-
1
-
-
0025142898
-
Natural history of B-cell dysfunction in NIDDM
-
Leahy, J. L. 1990. Natural history of B-cell dysfunction in NIDDM. Diabetes Care 13 992-1010.
-
(1990)
Diabetes Care
, vol.13
, pp. 992-1010
-
-
Leahy, J.L.1
-
2
-
-
0026110135
-
β-cells in type II diabetes mellitus
-
Porte, D., Jr. 1991 β-cells in type II diabetes mellitus. Diabetes 40:166-180
-
(1991)
Diabetes
, vol.40
, pp. 166-180
-
-
Porte Jr., D.1
-
3
-
-
0026511753
-
Beta-cell dysfunction induced by chronic hyperglycemia: Current ideas on the mechanism of the impaired glucose-induced insulin secretion
-
Leahy, J. L., S. Bonner-Weir, and G. C. Weir. 1992. Beta-cell dysfunction induced by chronic hyperglycemia: current ideas on the mechanism of the impaired glucose-induced insulin secretion Diabetes Care. 15:442-455.
-
(1992)
Diabetes Care
, vol.15
, pp. 442-455
-
-
Leahy, J.L.1
Bonner-Weir, S.2
Weir, G.C.3
-
4
-
-
0018773208
-
Potentiation of insulin secretory responses by plasma glucose levels in man: Evidence that hyperglycemia in diabetes compensates for impaired glucose potentiation
-
Halter, J. B , R. J. Graf, and D. Porte. Jr. 1979. Potentiation of insulin secretory responses by plasma glucose levels in man: evidence that hyperglycemia in diabetes compensates for impaired glucose potentiation. J. Clin. Endocrinol. & Metab 48.946-954.
-
(1979)
J. Clin. Endocrinol. & Metab
, vol.48
, pp. 946-954
-
-
Halter, J.B.1
Graf, R.J.2
Porte Jr., D.3
-
5
-
-
0021751981
-
Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
-
Ward, W. K , D C. Bolgiano, B. McKnight, J B. Halter, and D. Porte, Jr. 1984. Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J. Clin Invest. 74:1318-1328.
-
(1984)
J. Clin Invest.
, vol.74
, pp. 1318-1328
-
-
Ward, W.K.1
Bolgiano, D.C.2
McKnight, B.3
Halter, J.B.4
Porte Jr., D.5
-
6
-
-
0027385108
-
Beta-cell hypersensitivily for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats
-
Leahy, J. L , L. M. Bumbalo, and C. Chen. 1993. Beta-cell hypersensitivily for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats Diabetologia 36:1238-1244.
-
(1993)
Diabetologia
, vol.36
, pp. 1238-1244
-
-
Leahy, J.L.1
Bumbalo, L.M.2
Chen, C.3
-
7
-
-
0028107407
-
Diazoxide causes recovery of β-cell glucose responsiveness in 90% pancreatectomized diabetic rats
-
Leahy, J. L., L. M. Bumbalo, and C. Chen. 1994. Diazoxide causes recovery of β-cell glucose responsiveness in 90% pancreatectomized diabetic rats. Diabetes 43:173-179.
-
(1994)
Diabetes
, vol.43
, pp. 173-179
-
-
Leahy, J.L.1
Bumbalo, L.M.2
Chen, C.3
-
8
-
-
0025677462
-
Coupling of B-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats
-
Sako, Y., and V. E. Griil. 1990. Coupling of B-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats. Diabetes. 39:1580-1583.
-
(1990)
Diabetes
, vol.39
, pp. 1580-1583
-
-
Sako, Y.1
Griil, V.E.2
-
9
-
-
0027450505
-
β-cell insensitivity in vitro: Reversal by diaxoxide entails more than one event m stimulus-secretion coupling
-
Bjorklund, A., and V. Grill. 1993. β-cell insensitivity in vitro: reversal by diaxoxide entails more than one event m stimulus-secretion coupling. Endocrinology. 132:1319-1328.
-
(1993)
Endocrinology
, vol.132
, pp. 1319-1328
-
-
Bjorklund, A.1
Grill, V.2
-
10
-
-
0017239486
-
Improvement in insulin secretion in diabetes after diazoxidc
-
Greenwood, R. H , R. F. Mahler, and C. N. Hales. 1976. Improvement in insulin secretion in diabetes after diazoxidc. Lancet i:444-447.
