The ETS domain transcription factor Elk-1 contains a novel class of repression domain

Molecular and Cellular Biology

Volumn 22, Issue 14, 2002, Pages 5036-5046

  Yang, Shen Hsi ^a   Bumpass, Donna C ^a   Perkins, Neil D ^a   Sharrocks, Andrew D ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EGR 1; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEACETYLATION; GENE MAPPING; GENE REPRESSION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR EVOLUTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; TRANSCRIPTION INITIATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; ETS-DOMAIN PROTEIN ELK-1; EVOLUTION, MOLECULAR; GENES, REPORTER; HISTONE DEACETYLASES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PEPTIDE MAPPING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

CERVUS ELAPHUS;

EID: 0036293819     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.14.5036-5046.2002     Document Type: Article

References (40)

1. The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway
2. The PEA3 Ets transcription factor comprises multiple domains that regulate transactivation and DNA binding
3. Signal uptake by the c-fos serum response element
4. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation
5. The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades
6. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
7. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation
8. Net, a new ets transcription factor that is activated by Ras
9. The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex
10. Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction
11. A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy
12. Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase
13. Functional dissection of the transcription factor Elk-1
14. SAP1a is a nuclear target of signaling cascades involving ERKs
15. MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP
16. Differential splicing of the mouse B-myb gene
17. mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity
18. Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif
19. Transformation of mammalian cells by constitutively active MAP kinase kinase
20. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
21. Histone deacetylases: Silencers for hire
22. Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)
23. Generating yeast transcriptional activators containing no yeast protein sequences
24. New eukaryotic transcriptional repressors
25. Signal transduction within the nucleus by mitogen-activated protein kinase
26. The ETS-domain transcription factor family
27. The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1
28. Determinants of DNA binding specificity of ETS-domain transcription factors
29. A novel transcriptional repression domain mediates p21(WAF1/CIP1)induction of p300 transactivation
30. MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction
31. Ternary complex factors: Growth regulated transcriptional activators
32. Ets transcription factors: Nuclear effectors of the Ras-MAP-kinase signalling pathway
33. Transcriptional cross talk between NF-kappaB and p53
34. A motif-based profile scanning approach for genome-wide prediction of signaling pathways
35. The Elk-1 ETS-domain transcription factor contains a MAP kinase targeting motif
36. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1
37. The ETS-domain transcription factors: Lessons from the TCF subfamily
38. Targeting of p38 MAPKs to MEF2 transcription factors
39. Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS-domain transcription factor, Elk-1
40. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors