-
3
-
-
12144290775
-
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients
-
Wang TL, Diaz LA, Jr, Romans K, Bardelli A, Saha S, Galizia G, Choti M, Donehower R, Parmigiani G, Shih Ie M, Iacobuzio-Donahue C, Kinzler KW, et al. Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. Proc Natl Acad Sci USA 2004;101:3089-94.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3089-3094
-
-
Wang, T.L.1
Diaz Jr, L.A.2
Romans, K.3
Bardelli, A.4
Saha, S.5
Galizia, G.6
Choti, M.7
Donehower, R.8
Parmigiani, G.9
Shih, I.M.10
Iacobuzio-Donahue, C.11
Kinzler, K.W.12
-
4
-
-
0002011265
-
Gene amplificaton in human cancers: Biological and clinical significance
-
Kinzler KW, Vogelstein B, eds, 1st edn, New York: McGraw-Hill
-
Brodeur GM, Hogarty MD. Gene amplificaton in human cancers: biological and clinical significance. In: Kinzler KW, Vogelstein B, eds. The genetic basis of human cancer, 1st edn., vol. 1. New York: McGraw-Hill, 1998. 161-79.
-
(1998)
The genetic basis of human cancer
, vol.1
, pp. 161-179
-
-
Brodeur, G.M.1
Hogarty, M.D.2
-
5
-
-
13144279272
-
Apply innovative technologies to explore cancer genome
-
Shih Ie M, Wang TL. Apply innovative technologies to explore cancer genome. Curr Opin Oncol 2005;17:33-8.
-
(2005)
Curr Opin Oncol
, vol.17
, pp. 33-38
-
-
Shih, I.M.1
Wang, T.L.2
-
6
-
-
0037444379
-
Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: A gynecologic oncology group study
-
Farley J, Smith LM, Darcy KM, Sobel E, O'Connor D, Henderson B, Morrison LE, Birrer MJ. Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: a gynecologic oncology group study. Cancer Res 2003;63:1235-41.
-
(2003)
Cancer Res
, vol.63
, pp. 1235-1241
-
-
Farley, J.1
Smith, L.M.2
Darcy, K.M.3
Sobel, E.4
O'Connor, D.5
Henderson, B.6
Morrison, L.E.7
Birrer, M.J.8
-
7
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A, Press MF. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-12.
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
Holt, J.A.4
Wong, S.G.5
Keith, D.E.6
Levin, W.J.7
Stuart, S.G.8
Udove, J.9
Ullrich, A.10
Press, M.F.11
-
8
-
-
0026667730
-
AKT2, a putative oncogene encoding a member of a subfamily of protein- serine/threonine kinases, is amplified in human ovarian carcinomas
-
Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR. AKT2, a putative oncogene encoding a member of a subfamily of protein- serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA 1992; 89:9267-71.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 9267-9271
-
-
Cheng, J.Q.1
Godwin, A.K.2
Bellacosa, A.3
Taguchi, T.4
Franke, T.F.5
Hamilton, T.C.6
Tsichlis, P.N.7
Testa, J.R.8
-
9
-
-
0242669283
-
Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas
-
Wu R, Lin L, Beer DG, Ellenson LH, Lamb BJ, Rouillard JM, Kuick R, Hanash S, Schwartz DR, Fearon ER, Cho KR. Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas. Am J Pathol 2003;162:1603-10.
-
(2003)
Am J Pathol
, vol.162
, pp. 1603-1610
-
-
Wu, R.1
Lin, L.2
Beer, D.G.3
Ellenson, L.H.4
Lamb, B.J.5
Rouillard, J.M.6
Kuick, R.7
Hanash, S.8
Schwartz, D.R.9
Fearon, E.R.10
Cho, K.R.11
-
10
-
-
25444516265
-
Amplification of a chromatin remodeling gene, Rsf-I/HBXAP, in ovarian carcinoma
-
Shih Ie M, Sheu JJ, Santillan A, Nakayama K, Yen MJ, Bristow RE, Vang R, Parmigiani G, Kurman RJ, Trope CG, Davidson B, Wang TL. Amplification of a chromatin remodeling gene, Rsf-I/HBXAP, in ovarian carcinoma. Proc Natl Acad Sci USA 2005;102:14004-9.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 14004-14009
-
-
Shih, I.M.1
Sheu, J.J.2
Santillan, A.3
Nakayama, K.4
Yen, M.J.5
Bristow, R.E.6
Vang, R.7
Parmigiani, G.8
Kurman, R.J.9
Trope, C.G.10
Davidson, B.11
Wang, T.L.12
-
11
-
-
10744233204
-
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
-
Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, et al. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 2003;115:523-35.
