메뉴 건너뛰기




Volumn 97, Issue 1, 1996, Pages 180-186

Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagonlike peptide-1 (7-37)

Author keywords

animal models noninsulin dependent diabetes mellitus; fasting; insulin content; islet of Langerhans glucose metabolism; proinsulin biosynthesis

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 [7-37]; GLUCOSE; INSULIN; PROINSULIN; UNCLASSIFIED DRUG;

EID: 0030045655     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118387     Document Type: Article
Times cited : (71)

References (44)
  • 1
    • 0025142898 scopus 로고
    • Natural history of B-cell dysfunction in NIDDM
    • Leahy, J. L. 1990. Natural history of B-cell dysfunction in NIDDM. Diabetes Care 13 992-1010.
    • (1990) Diabetes Care , vol.13 , pp. 992-1010
    • Leahy, J.L.1
  • 2
    • 0026110135 scopus 로고
    • β-cells in type II diabetes mellitus
    • Porte, D., Jr. 1991 β-cells in type II diabetes mellitus. Diabetes 40:166-180
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte Jr., D.1
  • 3
    • 0026511753 scopus 로고
    • Beta-cell dysfunction induced by chronic hyperglycemia: Current ideas on the mechanism of the impaired glucose-induced insulin secretion
    • Leahy, J. L., S. Bonner-Weir, and G. C. Weir. 1992. Beta-cell dysfunction induced by chronic hyperglycemia: current ideas on the mechanism of the impaired glucose-induced insulin secretion Diabetes Care. 15:442-455.
    • (1992) Diabetes Care , vol.15 , pp. 442-455
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 4
    • 0018773208 scopus 로고
    • Potentiation of insulin secretory responses by plasma glucose levels in man: Evidence that hyperglycemia in diabetes compensates for impaired glucose potentiation
    • Halter, J. B , R. J. Graf, and D. Porte. Jr. 1979. Potentiation of insulin secretory responses by plasma glucose levels in man: evidence that hyperglycemia in diabetes compensates for impaired glucose potentiation. J. Clin. Endocrinol. & Metab 48.946-954.
    • (1979) J. Clin. Endocrinol. & Metab , vol.48 , pp. 946-954
    • Halter, J.B.1    Graf, R.J.2    Porte Jr., D.3
  • 5
    • 0021751981 scopus 로고
    • Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
    • Ward, W. K , D C. Bolgiano, B. McKnight, J B. Halter, and D. Porte, Jr. 1984. Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J. Clin Invest. 74:1318-1328.
    • (1984) J. Clin Invest. , vol.74 , pp. 1318-1328
    • Ward, W.K.1    Bolgiano, D.C.2    McKnight, B.3    Halter, J.B.4    Porte Jr., D.5
  • 6
    • 0027385108 scopus 로고
    • Beta-cell hypersensitivily for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats
    • Leahy, J. L , L. M. Bumbalo, and C. Chen. 1993. Beta-cell hypersensitivily for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats Diabetologia 36:1238-1244.
    • (1993) Diabetologia , vol.36 , pp. 1238-1244
    • Leahy, J.L.1    Bumbalo, L.M.2    Chen, C.3
  • 7
    • 0028107407 scopus 로고
    • Diazoxide causes recovery of β-cell glucose responsiveness in 90% pancreatectomized diabetic rats
    • Leahy, J. L., L. M. Bumbalo, and C. Chen. 1994. Diazoxide causes recovery of β-cell glucose responsiveness in 90% pancreatectomized diabetic rats. Diabetes 43:173-179.
    • (1994) Diabetes , vol.43 , pp. 173-179
    • Leahy, J.L.1    Bumbalo, L.M.2    Chen, C.3
  • 8
    • 0025677462 scopus 로고
    • Coupling of B-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats
    • Sako, Y., and V. E. Griil. 1990. Coupling of B-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats. Diabetes. 39:1580-1583.
