Chlorpromazine attenuates pancreatic β-cell function and mass through IRS2 degradation, while exercise partially reverses the attenuation

Journal of Psychopharmacology

Volumn 22, Issue 5, 2008, Pages 522-531

  Park, S ^a   Hong, S M ^a   Lee, J E ^a   Sung, S R ^a   Kim, S H ^b  

^a Hoseo University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

cell mass; Insulin secretion; IRS2; PKC ; Ubiquitin proteasome degradation

Indexed keywords

CHLORPROMAZINE; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 2; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN KINASE C DELTA; ROTTLERIN; UBIQUITIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; DIABETES MELLITUS; DISEASE EXACERBATION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; EXERCISE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIC CLAMP; INSULIN RELEASE; LOW DRUG DOSE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS RESECTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; SYMPTOM;

ACETOPHENONES; ANIMALS; ANTIPSYCHOTIC AGENTS; BENZOPYRANS; CHLORPROMAZINE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HOMEOSTASIS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; MALE; PHYSICAL CONDITIONING, ANIMAL; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; UBIQUITIN;

EID: 49349092822     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881106081529     Document Type: Article

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