Physical training may enhance β-cell function in type 2 diabetes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 287, Issue 5 50-5, 2004, Pages

  Dela, Flemming ^a   Von Linstow, Michael E ^b   Mikines, Kári Joensen ^a,c   Galbo, Henrik ^a,d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^d BISPEBJERG HOSPITAL   (Denmark)

Author keywords

Arginine; C peptide; Hyperglycemic clamp; Insulin

Indexed keywords

ARGININE; C PEPTIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN;

ADULT; ARTICLE; BICYCLE ERGOMETER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GLUCOSE HOMEOSTASIS; GLUCOSE UTILIZATION; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; LIFESTYLE; MALE; MUSCLE TRAINING; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

ADAPTATION, PHYSIOLOGICAL; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 2; EXERCISE; EXERTION; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; PHYSICAL FITNESS;

EID: 6044274618     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00056.2004     Document Type: Article

References (40)

1. Bogardus C, Ravussin E, Robbins DC, Wolfe RR, Horton ES, and Sims EAH. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes 33: 311-318, 1984.
2. Boule NG, Haddad E, Kenny GP, Wells GA, and Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus. A meta-analysis of controlled clinical trials. JAMA 286: 1218-1227, 2001.
3. DeFronzo RA, Bonadonna RC, and Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care 15: 318-368, 1992.
4. Dela F, Mikines KJ, and Galbo H. Physical activity and insulin resistance in man. In: Insulin Resistance, edited by Reaven GM and Laws A. Totowa, NJ: Humana, 1998, p. 97-120.
5. Dela F, Mikines KJ, Larsen JJ, Ploug T, Petersen LN, and Galbo H. Insulin-stimulated muscle glucose clearance in patients with type 2 diabetes mellitus. Effects of one-legged physical training. Diabetes 44: 1010-1020, 1995.
6. Dela F, Mikines KJ, Tronier B, and Galbo H. Diminished arginine-stimulated insulin secretion in trained men. J Appl Physiol 69: 261-267, 1990.
7. Durnin JV and Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32: 77-97, 1974.
8. Eriksson KF and Lindgärde F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. Diabetologia 34: 891-898, 1991.
9. Farrell PA, Caston AL, and Rodd D. Changes in insulin response to glucose after exercise training in partially pancreatectomized rats. J Appl Physiol 70: 1563-1568, 1991.
10. Flier SN, Kulkarni RN, and Kahn CR. Evidence for a circulating islet cell growth factor in insulin-resistant states. Proc Natl Acad Sci USA 98: 7475-7480, 2001.
11. Galbo H and Kjær M. Endocrinology and metabolism in exercise: future research directions. Can J Spt Sci 12, Suppl 1: 102S-107S, 1987.
12. Helmrich SP, Ragland DR, Leung RW, and Paffenbarger RS. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 325: 147-152, 1991.
13. ATP channel: molecular cloning, expression and biological properties. Proc Natl Acad Sci USA 95: 8387-8391, 1998.
14. Holten MK, Zacho M, Gaster M, Juel C, Wojtaszewski JFP, and Dela F. Strength training increases insulin-mediated glucose uptake, GLUT4 content and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes 53: 294-305, 2004.
15. Hu FB, Sigal RJ, Rich-Edwards JW, Colditz GA, Solomon CG, Willett WC, Speizer FE, and Manson JE. Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. JAMA 282: 1433-1439, 1999.
16. King DS, Dalsky GP, Staten MA, Clutter WE, Van Houten DR, and Holloszy JO. Insulin action and secretion in endurance-trained and untrained humans. J Appl Physiol 63: 2247-2252, 1987.
17. King DS, Feltmeyer TL, Baldus PJ, Sharp RL, and Nespor J. Effects of eccentric exercise on insulin secretion and action in humans. J Appl Physiol 75: 2151-2156, 1993.
18. King DS, Staten MA, Kohrt WM, Dalsky GP, Elahi D, and Holloszy JO. Insulin secretory capacity in endurance-trained and untrained young men. Am J Physiol Endocrinol Metab 259: E155-E161, 1990.
19. Kirwan JP, Kohrt WM, Wojta DM, Bourey RE, and Holloszy JO. Endurance exercise training reduces glucose-stimulated insulin levels in 60- to 70-year-old men and women. J Gerontol 48: M84-M90, 1993.
