-
1
-
-
0347627140
-
Amino acid signalling and the integration of metabolism
-
Meijer A.J., and Dubbelhuis P.F. Amino acid signalling and the integration of metabolism. Biochem Biophys Res Commun 313 2 (2004) 397-403
-
(2004)
Biochem Biophys Res Commun
, vol.313
, Issue.2
, pp. 397-403
-
-
Meijer, A.J.1
Dubbelhuis, P.F.2
-
2
-
-
0042322370
-
TOR action in mammalian cells and in Caenorhabditis elegans
-
Long X., Muller F., and Avruch J. TOR action in mammalian cells and in Caenorhabditis elegans. Curr Top Microbiol Immunol 279 (2004) 115-138
-
(2004)
Curr Top Microbiol Immunol
, vol.279
, pp. 115-138
-
-
Long, X.1
Muller, F.2
Avruch, J.3
-
4
-
-
0345732640
-
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
-
Fingar D.C., Richardson C.J., Tee A.R., et al. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 24 1 (2004) 200-216
-
(2004)
Mol Cell Biol
, vol.24
, Issue.1
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
-
5
-
-
0034644525
-
TOR, a central controller of cell growth
-
[see comment]
-
Schmelzle T., and Hall M.N. TOR, a central controller of cell growth. [see comment]. Cell 103 2 (2000) 253-262
-
(2000)
Cell
, vol.103
, Issue.2
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
6
-
-
0035312747
-
Regulation of translation initiation by FRAP/mTOR
-
Gingras A.C., Raught B., and Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev 15 7 (2001) 807-826
-
(2001)
Genes Dev
, vol.15
, Issue.7
, pp. 807-826
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
7
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers C.J., Martin M.M., Brunn G.J., et al. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 270 2 (1995) 815-822
-
(1995)
J Biol Chem
, vol.270
, Issue.2
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
-
8
-
-
0028239893
-
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
Sabatini D.M., Erdjument-Bromage H., Lui M., et al. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78 1 (1994) 35-43
-
(1994)
Cell
, vol.78
, Issue.1
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
-
9
-
-
0028598672
-
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
-
Chiu M.I., Katz H., and Berlin V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci U S A 91 26 (1994) 12574-12578
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, Issue.26
, pp. 12574-12578
-
-
Chiu, M.I.1
Katz, H.2
Berlin, V.3
-
10
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown E.J., Albers M.W., Shin T.B., et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369 6483 (1994) 756-758
-
(1994)
Nature
, vol.369
, Issue.6483
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
-
11
-
-
0037312507
-
Tor signalling in bugs, brain and brawn
-
[Published erratum appears in Nat Rev Mol Cell Biol 2003;4(3):249.]
-
Jacinto E., and Hall M.N. Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 4 2 (2003) 117-126 [Published erratum appears in Nat Rev Mol Cell Biol 2003;4(3):249.]
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, Issue.2
, pp. 117-126
-
-
Jacinto, E.1
Hall, M.N.2
-
12
-
-
0037020044
-
Identification of TOR signaling complexes: more TORC for the cell growth engine
-
Abraham R.T. Identification of TOR signaling complexes: more TORC for the cell growth engine. Cell 111 1 (2002) 9-12
-
(2002)
Cell
, vol.111
, Issue.1
, pp. 9-12
-
-
Abraham, R.T.1
-
13
-
-
0032105481
-
Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
-
[Reprint in Clin Biochem 2006;39(5):484-9, PMID: 16783879.]
-
Sehgal S.N. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem 31 5 (1998) 335-340 [Reprint in Clin Biochem 2006;39(5):484-9, PMID: 16783879.]
-
(1998)
Clin Biochem
, vol.31
, Issue.5
, pp. 335-340
-
-
Sehgal, S.N.1
-
14
-
-
0016724057
-
Rapamycin (AY-22989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
-
Vezina C., Kudelski A., and Sehgal S.N. Rapamycin (AY-22989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot 28 10 (1975) 721-726
-
(1975)
J Antibiot
, vol.28
, Issue.10
, pp. 721-726
-
-
Vezina, C.1
Kudelski, A.2
Sehgal, S.N.3
-
15
-
-
0016713286
-
Rapamycin (AY-22989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
Sehgal S.N., Baker H., and Vezina C. Rapamycin (AY-22989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot 28 10 (1975) 727-732
-
(1975)
J Antibiot
, vol.28
, Issue.10
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vezina, C.3
-
16
-
-
0024976525
-
Rapamycin for immunosuppression in organ allografting
-
[see comment]
-
Calne R.Y., Collier D.S., Lim S., et al. Rapamycin for immunosuppression in organ allografting. [see comment]. Lancet 2 8656 (1989) 227
-
(1989)
Lancet
, vol.2
, Issue.8656
, pp. 227
-
-
Calne, R.Y.1
Collier, D.S.2
Lim, S.3
-
17
-
-
33947193386
-
Use of sirolimus in solid organ transplantation
-
Augustine J.J., Bodziak K.A., and Hricik D.E. Use of sirolimus in solid organ transplantation. Drugs 67 3 (2007) 369-391
