Fluorine interactions at the thrombin active site: Protein backbone fragments H-Cα-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles

ChemBioChem

Volumn 5, Issue 5, 2004, Pages 666-675

  Olsen, Jacob A ^b   Banner, David W ^a   Seiler, Paul ^b   Wagner, Björn ^a   Tschopp, Thomas ^a   Obst Sander, Ulrike ^a   Kansy, Manfred ^a   Müller, Klaus ^a   Diederich, François ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ETH ZURICH   (Switzerland)

Author keywords

Enzyme inhibitors; Fluorine; Medicinal chemistry; Molecular recognition; Thrombin

Indexed keywords

ALIPHATIC COMPOUND; CARBON; FLUORINE; HYDROGEN; PROTEIN; THROMBIN; THROMBIN INHIBITOR;

ARTICLE; ATOMIC PARTICLE; CRYSTAL STRUCTURE; DATA BASE; DIPOLE; DRUG SYNTHESIS; ENVIRONMENT; PRIORITY JOURNAL; X RAY ANALYSIS;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FLUORINE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PANCREATIC ELASTASE; PROTEINS; STEREOISOMERISM; SWINE; THROMBIN;

EID: 4544318450     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200300907     Document Type: Article

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