu, Y., Shiotani, T., Tachizawa, H. and Itoh, T. (1994) Effects of nefiracetam on deficits in active avoidance response and hippocampal cholinergic and monoaminergic dysfunctions induced by AF64A in mice. Journal of Neural Transmission 95, 179-193.
2. Alonso, R. and Soubrié, P. (1991) Effects of serotoninergic denervation on the density and plasticity of brain muscarinic receptors in the rat. Synapse 8, 30-37.
3. Altman, H. J., Normile, H. J., Galloway, M. P., Ramirez, A. and Azmitia, E. C. (1990) Enhanced spatial discrimination learning in rats following 5,7-DHT-induced serotonergic deafferentation of the hippocampus. Brain Research 518, 61-66.
4. Anderson, K. J., Holets, V. R., Mazur, P. C., Lasher, R. S. and Cotman, C. W. (1986) Immunocytochemical localization of serotonin in the rat dentate gyrus following raphe transplants. Brain Research 369, 21-28.
5. Araujo, D. M., Lapchak, P. A. and Hefti, F. (1993) Effects of chronic basic fibroblast growth factor administration to rats with partial fimbrial transections on presynaptic cholinergic parameters and muscarinic receptors in the hippocampus: Comparison with nerve growth factor. Journal of Neurochemistry 61, 899-910.
6. Archer, T. (1982) The role of noradrenaline in learned behaviors: Studies using DSP4. Scandinavian Journal of Psychology Supplementum 1, 61-71.
7. Archer, T., Mohammed, A. K., Ross, S. B. and Södeberg, U. (1983) T-maze learning, spontaneous activity and food intake recovery following systemic administration of the noradrenaline neurotoxin, DSP4. Pharmacology Biochemistry and Behavior 19, 121-130.
8. Arendt, T., Allen, Y., Marchbanks, R., Shugens, M. M., Sinden, J., Lantos, P. L. and Gray, J. A. (1989) Cholinergic system and memory in the rat: Effects of chronic ethanol, embryonic basal forebrain transplants and excitotoxic lesions of cholinergic basal forebrain projection systems. Neuroscience 33, 435-462.
9. Asin, K. E., Wirtshafter, D. and Fibiger, H. C. (1985) Electrolytic, but not 5,7-dihydroxytryptamine, lesions of the nucleus medianus raphe impair acquisition of a radial arm maze task. Behavioral and Neural Biology 44, 415-424.
10. Aubert, I., Araujo, D. M., Cecyre, D., Robitaille, Y., Gauthier, S. and Quirion, R. (1992) Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases. Journal of Neurochemistry 58, 259-541.
11. Auerbach, S., Zhou, F., Jacobs, B. L. and Azmitia, E. (1985) Serotonin turnover in raphe neurons transplanted into rat hippocampus. Neuroscience Letters 61, 147-152.
12. Ayyagari, V., Harrell, L. E. and Parsons, D. S. (1991) Interaction of neurotransmitter systems in the hippocampus: A study of some behavioral effects of hippocampal sympathetic ingrowth. The Journal of Neuroscience 11, 2848-2854.
13. Azmitia, E. C. (1978) The serotonin-producing neurons of the midbrain median and dorsal raphe nuclei. In Handbook of Psychopharmacology, ed. L. L. Iversen, S. D. Iversen and S. H. Snyder, Vol. 9, pp. 233-314. Plenum Press, New York.
14. Azmitia, E. C. (1987) A serotonin-hippocampal model indicates adult neurons survive transplantation and aged target may be deficient in a soluble serotonergic growth factor. Annals of the New York Academy of Sciences 495, 363-377.
15. Azmitia, E. C., Buchan, A. M. and Williams, J. H. (1978) Structural and functional restoration by collateral sprouting of hippocampal 5-HT axons. Nature 274, 374-376.
16. Azmitia, E. C., Perlow, M. J., Brennan, M. J. and Lauder, J. M. (1981) Fetal raphe and hippocampal transplants into adult and aged C57BL/6N mice: A preliminary immunocytochemical study. Brain Research Bulletin 7, 703-710.
17. Azmitia, E. C. and Whitaker-Azmitia, P. M. (1995) Anatomy, cell biology and plasticity of the serotonergic system: Neuropsychopharmacological implications for the actions of psychotropic drugs. Psychopharmacology. The Fourth Generation of Progress, pp. 443-449. Raven Press, New York.
18. Barry, D. I., Kikvadze, I., Brundin, P., Bolwig, T. G., Björklund, A. and Lindvall, O. (1987) Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy. Proceedings of the National Academy of Sciences USA 84, 8712-8715.
19. Bauer, A., Schulz, J. B. and Zilles, K. (1992) Muscarinic desensitization after septal lesions in rat hippocampus: Evidence for the involvement of G-proteins. Neuroscience 47, 95-103.
20. Baumgarten, H. G., Björklund, A., Lachenmayer, L., Nobin, A. and Stenevi, U. (1971) Long-lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine. Acta Physiologica Scandinavica Supplementum 373, 1-15.
21. Baumgarten, H. G., Björklund, A., Lachenmayer, L. and Nobin, A. (1973) Evaluation of the effects of 5,7-dihydroxytryptamine on serotonin and catecholamine neurons in the rat CNS. Acta Physiological Scandinavica Supplementum 391, 1-19.
22. Baumgarten, H. G. and Lachenmayer, L. (1972) 5,7-dihydroxytryptamine improvement in chemical lesioning of indolamine neurons in mammalian brain. Zeitschrift für Zellforschung 135, 399-414.
23. Bengzon, J., Brundin, P., Kalén, P., Kokaia, M. and Lindvall, O. (1991) Host regulation of noradrenaline release from grafts of seizure-suppressant locus coeruleus neurons. Experimental Neurology 111, 49-54.
24. Bengzon, J., Kokaia, Z., Brundin, P. and Lindvall, O. (1990) Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: Evidence for an alpha2-adrenoreceptor mediated mechanism. Experimental Brain Research 81, 433-437.
25. Bengzon, J., Kokaia, Z. and Lindvall, O. (1993) Specific functions of grafted locus coeruleus neurons in the kindling model of epilepsy. Experimental Neurology 122, 143-154.
26. Bennett, M. C., Kaleta-Michaels, S., Arnold, M. and McGaugh, J. L. (1990) Impairment of active avoidance by the noradrenergic neurotoxin, DSP4: Attenuation by post-training epinephrine. Psychopharmacology 101, 505-510.
27. Benson, D. M., Blitzer, R. D., Haroutunian, V. and Landau, E. M. (1989) Functional muscarinic supersensitivity in denervated rat hippocampus. Brain Research 478, 399-402.
28. Berger-Sweeney, J., Heckers, S., Mesulam, M.-M., Wiley, R. G., Lappi, D. A. and Sharma, M. (1994) Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. The Journal of Neuroscience 14, 4507-4519.
29. Bermant, G., Glickman, S. E. and Davidson, J. M. (1968) Effects of limbic lesions on copulatory behaviour of male rats. Journal of Comparative and Physiological Psychology 65, 118-125.
30. Bernheimer, H. and Hornykiewicz, O. (1962) Das Verhalten einiger Enzymen im Gehirn normaler und Parkinson-kranker Menschen. Nauyn-Schmiedeberg's Archives of Experimental Pathology and Pharmacology 243, 295-296.
31. Berridge, C. W. and Dunn, A. J. (1990) DSP-4-induced depletion of brain norepinephrine produces opposite effects on exploratory behavior 3 and 14 days after treatment. Psychopharmacology 100, 504-508.
32. Björklund, A., Gage, F. H., Schmidt, R. H., Stenevi, U. and Dunnett, S. B. (1983a) Intracerebral grafting of neuronal cell suspensions. VII. Recovery of choline acetyltransferase activity and acetylcholine synthesis in the denervated hippocampus reinnervated by septal suspension implants. Acta Physiological Scandinavica Supplementum 522, 59-66.
33. Björklund, A., Gage, F. H., Stenevi, U. and Dunnett, S. B. (1983b) Intracerebral grafting of neuronal cell suspensions. VI Survival and growth of intrahippocampal implants of septal cell suspensions. Acta Physiological Scandinavica Supplementum 522, 49-58.
34. Björklund, A., Nornes, H. and Gage, H. F. (1986) Cell suspension grafts of noradrenergic locus coeruleus neurons in rat hippocampus and spinal cord: reinnervation and transmitter turnover. Neuroscience 18, 685-698.
35. Björklund, A. and Stenevi, U. (1977) Experimental reinnervation of the rat hippocampus by grafted sympathetic ganglia. I. Axonal regeneration along the hippocampal fimbria. Brain Research 138, 259-270.
36. Björklund, A. and Stenevi, U. (1979) Regeneration of monoaminergic and cholinergic neurons in the mammalian central nervous system. Physiological Reviews 59, 62-100.
37. Björklund, A. and Stenevi, U. (1981) In vivo evidence for a hippocampal adrenergic neuronotrophic factor specifically released on septal deafferentiation. Brain Research 229, 403-428.
38. Björklund, A. and Stenevi, U. (1985) Neural Grafting in the Mammalian CNS. Elsevier, Amsterdam, 709 pp.
39. Björklund, A., Stenevi, U. and Svendgaard, N. A. (1976) Growth of transplanted monoaminergic neurons into the adult hippocampus along the perforant path. Nature 262, 787-790.
40. Blottner, D. and Baumgarten, H. G. (1994) Neurotrophy and regeneration in vivo. Acta Anatomica 150, 235-245.
41. 1B heteroreceptors inhibiting acetylcholine release. European Journal of Pharmacology 242, 1-6.
42. 1B presynaptic heteroreceptors inhibiting acetylcholine release. Neuropharmacology 33, 77-81.
43. Book, A. A., Wiley, R. G. and Schweitzer, J. B. (1994) 192 IgG-saporin: I. Specific lethality for cholinergic neurons in the basal forebrain of the rat. Journal of Neuropathological and Experimental Neurology 53, 95-102.
44. Booze, R. M., Mactutus, C. F., Gutman, C. R. and Davis, J. N. (1993) Frequency analysis of catecholamine axonal morphology in human brain. II. Alzheimer's disease and hippocampal sympathetic ingrowth. Journal of the Neurological Sciences 119, 110-118.
45. Borker, A. S. and Mascarenhas, J. F. (1990) Variations in hoarding behavior following regional hippocampal lesions in rats. Indian Journal of Experimental Biology 28, 91-92.
46. Bortolotto, Z. A. and Cavalheiro, E. A. (1986) Effect of DSP-4 on hippocampal kindling in rats. Pharmacology Biochemistry and Behavior 24, 777-779.
47. Bortolotto, Z. A., Calderazzo, L. and Cavalheiro, E. A. (1990) Some evidence that intrahippocampal grafting of noradrenergic neurons suppresses spontaneous seizures in epileptic rats. Brazilian Journal of Medical Biology Research 23, 1267-1269.
48. Bowen, D. M., Allen, S. J., Benton, S. J., Goodhardt, M. J., Haan, E. A., Palmer, A. M., Sims, N. R., Smith, C. C. T., Spillane, J. A., Esiri, M. M., Neary, D., Snowdon, J. S., Wilcock, G. K. and Davison, A. N. (1983) Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease. Journal of Neurochemistry 41, 266-272.
49. Bowen, D. M., Smith, C. B., White, P., Flack, R. H. A., Carrasco, L. H., Gedye, J. L. and Davison, A. N. (1977) Chemical pathology of the organic dementias. Brain 100, 427-453.
50. Brandeis, R., Dachir, S., Sapir, M., Levy, A. and Fisher, A. (1990) Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102B. Pharmacology Biochemistry and Behavior 36, 89-95.
51. Bratt, A. M., Cassel, J.-C., Neufang, B., Greene, P. L., Jackisch, R., Hertting, G. and Will, B. E. (1995) Behavioural and neurochemical effects of superior cervical ganglionectomy in rats with septo-hippocampal lesions. Experimental Brain Research 102, 429-444.
52. Breese, G. R. and Cooper, B. R. (1975) Behavioral and chemical interactions of 5,7-dihydroxytryptamine with various drugs when administered intracysternally to adult and developping rats. Brain Research 98, 517-527.
53. Buzsàki, G., Freund, T., Björklund, A. and Gage, F. H. (1988) Restoration and deterioration of function by brain grafts in the septohippocampal system. Progress in Brain Research 78, 69-77.
54. Buzsàki, G. and Gage, F. H. (1989) Pathophysiology of the subcortically deafferented hippocampus - Improvement and deterioration of the function by fetal grafts. In Neuronal Grafting and Alzheimer's Disease, ed. F. Gage, A. Privat and Y. Christen, pp. 103-119. Springet-Verlag, Berlin.
55. Buzsàki, G., Hsu, M., Horvath, Z. and Gage, F. H. (1992) Physiological and behavioral consequences of delayed septal grafts in the subcortically denervated hippocampus. Restorative Neurology and Neuroscience 4, 369-380.
56. Cajal, S. R. (1928) Degeneration and Regeneration of the Nervous System. Oxford University Press, London, 750 pp.
57. Capobianco, S. and Hamilton, L. W. (1973) Increased activity following fornix transection in the female rat. Physiology and Behavior 2, 407-410.