-
(2007)
Drugs
, vol.67
, Issue.3
, pp. 369-391
-
-
Augustine, J.J.1
Bodziak, K.A.2
Hricik, D.E.3
-
18
-
-
10244235191
-
Temsirolimus: CCI 779, CCI-779, cell cycle inhibitor-779
-
Temsirolimus: CCI 779, CCI-779, cell cycle inhibitor-779. Drugs R D 5 6 (2004) 363-367
-
(2004)
Drugs R D
, vol.5
, Issue.6
, pp. 363-367
-
-
-
19
-
-
25444446423
-
Rapamycin, but not FK-506, increases endothelial tissue factor expression: implications for drug-eluting stent design
-
Steffel J., Latini R.A., Akhmedor A., et al. Rapamycin, but not FK-506, increases endothelial tissue factor expression: implications for drug-eluting stent design. Circulation 112 13 (2005) 2002-2011
-
(2005)
Circulation
, vol.112
, Issue.13
, pp. 2002-2011
-
-
Steffel, J.1
Latini, R.A.2
Akhmedor, A.3
-
20
-
-
0021164348
-
Activity of rapamycin (AY-22989) against transplanted tumors
-
Eng C.P., Sehgal S.N., and Vezina C. Activity of rapamycin (AY-22989) against transplanted tumors. J Antibiot 37 10 (1984) 1231-1237
-
(1984)
J Antibiot
, vol.37
, Issue.10
, pp. 1231-1237
-
-
Eng, C.P.1
Sehgal, S.N.2
Vezina, C.3
-
21
-
-
0020523643
-
Human brain tumor xenografts in nude mice as a chemotherapy model
-
Houchens D.P., Ovejera A.A., Riblet S.M., et al. Human brain tumor xenografts in nude mice as a chemotherapy model. Eur J Cancer Clin Oncol 19 6 (1983) 799-805
-
(1983)
Eur J Cancer Clin Oncol
, vol.19
, Issue.6
, pp. 799-805
-
-
Houchens, D.P.1
Ovejera, A.A.2
Riblet, S.M.3
-
22
-
-
0019870366
-
New antitumor substances of natural origin
-
Douros J., and Suffness M. New antitumor substances of natural origin. Cancer Treat Rev 8 1 (1981) 63-87
-
(1981)
Cancer Treat Rev
, vol.8
, Issue.1
, pp. 63-87
-
-
Douros, J.1
Suffness, M.2
-
23
-
-
0041802820
-
Targeting mTOR signaling for cancer therapy
-
Huang S., and Houghton P.J. Targeting mTOR signaling for cancer therapy. Curr Opin Pharmacol 3 4 (2003) 371-377
-
(2003)
Curr Opin Pharmacol
, vol.3
, Issue.4
, pp. 371-377
-
-
Huang, S.1
Houghton, P.J.2
-
24
-
-
19044364287
-
Quick guide: target of rapamycin
-
Dennis P.B., and Thomas G. Quick guide: target of rapamycin. Curr Biol 12 8 (2002) R269
-
(2002)
Curr Biol
, vol.12
, Issue.8
-
-
Dennis, P.B.1
Thomas, G.2
-
25
-
-
0032189483
-
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
-
Sarkaria J.N., Busby E.C., Tibbetts R.S., et al. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res 58 19 (1998) 4375-4382
-
(1998)
Cancer Res
, vol.58
, Issue.19
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Busby, E.C.2
Tibbetts, R.S.3
-
26
-
-
0032250339
-
The ataxia telangiectasia gene in familial and sporadic cancer
-
Yuille M.A., and Coignet L.J. The ataxia telangiectasia gene in familial and sporadic cancer. Recent Results Cancer Res 154 (1998) 156-173
-
(1998)
Recent Results Cancer Res
, vol.154
, pp. 156-173
-
-
Yuille, M.A.1
Coignet, L.J.2
-
27
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
Kim D.H., Sarbassor D.D., Ali S.M., et al. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 11 4 (2003) 895-904
-
(2003)
Mol Cell
, vol.11
, Issue.4
, pp. 895-904
-
-
Kim, D.H.1
Sarbassor, D.D.2
Ali, S.M.3
-
28
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K., Maruki Y., Long X., et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110 2 (2002) 177-189
-
(2002)
Cell
, vol.110
, Issue.2
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
-
29
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim D.H., Sarbassor D.D., Ali S.M., et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110 2 (2002) 163-175
-
(2002)
Cell
, vol.110
, Issue.2
, pp. 163-175
-
-
Kim, D.H.1
Sarbassor, D.D.2
Ali, S.M.3
-
30
-
-
0346366446
-
Raptor, a binding partner of target of rapamycin
-
Yonezawa K., Tokunaga C., Oshiro N., et al. Raptor, a binding partner of target of rapamycin. Biochem Biophys Res Commun 313 2 (2004) 437-441
-
(2004)
Biochem Biophys Res Commun
, vol.313
, Issue.2
, pp. 437-441
-
-
Yonezawa, K.1
Tokunaga, C.2
Oshiro, N.3
-
32
-
-
0037507252
-
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
-
Nojima H., Tokunaga C., Eguchi S., et al. The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem 278 18 (2003) 15461-15464
-
(2003)
J Biol Chem
, vol.278
, Issue.18
, pp. 15461-15464
-
-
Nojima, H.1
Tokunaga, C.2
Eguchi, S.3
-
33
-
-
0347627139
-
mTOR-mediated regulation of translation factors by amino acids
-
Proud C.G. mTOR-mediated regulation of translation factors by amino acids. Biochem Biophys Res Commun 313 2 (2004) 429-436
-
(2004)
Biochem Biophys Res Commun
, vol.313
, Issue.2
, pp. 429-436
-
-
Proud, C.G.1
-
35
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov D.D., Ali S.M., Kim D.H., et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14 14 (2004) 1296-1302
-
(2004)
Curr Biol
, vol.14
, Issue.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