20. Krotkiewski M, Lönnroth P, Mandroukas K, Wroblewski Z, and Rebuffé-Scrive M. The effects of physical training on insulin secretion and effectiveness and on glucose metabolism in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 28: 881-890, 1985.
21. Ligtenberg PC, Hoekstra JB, Bol E, Zonderland ML, and Erkelens DW. Effects of physical training on metabolic control in elderly type 2 diabetes mellitus patients. Clin Sci (Lond) 93: 127-135, 1997.
22. Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, and Hennekens CH. A prospective study of exercise and incidence of diabetes among United States male physicians. JAMA 268: 63-67, 1992.
23. Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, Rosner B, Hennekens CH, and Speizer FE. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338: 774-778, 1991.
24. Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, and Kahn CR. A model to explore the interaction between muscle insulin resistance and β-cell dysfunction in the development of type 2 diabetes. Diabetes 49: 2126-2134, 2000.
25. Mikines KJ. The influence of physical activity and inactivity on insulin action and secretion in man. Acta Physiol Scand 146, Suppl 609: 1-43, 1992.
26. Mikines KJ, Farrell PA, Sonne B, Tronier B, and Galbo H. Postexercise dose-response relationship between plasma glucose and insulin secretion. J Appl Physiol 64: 988-999, 1988.
27. Mikines KJ, Sonne B, Tronier B, and Galbo H. Effects of training and detraining on dose-response relationship between glucose and insulin secretion. Am J Physiol Endocrinol Metab 256: E588-E596, 1989.
28. Mourier A, Gautier JF, De Kerviler E, Bigard AX, Villette JM, Garnier JP, Duvallet A, Guezennec CY, and Cathelineau G. Mobilization of visceral adipose tissue related to the improvement in insulin sensitivity in response to physical training in NDDM. Effects of branched-chain amino acid supplements. Diabetes Care 20: 385-391, 1997.
29. 2 max. J Appl Physiol 66: 2206-2210, 1989.
30. Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, Hu ZX, Lin J, Xiao JZ, Cao HB, Liu PA, Jiang XG, Jiang YY, Wang JP, Zheng H, Zhang H, Bennett PH, and Howard BV. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20: 537-544, 1997.
31. Reitman JS, Vasquez B, Klimes I, and Nagulesparan M. Improvement of glucose homeostasis after exercise training in non-insulin-dependent diabetes. Diabetes Care 7: 434-441, 1984.
32. Rönnemaa T, Mattila K, Lehtonen A, and Kallio V. A controlled randomized study on the effect of long-term physical exercise on the metabolic control in type 2 diabetic patients. Acta Med Scand 220: 219-224, 1986.
33. Schneider SH, Amorosa LF, Khachadurian AK, and Ruderman NB. Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes. Diabetologia 26: 355-360, 1984.
34. Segal KR, Edano A, Abalos A, Albu J, Blando L, Tomas MB, and Pi-Sunyer FX. Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. J Appl Physiol 71: 2402-2411, 1991.
35. Trovati M, Carta Q, Cavalot F, Vitali S, Banaudi C, Lucchina PG, Fiocchi F, Emanuelli G, and Lenti G. Influence of physical training on blood glucose control, glucose tolerance, insulin secretion, and insulin action in non-insulin-dependent diabetic patients. Diabetes Care 7: 416-420, 1984.
36. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, and Uusitupa M. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344: 1343-1350, 2001.
37. Unger RH and Grundy S. Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 28: 119-121, 1985.
38. Wei M, Gibbons LW, Mitchell TL, Kampert JB, Lee CD, and Blair SN. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med 130: 89-96, 1999. [Erratum. Ann Intern Med 131: September 1999, p. 394.]
39. Wei M, Gibbons LW, Mitchell TL, Kampert JB, Lee CD, and Blair SN. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Ann Intern Med 130: 89-96, 1999. [Erratum. Ann Intern Med 131: September 1999, p. 394.]
40. Yamanouchi K, Shinozaki T, Chikada K, Nishikawa T, Ito K, Shimizu S, Ozawa N, Suzuki Y, Maeno H, Kato K, Oshida Y, and Sato YZ. Daily walking combined with diet therapy is a useful means for obese NIDDM patients not only to reduce body weight but also to improve insulin sensitivity. Diabetes Care 18: 775-778, 1995.