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Volumn 10, Issue 22, 2008, Pages

Critical molecular abnormalities in high-grade serous carcinoma of the ovary

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN E; EPIDERMAL GROWTH FACTOR RECEPTOR; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PLATINUM DERIVATIVE; PROTEIN P53; RETINOBLASTOMA PROTEIN; ROSCOVITINE; TRANSCRIPTION FACTOR E2F; TRASTUZUMAB; TYROSINE KINASE RECEPTOR;

EID: 49149110001     PISSN: 14623994     EISSN: 14623994     Source Type: Journal    
DOI: 10.1017/S146239940800077X     Document Type: Review
Times cited : (50)

References (92)
  • 2
    • 0035008525 scopus 로고    scopus 로고
    • Ovarian surface epithelium: Biology, endocrinology, and pathology
    • Auersperg, N. et al. (2001) Ovarian surface epithelium: Biology, endocrinology, and pathology. Endocr Rev 22, 255-288
    • (2001) Endocr Rev , vol.22 , pp. 255-288
    • Auersperg, N.1
  • 3
    • 36048974673 scopus 로고    scopus 로고
    • Lessons from BRCA: The tubal fimbria emerges as an origin for pelvic serous cancer
    • Crum, C.P. et al. (2007) Lessons from BRCA: The tubal fimbria emerges as an origin for pelvic serous cancer. Clin Med Res 5, 35-44
    • (2007) Clin Med Res , vol.5 , pp. 35-44
    • Crum, C.P.1
  • 4
    • 47749086997 scopus 로고    scopus 로고
    • Tumor cell type can reproducibly diagnosed and is of independent prognostic significance in patients with maximally debulked ovarian carcinoma
    • in press
    • Gilks, C.B. et al. (2008) Tumor cell type can reproducibly diagnosed and is of independent prognostic significance in patients with maximally debulked ovarian carcinoma. Hum Pathol (in press)
    • (2008) Hum Pathol
    • Gilks, C.B.1
  • 5
    • 0347511893 scopus 로고    scopus 로고
    • The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin
    • Seidman, J.D. et al. (2004) The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin. Int J Gynecol Pathol 23, 41-44
    • (2004) Int J Gynecol Pathol , vol.23 , pp. 41-44
    • Seidman, J.D.1
  • 6
    • 41349105997 scopus 로고    scopus 로고
    • Histologic subtypes of ovarian carcinoma: An overview
    • Soslow, R.A. (2008) Histologic subtypes of ovarian carcinoma: An overview. Int J Gynecol Pathol 27, 161-74
    • (2008) Int J Gynecol Pathol , vol.27 , pp. 161-174
    • Soslow, R.A.1
  • 7
    • 33646828032 scopus 로고    scopus 로고
    • Clear cell carcinoma of the ovary: A retrospective multicentre experience of 254 patients with complete surgical staging
    • Takano, M. et al. (2006) Clear cell carcinoma of the ovary: A retrospective multicentre experience of 254 patients with complete surgical staging. Br J Cancer 94, 1369-1374
    • (2006) Br J Cancer , vol.94 , pp. 1369-1374
    • Takano, M.1
  • 8
    • 0041329867 scopus 로고    scopus 로고
    • A randomized clinical trial of cisplatin/ paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer
    • duBois, A. et al. (2003) A randomized clinical trial of cisplatin/ paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst 95, 1320-1329
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1320-1329
    • duBois, A.1
  • 9
    • 0037125582 scopus 로고    scopus 로고
    • Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: The ICON3 randomised trial, 2002 Lancet 360, 505-515
    • Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: The ICON3 randomised trial. (2002) Lancet 360, 505-515
  • 10
    • 1942469352 scopus 로고    scopus 로고
    • Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis
    • Shih, I. and Kurman, R.J. (2004) Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis. Am J Pathol 164, 1511-1518
    • (2004) Am J Pathol , vol.164 , pp. 1511-1518
    • Shih, I.1    Kurman, R.J.2
  • 11
    • 47249164396 scopus 로고    scopus 로고
    • Interobserver variation in diagnosing mixed ovarian epithelial carcinoma with a clear cell component
    • Han, G. et al. (2008) Interobserver variation in diagnosing mixed ovarian epithelial carcinoma with a clear cell component. Am J Surg Pathol 32, 955-964
    • (2008) Am J Surg Pathol , vol.32 , pp. 955-964
    • Han, G.1
  • 12
    • 49149083196 scopus 로고    scopus 로고
    • A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary
    • in press
    • Köbel, M. et al. (2008) A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary. Am J Surg Pathol (in press)
    • (2008) Am J Surg Pathol
    • Köbel, M.1
  • 13
    • 11844275908 scopus 로고    scopus 로고
    • Immunohistochemical expression of wilms tumor gene protein in different histologic subtypes of ovarian carcinomas
    • Waldstrom, M. and Grove, A. (2005) Immunohistochemical expression of wilms tumor gene protein in different histologic subtypes of ovarian carcinomas. Arch Pathol Lab Med 129, 85-88
    • (2005) Arch Pathol Lab Med , vol.129 , pp. 85-88
    • Waldstrom, M.1    Grove, A.2
  • 14
    • 1542270080 scopus 로고    scopus 로고
    • WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma
    • Al Hussaini, M. et al. (2004) WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma. Histopathology 44, 109-115
    • (2004) Histopathology , vol.44 , pp. 109-115
    • Al Hussaini, M.1
  • 15
    • 1842581590 scopus 로고    scopus 로고
    • Grading ovarian serous carcinoma using a two-tier system
    • Malpica, A. et al. (2004) Grading ovarian serous carcinoma using a two-tier system. Am J Surg Pathol 28, 496-504
    • (2004) Am J Surg Pathol , vol.28 , pp. 496-504
    • Malpica, A.1
  • 16
    • 34547627444 scopus 로고    scopus 로고
    • Interobserver and intraobserver variability of a two-tier system for grading ovarian serous carcinoma
    • Malpica, A. et al. (2007) Interobserver and intraobserver variability of a two-tier system for grading ovarian serous carcinoma. Am J Surg Pathol 31, 1168-1174
    • (2007) Am J Surg Pathol , vol.31 , pp. 1168-1174
    • Malpica, A.1
  • 17
    • 0037454224 scopus 로고    scopus 로고
    • Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
    • Singer, G. et al. (2003) Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 95, 484-486
    • (2003) J Natl Cancer Inst , vol.95 , pp. 484-486
    • Singer, G.1
  • 18
    • 12844251290 scopus 로고    scopus 로고
    • Patterns of p53 mutations separate ovarian serous borderline tumors and low-and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: A mutational analysis with immunohistochemical correlation
    • Singer, G. et al. (2005) Patterns of p53 mutations separate ovarian serous borderline tumors and low-and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: A mutational analysis with immunohistochemical correlation. Am J Surg Pathol 29, 218-224
    • (2005) Am J Surg Pathol , vol.29 , pp. 218-224
    • Singer, G.1
  • 19
    • 0036149402 scopus 로고    scopus 로고
    • Response and survival in patients with progressive or recurrent serous ovarian tumors of low malignant potential
    • Crispens, M.A. et al. (2002) Response and survival in patients with progressive or recurrent serous ovarian tumors of low malignant potential. Obstet Gynecol 99, 3-10
    • (2002) Obstet Gynecol , vol.99 , pp. 3-10
    • Crispens, M.A.1
  • 20
    • 33748122161 scopus 로고    scopus 로고
    • Clinical behavior of stage II-IV low-grade serous carcinoma of the ovary
    • Gershenson, D.M. et al. (2006) Clinical behavior of stage II-IV low-grade serous carcinoma of the ovary. Obstet Gynecol 108, 361-368
    • (2006) Obstet Gynecol , vol.108 , pp. 361-368
    • Gershenson, D.M.1
  • 21
    • 41349100528 scopus 로고    scopus 로고
    • Pathogenesis of ovarian cancer: Lessons from morphology and molecular biology and their clinical implications
    • Kurman, R.J. and Shih, I. (2008) Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications. Int J Gynecol Pathol 27, 151-160
    • (2008) Int J Gynecol Pathol , vol.27 , pp. 151-160
    • Kurman, R.J.1    Shih, I.2
  • 22
    • 3042737680 scopus 로고    scopus 로고