58. Capobianco, S. and Hamilton, L. W. (1976) Effects of interruption of limbic system pathways on different measures of activity. Physiology and Behavior 17, 65-72.
59. Carli, M., Robbins, T. W., Evenden, J. L. and Everitt, B. J. (1983) Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behavioural Brain Research 9, 361-380.
60. Carre, G. and Harley, C. (1986) DSP-4 treatment accelerates kindling. Experimental Neurology 94, 812-816.
61. Cassel, J.-C., Ballough, G. P., Kelche, C., Hofferer, E., Cassel, S. and Will, B. E. (1993a) Injections of fluid or septal cell suspension grafts into the dentate gyrus induce granule cell degeneration. Neuroscience Letters 150, 89-94.
62. Cassel, J.-C., Jacksich, R., Duschek, M., Hornsperger, J.-M., Richards, M. H., Kelche, C., Hertting, G. and Will, B. E. (1991a) Long term effects of septohippocampal lesions and intrahippocampal grafts on acetylcholine concentration, muscarinic stimulated formation of inositol phospholipids and electrically evoked release of neurotransmitters in the rat hippocampus. Experimental Brain Research 83, 633-642.
63. Cassel, J.-C. and Jeltsch, H. (1995) Serotonergic modulation of cholinergic function in the central nervous system: Cognitive implications. Neuroscience 69, 1-41.
64. 1B-mediated modulation of [3H]acetylcholine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts of septal origin. Brain Research 704, 153-166.
65. Cassel, J.-C. and Kelche, C. (1989) Scopolamine treatment and fimbria-fornix lesions: Mimetic effects on radial maze performance. Physiology and Behavior 46, 347-353.
66. Cassel, J.-C., Kelche, C., Dalrymple-Alford, J. C. and Will, B. E. (1988) Effects of physostigmine and d-amphetamine on the behavior of rats with selective fimbria-fornix lesions and intrahippocampal fetal septal cell transplants. Behavioral and Neural Biology 50, 229-239.
67. Cassel, J.-C., Kelche, C., Hornsperger, J.-M., Jackisch, R., Hertting, G. and Will, B. E. (1990a) Graft-induced learning impairment despite graft-enhanced cholinergic functions in the hippocampus of rats with septohippocampal lesions. Brain Research 534, 295-298.
68. Cassel, J.-C., Kelche, C., Majchrzak, M. and Will, B. E. (1992a) Factors influencing structure and function of intracerebral grafts in the mammalian brain: A review. Restorative Neurology and Neuroscience 4, 65-96.
69. Cassel, J.-C., Kelche, C., Neufang, B., Will, B. E., Hertting, G. and Jackisch, R. (1992b) Graft-derived cholinergic reinnervation of the hippocampus prevents a lasting increase of hippocampal noradrenaline concentration induced by septohippocampal damage in rats. Neuroscience Letters 138, 32-36.
70. Cassel, J.-C., Kelche, C., Peterson, G., Ballough, G. P., Goepp, I. and Will, B. E. (1991b) Graft-induced behavioral recovery from subcallosal septohippocampal damage in rats depends on maturity stage of donor tissue. Neuroscience 45, 571-586.
71. Cassel, J.-C., Kelche, C. and Will, B. E. (1987) Susceptibility to pentylenetetrazol-induced and audiogenic seizures in rats with selective fimbria-fornix lesions and intrahippocampal septal grafts. Experimental Neurology 97, 564-576.
72. Cassel, J.-C., Kelche, C. and Will, B. E. (1990b) Time-dependent effects of intrahippocampal grafts in rats with fimbria-fornix lesions. Experimental Brain Research 81, 179-190.
73. Cassel, J.-C., Kelche, C. and Will, B. E. (1991c) Susceptibility to pentyleneterazol-induced and audiogenic seizures in rats given aspirative lesions of the fimbria-fornix pathways followed by intrahippocampal grafts: A time-course approach. Restorative Neurology and Neuroscience 3, 55-64.
74. Cassel, J.-C., Neufang, B., Kelche, C., Jeltsch, H., Will, B. E., Hertting, G. and Jackisch, R. (1993b) Effects of grafts containing cholinergic and/or serotonergic neurons on cholinergic, serotonergic and noradrenergic markers in the denervated rat hippocampus. Brain Research 604, 53-63.
75. Cassel, J.-C., Neufang, B., Kelche, C., Will, B. E., Hertting, G. and Jackisch, R. (1992c) Effects of septal and/or raphe cell suspension grafts on hippocampal choline acetyltransferase activity, high affinity synaptosomal uptake of choline and serotonin, and behavior in rats with extensive septohippocampal lesions. Brain Research 585, 243-254.
76. Cassel, J.-C. and Will, B. E. (1995) The structure, operation, and functionality of intracerebral grafts. Behavioral and Brain Sciences 18, 51-52.
77. Cenci, M. A., Nilsson, O. G., Kalén, P. and Björklund, A. (1993) Characterization of in vivo noradrenaline release from superior cervical ganglia or fetal locus coeruleus transplanted to the subcortically deafferented hippocampus in the rat. Experimental Neurology 122, 73-87.
78. Chaput, Y., Lesieur, P. and Montigny, C. (1990) Effects of short-term serotonin depletion on the efficacy of serotonin neurotransmission: Electrophysiological studies in the rat central nervous system. Synapse 6, 328-337.
79. Chen, L. S., Freund, T. F., Buzsàki, G., Baimbridge, K. J. and Gage, F. H. (1989) Reduction of parvalbumin-immunoreactivity in the subcortically-denervated hippocampus. Society for Neuroscience Abstracts 15, 700.
80. Chrobak, J. J., De Haven, D. L. and Walsh, T. J. (1985) Depletion of brain norepinephrine with DSP-4 does not alter acquisition or performance of a radial-arm maze task. Behavioral and Neural Biology 44, 144-150.
81. Chrobak, J. J., Spates, M. J., Stackman, R. W. and Walsh, T. J. (1989) Hemicholinium-3 prevents the working memory impairments and the cholinergic hypofunction induced by ethylcholine aziridium ino (AF64A). Brain Research 504, 269-275.
82. Chrobak, J. J. and Walsh, T. J. (1991) Dose-dependent and delay-dependent working/episodic memory impairments following intraventricular administration of ethylcholine aziridinium ion (AF64A). Behavioral and Neural Biology 56, 200-212.
83. Clarke, D. J. (1985) Cholinergic innervation of the rat dentate gyrus: A light and electron microscopical study using a monoclonal antibody to choline acetyltransferase. Brain Research 360, 349-354.
84. Clarke, D. J., Gage, F. H. and Björklund, A. (1986) Formation of cholinergic synapses by intrahippocampal septal grafts as revealed by choline acetyltransferase immunocytochemistry. Brain Research 369, 151-162.
85. Clarke, D. J., Nilsson, O. G., Brundin, P. and Björklund, A. (1990) Synaptic connections formed by grafts of different types of cholinergic neurons in the host hippocampus. Experimental Neurology 107, 11-22.
86. Collerton, D. (1986) Cholinergic function and intellectual decline in Alzheimer's disease. Neuroscience 19, 1-28.
87. Collier, T. J., Gash, D. M. and Sladek, J. R. Jr. (1988) Transplantation of norepinephrine neurons into aged rats improves performance of a learned task. Brain Research 448, 77-87.
88. Collier, T. J. and Sladek, J. R. Jr. (1989) Can fetal cell grafts be expected to ameliorate symptoms of human neurodegenerative disorders? Evidence from animal models. In Neuronal grafting and Alzheimer's disease, ed. F. Gage, A. Privat and Y. Christen, pp. 120-129. Springer-Verlag, Berlin.
89. Collier, T. J. and Springer, J. E. (1994) Neural graft augmentation through co-grafting: Implantation of cells as sources of survival and growth factors. Progress in Neurobiology 44, 309-331.
90. Connor, D. J. and Harrell, L. E. (1989) Chronic septal lesions cause upregulation of cholinergic but not noradrenergic hippocampal phosphoinositol hydrolysis. Brain Research 488, 387-389.
91. 3 receptors. Journal of Neurochemistry 62, 2254-2261.
92. Coover, G. D., Goldman, L. and Levine, S. (1971) Plasma corticosterone levels during extinction of a lever-press response in hippocampectomized rats. Physiology and Behavior 7, 727-732.
93. Corcoran, M. and Mason, S. (1980) Role of forebrain catecholamines in amygdaloid kindling. Brain Research 190, 473-484.
94. Cotman, C. W., Geddes, J. W. and Kahle, J. S. (1990) Axon sprouting in the rodent and Alzheimer's disease brain: A reactivation of developmental mechanisms?. Progress in Brain Research 83, 427-433.
95. Cotman, C. W., Nieto-Sampedro, M. and Harris, M. W. (1981) Synapse replacement in the nervous system of adult vertebrates. Physiological Reviews 61, 684-784.
96. Creese, I., Burt, D. R. and Snyder, D. H. (1977) Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity. Science 197, 596-598.
97. Crutcher, K. A. (1987) Sympathetic sprouting in the central nervous system: A model for studies of axonal growth in the mature mammalian brain. Brain Research Reviews 12, 203-233.
98. Crutcher, K. A. (1990) The regulation of axonal growth in the mature mammalian nervous system. Acta Neurobiologica Experimentalis 50, 115-124.
99. Crutcher, K. A. and Davis, J. N. (1981) Sympathetic noradrenergic sprouting in response to central cholinergic denervation. Trends in Neuroscience 4, 70-72.
100. Crutcher, K. A., Kesner, R. P. and Novak, J. M. (1983) Medial septal lesions, radial arm maze performance, and sympathetic sprouting: A study of recovery of function. Brain Research 262, 91-98.
101. Cuadra, G. R. and Molina, V. A. (1990) Behavioral reactivity following 5-MeODMT administration in 5,7-DHT-pretreated killer rats. Pharmacology Biochemistry and Behavior 36, 287-290.
102. Dahlström, A. and Fuxe, K. (1964) Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brainstem neurons. Acta Physiologica Scandinavica Supplementum 232, 1-55.
103. Dalrymple-Alford, J. C. (1994) Behavioral effects of basal forebrain grafts after dorsal septo-hippocampal pathway lesions. Brain Research 661, 243-258.
104. Dalrymple-Alford, J. C., Kelche, C., Cassel, J.-C., Toniolo, G., Pallage, V. and Will, B. E. (1988) Behavioral deficits after intrahippocampal fetal septal grafts in rats with selective fimbria-fornix lesions. Experimental Brain Research 69, 545-558.
105. Daniloff, J. K., Bodony, R. P., Low, W. C. and Wells, J. (1985) Cross-species embryonic septal transplants: Restoration of conditioned learning behavior. Brain Research 346, 176-180.
106. Daniloff, J. K., Wells, J. and Ellis, J. (1984) Cross-species septal transplants: Recovery of choline acetyltransferase activity. Brain Research 324, 151-154.
107. Daszuta, A., Chazal, G., Garcia, S., Oleskevich, S. and Descarries, L. (1991a) Ultrastructural features of serotonin neurons grafted to adult rat hippocampus: An immunocytochemical analysis of their cell bodies and axon terminals. Neuroscience 42, 793-811.
108. Daszuta, A., Kalén, P., Strecker, R. E., Brundin, P. and Björklund, A. (1989) Serotonin neurons grafted to the adult rat hippocampus. II. 5-HT release as studied by intracerebral microdialysis. Brain Research 498, 323-332.
109. Daszuta, A., Marocco, C. and Bosler, O. (1991b) Serotonin reinnervation of the suprachiasmatic nucleus by intrahypothalamic fetal raphe transplants, with special reference to possible influences of the target. European Journal of Neuroscience 3, 1330-1337.
110. Daszuta, A., Strecker, R. E., Brundin, P. and Björklund, A. (1988) Serotonin Neurons grafted to the adult rat hippocampus. I. Time course of growth as studied by immunohistochemistry and biochemistry. Brain Research 458, 1-19.
111. David, S. and Aguayo, A. J. (1985) Peripheral nerve transplantation techniques to study axonal regeneration from the CNS of adult mammals. In Neural Grafting in the Mammalian CNS, ed. A. Björklund and U. Stenevi, pp. 61-70. Elsevier, Amsterdam.
112. Davidson, T. L. and Jarrard, L. E. (1993) The hippocampus and metabolic state cues. Behavioral and Neural Biology 59, 167-171.
113. Davies, P. and Maloney, A. F. J. (1976) Selective loss of cerebral cholinergic neurons in Alzheimer's disease. Lancet 2, 1403.
114. Dawson, V. L., Gage, F. H., Hunt, M. A. and Wamsley, J. K. (1989) Normalization of subtype-specific muscarinic receptor binding in the denervated hippocampus by septodiagonal band grafts. Experimental Neurology 106, 115-124.
115. Dawson, V. L., Gage, F. H. and Wamsley, J. K. (1988) Alterations in muscarinic binding in rat hippocampus provides evidence for functional reinnervation of fimbria-fornix lesions by fetal septal transplants. Society for Neuroscience Abstracts 14, 588.