-
(1976)
Lancet
, vol.1
, pp. 444-447
-
-
Greenwood, R.H.1
Mahler, R.F.2
Hales, C.N.3
-
12
-
-
0014783701
-
The effect of fasting, diet, and actinomycin D on insulin secretion in the rat
-
Grey, N. J., S. Goldring, and D. M. Kipnis 1970 The effect of fasting, diet, and actinomycin D on insulin secretion in the rat. J. Clin. Invest 49:881-889.
-
(1970)
J. Clin. Invest
, vol.49
, pp. 881-889
-
-
Grey, N.J.1
Goldring, S.2
Kipnis, D.M.3
-
13
-
-
0017126877
-
The stimulus-secretion coupling of glucose-induced insulin release. XX. Fasting: A model of altered glucose recognition by the β-cell
-
Levy, J , A. Herchuelz, A. Sener, and W. J Malaisse. 1976. The stimulus-secretion coupling of glucose-induced insulin release. XX. Fasting: a model of altered glucose recognition by the β-cell. Metab. Clin. Exp. 25:583-591.
-
(1976)
Metab. Clin. Exp.
, vol.25
, pp. 583-591
-
-
Levy, J.1
Herchuelz, A.2
Sener, A.3
Malaisse, W.J.4
-
14
-
-
0017073780
-
3H]-L-phenylalanine into proinsulin-insulin and total protein in isolated rat pancreatic islets
-
3H]-L-phenylalanine into proinsulin-insulin and total protein in isolated rat pancreatic islets. Horm. Metab. Res. 8:261-266.
-
(1976)
Horm. Metab. Res.
, vol.8
, pp. 261-266
-
-
Tjioe, T.O.1
Bouman, P.R.2
-
15
-
-
0026463734
-
Differential expression of rat pancreatic islet beta-cell glucose transporter (GLUT 2). proinsulin, and islet amyloid polypeptide genes after prolonged fasting, insulin-induced hypoglycemia and dexamethasone treatment
-
Koranyi, L., R Bourey. J. Turk, M Meuckler, and M. A. Permutt. 1992. Differential expression of rat pancreatic islet beta-cell glucose transporter (GLUT 2). proinsulin, and islet amyloid polypeptide genes after prolonged fasting, insulin-induced hypoglycemia and dexamethasone treatment. Diabetologia. 35.1125-1132.
-
(1992)
Diabetologia
, vol.35
, pp. 1125-1132
-
-
Koranyi, L.1
Bourey, R.2
Turk, J.3
Meuckler, M.4
Permutt, M.A.5
-
16
-
-
0028559799
-
Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM
-
Féry, F., and E. O. Balasse. 1994. Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM. Diabetes. 43:1418-1425.
-
(1994)
Diabetes
, vol.43
, pp. 1418-1425
-
-
Féry, F.1
Balasse, E.O.2
-
17
-
-
0023107555
-
Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
-
Mosjov, S., G. C. Weir, and J. F. Habener. 1987. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J. Clin. Invest. 79:616-619.
-
(1987)
J. Clin. Invest.
, vol.79
, pp. 616-619
-
-
Mosjov, S.1
Weir, G.C.2
Habener, J.F.3
-
18
-
-
0027296621
-
Glucagon-like peptide I and the control of insulin secretion in the normal state and in NIDDM
-
Thorens, B., and G. Waeber. 1993. Glucagon-like peptide I and the control of insulin secretion in the normal state and in NIDDM. Diabetes 42: 1219-1225.
-
(1993)
Diabetes
, vol.42
, pp. 1219-1225
-
-
Thorens, B.1
Waeber, G.2
-
19
-
-
0024515406
-
Glucagonlike peptide 1 (7-37) actions on endocrine pancreas
-
Weir, G. C., S. Mojsov, G. K. Hendrick. and J. F. Habener. 1989. Glucagonlike peptide 1 (7-37) actions on endocrine pancreas. Diabetes. 38:338-342.
-
(1989)
Diabetes
, vol.38
, pp. 338-342
-
-
Weir, G.C.1
Mojsov, S.2
Hendrick, G.K.3
Habener, J.F.4
-
20
-
-
0020636495
-
Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
-
Bonner-Weir, S., D. F. Trent, and G. C. Weir 1983. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J. Clin Invest. 71:1544-1553.