    • Subclassification of ovarian surface epithelial tumors based on correlation of histologic and molecular pathologic data
    • Gilks, C.B. (2004) Subclassification of ovarian surface epithelial tumors based on correlation of histologic and molecular pathologic data. Int J Gynecol Pathol 23, 200-205
    • (2004) Int J Gynecol Pathol , vol.23 , pp. 200-205
    • Gilks, C.B.1
  • 23
    • 33645225423 scopus 로고    scopus 로고
    • The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome
    • Medeiros, F. et al. (2006) The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome. Am J Surg Pathol 30, 230-236
    • (2006) Am J Surg Pathol , vol.30 , pp. 230-236
    • Medeiros, F.1
  • 24
    • 33846624310 scopus 로고    scopus 로고
    • Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship
    • Kindelberger, D.W. et al. (2007) Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship. Am J Surg Pathol 31, 161-169
    • (2007) Am J Surg Pathol , vol.31 , pp. 161-169
    • Kindelberger, D.W.1
  • 25
    • 49149112132 scopus 로고    scopus 로고
    • Chromosomal instability in fallopian tube precursor lesions of serous carcinoma and frequent monoclonality of synchronous ovarian and fallopian tube mucosal serous carcinoma
    • in press
    • Salvador, S. et al. (2008) Chromosomal instability in fallopian tube precursor lesions of serous carcinoma and frequent monoclonality of synchronous ovarian and fallopian tube mucosal serous carcinoma. Gynecol Oncol (in press)
    • (2008) Gynecol Oncol
    • Salvador, S.1
  • 26
    • 49149088337 scopus 로고    scopus 로고
    • The Fallopian Tube: Primary Site of Most Pelvic High-Grade Serous Carcinomas
    • in press
    • Salvador, S. et al. (2008) The Fallopian Tube: Primary Site of Most Pelvic High-Grade Serous Carcinomas. Int J Gynecol Cancer (in press)
    • (2008) Int J Gynecol Cancer
    • Salvador, S.1
  • 27
    • 33746100822 scopus 로고    scopus 로고
    • Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer
    • Tutt, A.N. et al. (2005) Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer. Cold Spring Harb Symp Quant Biol 70, 139-148
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 139-148
    • Tutt, A.N.1
  • 28
    • 0035801472 scopus 로고    scopus 로고
    • Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences
    • Tutt, A. et al. (2001) Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. EMBO J 20, 4704-4716
    • (2001) EMBO J , vol.20 , pp. 4704-4716
    • Tutt, A.1
  • 29
    • 0035954651 scopus 로고    scopus 로고
    • Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation
    • Modan, B. et al. (2001) Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation. N Engl J Med 345, 235-240
    • (2001) N Engl J Med , vol.345 , pp. 235-240
    • Modan, B.1
  • 30
    • 0033927850 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer
    • Moslehi, R. et al. (2000) BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer. Am J Hum Genet 66, 1259-1272
    • (2000) Am J Hum Genet , vol.66 , pp. 1259-1272
    • Moslehi, R.1
  • 31
    • 0035098503 scopus 로고    scopus 로고
    • Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer
    • Risch, H.A. et al. (2001) Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet 68, 700-710
    • (2001) Am J Hum Genet , vol.68 , pp. 700-710
    • Risch, H.A.1
  • 32
    • 0037130885 scopus 로고    scopus 로고
    • Inactivation of BRCA1 and BRCA2 in ovarian cancer
    • Hilton, J.L. et al. (2002) Inactivation of BRCA1 and BRCA2 in ovarian cancer. J Natl Cancer Inst 94, 1396-1406
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1396-1406
    • Hilton, J.L.1
  • 33
    • 39549091276 scopus 로고    scopus 로고
    • Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities
    • Press, J.Z. et al. (2008) Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities. BMC Cancer 8, 17
    • (2008) BMC Cancer , vol.8 , pp. 17
    • Press, J.Z.1
  • 34
    • 0036784347 scopus 로고    scopus 로고
    • Histopathologic features of genetically determined ovarian cancer
    • Shaw, P.A. et al. (2002) Histopathologic features of genetically determined ovarian cancer. Int J Gynecol Pathol 21, 407-411
    • (2002) Int J Gynecol Pathol , vol.21 , pp. 407-411
    • Shaw, P.A.1
  • 35
    • 9444222467 scopus 로고    scopus 로고
    • Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer
    • Foster, K.A. et al. (1996) Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer. Cancer Res 56, 3622-3625
    • (1996) Cancer Res , vol.56 , pp. 3622-3625
    • Foster, K.A.1
  • 36
    • 0030818584 scopus 로고    scopus 로고
    • Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers
    • Collins, N. et al. (1997) Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers. Br J Cancer 76, 1150-1156
    • (1997) Br J Cancer , vol.76 , pp. 1150-1156
    • Collins, N.1
  • 37
    • 30444457408 scopus 로고    scopus 로고
    • Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas
    • Brown, L.A. et al. (2006) Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas. Gynecol Oncol 100, 264-270
    • (2006) Gynecol Oncol , vol.100 , pp. 264-270
    • Brown, L.A.1
  • 38
    • 24744443338 scopus 로고    scopus 로고
    • Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY
    • Raouf, A. et al. (2005) Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY. J Natl Cancer Inst 97, 1302-1306
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1302-1306
    • Raouf, A.1
  • 39
    • 0034600109 scopus 로고    scopus 로고
    • Clinicopathologic features of BRCA-linked and sporadic ovarian cancer
    • Boyd, J. et al. (2000) Clinicopathologic features of BRCA-linked and sporadic ovarian cancer. JAMA 283, 2260-2265
    • (2000) JAMA , vol.283 , pp. 2260-2265
    • Boyd, J.1
  • 40
    • 0037080115 scopus 로고    scopus 로고
    • Effect of BRCA mutations on the length of survival in epithelial ovarian tumors
    • Ben David, Y. et al. (2002) Effect of BRCA mutations on the length of survival in epithelial ovarian tumors. J Clin Oncol 20, 463-466
    • (2002) J Clin Oncol , vol.20 , pp. 463-466
    • Ben David, Y.1
  • 41
    • 37549025804 scopus 로고    scopus 로고
    • BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy
    • Quinn, J.E. et al. (2007) BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy. Clin Cancer Res 13, 7413-7420
    • (2007) Clin Cancer Res , vol.13 , pp. 7413-7420
    • Quinn, J.E.1
  • 42
    • 0034604716 scopus 로고    scopus 로고
    • The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
    • Bhattacharyya, A. et al. (2000) The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin. J Biol Chem 275, 23899-23903
    • (2000) J Biol Chem , vol.275 , pp. 23899-23903
    • Bhattacharyya, A.1
  • 43
    • 0036178190 scopus 로고    scopus 로고
    • Current understanding of the epidemiology and clinical implications of BRCA1 and BRCA2 mutations for ovarian cancer
    • Narod, S.A. and Boyd, J. (2002) Current understanding of the epidemiology and clinical implications of BRCA1 and BRCA2 mutations for ovarian cancer. Curr Opin Obstet Gynecol 14, 19-26
    • (2002) Curr Opin Obstet Gynecol , vol.14 , pp. 19-26
    • Narod, S.A.1    Boyd, J.2
  • 44
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer, H. et al. (2005) Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917-921
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1
  • 45
    • 39849106300 scopus 로고    scopus 로고
    • Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
    • Sakai, W. et al. (2008) Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature 451, 1116-1120
    • (2008) Nature , vol.451 , pp. 1116-1120
    • Sakai, W.1
  • 46
    • 39849097680 scopus 로고    scopus 로고
    • Resistance to therapy caused by intragenic deletion in BRCA2
    • Edwards, S.L. et al. (2008) Resistance to therapy caused by intragenic deletion in BRCA2. Nature 451, 1111-1115
    • (2008) Nature , vol.451 , pp. 1111-1115
    • Edwards, S.L.1
  • 47
    • 42349096328 scopus 로고    scopus 로고
    • Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
    • Swisher, E.M. et al. (2008) Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. Cancer Res 68, 2581-2586
    • (2008) Cancer Res , vol.68 , pp. 2581-2586
    • Swisher, E.M.1
  • 48
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein, B. and Kinzler, K.W. (2004) Cancer genes and the pathways they control. Nat Med 10, 789-799
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 49
    • 33749482498 scopus 로고    scopus 로고
    • A mouse model for the molecular characterization of brca1-associated ovarian carcinoma
    • Xing, D. and Orsulic, S. (2006) A mouse model for the molecular characterization of brca1-associated ovarian carcinoma. Cancer Res 66, 8949-8953
    • (2006) Cancer Res , vol.66 , pp. 8949-8953
    • Xing, D.1    Orsulic, S.2
  • 50
    • 0038756581 scopus 로고    scopus 로고
    • Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium
    • Flesken-Nikitin, A. et al. (2003) Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium. Cancer Res 63, 3459-3463
    • (2003) Cancer Res , vol.63 , pp. 3459-3463
    • Flesken-Nikitin, A.1
  • 51
    • 34047171574 scopus 로고    scopus 로고
    • Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/ Pten signaling pathways
    • Wu, R. et al. (2007) Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/ Pten signaling pathways. Cancer Cell 11, 321-333
    • (2007) Cancer Cell , vol.11 , pp. 321-333
    • Wu, R.1
  • 52
    • 0034001772 scopus 로고    scopus 로고
    • Loss of heterozygosity on chromosome 17q in epithelial ovarian tumors: Association with carcinomas with serous differentiation
    • Garcia, A. et al. (2000) Loss of heterozygosity on chromosome 17q in epithelial ovarian tumors: Association with carcinomas with serous differentiation. Int J Gynecol Pathol 19, 152-157
    • (2000) Int J Gynecol Pathol , vol.19 , pp. 152-157
    • Garcia, A.1
  • 53
    • 41149125616 scopus 로고    scopus 로고
    • Assessment of TP53 mutation using purified tissue samples of ovarian serous carcinomas reveals a higher mutation rate than previously reported and does not correlate with drug resistance
    • Salani, R. et al. (2008) Assessment of TP53 mutation using purified tissue samples of ovarian serous carcinomas reveals a higher mutation rate than previously reported and does not correlate with drug resistance. Int J Gynecol Cancer 18, 487-491
    • (2008) Int J Gynecol Cancer , vol.18 , pp. 487-491
    • Salani, R.1
  • 54
    • 0142087616 scopus 로고    scopus 로고
    • Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: A Gynecologic Oncology Group Study
    • Havrilesky, L. et al. (2003) Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: A Gynecologic Oncology Group Study. J Clin Oncol 21, 3814-3825
    • (2003) J Clin Oncol , vol.21 , pp. 3814-3825
    • Havrilesky, L.1
  • 56
    • 0034551724 scopus 로고    scopus 로고
    • p53 gene status and response to platinum/ paclitaxel-based chemotherapy in advanced ovarian carcinoma
    • Lavarino, C. et al. (2000) p53 gene status and response to platinum/ paclitaxel-based chemotherapy in advanced ovarian carcinoma. J Clin Oncol 18, 3936-3945
    • (2000) J Clin Oncol , vol.18 , pp. 3936-3945
    • Lavarino, C.1
  • 57
    • 0033971806 scopus 로고    scopus 로고
    • TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients
    • Kandioler-Eckersberger, D. et al. (2000) TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients. Clin Cancer Res 6, 50-56
    • (2000) Clin Cancer Res , vol.6 , pp. 50-56
    • Kandioler-Eckersberger, D.1
  • 58
    • 5144220224 scopus 로고    scopus 로고
    • Prognostic factors in ovarian cancer: Current evidence and future prospects. In The ECCO 12 Educational Book of Eur
    • Crijns, A.P. et al. (2003) Prognostic factors in ovarian cancer: Current evidence and future prospects. In The ECCO 12 Educational Book of Eur J Cancer, pp. 127-145
    • (2003) J Cancer , pp. 127-145
    • Crijns, A.P.1
  • 59
    • 0742317835 scopus 로고    scopus 로고
    • Distinct subtypes of serous ovarian carcinoma identified by p53 determination
    • Lassus, H. et al. (2003) Distinct subtypes of serous ovarian carcinoma identified by p53 determination. Gynecol Oncol 91, 504-512
    • (2003) Gynecol Oncol , vol.91 , pp. 504-512
    • Lassus, H.1
  • 60
    • 12844251290 scopus 로고    scopus 로고
    • Patterns of p53 mutations separate ovarian serous borderline tumors and low-and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: A mutational analysis with immunohistochemical correlation
    • Singer, G. et al. (2005) Patterns of p53 mutations separate ovarian serous borderline tumors and low-and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: A mutational analysis with immunohistochemical correlation. Am J Surg Pathol 29, 218-224
    • (2005) Am J Surg Pathol , vol.29 , pp. 218-224
    • Singer, G.1
  • 61
    • 0034649787 scopus 로고    scopus 로고
    • Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities
    • Ichimura, K. et al. (2000) Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res 60, 417-424
    • (2000) Cancer Res , vol.60 , pp. 417-424
    • Ichimura, K.1
  • 62
    • 28544452713 scopus 로고    scopus 로고
    • Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary
    • Bonome, T. et al. (2005) Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary. Cancer Res 65, 10602-10612
    • (2005) Cancer Res , vol.65 , pp. 10602-10612
    • Bonome, T.1
  • 63
    • 13844256742 scopus 로고    scopus 로고
    • Distinction between serous tumors of low malignant potential and serous carcinomas based on global mRNA expression profiling
    • Gilks, C.B. et al. (2005) Distinction between serous tumors of low malignant potential and serous carcinomas based on global mRNA expression profiling. Gynecol Oncol 96, 684-694
    • (2005) Gynecol Oncol , vol.96 , pp. 684-694
    • Gilks, C.B.1
  • 64
    • 13944279557 scopus 로고    scopus 로고
    • Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential
    • Meinhold-Heerlein, I. et al. (2005) Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential. Oncogene 24, 1053-1065
    • (2005) Oncogene , vol.24 , pp. 1053-1065
    • Meinhold-Heerlein, I.1
  • 65
    • 33846527856 scopus 로고    scopus 로고
    • Independent prognostic significance of cell cycle regulator proteins p16(lNK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: A translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group
    • Kommoss, S. et al. (2007) Independent prognostic significance of cell cycle regulator proteins p16(lNK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: A translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group. Br J Cancer 96, 306-313
    • (2007) Br J Cancer , vol.96 , pp. 306-313
    • Kommoss, S.1
  • 66
    • 0029024708 scopus 로고
    • Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance on 9q and rare alterations involving 9p, including CDKN2
    • Schultz, D.C. et al. (1995) Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance on 9q and rare alterations involving 9p, including CDKN2. Cancer Res 55, 2150-2157
    • (1995) Cancer Res , vol.55 , pp. 2150-2157
    • Schultz, D.C.1
  • 67
    • 4444284167 scopus 로고    scopus 로고
    • Methylation of tumor suppressor gene p16 and prognosis of epithelial ovarian cancer
    • Katsaros, D. et al. (2004) Methylation of tumor suppressor gene p16 and prognosis of epithelial ovarian cancer. Gynecol Oncol 94, 685-692
    • (2004) Gynecol Oncol , vol.94 , pp. 685-692
    • Katsaros, D.1
  • 68
    • 25444450573 scopus 로고    scopus 로고
    • Abnormalities of the RB1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16(INK4A) protein
    • Armes, J.E. et al. (2005) Abnormalities of the RB1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16(INK4A) protein. Int J Gynecol Pathol 24, 363-368
