In vitro DNA recombination by L-Shuffling during ribosome display affinity maturation of an anti-Fas antibody increases the population of improved variants

Protein Engineering, Design and Selection

Volumn 21, Issue 5, 2008, Pages 343-351

  Chodorge, Matthieu ^a   Fourage, Laurent ^b   Ravot, Gilles ^b   Jermutus, Lutz ^a   Minter, Ralph ^a  

^a MEDIMMUNE LTD   (United Kingdom)

^b Proteus SA   (France)

Author keywords

Affinity maturation; Directed evolution; Fas; In vitro recombination; Ribosome display

Indexed keywords

DNA; EVOLUTIONARY ALGORITHMS; GENES; NUCLEIC ACIDS; ORGANIC ACIDS;

AFFINITY MATURATION; COMBINATORIAL LIBRARIES; COOPERATIVE EFFECTS; DIRECTED EVOLUTION; DISPLAY TECHNOLOGIES; DNA RECOMBINATION; FAS; HIGH AFFINITY; IN VITRO AFFINITY MATURATION; IN VITRO RECOMBINATION; IN-VITRO; LARGE REGIONS; OPTIMAL SOLUTIONS; PARALLEL EVOLUTION; RANDOM MUTAGENESIS; RIBOSOME DISPLAY; SEQUENCE SPACES; SINGLE-CHAIN VARIABLE FRAGMENT;

ANTIBODIES;

FAS ANTIBODY; ANTIBODY; DNA; FAS ANTIGEN; PEPTIDE LIBRARY;

ANTIBODY AFFINITY; ARTICLE; BINDING KINETICS; COMBINATORIAL LIBRARY; DNA RECOMBINATION; DNA SHUFFLING; EVOLUTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; CHEMICAL STRUCTURE; CHEMISTRY; GENE LIBRARY; GENETIC RECOMBINATION; GENETIC VARIABILITY; KINETICS; METABOLISM; METHODOLOGY; MOLECULAR CLONING; MUTATION; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS;

ANTIBODIES; ANTIGENS, CD95; CLONING, MOLECULAR; DNA; GENE LIBRARY; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE LIBRARY; PROTEIN ENGINEERING; RECOMBINATION, GENETIC; RIBOSOMES; VARIATION (GENETICS);

EID: 48849098734     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzn013     Document Type: Article

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