    • (1990) Diabetes , vol.39 , pp. 1580-1583
    • Sako, Y.1    Griil, V.E.2
  • 9
    • 0027450505 scopus 로고
    • β-cell insensitivity in vitro: Reversal by diaxoxide entails more than one event m stimulus-secretion coupling
    • Bjorklund, A., and V. Grill. 1993. β-cell insensitivity in vitro: reversal by diaxoxide entails more than one event m stimulus-secretion coupling. Endocrinology. 132:1319-1328.
    • (1993) Endocrinology , vol.132 , pp. 1319-1328
    • Bjorklund, A.1    Grill, V.2
  • 10
    • 0017239486 scopus 로고
    • Improvement in insulin secretion in diabetes after diazoxidc
    • Greenwood, R. H , R. F. Mahler, and C. N. Hales. 1976. Improvement in insulin secretion in diabetes after diazoxidc. Lancet i:444-447.
    • (1976) Lancet , vol.1 , pp. 444-447
    • Greenwood, R.H.1    Mahler, R.F.2    Hales, C.N.3
  • 12
    • 0014783701 scopus 로고
    • The effect of fasting, diet, and actinomycin D on insulin secretion in the rat
    • Grey, N. J., S. Goldring, and D. M. Kipnis 1970 The effect of fasting, diet, and actinomycin D on insulin secretion in the rat. J. Clin. Invest 49:881-889.
    • (1970) J. Clin. Invest , vol.49 , pp. 881-889
    • Grey, N.J.1    Goldring, S.2    Kipnis, D.M.3
  • 13
    • 0017126877 scopus 로고
    • The stimulus-secretion coupling of glucose-induced insulin release. XX. Fasting: A model of altered glucose recognition by the β-cell
    • Levy, J , A. Herchuelz, A. Sener, and W. J Malaisse. 1976. The stimulus-secretion coupling of glucose-induced insulin release. XX. Fasting: a model of altered glucose recognition by the β-cell. Metab. Clin. Exp. 25:583-591.
    • (1976) Metab. Clin. Exp. , vol.25 , pp. 583-591
    • Levy, J.1    Herchuelz, A.2    Sener, A.3    Malaisse, W.J.4
  • 14
    • 0017073780 scopus 로고
    • 3H]-L-phenylalanine into proinsulin-insulin and total protein in isolated rat pancreatic islets
    • 3H]-L-phenylalanine into proinsulin-insulin and total protein in isolated rat pancreatic islets. Horm. Metab. Res. 8:261-266.
    • (1976) Horm. Metab. Res. , vol.8 , pp. 261-266
    • Tjioe, T.O.1    Bouman, P.R.2
  • 15
    • 0026463734 scopus 로고
    • Differential expression of rat pancreatic islet beta-cell glucose transporter (GLUT 2). proinsulin, and islet amyloid polypeptide genes after prolonged fasting, insulin-induced hypoglycemia and dexamethasone treatment
    • Koranyi, L., R Bourey. J. Turk, M Meuckler, and M. A. Permutt. 1992. Differential expression of rat pancreatic islet beta-cell glucose transporter (GLUT 2). proinsulin, and islet amyloid polypeptide genes after prolonged fasting, insulin-induced hypoglycemia and dexamethasone treatment. Diabetologia. 35.1125-1132.
    • (1992) Diabetologia , vol.35 , pp. 1125-1132
    • Koranyi, L.1    Bourey, R.2    Turk, J.3    Meuckler, M.4    Permutt, M.A.5
  • 16
    • 0028559799 scopus 로고
    • Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM
    • Féry, F., and E. O. Balasse. 1994. Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM. Diabetes. 43:1418-1425.
    • (1994) Diabetes , vol.43 , pp. 1418-1425
    • Féry, F.1    Balasse, E.O.2
  • 17
    • 0023107555 scopus 로고
    • Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • Mosjov, S., G. C. Weir, and J. F. Habener. 1987. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J. Clin. Invest. 79:616-619.
