Therapeutic potential of neutrophil-elastase inhibition in pulmonary disease

Journal of Investigative Medicine

Volumn 44, Issue 9, 1996, Pages 531-539

  Vender, Robert L ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCYTE ELASTASE; PROTEIN;

CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; LUNG DISEASE; METABOLISM; PHYSIOLOGY; REVIEW;

HUMANS; LEUKOCYTE ELASTASE; LUNG DISEASES; PROTEINS;

EID: 0030345018     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (88)

1. Sinha S, Watorek W, Karr S, Giles J, Bode W, Travis J. Primary structure of human neutrophil elastase. Proc Natl Acad Sci USA 1987;84:2228-32.
2. Fouret P, duBois RM, Bernaudin J-F, Takahashi H, Ferrans VJ, Crystal RG. Expression of the neutrophil elastase gene during human bone marrow cell differentiation. J Exp Med 1989;169:833-45.
3. Takahashi H, Nukiwa T, Basset P, Crystal RG. Myelomonocytic cell lineage expression of the neutrophil elastase gene. J Biol Chem 1988;263:2543-7.
4. Liou TG, Campbell EJ. Nonisotropic enzyme-inhibitor interactions: a novel nonoxidative mechanism for quantum proteolysis by human neutrophils. Biochemistry 1995;34:16171-7.
5. Damiano VV, Kucich U, Murer E, Laudenslager N, Weinbaum G. Ultrastructural quantitation of peroxidase-and elastase-containing granules in human neutrophils. Am J Pathol 1988;131:235-45.
6. Nakamura H, Yoshimura K, McElvaney NG, Crystal RG. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Invest 1992;89:1478-84.
7. McElvaney NG, Nakamura H, Birrer P, Hebert CA, Wong WL, Alphonso M, Baker JB, Catalano MA, Crystal RG. Modulation of airway inflammation in cystic fibrosis: in vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J Clin Invest 1992;90:1296-301.
8. Amitani R, Wilson R, Rutman A, Read R, Ward C, Burnett D, Stockley RA, Cole PJ. Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium. Am J Respir Cell Mol Biol 1991;4:26-32.
9. Sommerhoff CP, Nadel JA, Basbaum CB, Caughey GH. Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells. J Clin Invest 1990;85:682-9.
10. Breuer R, Christensen TG, Niles RM, Stone PJ, Snider GL. Human neutrophil elastase causes glycoconjugate release from the epithelial cell surface of hamster trachea in organ culture. Am Rev Respir Dis 1989;139:779-82.
11. Schuster A, Ueki I, Nadel JA. Neutrophil elastase stimulates tracheal submucosal gland secretion that is inhibited by ICI 200,355. Am J Physiol 262 (Lung Cell Mol Physiol 6) 1992; L86-L91.
12. Snider GL, Lucey EL, Christensen TG, Stone PJ, Calore JD, Catanese A, Franzblau C. Emphysema and bronchial secretory cell metaplasia induced in hamsters by human neutrophil products. Am Rev Respir Dis 1984;129:155-60.
13. Lucey EC, Stone PJ, Christensen TG, Breuer R, Snider GL. An 18-month study of the effects on hamster lungs of intratracheally administered human neutrophil elastase. Exp Lung Res 1988;14:671-86.
14. Harlan JM, Killen PD, Harker LA, Striker GE, Wright DG. Neutrophil-mediated endothelial injury in vitro: mechanisms of cell detachment. J Clin Invest 1981;68:1394-404.
15. Berger M, Sorensen RU, Tosi MF, Dearborn DG, Doring G. Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas-infected lung in cystic fibrosis. J Clin Invest 1989;84:1302-13.
16. Tosi MF, Zakem H, Berger M. Neutrophil elastase cleaves C3bi on opsonized Pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch. J Clin Invest 1990;86:300-8.
17. Hutchison DCS. The role of proteases and antiproteases in bronchial secretions. Eur J Respir Dis 1987;71:78-85.
