A quassinoid 6α-tigloyloxychaparrinone inhibits hypoxia-inducible factor-1 pathway by inhibition of eukaryotic translation initiation factor 4E phosphorylation

European Journal of Pharmacology

Volumn 592, Issue 1-3, 2008, Pages 41-47

  Jin, Xuejun ^a,b   Jin, Hong Ri ^a   Lee, Dongho ^c   Lee, Jeong Hyung ^d   Kim, Sang Kyum ^b   Lee, Jung Joon ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

^c Korea University   (South Korea)

^d Kangwon National University   (South Korea)

Author keywords

6 tigloyloxychaparrinone; Antitumor activity; eIF4E; HIF 1 translation; Quassinoid

Indexed keywords

6ALPHA TIGLOYLOXYCHAPARRINONE; DNA TOPOISOMERASE; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1BETA; INITIATION FACTOR 4E; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INTERACTING PROTEIN KINASE 1; QUASSINOID; UNCLASSIFIED DRUG; VASCULOTROPIN; 6 ALPHA TIGLOYLOXYCHAPARRINONE; 6 ALPHA-TIGLOYLOXYCHAPARRINONE; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE; QUASSINOID DERIVATIVE; VASCULOTROPIN A;

AILANTUS ALTISSIMA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HYPOXIA; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; STRUCTURE ACTIVITY RELATION; BIOSYNTHESIS; CANCER INVASION; CELL SURVIVAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; PHOSPHORYLATION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EUKARYOTIC INITIATION FACTOR-4E; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENES, REPORTER; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; LUCIFERASES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PROTEIN KINASES; QUASSINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 49749115202     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.104     Document Type: Article

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