Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system

Cancer Research

Volumn 63, Issue 15, 2003, Pages 4648-4655

  Lee, Dong Hoon ^a   Yang, Young ^a   Lee, Soon Jung ^b   Kim, Kun Yong ^a   Koo, Tae Hyeon ^a   Shin, Sun Mi ^a   Song, Kyu Sang ^b   Lee, Young Ho ^b   Kim, Yung Jin ^c   Lee, Jung Joon ^a   Choi, Inpyo ^a   Lee, Jeong Hyung ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

^c Pusan National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYTOKINE; MACROPHAGE INHIBITORY CYTOKINE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UROKINASE; UROKINASE RECEPTOR;

ARTICLE; CANCER GROWTH; CANCER INVASION; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STOMACH CANCER;

CELL DIVISION; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; STOMACH NEOPLASMS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; UP-REGULATION; URINARY PLASMINOGEN ACTIVATOR;

EID: 0042134847     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Sponi, M. B. The war on cancer. Lancet, 347: 1377-1381, 1996.
2. Aguirre Ghiso, J. A., Alonso, D. F., Farias, E. F., Gomez, D. E., and de Kier Joffe, E. B. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. Eur. J. Biochem., 263: 295-304, 1999.
3. Andreasen, P. A., Kjoller, L., Christensen, L., and Duffy, M. J. The urokinase-type plasminogen activator system in cancer metastasis. Int. J. Cancer, 72: 1-22, 1997.
4. Mignatti, P., and Rifkin, D. B. Biology and biochemistry of proteinases in tumor invasion. Physiol. Rev., 3: 161-195, 1993.
5. Reuning, U., Magdolen, V., Wilhelm, O., Fischer, K., Lutz, V., Graeff, H., and Schmitt, M. Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis. Int. J. Oncol., 13: 893-906, 1998.
6. Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S., Pryor, K., Walsh, B. J., Nicholson, R. C., Fairlie, W. D., Por, S. B., Robbins, J. M., and Breit, S. N. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily. Proc. Natl. Acad. Sci. USA, 94: 11514-11519, 1997.
7. Fairlie, W. D., Moore, A. G., Bauskin, A. R., Russell, P. K., Zhang, H. P., and Breit, S. N. MIC-1 is a novel TGF-β superfamily cytokine associated with macrophage activation. J. Leukocyte Biol., 65: 2-5, 1999.
8. Lawton, L. N., Bonaldo, M. F., Jelenc, P. C., Qiu, L., Baumes, S. A., Marcelino, R. A., de Jesus, G. M., Wellington, S., Knowles, J. A., Warburton, D., Brown, S., and Soares, M. B. Identification of a novel member of the TGF-β superfamily highly expressed in human placenta. Gene (Amst.), 203: 17-26, 1997.
9. Paralkar, V. M., Vail, A. L., Grasser, W. A., Brown, T. A., Xu, H., Vukicevic, S., Ke, H. Z., Qi, H., Owen, T. A., and Thompson, D. D. Cloning and characterization of a novel member of the transforming growth factor-β/bone morphogenetic protein family. J. Biol. Chem., 273: 13760-13767, 1998.
10. Bottner, M., Suter-Crazzolara, C., Schober, A., and Unsicker, K. Expression of a novel member of the TGF-β superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res., 297: 103-110, 1999.
11. Baek, S. J., Kim, K. S., Nixon, J. B., Wilson, L. C., and Eling, T. E. Cyclooxygenase inhibitors regulate the expression of a TGF-β superfamily member that has proapoptotic and antitumorigenic activities. Mol. Pharmacol., 59: 901-908, 2001.
12. Hromas, R., Hufford, M., Sutton, J., Xu, D., Li, Y., and Lu, L. PLAB, a novel placental bone morphogenetic protein. Biochim. Biophys. Acta, 1354: 40-44, 1997.
13. Bauskin, A. R., Zhang, H. P., Fairlie, W. D., Russell, P. K., Moore, A. G., Brown, D. A., Stanley, K. K., and Breit, S. N. The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-β superfamily member, acts as a quality control determinant for correctly folded MIC-1. EMBO J., 19: 2212-2220, 2000.
14. Fairlie, W. D., Zhang, H-P., Brown, P. K., Russell, P. K., Bauskin, A. R., and Breit, S. N. Expression of a TGF-β superfamily protein, macrophage inhibitory cytokine-1, in the yeast Pichia pastoris. Gene (Amst.), 254: 67-76, 2000.
15. Tan, M., Wang, Y., Guan, K., and Sun, Y. PTGF-β, a type beta transforming growth factor (TGF-β) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-β signaling pathway. Proc. Natl. Acad. Sci. USA, 97: 109-114, 2000.
16. Li, P. X., Wong, J., Ayed, A., Ngo, D., Brade, A. M., Arrowsmith, C., Austin, R. C., and Klamut, H. J. Placental transforming growth factor-β is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. J. Biol. Chem., 275: 20127-20135, 2000.
