A pivotal role for β-aminoisobutyric acid and oxidative stress in dihydropyrimidine dehydrogenase deficiency?

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 9-11, 2006, Pages 1103-1106

  Van Kuilenburg, A B P ^a   Stroomer, A E M ^a   Abeling, N G G M ^a   Van Gennip, A H ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Aminoisobutyric acid; 8 Hydroxydeoxyguanosine; Dihydropyrimidine dehydrogenase; Oxidative stress

Indexed keywords

3 AMINO 2 METHYLPROPIONIC ACID; 8 HYDROXYDEOXYGUANOSINE;

ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY; ENZYME DEFICIENCY; HUMAN; INBORN ERROR OF METABOLISM; INFANT; OXIDATIVE STRESS; PROTEIN URINE LEVEL; URINALYSIS;

AMINOISOBUTYRIC ACIDS; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANOSINE; DIHYDROURACIL DEHYDROGENASE (NADP); ELECTROCHEMISTRY; HUMANS; INFANT; OXIDATIVE STRESS; PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS;

EID: 33750466238     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600894097     Document Type: Article

References (3)

1. van Kuilenburg, A.B.P.; Stroomer, A.E.M.; van Lenthe, H.; Abeling, N.G.G.M.; van Gennip, A.H. New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for β-aminoisobutyric acid?. Biochem. J. 2004, 379, 119-124.
2. Van Kuilenburg, A.B.P.; Meinsma, R.; Beke, E.; Assmann, B.; Ribes, A.; Lorente, I.; Busch, R.; Mayatepek, E.; Abeling, N.G.G.M.; Van Cruchten, A.; Stroomer, A.E.M.; van Lenthe, H.; Zoetekouw, L.; Kulik, W.; Hoffmann, G.F.; Voit, T.; Wevers, R.A.; Rutsch, F.; van Gennip, A.H. β-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities. Hum. Mol. Genet. 2004, 13, 2793-2801.
3. Wu, L.L.; Chiou, C.-C.; Chang, P.-Y.; Wu, J.T. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin. Chim. Acta 2004, 339, 1-9.