116. Decker, M. W. and McGaugh, J. L. (1989) Effects of concurrent manipulations of cholinergic and noradrenergic function on learning and retention in mice. Brain Research 477, 29-37.
117. Decker, M. W. and McGaugh, J. L. (1991) The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 7, 151-168.
118. Doering, L. C. (1994) Nervous sytem modification by transplants and gene transfer. BioEssays 16, 825-831.
119. Dong, X. W., Hanin, I. and Lorens, S. A. (1994) AF64A affects septal choline acetyltransferase but not parvalbumin immunoreactive cells. Brain Research Bulletin 35, 217-220.
120. Donnerer, J., Humpel, C. and Saria, A. (1992) Effect of noradrenergic denervation by neonatal DSP-4 on peptide neurotransmitter systems in the rat brain. Neuropeptides 22, 103-106.
121. Dravid, A. R. and Van Deusen, E. B. (1983) recovery of choline acetyltransferase and acetylcholinesterase activities in the ipsilateral hippocampus following unilateral, partial transection of the fimbria in rats. Brain Research 277, 169-174.
122. Dravid, A. R. and Van Deusen, E. B. (1984) Recovery of enzyme markers for cholinergic terminals in septo-temporal regions of the hippocampus following selective fimbrial lesions in adult rats. Brain Research 324, 119-128.
123. Dringenberg, H. C., Hargreaves, E. L., Baker, G. B., Cooley, R. K. and Vanderwolf, C. H. (1995) ρ-chlorophenylalanine-induced serotonin depletion: Reduction in exploratory locomotion but no obvious sensory-motor deficits. Behavioural Brain Research 68, 229-237.
124. Dunnett, S. B. (1990) Neural transplantation in animal models of dementia. European Journal of Neuroscience 2, 567-587.
125. Dunnett, S. B. (1994) Behavioural consequences of neural transplantation. Journal of Neurology 241, S43-S53.
126. Dunnett, S. B. and Björklund, A. (1987) Mechanisms of function of neural grafts in the adult mammalian brain. Journal of Experimental Biology 132, 265-289.
127. Dunnett, S. B. and Björklund, A. (1994) Mechanisms of function of neural grafts in the injured brain. Functional Neural Transplantation 2, 157-195.
128. Dunnett, S. B., Low, W. C., Iversen, S. D., Stenevi, U. and Björklund, A. (1982) Septal transplants restore maze learning in rats with fornix-fimbria lesions. Brain Research 251, 335-348.
129. Dunnett, S. B., Martel, F. L., Rogers, D. C. and Finger, S. (1989) Factors affecting septal graft amelioration of differential reinforcement of low rates (DRL) and activity deficits after fimbria-fornix lesions. Restorative Neurology and Neuroscience 1, 83-92.
130. Dutar, P., Bassant, M. H., Senut, M. C. and Lamour, Y. (1995) The septohippocampal pathway: Structure and function of a central cholinergic system. Physiological Reviews 75, 393-427.
131. Dyon-Laurent, C., Herve, A. and Sara, S. J. (1994) Noradrenergic hyperactivity in hippocampus after partial denervation: Pharmacological, behavioral, and electrophysiological studies. Experimental Brain Research 99, 259-266.
132. Dyon-Laurent, C., Romand, S., Biegon, A. and Sara, S. J. (1993) Functional reorganization of the noradrenergic system after partial fornix section: A behavioral and autoradiographic study. Experimental Brain Research 96, 203-211.
133. Eagle, K. S., Chalmers, G. R., Clary, D. O. and Gage, F. H. (1995) Axonal regeneration and limited functional recovery following hippocampal deafferentiation. Journal of Comparative Neurology 363, 377-388.
134. Eichenbaum, H. (1992) The hippocampal system and declarative memory in animals. Journal of Cognitive Neuroscience 4, 217-231.
135. Eichenbaum, H., Otto, T. and Cohen, N. J. (1992) The hippocampus-What does irt do?. Behavioral and Neural Biology 57, 2-36.
136. Eichenbaum, H., Otto, T. and Cohen, N. J. (1994) Two functional components of the hippocampal memory system. Behavioral and Brain Sciences 17, 449-518.
137. Emerich, D. F., Black, B. A., Kesslak, J. P., Cotman, C. W. and Walsh, T. J. (1992) Transplantation of fetal cholinergic neurons into the hippocampus attenuates the cognitive and neurochemical deficits induced by AF64A. Brain Research Bulletin 28, 219-226.
138. Ezerman, E. B. and Kromer, L. F. (1987) Transplants of cholinergic septal explants reinnervate adult rodent hippocampus. Brain Research Bulletin 18, 337-343.
139. Finger, S. (1990) A 16th century request for brain tissue transplantation. Restorative Neurology and Neuroscience 1, 367-368.
140. Finger, S., Levere, T. E., Almli, C. R. and Stein, D. G. (1988) Brain Injury and Recovery. Theoretical and Controversial Issues. Plenum Press, New York, 368 pp.
141. Finger, S. and Stein, D. G. (1982) Brain Damage and Recovery. Academic Press, New York, 368 pp.
142. Finnegan, K. T., Ricaurte, G. A., Ritchie, L. D., Irwin, I., Peroutka, S. and Langston, J. W. (1988) Orally administered MDMA causes a long-term serotonin depletion in rat brain. Brain Research 447, 141-144.
143. 2 receptors throughout the rat central nervous system using qualitative autoradiography. Brain Research 421, 263-279.
144. Fisher, L. J. and Gage, F. H. (1993) Grafting in the mammalian central nervous system. Physiological Reviews 73, 583-616.
145. Fisher, L. J. and Gage, F. H. (1994) Intracerebral transplantation: Basic and clinical applications to the neostriatum. FASEB J. 8, 489-496.
146. Fisher, A. and Hanin, I. (1986) Potential animal models for senile dementia of Alzheimer's type, with emphasis on AF64A-induced cholinotoxicity. Annual Reviews of Pharmacology and Toxicology 26, 161-181.
147. Flynn, D. D., Ferrari-Dileo, G., Levey, A. I. and Mash, D. C. (1995a) Differential alterations in muscarinic receptor subtypes in Alzheimer's disease: Implications for cholinergic-based therapies. Life Sciences 56, 869-876.
148. Flynn, D. D., Ferrari-Dileo, G., Mash, D. C. and Levey, A. I. (1995b) Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer's disease. Journal of Neurochemistry 64, 1888-1891.
149. Fordyce, D. E. and Farrar, R. P. (1991) Enhancement of spatial learning in F344 rats by physical activity and related learning-associated alterations in hippocampal and cortical cholinergic functioning. Behavioural Brain Research 46, 123-133.
150. Forloni, G., Fisone, G., Guaitani, A., Ladinsky, H. and Consolo, S. (1986) Role of the hippocampus in the sex-dependent regulation of eating behavior: Studies with kainic acid. Physiology and Behavior 38, 321-326.
151. Forssman, J. (1900) Zur Kenntniss des Neurotropismus. Ziegler's Beiträge zur Pathologischen Anatomy XXVII, 407-430.
152. Foster, G. A., Brodin, E., Gage, F. H., Maxwell, D. J., Roberts, M. H. T. and Sharp, T. (1990) Restoration of function to the denervated spinal cord after implantation of embryonic 5-HT- and substance P-containing raphe neurones. In Progress in Brain Research, ed. S. B. Dunnett and S. J. Richards, Vol. 82, pp. 247-259. Elsevier, Amsterdam.
153. Frankfurt, M., Mendelson, S. D., McKittrick, C. R. and McEwen, B. S. (1993) Alterations of serotonin receptor binding in the hypothalamus following acute denervation. Brain Research 601, 349-352.
154. Freund, T. F. (1992) GABAergic septal and serotonergic median raphe afferents preferentially innervate inhibitory interneurons in the hippocampus and dentate gyrus. Epilepsy Research, Supplement 7, 79-91.
155. Freund, T. F. and Antal, M. (1988) GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus. Nature 336, 170-173.
156. Frotscher, M. (1988) Cholinergic neurons in the rat hippocampus do not compensate for the loss of septohippocampal cholinergic fibers. Neuroscience Letters 87, 18-22.
157. Fuji, K., Hiramatsu, M., Hayashi, S., Kameyama, T. and Nabeshima, T. (1993) Effects of propentofylline, a NGF synthesis stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats. Neuroscience Letters 150, 99-102.
158. Gaál, G., Potter, P. E., Hanin, I., Kakucska, I. and Vizi, E. S. (1986) Effects of intracerebroventricular AF64A administration on cholinergic, serotoninergic and catecholaminergic circuitry in rat dorsal hippocampus. Neuroscience 19, 1197-1205.
159. Gage, F. H. (1990) Intracerebral grafting of genetically modified cells acting as biological pumps. Trends in Pharmacological Sciences 11, 437-439.
160. Gage, F. H. and Björklund, A. (1986a) Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine sensitive mechanism. Journal of Neurosciences, 2837-2847.
161. Gage, F. H. and Björklund, A. (1986b) Compensatory collateral sprouting of aminergic systems in the hippocampal formation following partial deafferentation. In The hippocampus, ed. R. L. Isaacson and K. H. Pribram, Vol. 3, pp. 33-63. Plenum Press, New York.
162. Gage, F. H., Björklund, A. and Stenevi, U. (1983a) Reinnervation of the partially deafferented hippocampus by compensatory collateral sprouting from spared cholinergic and noradrenergic afferents. Brain Research 268, 27-37.
163. Gage, F. H., Björklund, A. and Stenevi, U. (1983b) Local regulation of compensatory noradrenergic hyperactivity in the partially denervated hippocampus. Nature 303, 819-821.
164. Gage, F. H., Björklund, A. and Stenevi, U. (1984a) Cells of origin of the ventral cholinergic septohippocampal pathway undergoing compensatory collateral sprouting following fimbria-fornix transection. Neuroscience Letters 44, 211-216.
165. Gage, F. H., Björklund, A., Stenevi, U. and Dunnett, S. B. (1983c) Functional correlates of compensatory collateral sprouting by aminergic and cholinergic afferents in the hippocampal formation. Brain Research 268, 39-47.
166. Gage, F. H., Björklund, A., Stenevi, U., Dunnett, S. B. and Kelly, P. A. T. (1984b) Intrahippocampal grafts ameliorate learning impairments in aged rats. Science 225, 533-536.
167. Gage, F. H., Wolff, J. A., Rosenberg, M. B., Xu, L., Yee, J. K., Shults, C. and Friedmann, T. (1987) Grafting genetically modified cells to the brain: Possibilities for the future. Neuroscience 23, 795-807.
168. Gash, D. M. (1984) Neural transplants in mammals: A historical overview. In Neural Transplants. Development and Function, ed. J. R. Jr. Sladeck and D. M. Gash, pp. 1-12. Plenum Press, New York.
169. Gasser, U. E. and Dravid, R. (1987) Noradrenergic, serotonergic, and cholinergic sprouting in the hippocampus that follows partial or complete transection of the septohippocampal pathways: Contribution of spared inputs. Experimental Neurology 96, 352-364.
170. 6 receptor messenger-RNA in the central nervous system of control and 5,7-dihydroxytryptamine-treated rats. Synapse 23, 164-173.
171. Gertz, H.-J. and Cervos-Navarro, J. (1990) Neuronal plasticity of the septo-hippocampal pathway in patients suffering from dementia of Alzheimer type. In Alzheimer's disease, ed. K. Maurer, K. Riederer and H. Beckmann, pp. 99-103. Springer Verlag, Berlin.
172. Gibbs, R. B., Anderson, K. and Cotman, C. W. (1986) Factors affecting innervation in the CNS: Comparison of three cholinergic cell types transplanted to the hippocampus of adult rats. Brain Research 383, 362-366.
173. Ginn, S. R. and Peterson, G. M. (1991) Colchicine-induced cholinergic denervation of the hippocampus elicits sympathetic ingrowth. Brain Research 554, 257-263.
174. Goldberger, M. E. and Murray, M. (1988) Patterns of sprouting and implications for recovery of function. In Advances in Neurology, ed. S. G. Waxman, pp. 361-385. Raven Press, New York.
175. Gordon, B., Allen, E. E. and Trombely, P. Q. (1988) The role of norepinephrine in plasticity of visual cortex. Progress in Neurobiology 30, 171-191.
176. Gower, A. J., Rousseau, D., Jamsin, P., Gobert, J., Hanin, I. and Wulfert, E. (1989) Behavioral and histological effects of low concentrations of intraventricular AF64A. European Journal of Pharmacology 166, 271-281.
177. Gray, J. A. and McNaughton, N. (1982) Comparison between the behavioral effects of septal and hippocampal lesions: A review. Neuroscience and Biobehavioral Reviews 7, 119-188.
178. Greene, P. L., Cassel, J.-C., Kelche, C., Jeltsch, H., Bratt, A. and Will, B. E. (1994) Differential behavioral effects of supracallosal and infracallosal lesions of the septohippocampal pathways: No ameliorative effects of oxotremorine or pilocarpine on radial-maze performance. Behavioral and Neural Biology 62, 4-14.