-
36
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D.D., Guertin D.A., Ali S.M., et al. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 5712 (2005) 1098-1101
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
-
37
-
-
34548528069
-
Phase I/II trial of temsirolimus combined with interferon alfa for advanced renal cell carcinoma
-
Motzer R.J., Hudes G.R., Curti B.D., et al. Phase I/II trial of temsirolimus combined with interferon alfa for advanced renal cell carcinoma. J Clin Oncol 25 25 (2007) 3958-3964
-
(2007)
J Clin Oncol
, vol.25
, Issue.25
, pp. 3958-3964
-
-
Motzer, R.J.1
Hudes, G.R.2
Curti, B.D.3
-
38
-
-
34047253075
-
RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer
-
Mabuchi S., Altomare D.A., Connolly D.C., et al. RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res 67 6 (2007) 2408-2413
-
(2007)
Cancer Res
, vol.67
, Issue.6
, pp. 2408-2413
-
-
Mabuchi, S.1
Altomare, D.A.2
Connolly, D.C.3
-
39
-
-
40649126759
-
mTOR is activated in the majority of malignant melanomas
-
Karbowniczek M., Spittle C.S., Morrison T., Wu H., and Henske E.P. mTOR is activated in the majority of malignant melanomas. J Invest Dermatol 128 4 (2008) 980-987
-
(2008)
J Invest Dermatol
, vol.128
, Issue.4
, pp. 980-987
-
-
Karbowniczek, M.1
Spittle, C.S.2
Morrison, T.3
Wu, H.4
Henske, E.P.5
-
40
-
-
34547683568
-
Rationale for a phase I trial of erlotinib and the mammalian target of rapamycin inhibitor everolimus (RAD001) for patients with relapsed non small cell lung cancer
-
Johnson B.E., Jackman D., and Janne P.A. Rationale for a phase I trial of erlotinib and the mammalian target of rapamycin inhibitor everolimus (RAD001) for patients with relapsed non small cell lung cancer. Clin Cancer Res 13 15 (2007) s4628-s4631
-
(2007)
Clin Cancer Res
, vol.13
, Issue.15
-
-
Johnson, B.E.1
Jackman, D.2
Janne, P.A.3
-
41
-
-
36049023679
-
Phase I study of everolimus in pediatric patients with refractory solid tumors
-
Fouladi M., Laningham F., Wu J., et al. Phase I study of everolimus in pediatric patients with refractory solid tumors. J Clin Oncol 25 30 (2007) 4806-4812
-
(2007)
J Clin Oncol
, vol.25
, Issue.30
, pp. 4806-4812
-
-
Fouladi, M.1
Laningham, F.2
Wu, J.3
-
42
-
-
33846396190
-
Aspects of mTOR biology and the use of mTOR inhibitors in non-Hodgkin's lymphoma
-
Costa L.J. Aspects of mTOR biology and the use of mTOR inhibitors in non-Hodgkin's lymphoma. Cancer Treat Rev 33 1 (2007) 78-84
-
(2007)
Cancer Treat Rev
, vol.33
, Issue.1
, pp. 78-84
-
-
Costa, L.J.1
-
43
-
-
33846866035
-
The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer
-
Cho D., Signoretti S., Regan M., et al. The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer. Clin Cancer Res 13 2 (2007) 758s-763s
-
(2007)
Clin Cancer Res
, vol.13
, Issue.2
-
-
Cho, D.1
Signoretti, S.2
Regan, M.3
-
44
-
-
33749002279
-
Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
-
Yee K.W., Zeng Z., Konoplera M., et al. Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 12 17 (2006) 5165-5173
-
(2006)
Clin Cancer Res
, vol.12
, Issue.17
, pp. 5165-5173
-
-
Yee, K.W.1
Zeng, Z.2
Konoplera, M.3
-
46
-
-
0842304369
-
Mammalian target of rapamycin inhibition as therapy for hematologic malignancies
-
Panwalkar A., Verstovsek S., and Giles F.J. Mammalian target of rapamycin inhibition as therapy for hematologic malignancies. Cancer 100 4 (2004) 657-666
-
(2004)
Cancer
, vol.100
, Issue.4
, pp. 657-666
-
-
Panwalkar, A.1
Verstovsek, S.2
Giles, F.J.3
-
47
-
-
33749824096
-
mTOR inhibitors in hematologic malignancies
-
Dancey J.E. mTOR inhibitors in hematologic malignancies. Clin Adv Hematol Oncol 1 7 (2003) 419-423
-
(2003)
Clin Adv Hematol Oncol
, vol.1
, Issue.7
, pp. 419-423
-
-
Dancey, J.E.1
-
48
-
-
34548085100
-
Activated mammalian target of rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma
-
Herberger B., Puhalla H., Lehnert M., et al. Activated mammalian target of rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma. Clin Cancer Res 13 16 (2007) 4795-4799
-
(2007)
Clin Cancer Res
, vol.13
, Issue.16
, pp. 4795-4799
-
-
Herberger, B.1
Puhalla, H.2
Lehnert, M.3
-
49
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin D.A., and Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 12 1 (2007) 9-22
-
(2007)
Cancer Cell
, vol.12
, Issue.1
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
50
-
-
34648833206
-
Evolving role of novel targeted agents in renal cell carcinoma
-
Hutson T.E., and Figlin R.A. Evolving role of novel targeted agents in renal cell carcinoma. Oncology 21 10 (2007) 1175-1180
-
(2007)
Oncology
, vol.21
, Issue.10
, pp. 1175-1180
-
-
Hutson, T.E.1
Figlin, R.A.2
-
51
-
-
33748274758
-
Morphoproteomic and pharmacoproteomic rationale for mTOR effectors as therapeutic targets in head and neck squamous cell carcinoma
