Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 19, 1999, Pages 10893-10898

  Smith, D E ^a   Roberts, J ^b   Gage, F H ^c   Tuszynski, M H ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Aging; Alzheimer's disease; Cholinergic systems; Nerve growth factor; Stereology

Indexed keywords

NERVE GROWTH FACTOR; NEUROTROPHIN;

AGED; AGING; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ATROPHY; CELL COUNT; CELL SIZE; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; FEMALE; FIBROBLAST; GENE TARGETING; GENE THERAPY; MALE; NERVE CELL DEGENERATION; NERVE FIBER GROWTH; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHESUS MONKEY; TREATMENT OUTCOME;

AGE FACTORS; AGING; ANIMALS; ATROPHY; BETA-GALACTOSIDASE; BRAIN; CELL COUNT; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC FIBERS; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; MACACA MULATTA; MAGNETIC RESONANCE IMAGING; MALE; NERVE GROWTH FACTORS; NEURODEGENERATIVE DISEASES; NEURONS; PROSENCEPHALON; RECEPTORS, NERVE GROWTH FACTOR;

ANIMALIA; MACACA MULATTA; PRIMATES;

EID: 0032845156     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.19.10893     Document Type: Article

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