-
(2003)
Cell
, vol.115
, pp. 523-535
-
-
Hughes-Davies, L.1
Huntsman, D.2
Ruas, M.3
Fuks, F.4
Bye, J.5
Chin, S.F.6
Milner, J.7
Brown, L.A.8
Hsu, F.9
Gilks, B.10
Nielsen, T.11
Schulzer, M.12
-
12
-
-
33745777614
-
Homozygous deletion of MKK4 in ovarian serous carcinoma
-
Nakayama K, Nakayama N, Davidson B, Katabuchi H, Kurman RJ, Velculescu VE, Shih Ie M, Wang TL. Homozygous deletion of MKK4 in ovarian serous carcinoma. Cancer Biol Ther 2006;5:630-4.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 630-634
-
-
Nakayama, K.1
Nakayama, N.2
Davidson, B.3
Katabuchi, H.4
Kurman, R.J.5
Velculescu, V.E.6
Shih, I.M.7
Wang, T.L.8
-
13
-
-
33751190974
-
Sequence mutations and amplificatin of PIK3CA and AKT2 genes in purified ovarian serous neoplasms
-
Nakayama K, Nakayama N, Kurman RJ, Cope L, Pohl G, Samuels Y, Velculescu V, Wang TL, Shih IM. Sequence mutations and amplificatin of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biol Ther 2006;5:779-85.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 779-785
-
-
Nakayama, K.1
Nakayama, N.2
Kurman, R.J.3
Cope, L.4
Pohl, G.5
Samuels, Y.6
Velculescu, V.7
Wang, T.L.8
Shih, I.M.9
-
14
-
-
2342647468
-
High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines
-
Janne PA, Li C, Zhao X, Girard L, Chen TH, Minna J, Christiani DC, Johnson BE, Meyerson M. High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines. Oncogene 2004;23:2716-26.
-
(2004)
Oncogene
, vol.23
, pp. 2716-2726
-
-
Janne, P.A.1
Li, C.2
Zhao, X.3
Girard, L.4
Chen, T.H.5
Minna, J.6
Christiani, D.C.7
Johnson, B.E.8
Meyerson, M.9
-
15
-
-
10844232112
-
Whole genome DNA copy number changes identified by high density oligonucleotide arrays
-
Huang J, Wei W, Zhang J, Liu G, Bignell GR, Stratton MR, Futreal PA, Wooster R, Jones KW, Shapero MH. Whole genome DNA copy number changes identified by high density oligonucleotide arrays. Hum Genomics 2004;1:287-99.
-
(2004)
Hum Genomics
, vol.1
, pp. 287-299
-
-
Huang, J.1
Wei, W.2
Zhang, J.3
Liu, G.4
Bignell, G.R.5
Stratton, M.R.6
Futreal, P.A.7
Wooster, R.8
Jones, K.W.9
Shapero, M.H.10
-
16
-
-
33745685874
-
Notch-3 gene amplification in ovarian cancer
-
Park JT, Li M, Nakayama N, Davidson B, Eberhart CG, Kurman RJ, Shih I-M, Wang T-L. Notch-3 gene amplification in ovarian cancer. Cancer Res 2006;66:6312-18.
-
(2006)
Cancer Res
, vol.66
, pp. 6312-6318
-
-
Park, J.T.1
Li, M.2
Nakayama, N.3
Davidson, B.4
Eberhart, C.G.5
Kurman, R.J.6
Shih, I.-M.7
Wang, T.-L.8
-
17
-
-
0027230693
-
p53 mutation is a common genetic event in ovarian carcinoma
-
Milner BJ, Allan LA, Eccles DM, Kitchener HC, Leonard RC, Kelly KF, Parkin DE, Haites NE. p53 mutation is a common genetic event in ovarian carcinoma. Cancer Res 1993;53:2128-32.
-
(1993)
Cancer Res
, vol.53
, pp. 2128-2132
-
-
Milner, B.J.1
Allan, L.A.2
Eccles, D.M.3
Kitchener, H.C.4
Leonard, R.C.5
Kelly, K.F.6
Parkin, D.E.7
Haites, N.E.8
-
18
-
-
12844251290
-
Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: A mutational analysis with immunohistochemical correlation
-
Singer G, Stohr R, Cope L, Dehari R, Hartmann A, Cao DF, Wang TL, Kurman RJ, Shih IM. Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation. Am J Surg Pathol 2005;29:218-24.
-
(2005)
Am J Surg Pathol
, vol.29
, pp. 218-224
-
-
Singer, G.1
Stohr, R.2
Cope, L.3
Dehari, R.4
Hartmann, A.5
Cao, D.F.6
Wang, T.L.7
Kurman, R.J.8
Shih, I.M.9
-
19
-
-
0041423391
-
Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma
-
Schraml P, Schwerdtfeger G, Burkhalter F, Raggi A, Schmidt D, Ruffalo T, King W, Wilber K, Mihatsch MJ, Moch H. Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. Am J Pathol 2003;163:985-92.
-
(2003)
Am J Pathol
, vol.163
, pp. 985-992
-
-
Schraml, P.1
Schwerdtfeger, G.2
Burkhalter, F.3
Raggi, A.4
Schmidt, D.5
Ruffalo, T.6
King, W.7
Wilber, K.8
Mihatsch, M.J.9
Moch, H.10
-
20
-
-
9644270281
-
Identification of DNA copy number changes in microdissected serous ovarian cancer tissue using a cDNA microarray platform
-
Tsuda H, Birrer MJ, Ito YM, Ohashi Y, Lin M, Lee C, Wong WH, Rao PH, Lau CC, Berkowitz RS, Wong KK, Mok SC. Identification of DNA copy number changes in microdissected serous ovarian cancer tissue using a cDNA microarray platform. Cancer Genet Cytogenet 2004;155:97-107.
-
(2004)
Cancer Genet Cytogenet
, vol.155
, pp. 97-107
-
-
Tsuda, H.1
Birrer, M.J.2
Ito, Y.M.3
Ohashi, Y.4
Lin, M.5
Lee, C.6
Wong, W.H.7
Rao, P.H.8
Lau, C.C.9
Berkowitz, R.S.10
Wong, K.K.11
Mok, S.C.12
-
21
-
-
22044440210
-
High-resolution mapping of genomic imbalance and identification of gene expression profiles associated with differential chemotherapy response in serous epithelial ovarian cancer
-
Bernardini M, Lee CH, Beheshti B, Prasad M, Albert M, Marrano P, Begley H, Shaw P, Covens A, Murphy J, Rosen B, Minkin S, et al. High-resolution mapping of genomic imbalance and identification of gene expression profiles associated with differential chemotherapy response in serous epithelial ovarian cancer. Neoplasia 2005;7:603-13.
-
(2005)
Neoplasia
, vol.7
, pp. 603-613
-
-
Bernardini, M.1
Lee, C.H.2
Beheshti, B.3
Prasad, M.4
Albert, M.5
Marrano, P.6
Begley, H.7
Shaw, P.8
Covens, A.9
Murphy, J.10
Rosen, B.11
Minkin, S.12
-
22
-
-
4644269690
-
Genomic analyses of primary and metastatic serous epithelial ovarian cancer
-
Israeli O, Gotlieb WH, Friedman E, Korach J, Friedman E, Goldman B, Zeltser A, Ben-Baruch G, Rienstein S, Aviram-Goldring A. Genomic analyses of primary and metastatic serous epithelial ovarian cancer. Cancer Genet Cytogenet 2004;154:16-21.
-
(2004)
Cancer Genet Cytogenet
, vol.154
, pp. 16-21
-
-
Israeli, O.1
Gotlieb, W.H.2
Friedman, E.3
Korach, J.4
Friedman, E.5
Goldman, B.6
Zeltser, A.7
Ben-Baruch, G.8
Rienstein, S.9
Aviram-Goldring, A.10
-
23
-
-
13944279557
-
Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential
-
Meinhold-Heerlein I, Bauerschlag D, Hilpert F, Dimitrov P, Sapinoso LM, Orlowska-Volk M, Bauknecht T, Park TW, Jonat W, Jacobsen A, Sehouli J, Luttges J, et al. Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential. Oncogene 2005;24:1053-65.
-
(2005)
Oncogene
, vol.24
, pp. 1053-1065
-
-
Meinhold-Heerlein, I.1
Bauerschlag, D.2
Hilpert, F.3
Dimitrov, P.4
Sapinoso, L.M.5
Orlowska-Volk, M.6
Bauknecht, T.7
Park, T.W.8
Jonat, W.9
Jacobsen, A.10
Sehouli, J.11
Luttges, J.12
-
24
-
-
27144519156
-
Molecular pathogenesis of ovarian borderline tumors: New insights and old challenges
-
Shih Ie M, Kurman RJ. Molecular pathogenesis of ovarian borderline tumors: new insights and old challenges. Clin Cancer Res 2005;11: 7273-9.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7273-7279
-
-
Shih, I.M.1
Kurman, R.J.2
-
25
-
-
1942469352
-
Ovarian tumorigenesis - a proposed model based on morphological and molecular genetic analysis
-
Shih I-M, Kurman RJ. Ovarian tumorigenesis - a proposed model based on morphological and molecular genetic analysis. Am J Pathol 2004;164:1511-8.