179. Hagan, J. J., Jansen, J. H. M. and Broekkamp, C. L. E. (1987) Blockade of spatial learning by the M1 muscarinic antagonist pirenzepine. Psychopharmacology 93, 470-476.
180. Hanin, I. (1990) AF64A-induced cholinergic hypofunction. Progress in Brain Research 84, 289-299.
181. Haroutunian, V., Kanof, P. D., Tsuboyama, G. and Davis, K. L. (1990) Restoration of cholinomimetic activity by clonidine in cholinergic plus noradrenergic lesioned rats. Brain Research 507, 261-266.
182. Harrell, L. E., Ayyagari, V., Parsons, D. S., Connor, D. J. and Peagler, A. (1992) Hippocampal phosphoinositide turnover is altered by hippocampal sympathetic ingrowth and cholinergic denervation. Pharmacology Biochemistry and Behavior 42, 277-284.
183. Harrell, L. E., Ayyagari, V., Peagler, A. and Parsons, D. S. (1994) Hippocampal sympathetic ingrowth and cholinergic denervation after hippocampal muscarinic cholinergic receptors. Hippocampus 4, 199-203.
184. Harrell, L. E., Goyal, M., Parsons, D. S. and Peagler, A. (1990a) The effects of gonadal steroids on the behavioral and biochemical effects of hippocampal sympathetic ingrowth. Physiology and Behavior 48, 507-513.
185. Harrell, L. E., Kolasa, K., Parsons, D. S. and Ayyagari, V. (1995) Hippocampal sympathetic ingrowth and cholinergic denervation uniquely alter muscarinic receptor subtypes in the hippocampus. Brain Research 676, 386-393.
186. Harrell, L. E. and Parsons, D. S. (1988) Role of gender in the behavioral effects of peripheral sympathetic ingrowth. Experimental Neurology 99, 315-325.
187. Harrell, L. E., Parsons, D. S., Peagler, A. and Barlow, T. S. (1987) Alterations in regulatory behaviors induced by medial septal lesions and superior cervical ganglionectomy. Brain Research 408, 131-140.
188. Harrell, L. E., Peagler, A. and Parsons, D. S. (1990b) Adrenoreceptor antagonist treatment influences recovery of learning following medial septal lesions and hippocampal sympathetic ingrowth. Pharmacology Biochemistry and Behavior 35, 21-28.
189. Harrell, L. E., Peagler, A., Parsons, D. S., Litersky, J. and Barlow, T. S. (1993) Female circulating sex hormones and hippocampal sympathetic ingrowth. Behavioural Brain Research 55, 29-38.
190. Harro, J., Jossan, S. S. and Oreland, L. (1992) Changes in cholecystokinin receptor binding in rat brain after selective damage of locus coeruleus projections by DSP-4 treatment. Naunyn-Schmiedeberg's Archives of Pharmacology 346, 425-431.
191. Harro, J., Oreland, L., Vasar, E. and Bradwejn, J. (1995) Impaired exploratory-behavior after DSP-4 treatment in rats - implications for the increased anxiety after noradrenergic denervation. European Neuropsychopharmacology 5, 447-455.
192. Heal, D. J., Butler, S. A., Prow, M. R. and Buckett, W. R. (1993) Quantification of presynaptic alpha-2-adrenoceptors in rat brain after short-term DSP-4 lesioning. European Journal of Pharmacology 249, 37-41.
193. Heckers, S., Ohtake, T., Wiley, R. G., Lappi, D. A., Geula, C. and Mesulam, M.-M. (1994) Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor. Journal of Neuroscience 14, 1271-1289.
194. Hefti, F., Hartikka, J. and Knüsel, B. (1989) Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases. Neurobiohgy of Aging 10, 515-533.
195. Hefti, F., Melamed, E. and Wurtman, R. J. (1980) Partial lesions of the dopaminergic nigrostriatal system in rat brain: Biochemical characterization. Brain Research 195, 123-137.
196. Heuschling, P., De Paermentier, F. and Van den Bosch de Aguilar, P. (1988) Topographical distribution in the adult rat brain of neurotrophic activities directed to central nervous system targets. Developmental Brain Research 38, 9-17.
197. Ho, M.-Y., Velazquez-Martinez, D. N., Lopez-Cabrera, M., Al-Zahrani, S. S. A., Bradshaw, C. M. and Szabadi, E. (1995) Retarded acquisition of a temporal discrimination following destruction of noradrenergic neurones by systemic treatment with DSP4. Psychopharmacology 118, 332-337.
198. Hodges, H., Allen, Y., Kershaw, T., Lantos, P. L., Gray, J. A. and Sinden, J. (1990) Cholinergic-rich neural transplants alleviate cognitive deficits in lesioned rats but exacerbate response to cholinergic drugs. In Neural Transplantation: From Molecular Basis to Clinical Application, ed S. B. Dunnett and S. J. Richards, pp. 347-358. Elsevier, Amsterdam.
199. Hodges, H., Allen, Y., Kershaw, T., Lantos, P. L., Gray, J. A. and Sinden, J. (1991a) The effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system. 1. Amelioration of cognitive deficits by transplants into cortex and hippocampus but not into basal forebrain. Neuroscience 45, 587-607.
200. Hodges, H., Allen, Y., Sinden, J., Lantos, P. L. and Gray, J. A. (1991b) The effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system. 2. Cholinergic drugs as probes to investigate lesion-induced deficits and transplant-induced functional recovery. Neuroscience 45, 609-623.
201. Hodges, H., Allen, Y., Sinden, J., Mitchell, S. N., Arendt, T., Lantos, P. L. and Gray, J. A. (1991c) The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats. Behavioural Brain Research 43, 7-28.
202. Hofferer, E. and Cassel, J.-C. (1996) A comparison of the effects of two fimbria-fornix lesion techniques on beam-walking performance in the rat: Aspiration versus electrolysis. Behavioural Brain Research 74, 175-180.
203. Hofferer, E., Cassel, J.-C., Kelche, C., Millemann, P. and Will, B. (1994) Morphological and behavioural effects of granule cell degeneration induced by intrahippocampal fluid injections in intact and fimbria-fornix lesioned rats. Behavioural Brain Research 63, 167-176.
204. Hofferer, E., Kelche, C., Will, B. and Cassel, J.-C. (1996) A comparison of behavioral effects and morphological features of grafts rich in cholinergic neurons placed in two sites of the denervated rat hippocampus. Experimental Brain Research 111, 187-207.
205. Hoffman, D., Breakefield, X. O., Short, M. P. and Aebisher, P. (1993) Transplantation of a polymer-encapsulated cell line genetically engineered to release NGF. Experimental Neurology 122, 100-106.
206. Hoffman, D., Wahlberg, L. and Aebischer, P. (1990) NGF released from a polymer matrix prevents loss of ChAT expression in basal forebrain neurons following a fimbria-fornix lesion. Experimental Neurology 110, 39-44.
207. Horellou, P., Brundin, P., Kalén, P., Mallet, J. and Björklund, A. (1990a) In vivo release of DOPA from genetically engineered cells grafted to the denervated rat striatum. Neuron 5, 393-402.
208. Horellou, P., Marlier, L., Privat, A. and Mallet, J. (1990b) Behavioural effect of engineered cells that synthesize L-DOPA or dopamine after grafting into the rat neostriatum. European Journal of Neuroscience 2, 116-119.
209. Hörtnagl, H., Berger, M. L., Reither, H. and Hornykiewicz, O. (1991a) Cholinergic deficit induced by ethylcholine aziridinium (AF64A) in rat hippocampus: Effect on glutamatergic systems. Naunym-Schmiedeberg's Archives of Pharmacology 344, 213-219.
210. Hörtnagl, H., Berger, M. L., Sperk, G. and Pifl, C. (1991b) Regional heterogeneity in the distribution of neurotransmitter markers in the rat hippocampus. Neuroscience 45, 261-271.
211. Hörtnagl, H. and Hanin, I. (1992) Toxins affecting the cholinergic system. Handbook of Experimental Pharmacology 102, 293-332.
212. Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R. and Humphrey, P. P. A. (1994) VII International Union of Pharmacology: Classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacological Reviews 46, 57-204.
213. Ikegami, S., Nihonmatsu, I., Hatanaka, H., Takei, N. and Kawamura, H. (1989a) Recovery of hippocampal cholinergic activity in AF64A treated rats. Neuroscience Letters 101, 17-22.
214. Ikegami, S., Nihonmatsu, I., Hatanaka, H., Takei, N. and Kawamura, H. (1989b) Transplantation of septal cholinergic neurons to the hippocampus improves memory impairments of spatial learning in rats treated with AF64A. Brain Research 496, 321-326.
215. Ikegami, S., Nihonmatsu, I. and Kawamura, H. (1991) Transplantation of ventral forebrain cholinergic neurons to the hippocampus ameliorates impairment of radial-arm maze learning in rats with AF64A treatment. Brain Research 548, 187-195.
216. 1A receptor enhances acetylcholine release in conscious rats. Journal of Neurochemistry 62, 1804-1808.
217. Jackisch, R., Neufang, B., Hertting, G., Jeltsch, H., Kelche, C., Will, B. E. and Cassel, J.-C. (1995) Sympathetic sprouting: Time course of changes of noradrenergic, cholinergic, and serotonergic markers in the denervated rat hippocampus. Journal of Neurochemistry 65, 329-337.
218. Jacobs, B. L. and Azmitia, E. C. (1992) Structure and function of the brain serotonin system. Physiological Reviews 72, 165-229.
219. Jacobson, L. and Sapolsky, R. (1991) The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocrine Reviews 12, 118-134.
220. Jäkälä, P., Sirviö, J., Jolkkonen, J., Riekkinen, P. Jr, Acsady, L. and Riekkinen, P. (1992) The effects of ρ-chlorophenylalanine-induced serotonin synthesis inhibition and muscarinic blockade on the performance of rats in a 5-choice serial reaction time task. Behavioural Brain Research 51, 29-40.
221. Jäkälä, P., Sirviö, J., Riekkinen, P. Jr and Riekkinen, P. Sr. (1993) Effects of ρ-chlorophenylalanine and methysergide on the performance of a working memory task. Pharmacology Biochemistry and Behavior 44, 411-418.
222. Jarrard, L. E. (1968) Behaviour of hippocampal lesioned rats in home cage and novel situations. Physiology and Behavior 3, 65-70.
223. Jarrard, L. E., Kant, G. J., Meyerhoff, J. L. and Levy, A. (1984a) Behavioral and neurochemical effects of intraventricular AF64A administration in rats. Pharmacology Biochemistry and Behavior 21, 273-280.
224. Jarrard, L. E., Okaichi, H., Steward, O. and Glodschmidt, R. B. (1984b) On the role of hippocampal connections in the performance of place and cue tasks: Comparisons with damage to hippocampus. Behavioral Neuroscience 96, 946-954.
225. Jeltsch, H., Cassel, J.-C., Jackisch, R., Greene, P. L., Kelche, C., Hertting, G. and Will, B. E. (1994a) Lesions of supracallosal or infracallosal hippocampal pathways in the rat: Behavioral, neurochemical, and histochemical effects. Behavioral and Neural Biology 62, 121-133.
226. Jeltsch, H., Cassel, J.-C., Neufang, B., Kelche, C., Hertting, G., Jackisch, R. and Will, B. E. (1994b) The effects of intrahippocampal raphe and/or septal grafts in rats with fimbria-fornix lesions depend on the origin of the grafted tissue and the behavioural task used. Neuroscience 63, 19-39.
227. Jeltsch, H., Cassel, J.-C., Simler, S., Lazarus, C., Kelche, C., Hertting, G., Jackisch, R. and Will, B. E. (1994c) Hippocampal amino acid concentrations after raphe and/or septal cell suspension grafts in rats with fimbria-fornix lesions. Neuroscience 63, 41-45.
228. Jimenez-Rivera, C., Voltura, A. and Weiss, G. K. (1987) Effects of locus coeruleus stimulation on the development of kindled seizures. Experimental Neurology 95, 13-20.
229. Joyce, J. N., Gibbs, R. B., Cotman, C. W. and Marshall, J. F. (1989) Regulation of muscarinic receptors in hippocampus following cholinergic denervation and reinnervation by septal and striatal transplants. The Journal of Neuroscience 9, 2776-2791.
230. Kalaria, R. N., Andorn, A. C., Tabaton, M., Whitehouse, P. J., Harik, S. I. and Unnerstall, J. R. (1989) Adrenergic receptors in aging and Alzheimer's disease-Increased Beta-2-receptors in prefrontal cortex and hippocampus. Journal of Neurochemistry 53, 1772-1781.
231. Kalén, P., Cenci, M. A., Lindvall, O. and Björklund, A. (1991a) Host brain regulation of fetal locus coeruleus neurons grafted to the hippocampus in 6-hydroxydopamine-treated rats. An intracerebral microdialysis study. European Journal of Neuroscience 3, 905-918.
232. Kalén, P., Kokaia, M., Lindvall, O. and Björklund, A. (1988) Basic characteristics of noradrenaline release in the hippocampus of intact and 6-hydroxydopamine-lesioned rats as studied by in vivo microdialysis. Brain Research 474, 374-379.
