A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex

Molecular and Cellular Biology

Volumn 21, Issue 10, 2001, Pages 3514-3522

  Sutton, A ^a   Heller, R C ^a   Landry, J ^a   Choy, J S ^a   Sirko, A ^a   Sternglanz, R ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; HISTONE; HISTONE H1; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN SUM1 1; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN CONDENSATION; COMPLEX FORMATION; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; GENE CASSETTE; GENE LOCUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SILENCER GENE; TRANSCRIPTION REGULATION;

FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HISTONE DEACETYLASES; NUCLEAR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIRTUINS; TRANS-ACTIVATION (GENETICS);

SACCHAROMYCES CEREVISIAE;

EID: 0035037796     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.10.3514-3522.2001     Document Type: Article

References (37)

1. Using the two-hybrid system to detect protein-protein interactions
2. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
3. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
4. SUM1-1, a dominant suppressor of SIR mutations in Saccharomyces cerevisiae, increases transcriptional silencing at telomeres and HM mating-type loci and decreases chromosome stability
5. The transcriptional program of sporulation in budding yeast
6. HST1, a new member of the SIR2 family of genes
7. Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae
8. Gene silencing: Two faces of SIR2
9. Yeast heterochromatin: Regulation of its assembly and inheritance by histones
10. Transcriptional regulation of sporulation genes in yeast
11. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system
12. Transcriptional silencing and longevity protein Sir2 is an NAD- dependent histone deacetylase
13. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase
14. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
15. SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae
16. Role of NAD(+) in the deacetylase activity of the SIR2-like proteins
17. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
18. SUM1-1: A suppressor of silencing defects in Saccharomyces cerevisiae
19. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants
20. The sum1-1 mutation affects silent mating-type gene transcription in Saccharomyces cerevisiae
21. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
22. The origin recognition complex in silencing, cell cycle progression, and DNA replication
23. Silencing and heritable domains of gene expression
24. Mechanisms of silencing in Saccharomyces cerevisiae
25. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
26. A role for a replicator dominance mechanism in silencing
27. The conserved core of a human SIR2 homologue functions in yeast silencing
28. RAP1: A protean regulator in yeast
29. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
30. Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle
31. SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast
32. The SIT4 protein phosphatase functions in late G1 for progression into S phase
33. Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
34. Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing
35. A new paradigm for biochemical energy coupling. Salmonella typhimurium nicotinate phosphoribosyltransferase
36. Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae