Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 8127-8135

  Eilfeld, Alexander ^a   González Tanarro, Camino M ^b   Frizler, Maxim ^b   Sieler, Joachim ^a   Schulze, Bärbel ^a   Gütschow, Michael ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Enzyme inhibition; Human leukocyte elastase; Isothiazol 3(2H) one 1,1 dioxides

Indexed keywords

2 (2,3,4,5,6 PENTAFLUOROPHENYL) 4,5,6,7 TETRAHYDRO 1,2 BENZISOTHIAZOL 3 ONE 1,1 DIOXIDE; 2 (2,3,5,6 TETRAFLUOROPYRIDIN 4 YL) 4,5,6,7 TETRAHYDRO 1,2 BENZISOTHIAZOL 3 ONE 1,1 DIOXIDE; 2 (3,5 DIFLUOROPYRIDIN 2 YL) 4,5,6,7 TETRAHYDRO 1,2 BENZISOTHIAZOL 3 ONE 1,1 DIOXIDE; 2 (6 BROMOPYRIDIN 2 YL) 4,5,6,7 TETRAHYDRO 1,2 BENZISOTHIAZOL 3 ONE 1,1 DIOXIDE; 2 (6 CHLOROPYRIDIN 2 YL) 4,5,6,7 TETRAHYDRO 1,2 BENZISOTHIAZOL 3 ONE 1,1 DIOXIDE; 2 PYRIDINYLISOTHIAZOL 3 ONE 1,1 DIOXIDE DERIVATIVE; 4,5 DIMETHYL 2 (2,3,5,6 TETRAFLUOROPYRIDIN 4 YL)ISOTHIAZOL 3 ONE 1,1 DIOXIDE; 5 METHYL 4 PHENYL 2 (2,3,5,6 TETRAFLUOROPYRIDIN 4 YL)ISOTHIAZOL 3 ONE 1,1 DIOXIDE; ACETYLCHOLINESTERASE; CATHEPSIN G; CATHEPSIN L; CHOLESTEROL ESTERASE; DIPEPTIDYL CARBOXYPEPTIDASE; ELASTASE; HALIDE; ISOTHIAZOLE DERIVATIVE; LEUKOCYTE ELASTASE; PYRIDINE 1 OXIDE; PYRIDINE DERIVATIVE; SERINE PROTEINASE; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME REACTIVATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; SYNTHESIS;

ACETYLCHOLINESTERASE; CATHEPSINS; CRYSTALLOGRAPHY, X-RAY; CYCLIC S-OXIDES; CYCLIZATION; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; LEUKOCYTE ELASTASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PEPTIDYL-DIPEPTIDASE A; SERINE ENDOPEPTIDASES; STEREOISOMERISM; STEROL ESTERASE; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPSIN;

EID: 50349094235     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.049     Document Type: Article

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