Β-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency

Obesity

Volumn 16, Issue 9, 2008, Pages 2053-2067

  Begriche, Karima ^a   Massart, Julie ^a   Abbey Toby, Adjé ^b   Igoudjil, Anissa ^a   Lettéron, Philippe ^a   Fromenty, Bernard ^a  

^a CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^b BEAUJON HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; 3 AMINO 2 METHYLPROPIONIC ACID; 3-AMINOISOBUTYRIC ACID; ALANINE AMINOTRANSFERASE; ANTIOXIDANT; CHOLESTEROL; LACTATE DEHYDROGENASE; LEPTIN; TRIACYLGLYCEROL;

ANIMAL; ARTICLE; BLOOD; BODY COMPOSITION; C3H MOUSE; DRUG EFFECT; ENZYMOLOGY; FAT INTAKE; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; MALE; METABOLISM; MOUSE; MOUSE MUTANT; OBESITY; PATHOLOGY; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ALANINE TRANSAMINASE; AMINOISOBUTYRIC ACIDS; ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; BODY COMPOSITION; CHOLESTEROL; DIETARY FATS; FATTY LIVER; GLUCOSE TOLERANCE TEST; L-LACTATE DEHYDROGENASE; LEPTIN; MALE; MICE; MICE, INBRED C3H; MICE, OBESE; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

MURINAE; MUS;

EID: 50649088582     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.337     Document Type: Article

References (60)