233. Kalén, P., Nilsson, O. G., Cenci, M. A., Rosegren, E., Lindvall, O. and Björklund, A. (1990) Intracerebral microdialysis as a tool to monitor transmitter release from grafted cholinergic and monoaminergic neurons. Journal of Neuroscience Methods 34, 107-115.
234. Kalen, P., Nilsson, O. G., Lindvall, O. and Björklund, A. (1991b) Release properties of intracerebrally grafted cholinergic and monoaminergic neurons as studied by the microdialysis technique. In Volume Transmission in the Brain: Novel Mechanisms for Neural Transmission, ed. K. Fuxe and L. F. Agnati, pp. 441-453. Raven Press, New York.
235. Kalén, P., Rosegren, E., Lindvall, O. and Björklund, A. (1989) Hippocampal noradrenaline and serotonin release over 24 hours as measured by the dialysis technique in freely moving rats: Correlation to behavioural activity state, effect of handling and tail-pinch. European Journal of Neuroscience 1, 181-188.
236. Kaseda, Y., Simon, J. R. and Low, W. C. (1989) Restoration of high affinity choline uptake in the hippocampal formation following septal cell suspension transplants in rats with fimbria-fornix lesions. Journal of Neurochemistry 53, 482-488.
237. Kelche, C., Dalrymple-Alford, J. C. and Will, B. E. (1988) Housing conditions modulate the effects of intracerebral grafts in rats with brain lesions. Behavioural Brain Research 28, 287-295.
238. Kelche, C., Roeser, C., Jeltsch, H., Cassel, J.-C. and Will, B. E. (1995) The effects of intrahippocampal grafts, training, and postoperative housing on behavioral recovery after septohippocampal damage in the rat. Neurobiology of Learning and Memory 63, 155-156.
239. Kesner, R. P. (1984) The neurobiology of memory: Implicit and explicit assumptions. In: The Neurobiology of Learning and Memory, ed J. L. McGaugh, G. Lynch and N. Weinberger, pp. 111-118. Guilford Press, New York.
240. 1 recognition sites in the rat hippocampus to partial denervation. Acta Neurobiologica Experimentalis 50, 213-218.
241. Kim, C. (1960) Sexual activity of male rats following ablation of hippocampus. Journal of Comparative and Physiological Psychology 53, 553-557.
242. Kimble, D. P., Anderson, S., Bremiller, R. and Dannen, E. (1979a) Hippocampal lesions, superior cervical ganglia removal, and behavior in rats. Physiology and Behavior 22, 461-466.
243. Kimble, D. P., Bremiller, R. and Schroeder, L. (1979b) Hippocampal lesions slow extinction of a conditioned taste aversion in rats. Physiology and Behavior 23, 217-222.
244. Kimble, D. P., Bremiller, R. and Perez-Polo, J. R. (1979c) Nerve growth factor fail to alter behavior of hippocampal lesioned rats. Physiological Reviews 23, 653-657.
245. Kimble, D. P., Bremiller, R. and Stickford, G. (1980) Failure to find a behavioral role for anomalous sympathetic innervation of the hippocampus in male rats. Physiology and Behavior 25, 675-681.
246. Kimble, D. P., Rogers, L. and Hendrickson, C. (1967) Hippocampal lesions disrupt maternal, not sexual, behaviour in the albino rat. Journal of Comparative and Physiological Psychology 63, 403-407.
247. King, B. M., Sam, H., Arceneaux, E. R. and Kass, J. M. (1994) effect on food intake and body weight of lesions in and adjacent to the posterodorsal amygdala in rats. Physiology and Behavior 55, 963-966.
248. Kiss, J., Patel, A. J., Baimbridge, K. G. and Freund, T. F. (1990) Topographical localization of neurons containing parvalbumin and choline acetyltransferase in the medial septum-diagonal band region of the rat. Neuroscience 36, 61-72.
249. Knüsel, B., Beck, K. D., Winslow, J. W., Rosenthal, A., Burton, A., Widmer, H. R., Nikolics, K. and Hefti, F. (1992) Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain. Journal of Neuroscience 12, 4391-4402.
250. Köhler, C., Chan-Palay, V. and Wu, J. Y. (1984) Septal neurons containing glutamic acid decarboxylase immunoreactivity project to the hippocampal region in the rat brain. Anatomy and Embryology 169, 41-44.
251. Kokaia, M., Bengzon, J., Kalén, P. and Lindvall, O. (1989) Noradrenergic mechanisms in hippocampal kindling with rapidly recurring seizures. Brain Research 491, 398-402.
252. Kokaia, M., Aebischer, P., Elmér, E., Bengzon, J., Kalén, Z., Kokaia, Z. and Lindvall, O. (1994a) Seizure suppression in kindling epilepsy by intracerebral implants of GABA- but not noradrenaline-releasing polymer matrices. Experimental Brain Research 100, 385-394.
253. Kokaia, M., Cenci, M. A., Elmer, E., Nilsson, O. G., Kokaia, Z., Björklund, A. and Lindvall, O. (1994b) Seizure development and noradrenaline release in kindling epilepsy after noradrenergic reinnervation of the subcortically deafferented hippocampus by superior cervical ganglion or fetal locus coeruleus grafts. Experimental Neurology 130, 351-361.
254. Kolasa, K., Harrell, L. E. and Parsons, D. S. (1995) The effect of hippocampal sympathetic ingrowth and cholinergic denervation on hippocampal M-2 cholinergic receptors. Brain Research 684, 201-205,
255. Kolb, B. and Nonneman, A. J. (1974) Frontolimbic lesions and social behaviour in the rat. Physiology and Behaviour 13, 637-643.
256. Kolb, B. and Sutherland, R. J. (1992) Noradrenaline depletion blocks behavioral sparing and alters cortical morphogenesis after neonatal frontal cortex damage in rats. The Journal of Neuroscience 12, 2321-2330.
257. Kordower, J. H., Liu, Y. T., Winn, S. and Emerich, D. F. (1995) Encapsulated PC12 cell transplants into hemiparkinsonian monkeys: A behavioral, neuroanatomical, and neurochemical analysis. Cell Transplantation 4, 155-172.
258. Kromer, L. F. (1982) Cholinergic axons from delayed septal implants and sympathetic fibers co-exist in the denervated dentate gyrus. Brain Research Bulletin 9, 539-544.
259. Kromer, L. F., Björklund, A. and Stenevi, U. (1981a) Regeneration of the septohippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridges. Brain Research 210, 153-172.
260. Kromer, L. F., Björklund, A. and Stenevi, U. (1981b) Regeneration of the septohippocampal implants as bridges. Brain Research 210, 173-200.
261. Lahtinen, H., Miettinen, R., Ylinen, A., Halonen, T. and Riekkinen, P. J. Sr. (1993) Biochemical and morphological changes in the rat hippocampus following transection of the fimbria-fornix. Brain Research Bulletin 31, 311-318.
262. Landau, W. M. (1990) Artificial intelligence: The brain transplant cure for parkinsonism. Neurology 40, 733-74
263. Langlais, P. J., Connor, D. J. and Thai, L. (1993) Comparison of the effects of single and combined neurotoxic lesions of the nucleus basalis magnocellularis and dorsal noradrenergic bundle on learning and memory in the rat. Behavioural Brain Research 54, 81-90.
264. Lapchak, P. A., Araujo, D. M. and Hefti, F. (1993) Regulation of hippocampal muscarinic receptor function by chronic nerve growth factor treatment in adult rats with fimbrial transections. Neuroscience 53, 379-394.
265. Lapchak, P. A., Jenden, D. J. and Hefti, F. (1991) Compensatory elevation of acetylcholine synthesis in vivo by cholinergic neurons surviving partial lesions of the septohippocampal pathways. Journal of Neuroscience 28, 375-386.
266. Leanza, G., Nilsson, O. G. and Björklund, A. (1993a) Compensatory changes of in vivo acetylcholine and noradrenaline release in the hippocampus after partial deafferentation, as monitored by microdialysis. Brain Research 615, 147-159.
267. Leanza, G., Nilsson, O. G. and Björklund, A. (1993b) Funtional activity of intrahippocampal septal grafts is regulated by catecholaminergic host afferent as studied by microdialysis of acetylcholine. Brain Research 618, 47-56.
268. Leanza, G., Nilsson, O. G., Nikkah, G., Wiley, R. G. and Björklund, A. (1996) Effects of neonatal lesions of the basal forebrain cholinergic system by 192-Immunoglobulin-G-Saporin-Biochemical, behavioral and morphological characterization. Neuroscience 74, 119-141.
269. Leanza, G., Nilsson, O. G., Wiley, R. G. and Björklund, A. (1995) Selective lesioning of the basal forebrain cholinergic system by intraventricular 192-IgG-saporin-Behavioral, biochemical and stereological studies in the rat. European Journal of Neuroscience 7, 329-343.
270. Levey, A. I., Edmunds, S. M., Koliatsos, V., Wiley, R. G. and Heilman, C. J. (1995) Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation. Journal of Neuroscience 15 Pt 2, 4077-4092.
271. Levey, A. I., Wainer, B. H., Mufson, E. J. and Mesulam, M. M. (1983) Co-localization of acetylcholinesterase and choline acetyltransferase in the rat cerebrum. Neuroscience 9, 9-22.
272. Levin, E. D., Decker, M. W. and Butcher, L. L. (1992) Neurotransmitter Interactions and Cognitive Function. Birkhäuser, Boston, 362 pp.
273. Lewis, E. R. and Cotman, C. W. (1983) Neurotransmitter characteristics of brain grafts: Striatal and septal tissues form the same laminated input to the hippocampus. Neuroscience 8, 57-66.
274. Lewis, P. R., Shute, C. C. D. and Silver, A. (1967) Confirmation from choline acetylase analyses of a massive cholinergic innervation to the rat hippocampus. Journal of Physiology 191, 215-224.
275. Li, Y. J., Simon, J. R. and Low, W. C. (1992) Intrahippocampal grafts of cholinergic-rich striatal tissue ameliorate spatial memory deficits in rats with fimbria-fornix lesions. Brain Research Bulletin 29, 147-155.
276. Lindvall, O. (1989) Transplantation into the human brain: Present status and future possibilities. J. Neurol. Neurosurg. Psychiat., Special Suppl., 39-54.
277. Lindvall, O. (1994a) Neural transplants in Parkinson's disease. In Functional Neural Transplantation, ed S. B. Dunnett and A. Björklund, pp. 103-137. Raven Press, New York.
278. Lindvall, O. (1994b) Clinical application of neuronal grafts in Parkinson's disease. Journal of Neurology 242, S54-S56.
279. Lindvall, O. and Björklund, A. (1974) The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta Physiologica Scandinavica Supplementum 412, 1-48.
280. Lindvall, O., Brundin, P., Widner, H., Rehncrona, S., Gustavii, B., Frackowiak, R., Leenders, K. L., Sawle, G., Rothwell, J. C., Marsden, C. D. and Björklund, A. (1990) Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 247, 574-577.
281. Lopez-Sanudo, S. and Arilla, E. (1992) Desmethylimipramine pretreatment prevents 6-hydroxydopamine induced somatostatin receptor reduction in the rat hippocampus. Regulatory Peptides 41, 227-236.
282. Lorente de No, R. (1934) Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system. Journal für Psychologie und Neurologie 46, 113-177.
283. Low, W. C., Lewis, P. R., Bunch, S. T., Dunnett, S. B., Thomas, S. R., Iversen, S. D., Björklund, A. and Stenevi, U. (1982) Function recovery following neural transplantation of embryonic septal nuclei in adult rats septohippocampal lesions. Nature 300, 260-262.
284. Loy, R., Milner, T. A. and Moore, R. Y. (1980) Sprouting of sympathetic axons in the hippocampal formation: Conditions necessary to elicit ingrowth. Experimental Neurology 67, 399-411.
285. Lucidi-Philippi, C. A., Gage, F. H., Shults, C. W., Jones, K. R., Reichardt, L. F. and Kang, U. J. (1995) Brain-derived neurotrophic factor-transduced fibroblasts: Production of BDNF and effects of grafting to the adult rat brain. Journal of Comparative Neurology 354, 361-376.
286. Maccari, S., Le Moal, M., Angelucci, L. and Mormede, P. (1990) Influence of 6-OHDA lesion of central noradrenergic systems on corticosteroid receptors and neuroendocrine responses to stress. Brain Research 533, 60-65.
287. Maccari, S., Mormede, P., Piazza, P. V., Simon, H., Angelucci, L. and Le Moal, M. (1992) Hippocampal type I and type II corticosteroid receptors are modulated by central noradrenergic Systems. Psychoneuroendocrinology 17, 103-112.
288. MacDonald E. and Sirviö J. (1993) Neurotoxins as tools in lesioning experiments. In Natural and Synthetic Neurotoxins, ed. A. Harvey, pp. 1-46. Academic Press, London.
289. Madison, R. and Davis, J. N. (1983) Sprouting of noradrenergic fibers in the hippocampus after medial septal lesions: Contributions of the central and peripheral nervous systems. Experimental Neurology 80, 167-177.
290. Mann, D. M. A. and Yates, P. O. (1986) Neurotransmitter deficits in Alzheimer's disease and in other dementing disorders. Human Neurobiology 5, 147-158.