-
Brown R.E., Zhang P.L., Lun M., et al. Morphoproteomic and pharmacoproteomic rationale for mTOR effectors as therapeutic targets in head and neck squamous cell carcinoma. Ann Clin Lab Sci 36 3 (2006) 273-282
-
(2006)
Ann Clin Lab Sci
, vol.36
, Issue.3
, pp. 273-282
-
-
Brown, R.E.1
Zhang, P.L.2
Lun, M.3
-
52
-
-
34548354859
-
Recent advances in targeted therapy for renal cell carcinoma
-
Clark P.E. Recent advances in targeted therapy for renal cell carcinoma. Curr Opin Urol 17 5 (2007) 331-336
-
(2007)
Curr Opin Urol
, vol.17
, Issue.5
, pp. 331-336
-
-
Clark, P.E.1
-
53
-
-
34147121375
-
Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis
-
Kobayashi S., Kishimoto T., Kamata S., et al. Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci 98 5 (2007) 726-733
-
(2007)
Cancer Sci
, vol.98
, Issue.5
, pp. 726-733
-
-
Kobayashi, S.1
Kishimoto, T.2
Kamata, S.3
-
54
-
-
34247279338
-
Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis
-
Huber S., Bruns C.J., Schmid G., et al. Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis. Kidney Int 71 8 (2007) 771-777
-
(2007)
Kidney Int
, vol.71
, Issue.8
, pp. 771-777
-
-
Huber, S.1
Bruns, C.J.2
Schmid, G.3
-
55
-
-
33947235680
-
Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer
-
Nathan C.O., Amirghahari N., Rong X., et al. Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer. Cancer Res 67 5 (2007) 2160-2168
-
(2007)
Cancer Res
, vol.67
, Issue.5
, pp. 2160-2168
-
-
Nathan, C.O.1
Amirghahari, N.2
Rong, X.3
-
56
-
-
33845227643
-
Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors
-
Buck E., Eyzaguirre A., Brown E., et al. Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors. Mol Cancer Ther 5 11 (2006) 2676-2684
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.11
, pp. 2676-2684
-
-
Buck, E.1
Eyzaguirre, A.2
Brown, E.3
-
57
-
-
33750884079
-
Mammalian target of rapamycin inhibitors in combination with letrozole in breast cancer
-
Chollet P., Abrial C., Tacca O., et al. Mammalian target of rapamycin inhibitors in combination with letrozole in breast cancer. Clin Breast Cancer 7 4 (2006) 336-338
-
(2006)
Clin Breast Cancer
, vol.7
, Issue.4
, pp. 336-338
-
-
Chollet, P.1
Abrial, C.2
Tacca, O.3
-
58
-
-
34548642127
-
Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside
-
Martelli A.M., Tazzari P.L., Evangelisti C., et al. Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside. Curr Med Chem 14 19 (2007) 2009-2023
-
(2007)
Curr Med Chem
, vol.14
, Issue.19
, pp. 2009-2023
-
-
Martelli, A.M.1
Tazzari, P.L.2
Evangelisti, C.3
-
59
-
-
34249308840
-
The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation
-
Follo M.Y., Mongiorgi S., Bosi C., et al. The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation. Cancer Res 67 9 (2007) 4287-4294
-
(2007)
Cancer Res
, vol.67
, Issue.9
, pp. 4287-4294
-
-
Follo, M.Y.1
Mongiorgi, S.2
Bosi, C.3
-
60
-
-
28844480101
-
mTOR regulates cell survival after etoposide treatment in primary AML cells
-
Xu Q., Thompson J.E., and Carroll M. mTOR regulates cell survival after etoposide treatment in primary AML cells. Blood 106 13 (2005) 4261-4268
-
(2005)
Blood
, vol.106
, Issue.13
, pp. 4261-4268
-
-
Xu, Q.1
Thompson, J.E.2
Carroll, M.3
-
61
-
-
33746490507
-
Mammalian target of rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab
-
Wanner K., Hipp S., Oelsner M., et al. Mammalian target of rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab. Br J Haematol 134 5 (2006) 475-484
-
(2006)
Br J Haematol
, vol.134
, Issue.5
, pp. 475-484
-
-
Wanner, K.1
Hipp, S.2
Oelsner, M.3
-
62
-
-
33746118057
-
Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
-
Vega F., Medeiros L.J., Leventaki V., et al. Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Cancer Res 66 13 (2006) 6589-6597
-
(2006)
Cancer Res
, vol.66
, Issue.13
, pp. 6589-6597
-
-
Vega, F.1
Medeiros, L.J.2
Leventaki, V.3
-
63
-
-
34948830177
-
Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells
-
Kawamata N., Chen J., and Koeffler H.P. Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells. Blood 110 7 (2007) 2667-2673
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2667-2673
-
-
Kawamata, N.1
Chen, J.2
Koeffler, H.P.3
-
64
-
-
33847235398
-
Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview
-
Huyghe E., Zairi A., Nohra J., et al. Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview. Transpl Int 20 4 (2007) 305-311
-
(2007)
Transpl Int
, vol.20
, Issue.4
, pp. 305-311
-
-
Huyghe, E.1
Zairi, A.2
Nohra, J.3
-
65
-
-
34548312082
-
Sirolimus-associated infertility: case report and literature review of possible mechanisms
-
Deutsch M.A., Kaczmarek I., Huber S., et al. Sirolimus-associated infertility: case report and literature review of possible mechanisms. Am J Transplant 7 10 (2007) 2414-2421
-
(2007)
Am J Transplant
