Cell-to-cell contact between activated CD4 + T lymphocytes and unprimed monocytes interferes with a T H1 response

Journal of Allergy and Clinical Immunology

Volumn 114, Issue 4, 2004, Pages 965-973

  Wittmann, Miriam ^a   Alter, Mareike ^a   Stünkel, Tanja ^a   Kapp, Alexander ^a   Werfel, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

human; Monocytes macrophages; skin; T lymphocytes; transcription factors

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN P42; PROTEIN P44; TRANSCRIPTION FACTOR;

ARTICLE; CELL CONTACT; CELL ISOLATION; CELL SURFACE; COCULTURE; CONTROLLED STUDY; ECZEMA; HUMAN; HUMAN CELL; MONOCYTE; PATCH TEST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN DEFECT; T LYMPHOCYTE;

ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELLS, CULTURED; HUMANS; INTERLEUKIN-12; MONOCYTES; SIGNAL TRANSDUCTION; TH1 CELLS;

EID: 4944257667     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.06.033     Document Type: Article

References (36)

1. P. Scott IL-12: initiation cytokine for cell-mediated immunity Science 260 1993 496 497
2. G. Trinchieri Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes Blood 84 1994 4008 4027
3. M. Cella, D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation J Exp Med 184 1996 747 752
4. R.J. Noelle CD40 and its ligand in host defense Immunity 4 1996 415 419
5. U. Shu, M. Kiniwa, C.Y. Wu, C. Maliszewski, N. Vezzio, and J. Hakimi Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction Eur J Immunol 25 1995 1125 1128
6. E.C. de Jong, P.L. Vieira, P. Kalinski, J.H. Schuitemaker, Y. Tanaka, and E.A. Wierenga Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals J Immunol 168 2002 1704 1709
7. G. Delespesse, Y. Ohshima, L.P. Yang, C. Demeure, and M. Sarfati OX40-mediated cosignal enhances the maturation of naive human CD4+ T cells into high IL-4-producing effectors Int Arch Allergy Immunol 118 1999 384 386
8. R. Josien, B.R. Wong, H.L. Li, R.M. Steinman, and Y. Choi TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells J Immunol 162 1999 2562 2568
9. M.P. Hayes, J. Wang, and M.A. Norcross Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes Blood 86 1995 646 650
10. X. Ma, J.M. Chow, G. Gri, G. Carra, F. Gerosa, and S.F. Wolf The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells J Exp Med 183 1996 147 157
11. A. Snijders, P. Kalinski, C.M. Hilkens, and M.L. Kapsenberg High-level IL-12 production by human dendritic cells requires two signals Int Immunol 10 1998 1593 1598
12. M.N. Avice, M. Sarfati, F. Triebel, G. Delespesse, and C.E. Demeure Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells J Immunol 162 1999 2748 2753
13. X. Peng, A. Kasran, P.A. Warmerdam, M. de Boer, and J.L. Ceuppens Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-gamma production Eur J Immunol 26 1996 1621 1627
14. M. Wittmann, P. Kienlin, S. Mommert, A. Kapp, and T. Werfel Suppression of IL-12 production by soluble CD40 ligand: evidence for involvement of the p44/42 mitogen-activated protein kinase pathway J Immunol 168 2002 3793 3800
15. M. Wittmann, V.A. Larsson, P. Schmidt, G. Begemann, A. Kapp, and T. Werfel Suppression of interleukin-12 production by human monocytes after preincubation with lipopolysaccharide Blood 94 1999 1717 1726
16. T. Werfel, J. Zwirner, M. Oppermann, A. Sieber, G. Begemann, and W. Drommer CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin J Immunol 157 1996 1729 1735
17. M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 2001 E45