17. Graichen, R., Liu, D., Sun, Y., Lee, K. O., and Lobie, P. E. Autocrine human growth hormone inhibits placental transforming growth factor-β gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells. J. Biol. Chem., 277: 26662-26672, 2002.
18. Wong, J., Li, P. X., and Klamut, H. J. A novel p53 transcriptional repressor element (p53TRE) and the asymmetrical contribution of two p53 binding sites modulate the response of the placental transforming growth factor-β promoter to p53. J. Biol. Chem., 277: 26699-266707, 2002.
19. Moore, A. G., Brown, D. A., Fairlie, W. D., Bauskin, A. R., Brown, P. K., Munier, M. L., Russell, P. K., Salamonsen, L. A., Wallace, E. M., and Breit, S. N. The transforming growth factor-β superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women. J. Clin. Endocrinol. Metab., 85: 4781-4788, 2000.
20. Welsh, J. B., Sapinoso, L. M., Su, A. I., Kern, S. G., Wang-Rodriguez, J., Moskaluk, C. A., Fierson, H. F., and Hampton, G. M., Jr. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res., 61: 5974-5978, 2001.
21. Karan, D., Kelly, D. L., Rizzino, A., Lin, M. F., and Batra, S. K. Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells. Carcinogenesis (Lond.), 23: 967-976, 2002.
22. Buckhaults, P., Rago, C., St. Croix, B., Romans, K. E., Saha, S., Zhang, L., Vogelstein, B., and Kinzler, K. W. Secreted and cell surface genes expressed in benign and malignant colorectal tumors. Cancer Res., 61: 6996-7001, 2001.
23. Park, J. G., Yang, H. K., Kim, W. H., Chung, J. K., Kang, M. S., Lee, J. H., Oh, J. H., Park, H. S., Yeo, K. S., Kang, S. H., Song, S. Y., Kang, Y. K., Bang, Y. J., Kim, Y. H., and Kim, J. P. Establishment and characterization of human gastric carcinoma cell lines. Int. J. Cancer, 70: 443-449, 1997.
24. Park, J. G., Frucht, H., LaRocca, R. V., Bliss, D. P., Jr., Kurita, Y., Chen, T. R., Henslee, J. G., Trepel, J. B., Jensen, R. T., and Johnson, B. E. Characteristics of cell lines established from human gastric carcinoma. Cancer Res., 50: 2773-2780, 1990.
25. Koo, T. H., Lee, J. J., Kim, E. M., Kim, K. W., Kim, H. D., and Lee, J. H. Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines. Oncogene, 21: 4080-4088, 2002.
26. Choi, N. S., and Kim, S. H. Two fibrin zymography methods for analysis of plasminogen activators on gels. Anal. Biochem., 281: 236-268, 2000.
27. Heussen, C., and Dowdle, E. B. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal. Biochem., 102: 196-202, 1980.
28. Kang, S. H., Bang, Y. J., Jong, H. S., Seo, J. Y., Kim, N. K., and Kim, S. J. Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-β-induced cell cycle arrest of gastric carcinoma cells. Br. J. Cancer, 80: 1144-1149, 1999.
29. Chang, J., Park, K., Bang, Y. J., Kim, W. S., Kim, D., and Kim, S. J. Expression of transforming growth factor β type II receptor reduces tumorigenicity in human gastric cancer cells. Cancer Res., 57: 2856-2859, 1997.
30. Park, K., Kim, S. J., Bang, Y. J., Park, J. G., Kim, N. K., Roberts, A. B., and Sporn, M. B. Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-β. Proc. Natl. Acad. Sci. USA, 91: 8772-8776, 1994.
31. Whitman, M. Smads and early developmental signaling by the TGFβ superfamily. Genes Dev., 12: 2445-2462, 1998.
32. Plebani, M., Herszenyi, L., Carraro, P., De Paoli, M., Roveroni, G., Cardin, R., Tulassay, Z., Naccarato, R., and Farinati, F. Urokinase-type plasminogen activator receptor in gastric cancer: tissue expression and prognostic role. Clin. Exp. Metastasis, 15: 418-425, 1997.
33. Albertoni, M., Shaw, P. H., Nozaki, M., Godard, S., Tenan, M., Hamou, M. F., Fairlie, D. W., Breit, S. N., Paralkar, V. M., de Tribolet, N., Van Meir, E. G., and Hegi, M. E. Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1. Oncogene, 21: 4212-4219, 2002.
34. Vaupel, P., Kelleher, D. K., and Hockel, M. Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy. Semin. Oncol., 28: 29-35, 2001.
35. Wakefield, L. M., and Roberts, A. B. TGF-beta signaling: positive and negative effects on tumorigenesis. Curr. Opin. Genet. Dev., 12: 22-29, 2002.
36. Wrana, J. L., Attisano, L., Carcamo, J., Zentella, A., Doody, J., Laiho, M., Wang, X. F., and Massague, J. TGF beta signals through a heteromeric protein kinase receptor complex. Cell, 71: 1003-1014, 1992.
37. Yingling, J. M., Datto, M. B., Wong, C., Frederick, J. P., Liberati, N. T., and Wang, X. F. Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. Mol. Cell. Biol., 17: 7019-7028, 1997.