, vol.7
, Issue.10
, pp. 2414-2421
-
-
Deutsch, M.A.1
Kaczmarek, I.2
Huber, S.3
-
66
-
-
33748451305
-
[Nephrotoxicity of sirolimus: experimental and clinical data]
-
Pallet N., Thervet E., Legendre C., et al. [Nephrotoxicity of sirolimus: experimental and clinical data]. Nephrol Ther 2 4 (2006) 183-190
-
(2006)
Nephrol Ther
, vol.2
, Issue.4
, pp. 183-190
-
-
Pallet, N.1
Thervet, E.2
Legendre, C.3
-
67
-
-
33845390576
-
Sirolimus-associated proteinuria and renal dysfunction
-
Rangan G.K. Sirolimus-associated proteinuria and renal dysfunction. Drug Saf 29 12 (2006) 1153-1161
-
(2006)
Drug Saf
, vol.29
, Issue.12
, pp. 1153-1161
-
-
Rangan, G.K.1
-
68
-
-
35448978367
-
Pharmacokinetic profile of temsirolimus with concomitant administration of cytochrome P450-inducing medications
-
Boni J., Leister C., Burns J., et al. Pharmacokinetic profile of temsirolimus with concomitant administration of cytochrome P450-inducing medications. J Clin Pharmacol 47 11 (2007) 1430-1439
-
(2007)
J Clin Pharmacol
, vol.47
, Issue.11
, pp. 1430-1439
-
-
Boni, J.1
Leister, C.2
Burns, J.3
-
69
-
-
33746617583
-
Characterisation of the lung toxicity of the cell cycle inhibitor temsirolimus
-
Duran I., Siu L.L., Oza A.M., et al. Characterisation of the lung toxicity of the cell cycle inhibitor temsirolimus. Eur J Cancer 42 12 (2006) 1875-1880
-
(2006)
Eur J Cancer
, vol.42
, Issue.12
, pp. 1875-1880
-
-
Duran, I.1
Siu, L.L.2
Oza, A.M.3
-
70
-
-
34547453885
-
Comparison of sirolimus and everolimus in their effects on blood lipid profiles and haematological parameters in heart transplant recipients
-
Tenderich G., Fuchs U., Zittermann A., et al. Comparison of sirolimus and everolimus in their effects on blood lipid profiles and haematological parameters in heart transplant recipients. Clin Transplant 21 4 (2007) 536-543
-
(2007)
Clin Transplant
, vol.21
, Issue.4
, pp. 536-543
-
-
Tenderich, G.1
Fuchs, U.2
Zittermann, A.3
-
71
-
-
0028923877
-
FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells
-
Fruman D.A., Wood M.A., Gjertson C.K., et al. FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells. Eur J Immunol 25 2 (1995) 563-571
-
(1995)
Eur J Immunol
, vol.25
, Issue.2
, pp. 563-571
-
-
Fruman, D.A.1
Wood, M.A.2
Gjertson, C.K.3
-
72
-
-
0029977949
-
Rapamycin resistance tied to defective regulation of p27Kip1
-
Luo Y., Marx S.O., Kiyokawa H., et al. Rapamycin resistance tied to defective regulation of p27Kip1. Mol Cell Biol 16 12 (1996) 6744-6751
-
(1996)
Mol Cell Biol
, vol.16
, Issue.12
, pp. 6744-6751
-
-
Luo, Y.1
Marx, S.O.2
Kiyokawa, H.3
-
73
-
-
0032538890
-
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
-
Shima H., Pende M., Chen Y., et al. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J 17 22 (1998) 6649-6659
-
(1998)
EMBO J
, vol.17
, Issue.22
, pp. 6649-6659
-
-
Shima, H.1
Pende, M.2
Chen, Y.3
-
74
-
-
0037134480
-
4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin
-
Dilling M.B., Germain G.S., Dudkin L., et al. 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin. J Biol Chem 277 16 (2002) 13907-13917
-
(2002)
J Biol Chem
, vol.277
, Issue.16
, pp. 13907-13917
-
-
Dilling, M.B.1
Germain, G.S.2
Dudkin, L.3
-
75
-
-
0029828590
-
The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases
-
Dennis P.B., Pullen N., Kozma S.C., et al. The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Mol Cell Biol 16 11 (1996) 6242-6251
-
(1996)
Mol Cell Biol
, vol.16
, Issue.11
, pp. 6242-6251
-
-
Dennis, P.B.1
Pullen, N.2
Kozma, S.C.3
-
76
-
-
0029902281
-
p70 S6 kinase sensitivity to rapamycin is eliminated by amino acid substitution of Thr229
-
Sugiyama H., Papst P., Gelfand E.W., et al. p70 S6 kinase sensitivity to rapamycin is eliminated by amino acid substitution of Thr229. J Immunol 157 2 (1996) 656-660
-
(1996)
J Immunol
, vol.157
, Issue.2
, pp. 656-660
-
-
Sugiyama, H.1
Papst, P.2
Gelfand, E.W.3
-
77
-
-
0038094504
-
Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)
-
Huang S., Shu L., Dilling M.B., et al. Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). Mol Cell 11 6 (2003) 1491-1501
-
(2003)
Mol Cell
, vol.11
, Issue.6
, pp. 1491-1501
-
-
Huang, S.1
Shu, L.2
Dilling, M.B.3
-
78
-
-
33750211376
-
Predicted mechanisms of resistance to mTOR inhibitors
-
Kurmasheva R.T., Huang S., and Houghton P.J. Predicted mechanisms of resistance to mTOR inhibitors. Br J Cancer 95 8 (2006) 955-960
-
(2006)
Br J Cancer
, vol.95
, Issue.8
, pp. 955-960
-
-
Kurmasheva, R.T.1
Huang, S.2
Houghton, P.J.3
-
79
-
-
0029781185
-
Rapamycin resistance in ataxia-telangiectasia
-
Beamish H., Williams R., Chen P., et al. Rapamycin resistance in ataxia-telangiectasia. Oncogene 13 5 (1996) 963-970
-
(1996)
Oncogene
, vol.13
, Issue.5
, pp. 963-970
-
-
Beamish, H.1
Williams, R.2
Chen, P.3
-
80
-
-
0032548058
-
