Differential regulation of leptin expression and function in A/J vs. C57BL/6J mice during diet-induced obesity

American Journal of Physiology - Endocrinology and Metabolism

Volumn 279, Issue 2 42-2, 2000, Pages

  Watson, Patricia M ^a   Commins, Scott P ^a   Beiler, Rudolph J ^a   Hatcher, Heather C ^a   Gettys, Thomas W ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Adipose tissue; Thermogenesis; Uncoupling proteins

Indexed keywords

LEPTIN; MESSENGER RNA; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENZYME ASSAY; LIPID DIET; LOW FAT DIET; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; STRAIN DIFFERENCE; THERMOGENESIS; WEIGHT GAIN; WHITE ADIPOSE TISSUE;

EID: 0033858098     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.279.2.e356     Document Type: Article

References (56)

1. Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells
2. Innervation of mammalian white adipose tissue: Implications for the regulation of total body fat
3. Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold
4. Increased level of mRNA for the uncoupling protein in brown adipose tissue of rats during thermogenesis induced by cold exposure or norepinephrine infusion
5. Obesity, a disorder of nutrient partitioning: The MONA LISA hypothesis
6. Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks
7. 3-adrenergic receptor agonist treatment of diet-induced obesity in mice
8. Impaired expression and functional activity of the β-3 and β-1 adrenergic receptor in adipose tissue of congenitally obese (C57BLJ6-ob/ob) mice
9. Pharmacologic manipulation of ob expression in a dietary model of obesity
10. Norepinephrine is required for leptin effects on gene expression in brown and white adipose tissue
11. Induction of uncoupling protein expression in brown and white adipose tissue by leptin
12. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma
13. Glucocorticoids induce the expression of the leptin gene through a nonclassical mechanism of transcriptional activation
14. Thyroid hormones influence serum leptin concentrations in the rat
15. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
16. 2 is a ligand for the adipocyte determination factor PPARgamma
17. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
18. 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes
19. Tissue specific alterations in G protein expression in genetic vs diet-induced models of NIDDM in the mouse
20. Age-dependent changes in β-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats
21. 3-adrenergic receptor expression in white adipocytes from C57BL/6J mice
22. RU-486 (Mifepristone) ameliorates diabetes but does not correct deficient β-adrenergic signaling in adipocytes from mature C57BL/6J-ob/ob mice
23. 3-adrenoceptor in the control of leptin expression
24. Cloning and characterization of an uncoupling protein homolog. A potential molecular mediator of human thermogenesis
25. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin
26. Analysis of human and rodent beta 3-adrenergic receptor messenger ribonucleic acids
27. Emergence of brown adipocytes in white fat in mice is under genetic control - Effects on body weight and adiposity
28. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
29. Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: Reversal by insulin
30. Brown adipose tissue metabolism and thermogenesis
31. Brown adipose tissue thermogenesis and obesity
32. Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice
33. Intracerebroventricular injection of leptin increases thermogenesis and mobilizes fat metabolism in ob/ob mice
34. Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
35. Mechanism and evolution of the uncoupling protein of brown adipose tissue
36. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
37. Obesity due to high fat diet decreases the sympathetic nervous and cardiovascular responses to intracerebroventricular leptin in rats
38. Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity
39. Thermogenic mechanisms in brown fat
40. Effects of the obese gene product on body weight regulation in ob/ob mice
41. Skeletal muscle UCP3 and UCP2 gene expression in response to inhibition of free fatty acid flux through mitochondrial β-oxidation
42. Regulation of the uncoupling protein gene expression
43. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice
44. Diet-induced type II diabetes in C57BL/6J mice
45. Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice
46. Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice
47. Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice
48. Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: Mediation by the sympathetic system
49. Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the β3-adrenoceptor agonists BRL 35135A and ZD2079
50. Diet-induced obese mice develop peripheral, but not central, resistance to leptin
51. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
52. Novel form of lipolysis induced by leptin
53. Elevated free fatty acids induce uncoupling protein 3 expression in muscle - A potential explanation for the effect of fasting
54. Dietary obesity in the mouse: Interaction of strain with diet composition
55. Positional cloning of the mouse obese gene and its human homologue
56. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation