Inhibition of cathepsin G by 2-amino-3,1-benzoxazin-4-ones: Kinetic investigations and docking studies

Archives of Biochemistry and Biophysics

Volumn 402, Issue 2, 2002, Pages 180-191

  Gutschow M ^a   Kuerschner, L ^b   Pietsch, M ^a   Ambrozak, A ^a   Neumann, U ^c   Gunther R ^b   Hofmann, H J ^b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Cathepsin G; Enzyme inhibition; Enzyme kinetics; Enzyme ligand interaction; Serine proteases

Indexed keywords

2 AMINO 3,1 BENZOXAZIN 4 ONE DERIVATIVE; BENZOXAZINONE DERIVATIVE; BENZYLAMINE DERIVATIVE; CATHEPSIN G; CHROMOGENIC SUBSTRATE; ENZYME INHIBITOR; PIPERAZINE DERIVATIVE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BINDING KINETICS; CATALYSIS; CHEMICAL REACTION KINETICS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; HYDROPHOBICITY; PRIORITY JOURNAL;

BENZOXAZOLES; BINDING SITES; CATHEPSINS; HUMANS; KINETICS; MODELS, MOLECULAR; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037098447     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9861(02)00054-1     Document Type: Article

References (28)