The 14-3-3 proteins positively regulate rapamycin-sensitive signaling
-
Bertram P.G., Zeng C., Thorson J., et al. The 14-3-3 proteins positively regulate rapamycin-sensitive signaling. Curr Biol 8 23 (1998) 1259-1267
-
(1998)
Curr Biol
, vol.8
, Issue.23
, pp. 1259-1267
-
-
Bertram, P.G.1
Zeng, C.2
Thorson, J.3
-
81
-
-
32944457518
-
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly K.E., Rojo F., She Q.B., et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 66 3 (2006) 1500-1508
-
(2006)
Cancer Res
, vol.66
, Issue.3
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
-
82
-
-
0029004755
-
Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma
-
Dumont F.J., Staruch M.J., Grammer T., et al. Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma. Cell Immunol 163 1 (1995) 70-79
-
(1995)
Cell Immunol
, vol.163
, Issue.1
, pp. 70-79
-
-
Dumont, F.J.1
Staruch, M.J.2
Grammer, T.3
-
83
-
-
19344374597
-
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival
-
Hammerman P.S., Fox C.J., Birnbaum M.J., et al. Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood 105 11 (2005) 4477-4483
-
(2005)
Blood
, vol.105
, Issue.11
, pp. 4477-4483
-
-
Hammerman, P.S.1
Fox, C.J.2
Birnbaum, M.J.3
-
84
-
-
0036735346
-
Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779
-
Shi Y., Gera J., Hu L., et al. Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779. Cancer Res 62 17 (2002) 5027-5034
-
(2002)
Cancer Res
, vol.62
, Issue.17
, pp. 5027-5034
-
-
Shi, Y.1
Gera, J.2
Hu, L.3
-
85
-
-
34248647440
-
Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma
-
Peponi E., Drakos E., Reyes G., et al. Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma. Am J Pathol 169 6 (2006) 2171-2180
-
(2006)
Am J Pathol
, vol.169
, Issue.6
, pp. 2171-2180
-
-
Peponi, E.1
Drakos, E.2
Reyes, G.3
-
86
-
-
35748958102
-
Expanding therapeutic options in mantle cell lymphoma
-
Goy A., and Feldman T. Expanding therapeutic options in mantle cell lymphoma. Clin Lymphoma Myeloma 7 suppl 5 (2007) S184-S191
-
(2007)
Clin Lymphoma Myeloma
, vol.7
, Issue.SUPPL. 5
-
-
Goy, A.1
Feldman, T.2
-
87
-
-
27144455334
-
Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells
-
Hipp S., Ringshausen I., Oelsner M., et al. Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells. Haematologica 90 10 (2005) 1433-1434
-
(2005)
Haematologica
, vol.90
, Issue.10
, pp. 1433-1434
-
-
Hipp, S.1
Ringshausen, I.2
Oelsner, M.3
-
88
-
-
34548653197
-
Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells
-
Baumann P., Mandl-Weber S., Emmerich B., et al. Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells. Exp Cell Res 313 16 (2007) 3592-3603
-
(2007)
Exp Cell Res
, vol.313
, Issue.16
, pp. 3592-3603
-
-
Baumann, P.1
Mandl-Weber, S.2
Emmerich, B.3
-
89
-
-
17444440115
-
Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone
-
Strömberg T., Dimberg A., Hammarberg A., et al. Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood 103 8 (2004) 3138-3147
-
(2004)
Blood
, vol.103
, Issue.8
, pp. 3138-3147
-
-
Strömberg, T.1
Dimberg, A.2
Hammarberg, A.3
-
90
-
-
33644516582
-
Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis
-
Yan H., Frost P., Shi Y., et al. Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis. Cancer Res 66 4 (2006) 2305-2313
-
(2006)
Cancer Res
, vol.66
, Issue.4
, pp. 2305-2313
-
-
Yan, H.1
Frost, P.2
Shi, Y.3
-
91
-
-
33845348883
-
Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma
-
Francis L.K., Alsayed Y., Leleu X., et al. Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma. Clin Cancer Res 12 22 (2006) 6826-6835
-
(2006)
Clin Cancer Res
, vol.12
, Issue.22
, pp. 6826-6835
-
-
Francis, L.K.1
Alsayed, Y.2
Leleu, X.3
-
92
-
-
23744494993
-
Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells
-
Avellino R., Romano S., Parasole R., et al. Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells. Blood 106 4 (2005) 1400-1406
-
(2005)
Blood
, vol.106
, Issue.4
, pp. 1400-1406
-
-
Avellino, R.1
Romano, S.2
Parasole, R.3
-
93
-
-
23844531209
-
Emerging drugs for adult acute lymphoblastic leukaemia
-
Thomas X. Emerging drugs for adult acute lymphoblastic leukaemia. Expert Opin Emerg Drugs 10 3 (2005) 591-617
-
(2005)
Expert Opin Emerg Drugs
, vol.10
, Issue.3
, pp. 591-617
-
-
Thomas, X.1
-
94
-
-
0345166113
-
Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
-
Brown V.I., Fang J., Alcom K., et al. Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling. Proc Natl Acad Sci U S A 100 25 (2003) 15113-15118
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.25
, pp. 15113-15118
-
-
Brown, V.I.1
Fang, J.2
Alcom, K.3
-
95
-
-
13544274110
-
Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells
-
Lal L., Li Y., Smith J., et al. Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. Blood 105 4 (2005) 1669-1677
-
(2005)
Blood
, vol.105
, Issue.4