-
(2004)
Am J Pathol
, vol.164
, pp. 1511-1518
-
-
Shih, I.-M.1
Kurman, R.J.2
-
26
-
-
0036154095
-
Micropapillary serous carcinoma of the ovary has distinct patterns of chromosomal imbalances by comparative genomic hybridization compared with atypical proliferative serous tumors and serous carcinomas
-
Staebler A, Heselmeyer-Haddad K, Bell K, Riopel M, Perlman E, Ried T, Kurman RJ. Micropapillary serous carcinoma of the ovary has distinct patterns of chromosomal imbalances by comparative genomic hybridization compared with atypical proliferative serous tumors and serous carcinomas. Hum Pathol 2002;33:47-59.
-
(2002)
Hum Pathol
, vol.33
, pp. 47-59
-
-
Staebler, A.1
Heselmeyer-Haddad, K.2
Bell, K.3
Riopel, M.4
Perlman, E.5
Ried, T.6
Kurman, R.J.7
-
27
-
-
0037454224
-
Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
-
Singer G, Oldt R, III, Cohen Y, Wang BG, Sidransky D, Kurman RJ, Shih Ie M. Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 2003;95:484-6.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 484-486
-
-
Singer, G.1
Oldt III, R.2
Cohen, Y.3
Wang, B.G.4
Sidransky, D.5
Kurman, R.J.6
Shih, I.M.7
-
28
-
-
0038679686
-
Cyclin E overexpression and amplification in human tumours
-
Schraml P, Bucher C, Bissig H, Nocito A, Haas P, Wilber K, Seelig S, Kononen J, Mihatsch MJ, Dirnhofer S, Sauter G. Cyclin E overexpression and amplification in human tumours. J Pathol 2003;200:375-82.
-
(2003)
J Pathol
, vol.200
, pp. 375-382
-
-
Schraml, P.1
Bucher, C.2
Bissig, H.3
Nocito, A.4
Haas, P.5
Wilber, K.6
Seelig, S.7
Kononen, J.8
Mihatsch, M.J.9
Dirnhofer, S.10
Sauter, G.11
-
29
-
-
0032484533
-
Analysis of cyclin E and CDK2 in ovarian cancer: Gene amplification and RNA overexpression
-
Marone M, Scambia G, Giannitelli C, Ferrandina G, Masciullo V, Bellacosa A, Benedetti-Panici P, Mancuso S. Analysis of cyclin E and CDK2 in ovarian cancer: gene amplification and RNA overexpression. Int J Cancer 1998;75:34-9.
-
(1998)
Int J Cancer
, vol.75
, pp. 34-39
-
-
Marone, M.1
Scambia, G.2
Giannitelli, C.3
Ferrandina, G.4
Masciullo, V.5
Bellacosa, A.6
Benedetti-Panici, P.7
Mancuso, S.8
-
30
-
-
33646374432
-
Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma
-
Rosen DG, Yang G, Deavers MT, Malpica A, Kavanagh JJ, Mills GB, Liu J. Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma. Cancer 2006;106:1925-32.
-
(2006)
Cancer
, vol.106
, pp. 1925-1932
-
-
Rosen, D.G.1
Yang, G.2
Deavers, M.T.3
Malpica, A.4
Kavanagh, J.J.5
Mills, G.B.6
Liu, J.7
-
31
-
-
0001457668
-
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK, Testa JR. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci USA 1996;93:3636-41.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
Sonoda, G.4
Altomare, D.A.5
Watson, D.K.6
Testa, J.R.7
-
32
-
-
20444374445
-
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
-
Samuels Y, Diaz LA, Jr, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 2005;7:561-73.
-
(2005)
Cancer Cell
, vol.7
, pp. 561-573
-
-
Samuels, Y.1
Diaz Jr, L.A.2
Schmidt-Kittler, O.3
Cummins, J.M.4
Delong, L.5
Cheong, I.6
Rago, C.7
Huso, D.L.8
Lengauer, C.9
Kinzler, K.W.10
Vogelstein, B.11
Velculescu, V.E.12
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