-
(1983)
J. Clin Invest.
, vol.71
, pp. 1544-1553
-
-
Bonner-Weir, S.1
Trent, D.F.2
Weir, G.C.3
-
21
-
-
0023224147
-
Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection
-
Gotoh, M., T. Maki, S. Satomi, J. Porter, S. Bonner-Weir, C. J. O'Hara, and A. P. Monaco. 1987. Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation. 43:725-730.
-
(1987)
Transplantation
, vol.43
, pp. 725-730
-
-
Gotoh, M.1
Maki, T.2
Satomi, S.3
Porter, J.4
Bonner-Weir, S.5
O'Hara, C.J.6
Monaco, A.P.7
-
22
-
-
0016197888
-
Glucagon secretion from the perfused rat pancreas: Studies with glucose and catecholamines
-
Weir, G. C., S. D. Knowlton, and D. B Martin. 1974. Glucagon secretion from the perfused rat pancreas: studies with glucose and catecholamines. J. Clin. Invest. 54:1403-1412.
-
(1974)
J. Clin. Invest.
, vol.54
, pp. 1403-1412
-
-
Weir, G.C.1
Knowlton, S.D.2
Martin, D.B.3
-
23
-
-
0015371351
-
A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties
-
Albano, J. D. M., R. P. Ekins, G. Maritz, and R. C. Turner. 1972. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol. 70:487-509.
-
(1972)
Acta Endocrinol.
, vol.70
, pp. 487-509
-
-
Albano, J.D.M.1
Ekins, R.P.2
Maritz, G.3
Turner, R.C.4
-
24
-
-
0015297746
-
The pentose cycle and insulin release in mouse pancreatic islets
-
Ashcroft, S. J. H., L. C. C. Weerasighe, J. M. Bassett, and P. J. Randle. 1972. The pentose cycle and insulin release in mouse pancreatic islets. Biochem. J. 126:525-532.
-
(1972)
Biochem. J.
, vol.126
, pp. 525-532
-
-
Ashcroft, S.J.H.1
Weerasighe, L.C.C.2
Bassett, J.M.3
Randle, P.J.4
-
25
-
-
0027418977
-
The biosynthesis of the subtilisin-related proprotein convertase PC3, but not that of the PC2 cortvertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets
-
Alarcón, C., B. Lincoln, and C. J. Rhodes. 1993. The biosynthesis of the subtilisin-related proprotein convertase PC3, but not that of the PC2 cortvertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J. Biol. Chem 268:4276-4280.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 4276-4280
-
-
Alarcón, C.1
Lincoln, B.2
Rhodes, C.J.3
-
26
-
-
0028912883
-
Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of noninsuhn-dependent diabetes mellitus
-
Alarcón, C., J. L. Leahy, G. T. Schuppin, and C. J Rhodes 1995. Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of noninsuhn-dependent diabetes mellitus. J. Clin. Invest. 95.1032-1039.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 1032-1039
-
-
Alarcón, C.1
Leahy, J.L.2
Schuppin, G.T.3
Rhodes, C.J.4
-
27
-
-
0023860467
-
Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats
-
Brockenbrough, J S., G. C. Weir, and S. Bonner-Weir. 1988. Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes. 37:232-236.
-
(1988)
Diabetes
, vol.37
, pp. 232-236
-
-
Brockenbrough, J.S.1
Weir, G.C.2
Bonner-Weir, S.3
-
28
-
-
13344266943
-
Growth of regenerating islet tissue is enhanced by VMH lesions
-
Abstr.
-
Bonner-Weir, S , D. Deery, and G. C. Weir. 1986. Growth of regenerating islet tissue is enhanced by VMH lesions. Diabetes. 35(Suppl. 1):97a. (Abstr.)
-
(1986)
Diabetes
, vol.35
, Issue.1 SUPPL.
-
-
Bonner-Weir, S.1
Deery, D.2
Weir, G.C.3
-
29
-
-
0028082510
-
Management of non-insulin-dependent diabetes mellitus
-
Williams, G. 1994. Management of non-insulin-dependent diabetes mellitus. Lancet 343:95-100.