291. Marshall, J. F. (1984) Brain function: Neural adaptations and recovery from injury. Annual Reviews in Psychology 35, 277-308.
292. Marshall, J. F. (1985) Neural plasticity and recovery of function after brain injury. International Reviews in Neurobiology 26, 201-247.
293. Mason, J. W. (1958) The central nervous system regulation of ACTH secretion. In Reticular Formation of the Brain, ed. H. H. Jasper, L. D. Proctor, R. S. Knighton, W. C. Noshay and R. T. Costello, pp. 645-662. Little Brown, Boston.
294. Mason, S. T. and Iversen, S. D. (1975) Learning in the absence of forebrain noradrenaline. Nature 258, 422-424.
295. Mason, S. T. and Iversen, S. D. (1977) Effects of selective forebrain noradrenaline loss on behavioral inhibition in the rat. Journal of Comparative and Physiological Psychology 91, 165-173.
296. Matsuoka, N., Maeda, N., Ohkubo, Y. and Yamaguchi, I. (1991) Differential effects of physostigmine and pilocarpine on the spatial memory deficits produced by two septo-hippocampal deafferentations in rats. Brain Research 559, 233-240.
297. Matsuoka, N., Maeda, N., Yamazaki, M., Ohkubo, Y. and Yamaguchi, I. (1992) Effect of FR121196, a novel cognitive enhancer, on the memory impairment of rats in passive avoidance and radial arm maze tasks. Journal of Pharmacology and Experimental Therapeutics 263, 436-444.
298. McEwen, B. S. and Parsons, B. (1982) Gonadal steroid action on the brain: Neurochemistry and Neuropharmacology. Annual Reviews of Pharmacology and Toxicology 22, 555-598.
299. McIntyre, D. C. and Edson, N. (1982) Effect of norepinephrine depletion on dorsal hippocampus kindling in rats. Experimental Neurology 77, 700-704.
300. Mennini, T. and Miari, A. (1991) Modulation of tritiated glutamate binding by serotonin in the rat hippocampus: an autoradiographic study. Life Sciences 49, 283-292.
301. Messersmith, D. J., Fabrazzo, M., Mocchetti, I. and Kromer, L. F. (1991) Effects of sciatic nerve transplants after fimbria-fornix lesion: Examination of the role of nerve growth factor. Brain Research 557, 293-297.
302. Mesulam, M. M. and Geula, C. (1992) Overlap between acerylcholinesterase-rich and choline acetyltransferase positive (cholinergic) axons in human cerebral cortex. Brain Research 577, 112-120.
303. Mesulam, M. M., Mufson, E. J., Wainer, B. H. and Levey, A. I. (1983) Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience 10, 1185-1201.
304. Milner, T. A. and Amaral, D. G. (1984) Evidence for a ventral septal projection to the hippocampal formation of the rat. Experimental Brain Research 55, 579-585.
305. Milner, T. A. and Loy, R. (1980) A delayed sprouting response to partial hippocampal deafferentiation: Time course of sympathetic ingrowth following fimbrial lesions. Brain Research 197, 391-399.
306. 1A receptor mRNA in rat brain. Molecular Brain Research 14, 357-362.
307. Mohammed, A. K., Jonsson, G. and Archer, T. (1986) Selective lesioning of forebrain noradrenaline neurons at birth abolishes the improved maze learning performance induced by rearing in complex environment. Brain Research 398, 6-10.
308. Montero-Menei, C. N., Pouplard-Barthelaix, A., Gumpel, M. and Baron-Van Evercooren, A. (1992) Pure Schwann cell suspension grafts promote regeneration of the lesioned septo-hippocampal cholinergic pathway. Brain Research 570, 198-208.
309. Moran, P. M., LeMaitre, M. H., Philouze, V., Reymann, J. M., Allain, H. and Leonard, B. E. (1992) Reversal of learning and memory impairments following lesion of the nucleus basalis magnocellularis (NBM) by concurrent noradrenergic depletion using DSP4 in the rat. Brain Research 595, 327-333.
310. Morris, R. G. M. (1983) An attempt to dissociate "spatial mapping" and "working memory" theories of hippocampal functions. In Neurobiology of the Hippocampus, ed. W. Seifert, pp. 405-432. Academic Press, London.
311. Morrow, A. L., Loy, R. and Creese, I. (1983) Septal deafferentation increases hippocampal adrenergic receptors: correlation with sympathetic axon sprouting. Proceedings of the National Academy of Sciences USA 80, 6718-6722.
312. Morrow, A. L., Norman, A. B., Battaglia, G., Loy, R. and Creese, I. (1985) Up-regulation of serotonergic binding sites by [3H]WB4101 following fimbrial transection and 5,7-dihydroxytryptamine-induced lesions. Life Sciences 37, 1913-1922.
313. Morse, J. K., Wiegand, S. J., Anderson, K., You, Y., Cai, N., Carnahan, J., Miller, J., DiStefano, P. S., Altar, C. A., Lindsay, R. M. and Anderson, R. F. (1993) Brain derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection. Journal of Neuroscience 13, 4146-4156.
314. Nakadate, G. M. and de Groot, J. (1963) Fornix transection and adrenocortical function in rats. Anat. Rec. 145, 338
315. Nelson, D. L., Herbert, A., Bourgoin, S., Glowinski, J. and Hamon, M. (1978) Characteristics of central 5-HT receptors and their adaptative changes following intracerebral 5,7-Dihydroxytriptamine administration in the rat. Molecular Pharmacology 14, 983-995.
316. Neuberger, T. J., Cornbrooks, C. J. and Kromer, L. F. (1992) Effects of delayed transplantation of cultured Schwann cells on axonal regeneration from central nervous system cholinergic neurons. The Journal of Comparative Neurology 315, 16-33.
317. Neuwelt, E. A., Pagel, M. A., Geller, A. and Muldoon, L. L. (1995) Gene replacement therapy in the central nervous system: Viral vector-mediated therapy of global neurodegenerative disease. Behavioral and Brain Sciences 18, 1-9.
318. Nilsson, O. G. and Björklund, A. (1992) Behaviour-dependent changes in acetylcholine release in normal and graft-reinnervated hippocampus: Evidence for host regulation of grafted cholinergic neurons. Neuroscience 49, 33-44.
319. Nilsson, O. G., Brundin, P. and Björklund, A. (1990a) Amelioration of spatial memory impairment by intrahippocampal grafts of mixed septal and raphe tissue in rats with combined cholinergic and serotonergic denervation of the forebrain. Brain Research 515, 193-206.
320. Nilsson, O. G., Clarke, D. J., Brundin, P. and Björklund, A. (1988a) Comparison of growth and reinnervation properties of cholinergic neurons from different brain regions grafted to the hippocampus. Journal of Comparative Neurology 268, 204-222.
321. Nilsson, O. G., Kalén, P., Rosengren, E. and Björklund, A. (1990b) Acetylcholine release from intrahippocampal septal grafts is under the control of the host brain. Proceedings of the National Academy of Sciences USA 87, 2647-2651.
322. Nilsson, O. G., Leanza, G. and Björklund, A. (1992a) Acetylcholine release in the hippocampus: Regulation by monoaminergic afferent as assessed by in vivo microdialysis. Brain Research 584, 132-140.
323. Nilsson, O. G., Leanza, G., Rosenblad, C., Lippa, D. A., Wiley, R. G. and Björklund, A. (1992b) Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system. Neuroreport 3, 1005-1008.
324. Nilsson, O. G., Shapiro, M. L., Gage, F. H., Olton, D. S. and Björklund, A. (1987) Spatial learning and memory following fimbria-fornix transection and grafting of fetal septal neurons to the hippocampus. Experimental Brain Research 67, 195-215.
325. Nilsson, O. G., Strecker, R. E., Daszuta, A. and Björklund, A. (1988b) Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat. Brain Research 453, 235-246.
326. Nordberg, A., Larsson, C., Adolfsson, R., Alafuzoff, I. and Winblad, B. (1983) Muscarinic receptor compensation in hippocampus of Alzheimer patients. Journal of Neural Transmission 56, 13-19.
327. Novotney, S. and Lowy, M. T. (1995) Short-term and long-term effects of p-chloroamphetamine on hippocampal serotonin and corticosteroid receptor levels. Brain Research 684, 19-25.
328. Ogawa, T., Mikuni, M., Kuroda, Y., Muneoka, K., Mori, K. J. and Takahashi, K. (1994) Effects of the altered serotonergic signalling by neonatal treatment with 5,7-dihydroxytryptamine, ritanserin or clomipramine on the adrenocortical stress response and the glucocorticoid receptor binding in the hippocampus in adult rats. Journal of Neural Transmission General Section 96, 113-123.
329. Ohno, M., Yamamoto, T., Kobayashi, M. and Watanabe, S. (1993) Impairment of working memory induced by scopolamine in rats with noradrenergic DSP-4 lesions. European Journal of Pharmacology 238, 117-120.
330. Ohta, H., Ni, X. H., Matsumoto, K. and Watanabe, H. (1991) Working memory deficit in aged rats in delayed nonmatching to position task and effect of physostigmine on performance of youn and aged rats. Japanese Journal of Pharmacology 56, 303-309.
331. O'Keefe, J. and Nadel, L. (1978) The Hippocampus as a Cognitive Map. Oxford University Press, Oxford, 570 pp.
332. O'Keefe, J., Nadel, L., Keightly, S. and Kill, D. (1975) Fornix lesions selectively abolish place learning in the rat. Experimental Neurology 48, 152-166.
333. Oleskevich, S., Descarries, L., Watkins, K. C., Séguéla, P. and Daszuta, A, (1991) Ultrastructural features of the serotonin innervation in adult rat hippocampus: An immunocytochemical description in single and serial thin sections. Neuroscience 42, 777-791.
334. Olton, D. S., Becker, J. T. and Handelmann, G. E. (1979) Hippocampus, space and memory. Behavioral Brain Sciences 2, 313-365.
335. Olton, D. S., Walker, J. A. and Gage, F. H. (1978) Hippocampal connections and spatial discrimination. Brain Research 139, 295-308.
336. Olton, D. S. and Wenk, G. L. (1987) Dementia: Animals models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system. In Psychopharmacology. The Third Generation of Progress, ed. H. Y. Meltzer, pp. 941-953. Raven Press, New York.
337. Osborne, B. and Dodek, A. B. (1986) Disrupted patterns of consummatory behavior in rats with fornix transections. Behavioral and Neural Biology 45, 212-222.
338. Pallage, V. (1990) Effects of nerve growth factor on functional recovery in rats receiving grafts after septal lesions: A preliminary report. Medical Science Research 18, 511-513.
339. Pallage, V., Toniolo, G., Will, B. E. and Hefti, F. (1986) Long-term effects of nerve growth factor and neural transplants on behavior of rats with medial septal lesions. Brain Research 386, 197-208.
340. Pappas, B. A., Saari, M., Smythe, J., Murtha, S., Stange, K. and Ings, R. (1987) Forebrain norepinephrine and neurobehavioral plasticity: Neonatal 6-hydroxydopamine eliminates enriched-impoverished experience effects on maze performance. Pharmacology Biochemistry and Behavior 27, 153-158.
341. 1A receptor immunoreactivity in the rat hippocampus following 5,7-dihydroxytryptamine lesions in the cingulum bundle and fimbria-fornix. Behavioural Brain Research 73, 319-323.
342. Perry, E. K., Gibson, P. H., Blessed, G., Perry, R. H. and Tomlinson, B. O. (1977a) Neurotransmitter enzyme abnormalities in senile dementia. Journal of Neurological Sciences 34, 247-265.
343. Perry, E. K., Perry, R. H., Blessed, G. and Tomlinson, B. O. (1977b) Necropsy evidence of cerebral cholinergic deficits in senile dementia. Lancet 1, 189.
344. Peterson, G. M. (1989) A quantitative analysis of the crossed septohippocampa) projection in the rat brain. Anatomy and Embryology 180, 421-425.
345. Peterson, G. M. (1994) Differential projections to the hippocampus by neurons of the medial septum and vertical limb of the diagonal band. Brain Research 646, 129-134.
346. Pisa, M. and Fibiger, H. C. (1983a) Intact selective attention in rats with lesions of the dorsal noradrenergic bundle. Behavioral Neuroscience 97, 519-529.
347. Pisa, M. and Fibiger, H. C. (1983b) Evidence against a role of the rat's dorsal noradrenergic bundle in selective attention and place memory. Brain Research 272, 319-329.
348. Porsolt, R. D., Roux, S. and Wettstein, J. G. (1995) Animals models of dementia. Drug Development Research 33, 214-229.
349. Potter, P. E., Harsing, L. G. Jr, Kakucska, L., Gaál, G. and Vizi, E. S. (1986) Selective impairment of acetylcholine release and content in the central nervous system following intracerebroventricular administration of ethylcholine mustard aziridinium ion (AF64A) in the rat. Neurochemistry International 8, 199-206.
350. Potter, P. E. and Nitta, S. (1993) Alterations in modulation of acetylcholine release following lesion of hippocampal cholinergic neurons with the neurotoxin AF64A. Neuropharmacology 32, 519-526.