    • (1987) J. Clin. Invest. , vol.79 , pp. 616-619
    • Mosjov, S.1    Weir, G.C.2    Habener, J.F.3
  • 18
    • 0027296621 scopus 로고
    • Glucagon-like peptide I and the control of insulin secretion in the normal state and in NIDDM
    • Thorens, B., and G. Waeber. 1993. Glucagon-like peptide I and the control of insulin secretion in the normal state and in NIDDM. Diabetes 42: 1219-1225.
    • (1993) Diabetes , vol.42 , pp. 1219-1225
    • Thorens, B.1    Waeber, G.2
  • 19
    • 0024515406 scopus 로고
    • Glucagonlike peptide 1 (7-37) actions on endocrine pancreas
    • Weir, G. C., S. Mojsov, G. K. Hendrick. and J. F. Habener. 1989. Glucagonlike peptide 1 (7-37) actions on endocrine pancreas. Diabetes. 38:338-342.
    • (1989) Diabetes , vol.38 , pp. 338-342
    • Weir, G.C.1    Mojsov, S.2    Hendrick, G.K.3    Habener, J.F.4
  • 20
    • 0020636495 scopus 로고
    • Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
    • Bonner-Weir, S., D. F. Trent, and G. C. Weir 1983. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J. Clin Invest. 71:1544-1553.
    • (1983) J. Clin Invest. , vol.71 , pp. 1544-1553
    • Bonner-Weir, S.1    Trent, D.F.2    Weir, G.C.3
  • 21
    • 0023224147 scopus 로고
    • Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection
    • Gotoh, M., T. Maki, S. Satomi, J. Porter, S. Bonner-Weir, C. J. O'Hara, and A. P. Monaco. 1987. Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation. 43:725-730.
    • (1987) Transplantation , vol.43 , pp. 725-730
    • Gotoh, M.1    Maki, T.2    Satomi, S.3    Porter, J.4    Bonner-Weir, S.5    O'Hara, C.J.6    Monaco, A.P.7
  • 22
    • 0016197888 scopus 로고
    • Glucagon secretion from the perfused rat pancreas: Studies with glucose and catecholamines
    • Weir, G. C., S. D. Knowlton, and D. B Martin. 1974. Glucagon secretion from the perfused rat pancreas: studies with glucose and catecholamines. J. Clin. Invest. 54:1403-1412.
    • (1974) J. Clin. Invest. , vol.54 , pp. 1403-1412
    • Weir, G.C.1    Knowlton, S.D.2    Martin, D.B.3
  • 23
    • 0015371351 scopus 로고
    • A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties
    • Albano, J. D. M., R. P. Ekins, G. Maritz, and R. C. Turner. 1972. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol. 70:487-509.
    • (1972) Acta Endocrinol. , vol.70 , pp. 487-509
    • Albano, J.D.M.1    Ekins, R.P.2    Maritz, G.3    Turner, R.C.4
  • 24
  • 25
    • 0027418977 scopus 로고
    • The biosynthesis of the subtilisin-related proprotein convertase PC3, but not that of the PC2 cortvertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets
    • Alarcón, C., B. Lincoln, and C. J. Rhodes. 1993. The biosynthesis of the subtilisin-related proprotein convertase PC3, but not that of the PC2 cortvertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J. Biol. Chem 268:4276-4280.
    • (1993) J. Biol. Chem , vol.268 , pp. 4276-4280
    • Alarcón, C.1    Lincoln, B.2    Rhodes, C.J.3
  • 26
    • 0028912883 scopus 로고
    • Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of noninsuhn-dependent diabetes mellitus
    • Alarcón, C., J. L. Leahy, G. T. Schuppin, and C. J Rhodes 1995. Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of noninsuhn-dependent diabetes mellitus. J. Clin. Invest. 95.1032-1039.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1032-1039
    • Alarcón, C.1    Leahy, J.L.2    Schuppin, G.T.3    Rhodes, C.J.4
  • 27
    • 0023860467 scopus 로고
    • Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats
    • Brockenbrough, J S., G. C. Weir, and S. Bonner-Weir. 1988. Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes. 37:232-236.