-
(1994)
Lancet
, vol.343
, pp. 95-100
-
-
Williams, G.1
-
30
-
-
0027176050
-
Diet treatment of newly presenting type 2 diabetes improves insulin secretory capacity, but has no effect on insulin sensitivity
-
Hosker, J. P., S. Kumar, C. Gordon, D. Bhatnagar, M. France, and A. J. Boulton. 1993. Diet treatment of newly presenting type 2 diabetes improves insulin secretory capacity, but has no effect on insulin sensitivity. Diabetic Med. 10:509-513.
-
(1993)
Diabetic Med
, vol.10
, pp. 509-513
-
-
Hosker, J.P.1
Kumar, S.2
Gordon, C.3
Bhatnagar, D.4
France, M.5
Boulton, A.J.6
-
31
-
-
0021924908
-
Influence of a 60-hour fast on insulin-mediated splanchnic and peripheral glucose metabolism in humans
-
Bjorkman, O., and L. S. Eriksson. 1985 Influence of a 60-hour fast on insulin-mediated splanchnic and peripheral glucose metabolism in humans. J Clin. Invest 76:87-92.
-
(1985)
J Clin. Invest
, vol.76
, pp. 87-92
-
-
Bjorkman, O.1
Eriksson, L.S.2
-
32
-
-
0017284222
-
The stimulus-secretion coupling of glucose-induced insulin release. XXI. Fasting-induced adaption of key glycolytic enzymes in isolated islets
-
Malaisse, W. J., A. Sener, and J. Levy. 1976. The stimulus-secretion coupling of glucose-induced insulin release. XXI. Fasting-induced adaption of key glycolytic enzymes in isolated islets. J. Biol. Chem. 251:1731-1737.
-
(1976)
J. Biol. Chem.
, vol.251
, pp. 1731-1737
-
-
Malaisse, W.J.1
Sener, A.2
Levy, J.3
-
33
-
-
0019641366
-
Adaption of glycolytic enzymes: Glucose use and insulin release in rat pancreatic islets during fasting and refeeding
-
Burch, P. T., M. D. Trus, D K. Berner, A. Leontire, K. C. Zawalich, and F. M. Matschinsky. 1981. Adaption of glycolytic enzymes: glucose use and insulin release in rat pancreatic islets during fasting and refeeding. Diabetes. 30 923-928
-
(1981)
Diabetes
, vol.30
, pp. 923-928
-
-
Burch, P.T.1
Trus, M.D.2
Berner, D.K.3
Leontire, A.4
Zawalich, K.C.5
Matschinsky, F.M.6
-
34
-
-
0022467904
-
Pancreatic islet glucose metabolism and regulation of insulin secretion
-
Meglasson, M. D., and F. M. Matschinsky. 1986. Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev. 2:163-214
-
(1986)
Diabetes Metab Rev.
, vol.2
, pp. 163-214
-
-
Meglasson, M.D.1
Matschinsky, F.M.2
-
35
-
-
0027449197
-
A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
-
Bonner-Weir, S., L. A. Baxter, G. T. Schuppin, and F. E Smith. 1993. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42:1715-1720.
-
(1993)
Diabetes
, vol.42
, pp. 1715-1720
-
-
Bonner-Weir, S.1
Baxter, L.A.2
Schuppin, G.T.3
Smith, F.E.4
-
36
-
-
0025880271
-
B-cell dysfunction in hyperglycaemic rat models. Recovery of glucose-induced insulin secretion with lowering of the ambient glucose level
-
Leahy, J. L., and G. C. Weir. 1991 B-cell dysfunction in hyperglycaemic rat models. Recovery of glucose-induced insulin secretion with lowering of the ambient glucose level. Diabetologia 34:640-647.
-
(1991)
Diabetologia
, vol.34
, pp. 640-647
-
-
Leahy, J.L.1
Weir, G.C.2
-
37
-
-
0018140326
-
The effect of sugars on (pro)insulin biosynthesis
-
Ashcroft, S. J. H., J. Bunce, M. Lowry, S. E. Hansen, and C J. Hedeskov. 1978. The effect of sugars on (pro)insulin biosynthesis. Biochem. J. 174: 517-526.
-
(1978)
Biochem. J.