18. Travis J. Structure, function and control of neutrophil proteinase. Am J Med 1988;84:37-42.
19. Owen CA, Campbell MA, Sannes PL, Boukedes SS, Campbell EJ. Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, nonoxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases. J Cell Biol 1995;131:775-89.
20. Rice WG, Weiss SJ. Regulation of proteolysis at the neutrophil-substrate interface by secretory leukoprotease inhibitor. Science 1990;249:178-81.
21. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989;320:365-76.
22. FitzSimmons SC. The changing epidemiology of cystic fibrosis. J Pediatr 1993;122:1-9.
23. Collins FS. Cystic fibrosis: molecular biology and therapeutic implications. Science 1992;256:774-9.
24. Regelmann WE, Elliott GR, Warwick WJ, Clawson CC. Reduction of sputum Pseudomonas aeruginosa density by antibiotics improves lung function in cystic fibrosis more than do bronchodilators and chest physiotherapy alone. Am Rev Respir Dis 1990;141:914-21.
25. Berger M. Inflammation in the lung in cystic fibrosis. Clin Rev Allergy 1991;9:119-42.
26. Konstan MW, Hilliard KA, Norvell TM, Berger M. Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am J Respir Crit Care Med 1994;150:448-54.
27. Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, Riches DWH. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995;151:1075-82.
28. Banda MJA, Rice AG, Griffin GL. Senior RM. The inhibitory complex of human alpha 1 proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant. J Exp Med 1988;167:1608-17.
29. Fick RB Jr, Naegel GP, Squier SU, Wood RE, Gee JBL, Reynolds HY. Proteins of the cystic fibrosis respiratory tract: fragmented immunoglobulin G opsonic antibody causing defective opsonophagocytosis. J Clin Invest 1984;74:236-48.
30. 1-antitrypsin treatment for cystic fibrosis. Lancet 1991;337:392-4.
31. Woods DE, Bass JA, Johanson WG Jr, Straus DC. Role of adherence in the pathogenesis of Pseudomonas aeruginosa lung infection in cystic fibrosis patients. Infect Immun 1980;30:694-9.
32. Schuster A, Fahy JV, Ueki I, Nadel JA. Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors. Eur Respir J 1995;8:10-14.
33. Nadel JA, Massion PP, Inoue H. Role of airway epithelium in the pathophysiology of airway hypersecretion. Eur Respir Rev 1994;4:363-7.
34. Dunn MM, Dunne M, Kamp DW. Polymorphonuclear leukocyte- and Pseudomonas aeruginosa-induced damage to a human pulmonary epithelial cell line. J Infect Dis 1990;162:172-7.
35. Suter S. The imbalance between granulocyte neutral proteases and antiproteases in bronchial secretions from patients with cystic fibrosis. In: Hoiby N, Pedersen SS, Shand GH, Doring G, Holder IA, eds. Pseudomonas aeruginosa infecton. Antibiotics and Chemotherapy. Basel: Karger 1989:158-68.
36. Suter S, Schaad UB, Morgenthaler JJ, Chevallier I, Schnebli HP. Fibronectin-cleaving activity in bronchial secretions of patients with cystic fibrosis. J Infect Dis 1988;158:89-100.
37. Rees DD, Brain JD. Effects of cystic fibrosis airway secretions on rat lung: role of neutrophil elastase. Am J Physiol 269 (Lung Cell Mol Physiol) 1995;13:L195-L202
38. Bruce MC, Poncz L, Klinger JD, Stern RC, Tomashefski JF Jr, Dearborn DG. Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis. Am Rev Respir Dis 1985;132:529-35.
39. Stone PJ, Konstan MW, Berger M, Dorkin HL, Franzblau C, Snider GL. Elastin and collagen degradation products in urine of patients with cystic fibrosis. Am J Respir Crit Care Med 1995;152:157-62.