    • (1988) Diabetes , vol.37 , pp. 232-236
    • Brockenbrough, J.S.1    Weir, G.C.2    Bonner-Weir, S.3
  • 28
    • 13344266943 scopus 로고
    • Growth of regenerating islet tissue is enhanced by VMH lesions
    • Abstr.
    • Bonner-Weir, S , D. Deery, and G. C. Weir. 1986. Growth of regenerating islet tissue is enhanced by VMH lesions. Diabetes. 35(Suppl. 1):97a. (Abstr.)
    • (1986) Diabetes , vol.35 , Issue.1 SUPPL.
    • Bonner-Weir, S.1    Deery, D.2    Weir, G.C.3
  • 29
    • 0028082510 scopus 로고
    • Management of non-insulin-dependent diabetes mellitus
    • Williams, G. 1994. Management of non-insulin-dependent diabetes mellitus. Lancet 343:95-100.
    • (1994) Lancet , vol.343 , pp. 95-100
    • Williams, G.1
  • 30
    • 0027176050 scopus 로고
    • Diet treatment of newly presenting type 2 diabetes improves insulin secretory capacity, but has no effect on insulin sensitivity
    • Hosker, J. P., S. Kumar, C. Gordon, D. Bhatnagar, M. France, and A. J. Boulton. 1993. Diet treatment of newly presenting type 2 diabetes improves insulin secretory capacity, but has no effect on insulin sensitivity. Diabetic Med. 10:509-513.
    • (1993) Diabetic Med , vol.10 , pp. 509-513
    • Hosker, J.P.1    Kumar, S.2    Gordon, C.3    Bhatnagar, D.4    France, M.5    Boulton, A.J.6
  • 31
    • 0021924908 scopus 로고
    • Influence of a 60-hour fast on insulin-mediated splanchnic and peripheral glucose metabolism in humans
    • Bjorkman, O., and L. S. Eriksson. 1985 Influence of a 60-hour fast on insulin-mediated splanchnic and peripheral glucose metabolism in humans. J Clin. Invest 76:87-92.
    • (1985) J Clin. Invest , vol.76 , pp. 87-92
    • Bjorkman, O.1    Eriksson, L.S.2
  • 32
    • 0017284222 scopus 로고
    • The stimulus-secretion coupling of glucose-induced insulin release. XXI. Fasting-induced adaption of key glycolytic enzymes in isolated islets
    • Malaisse, W. J., A. Sener, and J. Levy. 1976. The stimulus-secretion coupling of glucose-induced insulin release. XXI. Fasting-induced adaption of key glycolytic enzymes in isolated islets. J. Biol. Chem. 251:1731-1737.
    • (1976) J. Biol. Chem. , vol.251 , pp. 1731-1737
    • Malaisse, W.J.1    Sener, A.2    Levy, J.3
  • 33
    • 0019641366 scopus 로고
    • Adaption of glycolytic enzymes: Glucose use and insulin release in rat pancreatic islets during fasting and refeeding
    • Burch, P. T., M. D. Trus, D K. Berner, A. Leontire, K. C. Zawalich, and F. M. Matschinsky. 1981. Adaption of glycolytic enzymes: glucose use and insulin release in rat pancreatic islets during fasting and refeeding. Diabetes. 30 923-928
    • (1981) Diabetes , vol.30 , pp. 923-928
    • Burch, P.T.1    Trus, M.D.2    Berner, D.K.3    Leontire, A.4    Zawalich, K.C.5    Matschinsky, F.M.6
  • 34
    • 0022467904 scopus 로고
    • Pancreatic islet glucose metabolism and regulation of insulin secretion
    • Meglasson, M. D., and F. M. Matschinsky. 1986. Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev. 2:163-214
    • (1986) Diabetes Metab Rev. , vol.2 , pp. 163-214
    • Meglasson, M.D.1    Matschinsky, F.M.2
  • 35
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
    • Bonner-Weir, S., L. A. Baxter, G. T. Schuppin, and F. E Smith. 1993. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42:1715-1720.