    • (2005) Int J Gynecol Pathol , vol.24 , pp. 363-368
    • Armes, J.E.1
  • 69
    • 4143107930 scopus 로고    scopus 로고
    • Cyclin D1, p53, and p21Waf1/Cip1 expression is predictive of poor clinical outcome in serous epithelial ovarian cancer
    • Bali, A. et al. (2004) Cyclin D1, p53, and p21Waf1/Cip1 expression is predictive of poor clinical outcome in serous epithelial ovarian cancer. Clin Cancer Res 10, 5168-5177
    • (2004) Clin Cancer Res , vol.10 , pp. 5168-5177
    • Bali, A.1
  • 70
    • 0027957569 scopus 로고
    • Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression
    • Kim, T.M. et al. (1994) Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression. Cancer Res 54, 605-609
    • (1994) Cancer Res , vol.54 , pp. 605-609
    • Kim, T.M.1
  • 71
    • 34548099690 scopus 로고    scopus 로고
    • High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications
    • Gorringe, K.L. et al. (2007) High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications. Clin Cancer Res 13, 4731-4739
    • (2007) Clin Cancer Res , vol.13 , pp. 4731-4739
    • Gorringe, K.L.1
  • 72
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris, S.L. and Levine, A.J. (2005) The p53 pathway: Positive and negative feedback loops. Oncogene 24, 2899-2908
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 73
    • 34247469336 scopus 로고    scopus 로고
    • Amplicon profiles in ovarian serous carcinomas
    • Nakayama, K. et al. (2007) Amplicon profiles in ovarian serous carcinomas. Int J Cancer 120, 2613-2617
    • (2007) Int J Cancer , vol.120 , pp. 2613-2617
    • Nakayama, K.1
  • 74
    • 33748485372 scopus 로고    scopus 로고
    • Chromosomal losses of regions on 5q and lack of high-level amplifications at 8q24 are associated with favorable prognosis for ovarian serous carcinoma
    • Staebler, A. et al. (2006) Chromosomal losses of regions on 5q and lack of high-level amplifications at 8q24 are associated with favorable prognosis for ovarian serous carcinoma. Genes Chromosomes Cancer 45, 905-917
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 905-917
    • Staebler, A.1
  • 75
    • 0036781812 scopus 로고    scopus 로고
    • c-MYC: More than just a matter of life and death
    • Pelengaris, S. et al. (2002) c-MYC: More than just a matter of life and death. Nat Rev Cancer 2, 764-776
    • (2002) Nat Rev Cancer , vol.2 , pp. 764-776
    • Pelengaris, S.1
  • 76
    • 0037444379 scopus 로고    scopus 로고
    • Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: A Gynecologic Oncology Group study
    • Farley, J. et al. (2003) Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: A Gynecologic Oncology Group study. Cancer Res 63, 1235-1241
    • (2003) Cancer Res , vol.63 , pp. 1235-1241
    • Farley, J.1
  • 77
    • 0035996220 scopus 로고    scopus 로고
    • Molecular mechanisms in signal transduction: New targets for the therapy of gynecologic malignancies
    • Gabriel, B. et al. (2002) Molecular mechanisms in signal transduction: new targets for the therapy of gynecologic malignancies. Onkologie 25, 240-247
    • (2002) Onkologie , vol.25 , pp. 240-247
    • Gabriel, B.1
  • 78
    • 0037440042 scopus 로고    scopus 로고
    • Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: A phase II trial of the Gynecologic Oncology Group
    • Bookman, M.A. et al. (2003) Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: A phase II trial of the Gynecologic Oncology Group. J Clin Oncol 21, 283-290
    • (2003) J Clin Oncol , vol.21 , pp. 283-290
    • Bookman, M.A.1
  • 79
    • 4644310838 scopus 로고    scopus 로고
    • The prognostic and predictive value of immunohistochemically detected HER-2/neu overexpression in 361 patients with ovarian cancer: A multicenter study
    • Riener, E.K. et al. (2004) The prognostic and predictive value of immunohistochemically detected HER-2/neu overexpression in 361 patients with ovarian cancer: A multicenter study. Gynecol Oncol 95, 89-94