1. Kopelman PG. Obesity as a medical problem. Nature 2000;404:635-643.
2. Begriche K, Igoudjil A, Pessayre D, Fromenty B. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 2006;6:1-38.
3. Padwal RS, Majumdar SR. Drugs treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet 2007;369:71-77.
4. Ronnett GV, Kim EK, Landree LE, Tu Y. Fatty acid metabolism as a target for obesity treatment. Physiol Behav 2005;85:25-35.
5. Viollet B, Foretz M, Guigas B et al. Activation of AMP-activated protein kinase in the liver: anew strategy for the management of metabolic hepatic disorders. J Physiol 2006;574:41-53.
6. Note R, Maisonneuve C, LettéP et al. Mitochondrial and metabolic effects of nucleoside reverse-transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments. Antimicrob Agents Chemother 2003;47:3384-3392.
7. Maisonneuve C, Igoudjil A, Begriche K et al. Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting. Antivir Ther 2004;9:801-810.
8. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-770.
9. Camus MC, Aubert R, Bourgeois F et al. Serum lipoprotein and apolipoprotein profiles of the genetically obese ob/ob mouse. Biochim Biophys Acta 1988;961:53-64.
10. Li Z, Yang S, Lin H et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003;37:343-350.
11. Robin MA, Demeilliers C, Sutton A et al. Alcohol increases TNF-α and decreases NF-κB to activate hepatic apoptosis in genetically obese mice. Hepatology 2005;42:1280-1290.
12. Leclercq IA, Farrell GC, Schriemer R, Robertson GR. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 2002;37:206-213.
13. Attoub S, Levasseur S, Buyse M et al. Physiological role of cholecystokinin B/gastrin receptor in leptin secretion. Endocrinology 1999;140:4406-4410.
14. Bado A, Levasseur S, Attoub S et al. The stomach is a source of leptin. Nature 1998;394:790-793.
15. Igoudjil A, Abbey-Toby A, Begriche K et al. High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice. Antivir Ther 2007;12:389-400.
16. Stansbie D, Brownsey RW, Crettaz M, Denton RM. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. Biochem J 1976;160:413-416.
17. LettéP, Sutton A, Mansouri A, Fromenty B, Pessayre D. Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice. Hepatology 2003;38:133-140.
18. Robin MA, Maratrat M, Loeper J et al. Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes. Gastroenterology 1995;108:1110-1123.
19. Fisch C, Robin MA, Letté Pet al. Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo. Gastroenterology 1996;110:210-220.
20. Honnor RC, Dhillon GS, Londos C. cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behaviour. J Biol Chem 1985;260:15122-15129.
21. Martins-AfféMP, Festuccia WT, Navegantes LC et al. Response to intra- and extracellular lipolytic agents and hormone-sensitive lipase translocation are impaired in adipocytes from rats adapted to a high-protein, carbohydrate-free diet. J Nutr 2004;134:2919-2923.
22. Xiong Y, Miyamoto N, Shibata K et al. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci USA 2004;101:1045-1050.
23. Doh KO, Kim YW, Park SY et al. Interrelation between long-chain fatty acid oxidation and carnitine palmitoyltransferase 1 activity with different isoforms in rat tissues. Life Sci 2005;77:435-443.
24. Watson PM, Commins SP, Beiler RJ, Hatcher HC, Gettys TW. Differential regulation of leptin expression and function in A/J vs. C57BL/6J mice during diet-induced obesity. Am J Physiol Endocrinol Metab 2000;279: E356-E365.
25. Zhang J, Matheny MK, Tümer N, Mitchell MK, Scarpace PJ. Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent. Am J Physiol Regul Integr Comp Physiol 2007;292:R868-R874.
26. Guilmeau S, Buyse M, Bado A. Gastric leptin: a new manager of gastrointestinal function. Curr Opin Pharmacol 2004;4:561-566.
27. Berthoud HR. A new role for leptin as a direct satiety signal from the stomach. Am J Physiol Regul lntegr Comp Physiol 2005;288:R796-R797.
28. Cammisotto PG, Gingras D, Bendayan M. Transcytosis of gastric leptin through the rat duodenal mucosa. Am J Physiol Gastrointest Liver Physiol 2007;293:G773-G779.
29. Huang W, Dedousis N, Bandi A, Lopaschuk GD, O'Doherty RM. Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo. Endocrinology 2006;147:1480-1487.
30. Huang W, Dedousis N, Bhatt BA, O'Doherty RM. Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. J Biol Chem 2004;279: 21895-21700.
31. Ceddia RB, Lopes G, Souza HM et al. Acute effects of leptin on glucose metabolism of in situ rat perfused livers and isolated hepatocytes. Int J Obes Relat Metab Disord 1999;23:1207-1212.
32. Zhao AZ, Shinohara MM, Huang D et al. Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem 2000;275:11348-11354.
33. Cammisotto PG, GéY, Deshaies Y, Bukowiecki LJ. Regulation of leptin secretion from white adipocytes by insulin, glycolytic substrates, and amino acids. Am J Physiol Endocrinol Metab 2005;289:E166-E171.
34. Larsen TS, Nilsson NO, Blix AS. Effects of volatile fatty acids and ketone bodies on lipolysis in isolated adipocytes from Norwegian reindeer (Rangifer tarandus). Acta Physiol Scand 1983;117:451-455.
35. Hong YH, Nishimura Y, Hishikawa D et al. Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology 2005;146:5092-5099.
36. Lee Y, Wang MY, Kakuma T et al. Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem 2001;276:5629-5635.
37. Wang ZW, Pan WT, Lee Y et al. The role of leptin resistance in the lipid abnormalities of aging. FASEB J 2001;15:108-114.
38. Yamagishi SI, Edelstein D, Du XL et al. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 2001;276:25096-25100.
39. Rossetti L, Massillon D, Barzilai N et al. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 1997;272:27758-27763.
40. Toyoshima Y, Gravilova O, Yakar Set al. Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes. Endocrinology 2005;146:4024-4035.
41. Schmieden V, Betz H. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol 1995;48:919-927.
42. Froh M, Thurman RG, Wheeler MD. Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Am J Physiol Gastrointest Liver Physiol 2002;283:G856-G863.
43. Zhong Z, Wheeler M, Li X et al. L-Glycine: a novel anti-inflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care 2003;8:229-240.
44. Van Kuilenburg AB, Meinsma R, Beke E et al. β- Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities. Hum Mol Genet 2004;13:2793-2801.
45. Van Kuilenburg AB, Stroomer AE, Abeling ng, van Gennip AH. A pivotal role for β-aminoisobutyric acid and oxidative stress in dihydropyrimidine dehydrogenase deficiency? Nucleosides Nucleotides Nucleic Acids 2006;25:1103-1106.
46. Malaguarnera L, Madeddu R, Palio E, Arena N, Malaguarnera M. Heme oxygenase-1 levels and oxidative stress-related parameters in nonalcoholic fatty liver disease patients. J Hepatol 2005;42:585-591.
47. Mandato C, Lucariello S, Licenziati MR et al. Metabolic, hormonal, oxidative, and inflammatory factors in pediatric obesity-related liver disease. J Pediatr 2005;147:62-66.
48. Tran TN, Eubanks SK, Schaffer KJ, Zhou CY, Linder MC. Secretion of ferritin by rat hepatoma cells and its regulation by inflammatory cytokines and iron. Blood 1997;90:4979-4986.
49. Carlsson B, Lindell K, Gabrielsson B et al. Obese (ob) gene defects are rare in human obesity. Obes Res 1997;5:30-35.
50. Le Stunff C, Le Bihan C, Schork NJ, Bougneres P. A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls. Diabetes 2000;49: 2196-2200.
51. Mammè O, Betoulle D, Aubert R et al. Novel polymorphisms in the 5′ region of the LEP gene. Association with leptin levels and response to low-calorie diet in human obesity. Diabetes 1998;47:487-489.
52. Hager J, Clément K, Francke Set al. A polymorphism in the 5′ untranslated region of the human ob gene is associated with low leptin levels. Int J Obes Relat Metab Disord 1998;22:200-205.
53. Hoffstedt J, Eriksson P, Mottagui-Tabar S, Amer P. A polymorphism in the leptin promoter region (-2548G/A) influences gene expression and adipose tissue secretion of leptin. Norm Metab Res 2002;34:355-359.
54. Templeman LA, Reynolds GP, Arranz B, San L. Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic druginduced weight gain in Caucasian subjects with a first-episode psychosis. Pharmacogenet Genomics 2005;15:195-200.
55. Chung WK, Belfi K, Chua M et al. Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice. Am J Physiol 1998;274:R985-R990.
56. Ravussin E, Pratley RE, Maffei M et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med 1997;3: 238-240.
57. Farooqi IS, Keogh JM, Kamath S et al. Partial leptin deficiency and human adiposity. Nature 2001;414:34-35.
58. Heymsfield SB, Greenberg AS, Fujioka K et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999;282:1568-1575.
59. Griffith OW. p-Amino acids: mammalian metabolism and utility as α-amino acid analogues. Annu Rev Biochem 1986;55:855-878.
60. Gejyo F, Kinoshita Y, Ikenaka T. Elevation of serum levels of β-amino-isobutyric acid in uremic patients and the toxicity of the amino acid. Clin Nephrol 1997;8:520-525.