    • (1993) Diabetes , vol.42 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 36
    • 0025880271 scopus 로고
    • B-cell dysfunction in hyperglycaemic rat models. Recovery of glucose-induced insulin secretion with lowering of the ambient glucose level
    • Leahy, J. L., and G. C. Weir. 1991 B-cell dysfunction in hyperglycaemic rat models. Recovery of glucose-induced insulin secretion with lowering of the ambient glucose level. Diabetologia 34:640-647.
    • (1991) Diabetologia , vol.34 , pp. 640-647
    • Leahy, J.L.1    Weir, G.C.2
  • 38
    • 0021137065 scopus 로고
    • Hexose metabolism in pancreatic islets. Inhibition of hexokinase
    • Malaisse, W. J. 1984. Hexose metabolism in pancreatic islets. Inhibition of hexokinase. Biochem. J. 223:447-453.
    • (1984) Biochem. J. , vol.223 , pp. 447-453
    • Malaisse, W.J.1
  • 39
    • 0028799912 scopus 로고
    • Upregulated hexokinase activity in isolated islets from diabetic 90% pancreatectomy rats
    • Hosokawa, H., Y. A Hosokawa, and J L Leahy. 1995. Upregulated hexokinase activity in isolated islets from diabetic 90% pancreatectomy rats Diabetes. 44:1328-1333.
    • (1995) Diabetes , vol.44 , pp. 1328-1333
    • Hosokawa, H.1    Hosokawa, Y.A.2    Leahy, J.L.3
  • 40
    • 0027994097 scopus 로고
    • Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels
    • Becker, T. C., H. BeltrandelRio, R. J. Noel, J. H. Johnson, and C. B Newgard. 1994. Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels J Biol Chem. 269:21234-21238.
    • (1994) J Biol Chem. , vol.269 , pp. 21234-21238
    • Becker, T.C.1    BeltrandelRio, H.2    Noel, R.J.3    Johnson, J.H.4    Newgard, C.B.5
  • 41
    • 0028000671 scopus 로고
    • Overexpression of hexokinase I but not GLUT1 glucose transporter alters concentration dependence of glucose-stimulated insulin secretion in pancreatic β-cell line MIN6
    • Ishihara, H., T. Asano, K. Tsukuda, H. Katagiri, K. Inukai, M. Anai, M Kikuchi, Y. Yazaki, J.-i. Miyazaki, and Y. Oka 1994. Overexpression of hexokinase I but not GLUT1 glucose transporter alters concentration dependence of glucose-stimulated insulin secretion in pancreatic β-cell line MIN6. J. Biol. Chem 269:3081-3087.
    • (1994) J. Biol. Chem , vol.269 , pp. 3081-3087
    • Ishihara, H.1    Asano, T.2    Tsukuda, K.3    Katagiri, H.4    Inukai, K.5    Anai, M.6    Kikuchi, M.7    Yazaki, Y.8    Miyazaki, J.-I.9    Oka, Y.10
  • 42
    • 0028198490 scopus 로고
    • Increased catalytic activity of glucokinase in isolated islets from hyperinsulinemic rats
    • Chen, C., L. M. Bumbalo, and J. L. Leahy. 1994. Increased catalytic activity of glucokinase in isolated islets from hyperinsulinemic rats. Diabetes 43: 684-689.
    • (1994) Diabetes , vol.43 , pp. 684-689
    • Chen, C.1    Bumbalo, L.M.2    Leahy, J.L.3
  • 44
    • 0025124031 scopus 로고
    • Impairment of the mitochondrial oxidative response to D-glucose in pancreatic islets from adult rats injected with streptozotocin during the neonatal period
    • Giroix, M.-H., A. Sener, D. Bailbe, B. Portha, and W. J. Malaisse. 1990. Impairment of the mitochondrial oxidative response to D-glucose in pancreatic islets from adult rats injected with streptozotocin during the neonatal period. Diabetologia. 33:654-660.
    • (1990) Diabetologia , vol.33 , pp. 654-660
    • Giroix, M.-H.1    Sener, A.2    Bailbe, D.3    Portha, B.4    Malaisse, W.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.