    • (2004) Gynecol Oncol , vol.95 , pp. 89-94
    • Riener, E.K.1
  • 81
    • 33644855172 scopus 로고    scopus 로고
    • HER-2/neu gene amplification in ovarian tumours: A comprehensive immunohistochemical and FISH analysis on tissue microarrays
    • Mayr, D. et al. (2006) HER-2/neu gene amplification in ovarian tumours: a comprehensive immunohistochemical and FISH analysis on tissue microarrays. Histopathology 48, 149-156
    • (2006) Histopathology , vol.48 , pp. 149-156
    • Mayr, D.1
  • 82
    • 15244355937 scopus 로고    scopus 로고
    • Assessment of Her-1, Her-2, And Her-3 expression and Her-2 amplification in advanced stage ovarian carcinoma
    • Lee, C.H. et al. (2005) Assessment of Her-1, Her-2, And Her-3 expression and Her-2 amplification in advanced stage ovarian carcinoma. Int J Gynecol Pathol 24, 147-152
    • (2005) Int J Gynecol Pathol , vol.24 , pp. 147-152
    • Lee, C.H.1
  • 83
    • 1242334764 scopus 로고    scopus 로고
    • Biologic and immunologic therapies for ovarian cancer
    • Berek, J.S. et al. (2003) Biologic and immunologic therapies for ovarian cancer. J Clin Oncol 21, 168s-174s
    • (2003) J Clin Oncol , vol.21
    • Berek, J.S.1
  • 84
    • 40749120501 scopus 로고    scopus 로고
    • A comprehensive modular map of molecular interactions in RB/E2F pathway
    • Calzone, L. et al. (2008) A comprehensive modular map of molecular interactions in RB/E2F pathway. Mol Syst Biol 4, 173
    • (2008) Mol Syst Biol , vol.4 , pp. 173
    • Calzone, L.1
  • 85
    • 33947512381 scopus 로고    scopus 로고
    • An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer
    • Dressman, H.K. et al. (2007) An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer. J Clin Oncol 25, 517-525
    • (2007) J Clin Oncol , vol.25 , pp. 517-525
    • Dressman, H.K.1
  • 86
    • 0043240182 scopus 로고    scopus 로고
    • Ovarian cancer: Strategies for overcoming resistance to chemotherapy
    • Agarwal, R. and Kaye, S.B. (2003) Ovarian cancer: Strategies for overcoming resistance to chemotherapy. Nat Rev Cancer 3, 502-516
    • (2003) Nat Rev Cancer , vol.3 , pp. 502-516
    • Agarwal, R.1    Kaye, S.B.2
  • 87
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou, C.M. et al. (2000) Molecular portraits of human breast tumours. Nature 406, 747-752
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 88
    • 0034598746 scopus 로고    scopus 로고
    • Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    • Alizadeh, A.A. et al. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, 503-511
    • (2000) Nature , vol.403 , pp. 503-511
    • Alizadeh, A.A.1
  • 89
    • 46449095106 scopus 로고    scopus 로고
    • Mapping translocation breakpoints by next-generation sequencing
    • May 21, Epub ahead of print
    • Chen, W. et al. (2008) Mapping translocation breakpoints by next-generation sequencing. Genome Res (May 21, Epub ahead of print)
    • (2008) Genome Res
    • Chen, W.1
  • 90
    • 17144403478 scopus 로고    scopus 로고
    • Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer
    • Bapat, S.A. et al. (2005) Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res 65, 3025-3029
    • (2005) Cancer Res , vol.65 , pp. 3025-3029
    • Bapat, S.A.1
  • 91
    • 13244256870 scopus 로고    scopus 로고
    • Origins and molecular pathology of ovarian cancer
    • Bell, D.A. (2005) Origins and molecular pathology of ovarian cancer. Mod Pathol 18 (Suppl. 2), S19-S32
    • (2005) Mod Pathol , vol.18 , Issue.SUPPL. 2
    • Bell, D.A.1
  • 92
    • 33846185401 scopus 로고    scopus 로고
    • The distal fallopian tube: A new model for pelvic serous carcinogenesis
    • Crum, C.P. et al. (2007) The distal fallopian tube: A new model for pelvic serous carcinogenesis. Curr Opin Obstet Gynecol 19, 3-9
    • (2007) Curr Opin Obstet Gynecol , vol.19 , pp. 3-9
    • Crum, C.P.1


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