351. 1A sites and 5-HT transporter sites. Neurochemical Research 19, 311-315.
352. Pranzatelli, M. R., Durkin, M. M. and Barkai, A. I. (1994) Quantitative autoradiography of 5-hydroxytryptamine-1A binding sites in rats with chronic neonatal 5,7-dihydroxytryptamine lesions. Developmental Brain Research 80, 1-6.
353. Probst, A., Cortes, R., Ulrich, J. and Palacios, J. M. (1988) Differential modification of muscarinic cholinergic receptors in the hippocampus of patients with Alzheimer's disease: An autoradiographic study. Brain Research 450, 190-201.
354. 1A receptors in rat midbrain. European Journal of Pharmacology 90, 377-384.
355. Quinn, N. P. (1990) The clinical application of cell grafting techniques in patients with Parkinson's disease. In Neural Transplantation: from Molecular Basis to Clinical Application, ed. S. B. Dunnett and S. J. Richards, pp. 619-625. Progress in Brain Research 82, Elsevier, Amsterdam.
356. Quirion, R. and Richard, J. (1987) Differential effects of selective lesions of cholinergic and dopaminergic neurons on serotonin-type 1 receptors in the rat brain. Synapse 1, 124-130.
357. Reader, T. A. (1989) Neurotoxins that affect central indolamine neurons. In Drugs as Tools in Neurotransmitter Research, ed. A. A. Boulton, G. B. Baker and A. V. Juorio, pp. 49-102. Humana Press, Clifton.
358. Ricaurte, G. A., Delanney, L. E., Irwin, I. and Langston, J. W. (1988) Toxic effects of MDMA on central serotonergic neurons in the primate: Importance of route and frequency of drug administration. Brain Research 446, 165-168.
359. Richter-Levin, G., Greenberger, V. and Segal, M. (1993) Regional specificity of raphe graft-induced recovery of behavioral functions impaired by combined serotonergic/cholinergic lesions. Experimental Neurology 121, 256-260.
360. Richter-Levin, G., Greenberger, V. and Segal, M. (1994) The effects of general and restricted serotonergic lesions on hippocampal electrophysiology and behavior. Brain Research 642, 111-116.
361. Richter-Levin, G. and Segal, M. (1989) Spatial performance is severely impaired in rats with combined reduction of serotonergic and cholinergic transmission. Brain Research 477, 404-407.
362. Richter-Levin, G. and Segal, M. (1991) The effects of serotonin depletion and raphe grafts on hippocampal electrophysiology and behavior. Journal of Neuroscience 11, 1585-1596.
363. Ridley, R. M. (1995) Thinking about repairing thinking. Behavioral Brain Sciences 18, 67.
364. Riekkinen, P. Jr, Aaltonen, M., Sirviö, J. and Riekkinen, P. (1991a) Tetrahydroaminoacridine alleviates medial septal lesion-induced and age-related spatial reference but not working memory deficits. Physiology and Behavior 49, 1147-1152.
365. Riekkinen, P. Jr, Riekkinen, M., Lahtinen, H., Sirviö, J., Valjakka, A. and Riekkinen, P. (1991b) Tetrahydroaminoacridine improves passive avoidance retention defects induced by aging and medial septal lesion but not by fimbria-fornix lesion. Brain Research Bulletin 27, 587-594.
366. Riekkinen, P., Sirviö, J., Ekonsalo, T. and Riekkinen, P. (1992) Effects of noradrenergic DSP4 lesion on the effectiveness of pilocarpine in reversing scopolamine-induced amnesia. Brain Research Bulletin 28, 919-922.
367. Riekkinen, P., Sirviö, J., Jäkälä, P., Lammintausta, R. and Riekkinen, P. (1990) Interaction between the alpha2-noradrenergic and muscarinic systems in the regulation of neocortical high voltage spindles. Brain Research Bulletin 25, 31-36.
368. Rocha, B., Di Scala, G., Rigo, M., Hoyer, D. and Sandner, G. (1993) Effect of 5,7-dihydroxytryptamine lesion on mianserin-induced conditioned place aversion and on 5-hydroxytryptamine-1C receptors in the rat brain. Neuroscience 56, 687-693.
369. Room, P., Postema, F. and Korf, J. (1981) Divergent axon collaterals or rat locus coeruleus. demonstration by a fluorescent double labeling technique. Brain Research 221, 219-230.
370. Rosenberg, M. B., Fridmann, T., Robertson, R. C., Tuszynski, M., Wolff, J. A., Breakfield, X. O. and Gage, F. H. (1988) Grafting genetically modified cells to the damaged brain: Restorative effects of NGF expression. Science 242, 1575-1578.
371. Rosenzweig, M. R., Bennett, E. L. and Diamond, M. C. (1972) Brain changes in response to experience. Scientific American 226, 22-29.
372. Rossner, S., Schliebs, R., Hartig, W. and Bigl, V. (1995) 192-IgG-saporin-induced selective lesion of cholinergic basal forebrain system-Neurochemical effects on cholinergic neurotransmission in rat cerebral cortex and hippocampus. Brain Research Bulletin 38, 371-381.
373. Rossner, S., Yu, J., Pizzo, D., Werrbach-Perez, K., Schliebs, R., Bigl, V. and Perez-Polo, J. R. (1996) Effects of intraventricular transplantation of NGF-secreting cells on cholinergic basal forebrain neurons after partial immunolesions. Journal of Neuroscience Research 45, 40-56.
374. Saltykow, S. (1905) Versuche über Gehirnplantation zugleich ein Beitrag zur Kenntniss der Vorgänge an den zellingen Gehirnelementen. Archives für Psychiatrische NervenKrankheiten 40, 329-388.
375. Santucci, A. C., Moody, E. and Demetriades, J. (1995) Effects of scopolamine on spatial working memory in rats pretreated with the serotonergic depleter ρ-chloroamphetamine. Neurology of Learning and Memory 63, 286-290.
376. Sara, S. J., Dyon-Laurent, C., Guibert, B. and Leviel, V. (1992) Noadrenergic hyperactivity after partial fornix section: Role in cholinergic dependent memory performance. Experimental Brain Research 89, 125-132.
377. Schinstine, M., Fiore, D. M., Winn, S. R. and Emerich, D. F. (1995) Polymer-encapsulated schwannoma cells expressing human nerve growth factor promote the survival of cholinergic neurons after a fimbria-fornix transection. Cell Transplantation 4, 93-102.
378. Schmidt, C. J. and Kehne, J. H. (1990) Neurotoxicity of MDMA: Neurochemical effects. In The neuropharmacology of serotonin. Annals of the New York Academy of Sciences 600, 665-681.
379. Scoville, W. B. and Milner, B. (1957) Loss of recent memory after bilateral hippocampal lesion. J. Neurol. Neurosurg. Psychiat. 20, 11-21.
380. Segal, M. (1987) Interactions between serotonin neurons and adult host rat hippocampus. Annals New York Academy of Sciences 495, 284-295.
381. Segal, M., Azmitia, E. C., Björklund, A., Greenberger, V. and Richter-Levin, G. (1988) Physiology of graft-host interactions in the rat hippocampus. Progress in Brain Research 78, 95-102.
382. Segal, M., Greenberger, V. and Pearl, E. (1989) Septal transplants ameliorate spatial deficits and restore cholinergic functions in rats with a damaged septo-hippocampal connection. Brain Research 500, 139-148.
383. Segal, M., Stenevi, U. and Björklund, A. (1981) Reformation in adult rats of functional septo-hippocampal connections by septal neurons regenerating across an embryonic hippocampal tissue bridge. Neuroscience Letters 27, 7-12.
384. Selden, N. R. W., Cole, B. J., Everitt, B. J. and Robbins, T. W. (1990) Damage to ceruleo-cortical noradrenergic projections impairs locally cued but enhanced spatially cued water maze acquisition. Behavioural Brain Research 39, 29-51.
385. Semenova, T. P., Gromova, E. A., Grischenko, N. I., Nesterova, I. V., Kulikov, A. V., Smirnova, G. N., Tretiak, T. M., Bragin, A. G. and Vinogradova, O. S. (1987) Behavioural, biochemical and histochemical effects of locus coeruleus transplantation in rats with neurotoxic lesions of the catecholaminergic system. Neuroscience 22, 993-1002.
386. Shapiro, M. L., Simon, D. K., Olton, D. S., Gage, F. H. III, Nilsson, O. and Björklund, A. (1989) Intrahippocampal grafts of fetal basal forebrain tissue alter place fields in the hippocampus of rats with fimbria-fornix lesions. Neuroscience 32, 1-18.
387. Sharp, T. and Foster, G. A. (1989) In vivo measurement using microdialysis of the release and metabolism of 5-hydroxytryptamine in raphe neurones grafted to the rat hippocampus. Journal of Neurochemistry 53, 303-306.
388. 1A autoreceptors. Neuroscience Letters 132, 179-182.
389. 1 receptors and offensive aggression in rats: A combined behavioural and autoradiographic study with eltoprazine. Pharmacology Biochemistry and Behavior 38, 447-458.
390. Sinden, J. D., Hodges, H. and Gray, J. A. (1995) Neural transplantation and recovery of cognitive function. Behavioral and Brain Sciences 18, 10-35.
391. Sinhababu, A. K. and Borchardt, R. T. (1985) Mechanism and products of autooxydation of 5,7-dihydroxytryptamine. Journal of the American Chemistry Society 107, 7618-7627.
392. Sirviö, J., Harju, M., Riekkinen, P. Jr, Haapalinna, A. and Riekkinen, P. J. (1992) Comparative effects of alpha-2 receptors agents and THA on the performance of adult and aged rats in the delayed non-matching to position task. Psychopharmacology 109, 127-133.
393. Sirviö, J., Riekkinen, P. Jr., Jäkälä, P. and Riekkinen, P. J. (1994) Experimental studies on the role of serotonin in cognition. Progress in Neurobiology 43, 363-379.
394. Sladek, J. R. Jr. and Gash, D. M. (1984) Neural Transplants. Development and Function. Plenum Press, New York, pp. 454.
395. Soulairac, A. and Soulairac, M. L. (1978) Interrelations between the hippocampus, amygdaloid complex and posterior hypothalamus in sexual and emotional behaviour (psychophysiological and clinical data). In Clinical Psychoneuroendocrinology in Reproduction, Sereno Symposia 22, pp. 109-126. Academic Press, New York.
396. Springer, J. E., Collier, T. J., Notter, M. F. D., Loy, R. and Sladek, J. R. Jr. (1988) Central nervous system grafts of nerve growth factor-rich tissue as an alternative source of trophic support for axotomized cholinergic neurons. Progress in Brain Research 78, 401-407.
397. Squire, L. R. (1992) Memory and the hippocampus: A synthesis of findings with rats, monkeys, and humans. Psychological Reviews 99, 195-231.
398. Stamp, J. A. and Semba, K. (1995) Extent of colocalizationof serotonin and GABA in the neurons of the rat raphe nuclei. Brain Research 677, 39-49.
399. Starke, K., Göthert, M. and Kilbinger, H. (1989) Modulation of neurotransmitter release by presynaptic autoreceptors. Physiological Reviews 69, 864-988.
400. Steckler, T., Keith, A. B., Wiley, R. G. and Sahgal, A. (1995) Cholinergic lesions by 192-IgG-Saporin and short-term recognition memory-Role of the septohippocampal projection. Neuroscience 66, 101-114.
401. Steckler, T. and Sahgal, A. (1995) The role of serotonergic-cholinergic interactions in the mediation of cognitive behaviour. Behavioural Brain Research 67, 165-199.
402. Stein, D. G., Brailowsky, S. and Will, B. E. (1995) Brain Repair. Oxford University Press, New York, 156 pp.
403. Steinbusch, H. W. M. (1981) Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 4, 557-618.
404. Steinbusch, H. W. M., Beek, A., Frankhuyzen, A. L., Tonnaer, J. A. D. M., Gage, F. H. and Björklund, A. (1987) Functional activity of raphe neurons transplanted to the hippocampus and caudate-putamen. Annals of the New York Academy of Sciences 495, 169-184.
405. Stenevi, U., Kromer, L. F., Gage, F. H. and Björklund, A. (1985) Solid neural grafts in intracerebral transplantation cavities. In Neural Grafting in the Mammalian CNS, ed. A. Björklund and U. Stenevi, pp. 41-49. Elsevier, Amsterdam.
406. Steward, O. (1989) Reorganization of neuronal connections following CNS trauma: Principles and experimental paradigms. Journal of Neurotrauma 6, 99-150.
407. Storm-Mathisen, J. and Guldberg, H. C. (1974) 5-hydroxytryptamine and noradrenaline in the hippocampal region: Effect of transection of afferent pathways on endogenous levels, high affinity uptake and some transmitter-related enzymes. Journal of Neurochemistry 22, 793-803.
408. Sutherland, R. J., Kolb, B., Whishaw, I. Q. and Becker, J. B. (1982) Cortical noradrenaline depletion eliminates sparing of spatial learning after neonatal frontal cortex damage in the rat. Neuroscience Letters 32, 125-130.