40. Cantin A. Cystic fibrosis lung inflammation: early, sustained, severe. Am J Respir Crit Care Med 1995;151:939-41.
41. Kerem E, Reisman J, Corey M, Canny GL, Levison H. Prediction of mortality in patients with cystic fibrosis. N Engl J Med 1992;326:1187-91.
42. Stockley RA. Bronchiectasis - new therapeutic approaches based on pathogenesis. Clinics Chest Medicine 1987;8:481-93.
43. Fahy JV, Schuster A, Ueki I, Boushey HA, Nadel JA. Mucus hypersecretion in bronchiectasis: the role of neutrophil proteases. Am Rev Respir Dis 1992;146:1430-3.
44. Crystal RG. α1-antitrypsin deficiency, emphysema and liver disease. Genetic basis and strategies for therapy. J Clin Invest 1990;85:1343-52.
45. 1-antitrypsin deficiency. Chest 1995;107 535-45.
46. 1-antitrypsin deficiency associated with emphysema. N Engl J Med 1987;316:1055-62.
47. 1-antichymotrypsin. J Biol Chem 1980;255:3931-4.
48. Ohlsson K, Laurell CB. The disappearance of enzyme-inhibitor complexes from the circulation of man. Clin Sci Mol Med 1976;51:87-92.
49. 1-antitrypsin. Chest 1994;106:1223-32.
50. 1-antitrypsin deficiency, PiZZ. J Clin Epidmiol 1988;41:1157-65.
51. Weitz JI, Silverman EK, Thong B, Campbell EJ. Plasma levels of elastase-specific fibrinopeptides correlate with proteinase inhibitor phenotype. J Clin Invest 1992;89:766-73.
52. 1-antitrypsin-deficient humans. Respiration 1995;62:76-9.
53. 1-antitrypsin deficiency, a rare occurrence? Chest 1993;104:1384-6.
54. 1-antitrypsin deficiency type PiZZ. Am J Respir Crit Care Med 1995;152:1922-5.
55. Snider GL, Ciccolella DE, Morris SM, Stone PJ, Lucey EC. Putative role of neutrophil elastase in the pathogenesis of emphysema. Ann NY Acad Sci 1991;624:45-59.
56. Fera T, Abboud RT, Richter A, Johal, SS. Acute effect of smoking on elastase like esterase activity and immunologic neutrophil elastase levels in bronchoalveolar lavage fluid. Am Rev Respir Dis 1985;133:568-73.
57. Hunninghake GW, Crystal, RG. Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers. Am Rev Respir Dis 1983;128:833-8.
58. Fujita J, Nelson NL, Daughton DM, Dobry CA, Spurzem JR, Irino S, Rennard SI. Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema. Am Rev Respir Dis 1990;142:57-62.
59. Weitz JI, Crowley KA, Landman SL, Lipman BI, Yu J. Increased neutrophil elastase activity in cigarette smokers. Ann Int Med 1987;107:680-2.
60. Stone PJ, Gottlieb DJ, O'Connor GT, Ciccolella E, Breuer R, Bryan-Rhadfi J, Shaw HA, Franzblau C, Snider GL. Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995;151:952-9.
61. 1-proteinase inhibitor in vitro. J Clin Invest 1980;66:987-95.
62. Yoshioka A, Betsuyaku T, Nishimura M, Miyamoto K, Kondo T, Kawakami, Y. Excessive neutrophil elastase in bronchoalveolar lavage fluid in subclinical emphysema. Am J Respir Crit Care Med 1995;152:2127-32.
63. Campbell, EJ. Preventive therapy of emphysema, lessons from the elastase model. Am Rev Respir Dis 1986;123:435-7.
64. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall MR, Morris A, Spragg R, the Consensus Committee. The American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes, clinical trial coordination. Am J Respir Crit Care Med 1994;149:818-24.
65. Milberg JA, Davis DR, Steinberg KP, Hudson LD. Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993. JAMA 1995;273:306-9.
66. Rinaldo JE, Rogers RM. Adult respiratory-distress syndrome: changing concepts of lung injury and repair. N Engl J Med 1981;306:900-7.
67. Heflin AC Jr, Brigham KL. Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia. J Clin Invest 1981;68:1253-60.