, pp. 1669-1677
-
-
Lal, L.1
Li, Y.2
Smith, J.3
-
96
-
-
33745304265
-
[The PI3K/Akt/mTOR pathway: a new therapeutic target in the treatment of acute myeloid leukemia]
-
Dos Santos C., Récher C., Demur C., et al. [The PI3K/Akt/mTOR pathway: a new therapeutic target in the treatment of acute myeloid leukemia]. Bull Cancer 93 5 (2006) 445-447
-
(2006)
Bull Cancer
, vol.93
, Issue.5
, pp. 445-447
-
-
Dos Santos, C.1
Récher, C.2
Demur, C.3
-
97
-
-
20144363954
-
Antileukemic activity of rapamycin in acute myeloid leukemia
-
Récher C., Beyne-Rauzy O., Demur C., et al. Antileukemic activity of rapamycin in acute myeloid leukemia. Blood 105 6 (2005) 2527-2534
-
(2005)
Blood
, vol.105
, Issue.6
, pp. 2527-2534
-
-
Récher, C.1
Beyne-Rauzy, O.2
Demur, C.3
-
98
-
-
27744507024
-
mTOR, a new therapeutic target in acute myeloid leukemia
-
Récher C., Dos Santos C., Demur C., et al. mTOR, a new therapeutic target in acute myeloid leukemia. Cell Cycle 4 11 (2005) 1540-1549
-
(2005)
Cell Cycle
, vol.4
, Issue.11
, pp. 1540-1549
-
-
Récher, C.1
Dos Santos, C.2
Demur, C.3
-
99
-
-
28544444116
-
Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
-
Xu R.H., Pelicano H., Zhang H., et al. Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells. Leukemia 19 12 (2005) 2153-2158
-
(2005)
Leukemia
, vol.19
, Issue.12
, pp. 2153-2158
-
-
Xu, R.H.1
Pelicano, H.2
Zhang, H.3
-
100
-
-
33845190126
-
Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL-expressing cells
-
Yoon P., Giafis N., Smith J., et al. Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL-expressing cells. Mol Cancer Ther 5 11 (2006) 2815-2823
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.11
, pp. 2815-2823
-
-
Yoon, P.1
Giafis, N.2
Smith, J.3
-
101
-
-
0141508021
-
Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin
-
Ly C., Arechiga A.F., Melo J.V., et al. Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. Cancer Res 63 18 (2003) 5716-5722
-
(2003)
Cancer Res
, vol.63
, Issue.18
, pp. 5716-5722
-
-
Ly, C.1
Arechiga, A.F.2
Melo, J.V.3
-
102
-
-
27144526660
-
Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development
-
Burchert A., Wang Y., Cai D., et al. Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development. Leukemia 19 10 (2005) 1774-1782
-
(2005)
Leukemia
, vol.19
, Issue.10
, pp. 1774-1782
-
-
Burchert, A.1
Wang, Y.2
Cai, D.3
-
103
-
-
20444445152
-
Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells
-
Mayerhofer M., Aichberger K.J., Florian S., et al. Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells. FASEB J 19 8 (2005) 960-962
-
(2005)
FASEB J
, vol.19
, Issue.8
, pp. 960-962
-
-
Mayerhofer, M.1
Aichberger, K.J.2
Florian, S.3
-
104
-
-
27144554961
-
Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells
-
Parmar S., Smith J., Sassano A., et al. Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells. Blood 106 7 (2005) 2436-2443
-
(2005)
Blood
, vol.106
, Issue.7
, pp. 2436-2443
-
-
Parmar, S.1
Smith, J.2
Sassano, A.3
-
105
-
-
23944453915
-
A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein {beta} and NF-{kappa}B activity in Hodgkin and anaplastic large cell lymphomas
-
Jundt F., Raetzel N., Müller C., et al. A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein {beta} and NF-{kappa}B activity in Hodgkin and anaplastic large cell lymphomas. Blood 106 5 (2005) 1801-1807
-
(2005)
Blood
, vol.106
, Issue.5
, pp. 1801-1807
-
-
Jundt, F.1
Raetzel, N.2
Müller, C.3
-
106
-
-
12744279721
-
Mammalian target of rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: a new therapeutic option
-
Ringshausen I., Peschel C., and Decker T. Mammalian target of rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: a new therapeutic option. Leuk Lymphoma 46 1 (2005) 11-19
-
(2005)
Leuk Lymphoma
, vol.46
, Issue.1
, pp. 11-19
-
-
Ringshausen, I.1
Peschel, C.2
Decker, T.3
-
107
-
-
33845500278
-
Syk-dependent mTOR activation in follicular lymphoma cells
-
Leseux L., Hamdi S.M., Al Saati T., et al. Syk-dependent mTOR activation in follicular lymphoma cells. Blood 108 13 (2006) 4156-4162
-
(2006)
Blood
, vol.108
, Issue.13
, pp. 4156-4162
-
-
Leseux, L.1
Hamdi, S.M.2
Al Saati, T.3
-
108
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
Raymond E., Alexandre J., Faivre S., et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 22 12 (2004) 2336-2347
-
(2004)
J Clin Oncol
, vol.22
, Issue.12
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
-
109
-
-
33750321673
-
A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer
-
Hidalgo M., Buckner J.C., Erlichman C., et al. A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer. Clin Cancer Res 12 19 (2006) 5755-5763
-
(2006)
Clin Cancer Res
, vol.12
, Issue.19
, pp. 5755-5763
-
-
Hidalgo, M.1
Buckner, J.C.2
Erlichman, C.3
-
110
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins M.B., Hidalgo M., Stadler W.M., et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 22 5 (2004) 909-918
-
(2004)
J Clin Oncol
, vol.22
, Issue.5
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
-
111
-
-
0041662261
-
Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients
-
Peralba J.M., DeGraffenreid L., Friedrichs W., et al. Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients. Clin Cancer Res 9 8 (2003) 2887-2892
-
(2003)
Clin Cancer Res
, vol.9
, Issue.8
, pp. 2887-2892
-
-
Peralba, J.M.1
DeGraffenreid, L.2
Friedrichs, W.3
-
112
-
-
23944481410
-
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
-
Witzig T.E., Geyer S.M., Ghobrial I., et al. Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J Clin Oncol 23 23 (2005) 5347-5356
-
(2005)
J Clin Oncol
, vol.23
, Issue.23
, pp. 5347-5356
-
-
Witzig, T.E.1
Geyer, S.M.2
Ghobrial, I.3
-
113
-
-
0036808641
-
Drug-eluting stents: clinical experiences and perspectives
-
Grube E., Gerckens U., and Buellesfeld L. Drug-eluting stents: clinical experiences and perspectives. Minerva Cardioangiol 50 5 (2002) 469-473
-
(2002)
Minerva Cardioangiol
, vol.50
, Issue.5
, pp. 469-473
-
-
Grube, E.1
Gerckens, U.2
Buellesfeld, L.3
-
114
-
-
0034636055
-
The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: a potential approach to prevention and treatment of posttransplant lymphoproliferative disorders
-
Majewski M., Korecka M., Kossev P., et al. The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: a potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. Proc Natl Acad Sci U S A 97 8 (2000) 4285-4290
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, Issue.8
, pp. 4285-4290
-
-
Majewski, M.1
Korecka, M.2
Kossev, P.3
-
115
-
-
19244366021
-
Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients
-
Eisen H.J., Tuzcu E.M., Dorent R., et al. Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients. N Engl J Med 349 9 (2003) 847-858
-
(2003)
N Engl J Med
, vol.349
, Issue.9
, pp. 847-858
-
-
Eisen, H.J.1
Tuzcu, E.M.2
Dorent, R.3
-
116
-
-
0038054547
-
Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from posttransplant lymphoproliferative disorder at allograft-protecting doses
-
Majewski M., Korecka M., Joergensen J., et al. Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from posttransplant lymphoproliferative disorder at allograft-protecting doses. Transplantation 75 10 (2003) 1710-1717
-
(2003)
Transplantation
, vol.75
, Issue.10
, pp. 1710-1717
-
-
Majewski, M.1
Korecka, M.2
Joergensen, J.3
-
117
-
-
0742322206
-
Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation
-
Azzola A., Havry K.A., Chhajed P., et al. Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation. Transplantation 77 2 (2004) 275-280
-
(2004)
Transplantation
, vol.77
, Issue.2
, pp. 275-280
-
-
Azzola, A.1
Havry, K.A.2
Chhajed, P.3
-
118
-
-
33745801296
-
Everolimus in clinical practice: renal transplantation
-
Pascual J. Everolimus in clinical practice: renal transplantation. Nephrol Dial Transplant 21 suppl 3 (2006) iii18-iii23
-
(2006)
Nephrol Dial Transplant
, vol.21
, Issue.SUPPL. 3
-
-
Pascual, J.1
-
120
-
-
9144233506
-
Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells
-
Boulay A., Zumstein-Mecker S., Stephan C., et al. Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res 64 1 (2004) 252-261
-
(2004)
Cancer Res
, vol.64
, Issue.1
, pp. 252-261
-
-
Boulay, A.1
Zumstein-Mecker, S.2
Stephan, C.3
-
121
-
-
33846516354
-
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
-
Haritunians T., Mori A., O'Kelly J., et al. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia 21 2 (2007) 333-339
-
(2007)
Leukemia
, vol.21
, Issue.2
, pp. 333-339
-
-
Haritunians, T.1
Mori, A.2
O'Kelly, J.3
-
122
-
-
48949114252
-
-
Feldman E, Giles F, Roboz G, et al. A phase 2 clinical trial of AP23573, an mTOR inhibitor, in patients with relapsed or refractory hematologic malignancies. J Clin Oncol 2005 ASCO Annual Meeting Proceedings. Vol 23, No. 16S, Part I of II (June 1 Supplement), Abstract 6631, 2005.
-
Feldman E, Giles F, Roboz G, et al. A phase 2 clinical trial of AP23573, an mTOR inhibitor, in patients with relapsed or refractory hematologic malignancies. J Clin Oncol 2005 ASCO Annual Meeting Proceedings. Vol 23, No. 16S, Part I of II (June 1 Supplement), Abstract 6631, 2005.
-
-
-
-
123
-
-
33745154372
-
A phase 2 clinical trial of AP23573, an mTOR inhibitor, in patients with relapsed or refractory hematologic malignancies
-
Abstract 2980
-
Rizzieri D.A., Feldman E., Moore J.O., et al. A phase 2 clinical trial of AP23573, an mTOR inhibitor, in patients with relapsed or refractory hematologic malignancies. Blood 106 11 (2005) Abstract 2980
-
(2005)
Blood
, vol.106
, Issue.11
-
-
Rizzieri, D.A.1
Feldman, E.2
Moore, J.O.3
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