18. C.L. Karp, M. Wysocka, X. Ma, M. Marovich, R.E. Factor, and T. Nutman Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance Eur J Immunol 28 1998 3128 3136
19. J. Hodge-Dufour, M.W. Marino, M.R. Horton, A. Jungbluth, M.D. Burdick, and R.M. Strieter Inhibition of interferon gamma induced interleukin 12 production: a potential mechanism for the anti-inflammatory activities of tumor necrosis factor Proc Natl Acad Sci U S A 95 1998 13806 13811
20. G.J. Feng, H.S. Goodridge, M.M. Harnett, X.Q. Wei, A.V. Nikolaev, and A.P. Higson Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase J Immunol 163 1999 6403 6412
21. H. Hacker, H. Mischak, T. Miethke, S. Liptay, R. Schmid, and T. Sparwasser CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation EMBO J 17 1998 6230 6240
22. P.O. Vidalain, O. Azocar, C. Servet-Delprat, C. Rabourdin-Combe, D. Gerlier, and S. Manie CD40 signaling in human dendritic cells is initiated within membrane rafts EMBO J 19 2000 3304 3313
23. S.E. Plevy, J.H. Gemberling, S. Hsu, A.J. Dorner, and S.T. Smale Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins Mol Cell Biol 17 1997 4572 4588
24. S.H. Yang, D.C. Bumpass, N.D. Perkins, and A.D. Sharrocks The ETS domain transcription factor Elk-1 contains a novel class of repression domain Mol Cell Biol 22 2002 5036 5046
25. J.T. Chang, E.M. Shevach, and B.M. Segal Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells J Exp Med 189 1999 969 978
26. L. Rogge, L. Barberis-Maino, M. Biffi, N. Passini, D.H. Presky, and U. Gubler Selective expression of an interleukin-12 receptor component by human T helper 1 cells J Exp Med 185 1997 825 831
27. L. Rogge, A. Papi, D.H. Presky, M. Biffi, L.J. Minetti, and D. Miotto Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo J Immunol 162 1999 3926 3932
28. S.J. Szabo, A.S. Dighe, U. Gubler, and K.M. Murphy Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells J Exp Med 185 1997 817 824
29. S.J. Szabo, S.T. Kim, G.L. Costa, X. Zhang, C.G. Fathman, and L.H. Glimcher A novel transcription factor, T-bet, directs Th1 lineage commitment Cell 100 2000 655 669
30. A.C. Mullen, F.A. High, A.S. Hutchins, H.W. Lee, A.V. Villarino, and D.M. Livingston Role of T-bet in commitment of TH1 cells before IL-12-dependent selection Science 292 2001 1907 1910
31. M. Grewe, C.A. Bruijnzeel-Koomen, E. Schopf, T. Thepen, A.G. Langeveld-Wildschut, and T. Ruzicka A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis Immunol Today 19 1998 359 361
32. A. Rowe, and C.B. Bunker Interleukin-4 and the interleukin-4 receptor in allergic contact dermatitis Contact Dermatitis 38 1998 36 39
33. J.C. Szepietowski, R.C. McKenzie, S.G. Keohane, R.D. Aldridge, and J.A. Hunter Atopic and non-atopic individuals react to nickel challenge in a similar way: a study of the cytokine profile in nickel-induced contact dermatitis Br J Dermatol 137 1997 195 200
34. T. Thepen, E.G. Langeveld-Wildschut, I.C. Bihari, D.F. van Wichen, F.C. van Reijsen, and G.C. Mudde Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical study J Allergy Clin Immunol 97 1996 828 837
35. T. Werfel, M. Hentschel, A. Kapp, and H. Renz Dichotomy of blood- and skin-derived IL-4-producing allergen-specific T cells and restricted V beta repertoire in nickel-mediated contact dermatitis J Immunol 158 1997 2500 2505
36. Q. Hamid, T. Naseer, E.M. Minshall, Y.L. Song, M. Boguniewicz, and D.Y. Leung In vivo expression of IL-12 and IL-13 in atopic dermatitis J Allergy Clin Immunol 98 1996 225 231