409. Sutherland, R. J. and Rudy, J. W. (1989) Configural association theory: The role of the hippocampal formation in learning, memory, and amnesia. Psychobiology 17, 129-144.
410. Tabatabaie, T., Goyal, R. N., LeRoy Blank, C. and Dryhurst, G. (1993) Further insights into the molecular mechanisms of action of the serotonergic neurotoxin 5,7-Dihydrotryptamine. Journal of Medicinal Chemistry 36, 229-236.
411. Tarricone, B. J., Keim, S. R., Simon, J. R. and Low, W. C. (1991) Intrahippocampal transplants of septal cholinergic neurons: High-affinity choline uptake and spatial memory functions. Brain Research 548, 55-62.
412. Tarricone, B. J., Simon, J. R., Li, Y. J. and Low, W. C. (1996) Neural grafting of cholinergic neurons in the hippocampal formation. Behavioural Brain Research 74, 25-44.
413. Tarricone, B. J., Simon, J. R. and Low, W. C. (1993) Intrahippocampal transplants of septal cholinergic neurons: Choline acetyltransferase activity, muscarinic receptor binding, and spatial memory function. Brain Research 632, 41-47.
414. Thompson, W. G. (1890) Successful brain grafting. New York Medical Journal 51, 701-702.
415. Thorne, B. and Potter, P. E. (1995) Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function. Brain Research Bulletin 38, 121-127.
416. Trulson, M. E., Hosseini, A. and Trulson, T. J. (1986) Serotonin neuron transplants: electrophysiological unit activity of intrahippocampal raphe grafts in freely moving cats. Brain Research Bulletin 17, 461-468.
417. Tuszynski, M. H., Armstrong, D. M. and Gage, F. H. (1990a) Basal forebrain cell loss following fimbria/fornix transection. Brain Research 508, 241-248.
418. Tuszynski, M. H., Buzsàki, G. and Gage, F. H. (1990b) Nerve growth factor infusions combined with fetal hippocampal grafts enhance reconstruction of the lesioned septohippocampal projection. Neuroscience 36, 33-44.
419. Tuszynski, M. H. and Gage, F. H. (1995) Bridging grafts and transient nerve growth factor infusions promote long-terme central nervous system neuronal rescue and partial functional recovery. Proceedings of the National Academy of Sciences USA 92, 4621-4625.
420. Ungerstedt, U. (1971) Postsynaptic supersensitivity after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine system. Acta Physiologica Scandinavica Supplementum 367, 69-93.
421. Vanderwolf, C. H., Baker, G. B. and Dickson, C. (1990) Serotonergic control of cerebral activity and behavior: models of dementia, pp. 366-383. In The Neuropharmacology of Serotonin. Annals of the New York Academy of Sciences 600. New York.
422. Van Luijtelaar, M. G. P. A., Tonnaer, J. A. D. M., Frankhuijzen, A. L., Dijkstra, H., Hagan, J. J. and Steinbusch, H. W. M. (1991) Morphological, neurochemical, and behavioral studies on serotonergic denervation and graft-induced reinnervation of the rat hippocampus. Neuroscience 42, 365-377.
423. Varon, S. S., Conner, J. M. and Kuang, R.-Z. (1995) Neurotrophic factors: Repair and regeneration in the central nervous system. Restorative Neurology and Neuroscience 8, 85-94.
424. Varon, S., Hagg, T., Vahlsing, H. L. and Manthorpe, M. (1991) Peripheral nerve bridges for central nervous system regeneration. Cells and Materials 1, 83-91.
425. Villani, L., Contestabile, A., Migani, P., Poli, A. and Fonnum, F. (1986) Ultrastructural and neurochemical effects of the presumed cholinergic toxin AF64A in the rat interpeduncular nucleus. Brain Research 379, 223-231.
426. Vinogradova, O. S. (1995) Expression, control, and probable functional significance of the neuronal theta-rhythm. Progress in Neurobiology 45, 523-583.
427. Vogt, B. A., Crino, P. B. and Volicer, L. (1991) Laminar alterations in gamma-aminobutyric acida, muscarinic, and beta-adrenoreceptors and neuron degeneration in cingulate cortex in Alzheimer's disease. Journal of Neurochemistry 57, 282-290.
428. Volpe, B. T., Hendrix, C. S., Park, D. H., Towle, A. C. and Davis, H. P. (1992) Early post-natal administration of 5,7-dihydrotryptamine destroys 5-HT neurons but does not affect spatial memory. Brain Research 589, 262-267.
429. Waite, J. J., Chen, A. D., Wardlow, M. L., Wiley, R. G., Lappi, D. A. and Thai, L. J. (1995) 192 immunoglobulin G-saporin produces graded behavioral and chemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells. Neuroscience 65, 463-476.
430. Waite, J. J., Wardlow, M. L., Chen, A. C., Lappi, D. A., Wiley, R. G. and Thai, L. J. (1994) Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192-IgG-saporin. Neuroscience Letters 169, 154-158.
431. Wall, S. J., Wolfe, B. B. and Kromer, L. F. (1994) Cholinergic deafferentation of dorsal hippocampus by fimbria-fornix lesioning differentially regulates subtypes (m1-m5) of muscarinic receptors. Journal of Neurochemistry 62, 1345-1351.
432. Walsh, T. J., Kelly, R. M., Dougherty, K. D., Stackman, R. W., Wiley, R. G. and Kutscher, C. L. (1995) Behavioral and neurobiological alterations induced by the immunotoxin 192-IgG-saporin: Cholinergic and non-cholinergic effects following icv injection. Brain Research 702, 1-2.
433. Walsh, T. J., Herzog, C. D., Gandhi, C., Stackman, R. W. and Wiley, R. G. (1996) Injection of IgG 192-saporin into the medial septum produces cholinergic hypofunction and dose-dependent working memory deficits. Brain Research 726, 69-79.
434. Walsh, T. J. and Opello, K. D. (1994) The use of AF64A to model Alzheimer's disease. In Toxin-induced Models of Neurological Disorders, ed. M. Woodruff and A. Nonneman, pp. 259-279. Plenum Press, New York.
435. Wang, A.-J., Hu, M.-X., Xie, H., Fan, Y.-Z. and Sun, C.-L. (1994) Improvement of memory function of fornix-fimbria transected rats by transplantation of the superior cervical ganglion into hippocampus. Acta Physiologica Sinica 46, 90-94.
436. Wells, J., Vietje, B. P. and McKeon, R. J. (1991) Cross-species septohippocampal transplants: ultrastructure of Thy-1.2-labeled donor fibers into the dentate gyrus. The Journal of Comparative Neurology 312, 242-250.
437. Wenk, G. L., Hughey, D., Boundy, V., Kim, A., Walker, L. and Olton, D. (1987) Neurotransmitters and memory: Role of cholinergic, serotonergic and noradrenergic systems. Behavioral Neuroscience 101, 325-332.
438. Whitaker-Azmitia, P. M. and Peroutka, S. J. (Eds.) The Neuropharmacology of Serotonin. Annals of the New York Academy of Sciences 600, New York, 718 pp.
439. White, P., Goodhardt, M. J., Keet, J. P., Hiley, C. R., Carrasco, L. H., Williams, I. E. I. and Bowen, D. M. (1977) Neocortical cholinergic neurons in elderly people. Lancet 1, 668-671.
440. Whittemore, S. R., Holets, V. R., Kean, R. W., Levy, D. J. and McKay, R. D. G. (1991) Transplantation of a temperature-sensitive, nerve growth factor-secreting, neuroblastoma cell line into adult rats with fimbria-fornix lesions rescues cholinergic septal neurons. Journal of Neuroscience 28, 156-170.
441. Widner, H. and Brundin, P. (1988) Immunological aspects of grafting in mammalian central nervous system. A review and speculative synthesis. Brain Research Reviews 13, 287-324.
442. Wiley, R. G. (1992) Neural lesioning with ribosome-inactivating proteins: Suicide transport and immunolesioning. Trends in Neuroscience 15, 285-290.
443. Wiley, R. G., Berbos, T. G., Deckwerth, T. L., Johnson, E. M. Jr and Lappi, D. A. (1995) Destruction of the cholinergic basal forebrain using immunotoxin to rat NGF receptor: Modeling the cholinergic degeneration of Alzheimer's disease. Journal of the Neurological Sciences 128, 157-166.
444. Wiley, R. G., Oeltmann, T. N. and Lappi, D. A. (1991) Immunolesioning: Selective destruction of neurons using immunotoxin to rat NGF receptor. Brain Research 562, 149-153.
445. 1A receptor activation increases hippocampal acetylcholine efflux and motor activity in the guinea pig: Agonist efficacy influences functional activity in vivo. Journal of Pharmacology and Experimental Therapeutics 270, 656-664.
446. Will, B.E., Cassel, J.C. and Kelche, C. (1989) Deleterious and "overshoot" effects of intracerebral transplants. In: Neural Grafting and Alzheimer's Disease. Eds. F. Gage, A. Privat and Y. Christen, pp. 189-198. Springer Verlag: Berlin.
447. Will, B. E. and Hefti, F. (1985) Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions. Behavioural Brain Research 17, 17-24.
448. Williams, J. H., Meara, J. R. and Azmitia, E. C. (1990) Effects of 5,7-dihydrotryptamine injections in the fornix-fimbria on locomotor activity in photocell cages and the open field. Behavioural Brain Research 40, 37-44.
449. Williams, L. R., Varon, S., Peterson, G. M., Wiktorin, K., Fisher, W., Björklund, A. and Gage, F. H. (1986) Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection. Proceedings of the National Academy of Sciences USA 83, 9231-9235.
450. Willson, C. A. and Hanin, I. (1995) Effect of nerve growth factor in ethylcholine mustard aziridinium (AF64A)-treated rats: Sensitization of cholinergic enzyme activity in the septohippocampal pathway. Journal of Neurochemistry 65, 856-862.
451. Wolfman, C., Abo, V., Calvo, D., Medina, J., Dajas, F. and Silveira, R. (1994) Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4. Neurochemistry International 25, 395-400.
452. Wright, A. K., Arbuthnott, G. W. and Dunnett, S. B. (1991) Serotonin hyperinnervation after foetal nigra or raphe transplantation in the neostriatum of adult rats. Neuroscience Letters 128, 281-284.
453. Yamazaki, M., Matsuoka, N., Maeda, N., Kuratani, K., Ohkubo, Y. and Yamaguchi, I. (1995) FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze. The Journal of Pharmacology and Experimental Therapeutics 272, 256-263.
454. Yau, J. L. W., Kelly, P. A. T. and Seckl, J. R. (1994) Increased glucocorticoid receptor gene expression in the rat hippocampus following combined serotonergic and medical septal cholinergic lesions. Molecular Brain Research 27, 174-178.
455. Yehuda, S., Carraso, R. L. and Mostofsky, D. I. (1995) Essential fatty acid preparation (SR-3) rehabilitates learning deficits induced by AF64A and 5,7-DHT. NeuroReport 6, 511-515.
456. Zagrodzka, J., Wieczorek, M. and Romaniuk, A. (1994) Social interactions in rats: Behavioral and neurochemical alterations in DSP-4-treated rats. Pharmacology Biochemistry and Behavior 49, 541-548.
457. Zahniser, N. R., Weiner, G. R., Worth, T., Philpott, K., Yasuda, R. P., Jonsson, G. and Dunwiddie, T. V. (1986) DSP4-induced noradrenergic lesions increase β-adrenergic receptors and hippocampal electrophysiological responsiveness. Pharmacology Biochemistry and Behavior 24, 1397-1402.
458. Zhang, X., Zuo, D. M. and Yu, P. H. (1995) Neuroprotection by R(-)-deprenyl and N-2-hexyl-N-methylpropargylamine on DSP-4, a neurotoxin, induced degeneration of noradrenergic neurons in the rat locus coeruleus. Neuroscience Letters 186, 45-48.
459. Zhou, F. C., Auerbach, S. B. and Azmitia, E. C. (1987) Stimulation of serotonergic neuronal maturation after fetal mesencephalic raphe transplantation into the 5,7-DHT lesioned hippocampus of the adult rat. In Cell and Tissue Transplantation into the Adult Brain, ed. E. C. Azmitia and A. Björklund, pp. 138-152. Annals of the New York Academy of Sciences 495, New York.
460. Zhou, F. C., Auerbach, S. B. and Azmitia, E. C. (1988) Transplanted raphe and hippocampal fetal neurons do not displace afferent inputs to the dorsal hippocampus from serotonergic neurons in the median raphe nucleus of the rat. Brain Research 450, 51-59.
461. Zhou, F. C. and Azmitia, E. C. (1984) Induced homotypic collateral sprouting of serotonergic fibers in hippocampus. Brain Research 308, 53-62.
462. Zhou, F. C. and Azmitia, E. C. (1990) Neurotrophic factor for serotonergic neurons prevents degeneration of grafted raphe neurons in the cerebellum. Brain Research 507, 301-308.
463. Zilles, K., Qu, M., Schleicher, A., Schroeter, M., Kraemer, M. and Witte, O. W. (1995) Plasticity and neurotransmitter receptor changes in Alzheimer's disease and experimental cortical infarct. Artzneimittel Forschung/Drug Research 45, 361-366.