68. Weiland JE, Davis WB, Holter JF, Mohammed JR, Dorinsky PM, Gadek JE. Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance. Am Rev Respir Dis 1986;133:218-25.
69. Suter PM, Suter S, Girardin E, Roux-Lombard P, Grau GE, Dayer J-M. High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am Rev Respir Dis 1992;145:1016-22.
70. Idell S, Kucich U, Fein A, Kueppers F, James HL, Walsh PN, Weinbaum G, Colman RW, Cohen AB. Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome. Am Rev Respir Dis 1985;132:1098-105.
71. Lee CT, Fein AM, Lippmann M, Holtzman H, Kimbel P, Weinbaum G. Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory distress syndrome. N Engl J Med 1981;304:192-6.
72. 2-macroglobulin. J Clin Invest 1988;82:1260-7.
73. McGuire WW, Spragg R, Cohen AB, Cochrane CG. Studies on the pathogenesis of the adult respiratory distress syndrome. J Clin Invest 1981;69:543-53.
74. Smedly LA, Tonnesen MG, Sandhaus RA, Haslett C, Guthrie LA, Johnson RB Jr, Henson PM, Worthen GS. Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase. J Clin Invest 1986;77:1233-43.
75. Sakamaki F, Ishizaka A, Urano T, Sayama K, Nakamura H, Terashima T, Waki Y, Tasaka S, Hasegawa N, Sato K, Nakagawa N, Obata T, Kanazawa M. Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury. Am J Respir Crit Care Med 1996;153:391-7.
76. Gossage JR, Kuratomi Y, Davidson JM, Lefferts PL, Snapper JR. Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep. Am Rev Respir Dis 1993;147:1371-9.
77. Jochum M, Gippner-Steppert C, Machleidt W, Fritz H. The role of phagocyte proteinases and proteinase inhibitors in multiple organ failure. Am J Respir Crit Care Med 1994;150:S123-30.
78. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987;136:225-44.
79. Mullen JBM, Wright JL, Wiggs BR, Pare PD, Hogg JC. Reassessment of inflammation of airways in chronic bronchitis. Brit Med J 1985;291:1235-9.
80. Martin TR, Raghu G, Maunder RJ, Springmeyer SC. The effects of chronic bronchitis and chronic air-flow obstruction on lung cell populations recovered by bronchoalveolar lavage. Am Rev Resp Dis 1985;132:254-60.
81. Thompson AB, Daughton D, Robbins RA, Ghafouri MA, Oehlerking M, Rennard SI. Intraluminal airway inflammation in chronic bronchitis: characterization and correlation with clinical parameters. Am Rev Respir Dis 1969;140:1527-37.
82. Stockley RA. The role of proteinases in the pathogenesis of chronic bronchitis. Am J Respir Crit Care Med 1994;150:S109-13.
83. Howarth PH, Bradding P, Montefort S, Peroni D, Dujkanovic R, Carroll MP, Holgate ST. Mucosal inflammation and asthma. Am J Respir Crit Care Med 1994;150:S18-S22.
84. Sur S, Crotty TB, Kephart GM, Hyma BA, Colby TV, Reed CE, Hunt LW, Gleich GJ. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am Rev Respir Dis 1993;148:713-9.
85. Tabachnik E, Schuster A, Gold WM, Nadel JA. Role of neutrophil elastase in allergen-induced lysozyme secretion in the dog trachea. J Appl Physiol 1992 73(2):695-700.
86. Nunley DR, Dauber JH, Iacona AT, Keenan RJ, Cornwell R, Love R, Meyer KC. Neutrophil elastase in bronchoalveolar lavage from transplant recipients with cystic fibrosis. Am J Resp Crit Care Med 1996;153(4):A262.
87. Yamashita J, Tashiro K, Yoneda S, Kawahara K, Shirakusa T. Local increase in polymorphonuclear leukocyte elastase is associated with tumor invasiveness in non-small cell lung cancer. Chest 1996;109:1328-34.
88. 1-proteinase inhibitor complexes in lung cancer. Eur Respir J 1989;2:623-9.