, vol.174
, pp. 517-526
-
-
Ashcroft, S.J.H.1
Bunce, J.2
Lowry, M.3
Hansen, S.E.4
Hedeskov, C.J.5
-
38
-
-
0021137065
-
Hexose metabolism in pancreatic islets. Inhibition of hexokinase
-
Malaisse, W. J. 1984. Hexose metabolism in pancreatic islets. Inhibition of hexokinase. Biochem. J. 223:447-453.
-
(1984)
Biochem. J.
, vol.223
, pp. 447-453
-
-
Malaisse, W.J.1
-
39
-
-
0028799912
-
Upregulated hexokinase activity in isolated islets from diabetic 90% pancreatectomy rats
-
Hosokawa, H., Y. A Hosokawa, and J L Leahy. 1995. Upregulated hexokinase activity in isolated islets from diabetic 90% pancreatectomy rats Diabetes. 44:1328-1333.
-
(1995)
Diabetes
, vol.44
, pp. 1328-1333
-
-
Hosokawa, H.1
Hosokawa, Y.A.2
Leahy, J.L.3
-
40
-
-
0027994097
-
Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels
-
Becker, T. C., H. BeltrandelRio, R. J. Noel, J. H. Johnson, and C. B Newgard. 1994. Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels J Biol Chem. 269:21234-21238.
-
(1994)
J Biol Chem.
, vol.269
, pp. 21234-21238
-
-
Becker, T.C.1
BeltrandelRio, H.2
Noel, R.J.3
Johnson, J.H.4
Newgard, C.B.5
-
41
-
-
0028000671
-
Overexpression of hexokinase I but not GLUT1 glucose transporter alters concentration dependence of glucose-stimulated insulin secretion in pancreatic β-cell line MIN6
-
Ishihara, H., T. Asano, K. Tsukuda, H. Katagiri, K. Inukai, M. Anai, M Kikuchi, Y. Yazaki, J.-i. Miyazaki, and Y. Oka 1994. Overexpression of hexokinase I but not GLUT1 glucose transporter alters concentration dependence of glucose-stimulated insulin secretion in pancreatic β-cell line MIN6. J. Biol. Chem 269:3081-3087.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 3081-3087
-
-
Ishihara, H.1
Asano, T.2
Tsukuda, K.3
Katagiri, H.4
Inukai, K.5
Anai, M.6
Kikuchi, M.7
Yazaki, Y.8
Miyazaki, J.-I.9
Oka, Y.10
-
42
-
-
0028198490
-
Increased catalytic activity of glucokinase in isolated islets from hyperinsulinemic rats
-
Chen, C., L. M. Bumbalo, and J. L. Leahy. 1994. Increased catalytic activity of glucokinase in isolated islets from hyperinsulinemic rats. Diabetes 43: 684-689.
-
(1994)
Diabetes
, vol.43
, pp. 684-689
-
-
Chen, C.1
Bumbalo, L.M.2
Leahy, J.L.3
-
43
-
-
0028985060
-
Pancreatic β-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids
-
Milburn, J. L., Jr., H. Hirose, Y. H. Lee, Y. Nagasawa, A. Ogawa, M Ohneda, H. BeltrandelRio, C. B. Newgard, J. H. Johnson, and R. H. Unger. 1995. Pancreatic β-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids J Biol Chem. 270:1295-1299.
-
(1995)
J Biol Chem.
, vol.270
, pp. 1295-1299
-
-
Milburn Jr., J.L.1
Hirose, H.2
Lee, Y.H.3
Nagasawa, Y.4
Ogawa, A.5
Ohneda, M.6
Beltrandelrio, H.7
Newgard, C.B.8
Johnson, J.H.9
Unger, R.H.10
-
44
-
-
0025124031
-
Impairment of the mitochondrial oxidative response to D-glucose in pancreatic islets from adult rats injected with streptozotocin during the neonatal period
-
Giroix, M.-H., A. Sener, D. Bailbe, B. Portha, and W. J. Malaisse. 1990. Impairment of the mitochondrial oxidative response to D-glucose in pancreatic islets from adult rats injected with streptozotocin during the neonatal period. Diabetologia. 33:654-660.
-
(1990)
Diabetologia
, vol.33
, pp. 654-660
-
-
Giroix, M.-H.1
Sener, A.2
Bailbe, D.3
Portha, B.4
Malaisse, W.J.5
|