메뉴 건너뛰기




Volumn 7, Issue 3, 2008, Pages 445-465

Biosynthesis and genetic engineering of proanthocyanidins and (iso)flavonoids

Author keywords

Genetic engineering; Isoflavone; Nutraceutical; Proanthocyanidin

Indexed keywords

8 PRENYLNARINGENIN; AFZELECHIN; ANTHOCYANIDIN REDUCTASE; ANTHOCYANIDIN SYNTHASE; CATECHIN; CYP93C2 PROTEIN; DIHYDROFLAVONOL REDUCTASE; EPICATECHIN; FLAVANONE; GALLOCATECHIN; GRAPE SEED EXTRACT; ISOFLAVONE; ISOFLAVONOID; LEUKOANTHOCYANIDIN REDUCTASE; LUTEONE; MUTANT PROTEIN; MYC PROTEIN; NORXANTHOHUMOL; NUTRACEUTICAL; OSAJIN; PHASEOLINONE; PHYTOESTROGEN; PLANT MEDICINAL PRODUCT; POLYPHENOL; PORNIFERIN; PROANTHOCYANIDIN DERIVATIVE; PROTEIN MYB; UNINDEXED DRUG; WIGHTEONE; XANTHOHUMOL;

EID: 48449097118     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1007/s11101-007-9076-y     Document Type: Conference Paper
Times cited : (76)

References (134)
  • 1
    • 15544364507 scopus 로고    scopus 로고
    • Genomics-based selection and functional characterization of triterpene glycosyltransferases from the model legume Medicago truncatula
    • L Achnine DV Huhman MA Farag 2005 Genomics-based selection and functional characterization of triterpene glycosyltransferases from the model legume Medicago truncatula Plant J 41 875 887
    • (2005) Plant J , vol.41 , pp. 875-887
    • Achnine, L.1    Huhman, D.V.2    Farag, M.A.3
  • 2
    • 0036072803 scopus 로고    scopus 로고
    • Phyto-oestrogens and cancer
    • H Adlercreutz 2002 Phyto-oestrogens and cancer Lancet Oncol 3 364 373
    • (2002) Lancet Oncol , vol.3 , pp. 364-373
    • Adlercreutz, H.1
  • 3
    • 0034655603 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kB in cancer cells versus normal cells
    • N Ahmad S Gupta H Mukhtar 2000 Green tea polyphenol epigallocatechin-3- gallate differentially modulates nuclear factor kB in cancer cells versus normal cells Arch Biochem Biophys 376 338 346
    • (2000) Arch Biochem Biophys , vol.376 , pp. 338-346
    • Ahmad, N.1    Gupta, S.2    Mukhtar, H.3
  • 4
    • 0032541027 scopus 로고    scopus 로고
    • Identification of a cytochrome P450 cDNA encoding (2S)-flavanone 2-hydroxylase of licorice (Glycyrrhiza echinata L.; Fabaceae) which represents licodione synthase and flavone synthase II
    • T Akashi T Aoki S Ayabe 1998 Identification of a cytochrome P450 cDNA encoding (2S)-flavanone 2-hydroxylase of licorice (Glycyrrhiza echinata L.; Fabaceae) which represents licodione synthase and flavone synthase II FEBS Lett 431 287 290
    • (1998) FEBS Lett , vol.431 , pp. 287-290
    • Akashi, T.1    Aoki, T.2    Ayabe, S.3
  • 5
    • 0033230703 scopus 로고    scopus 로고
    • Cloning and functional expression of a cytochrome P450 cDNA encoding 2-hydroxyisoflavanone synthase involved in biosynthesis of the isoflavonoid skeleton in licorice
    • T Akashi T Aoki S Ayabe 1999 Cloning and functional expression of a cytochrome P450 cDNA encoding 2-hydroxyisoflavanone synthase involved in biosynthesis of the isoflavonoid skeleton in licorice Plant Physiol 121 821 828
    • (1999) Plant Physiol , vol.121 , pp. 821-828
    • Akashi, T.1    Aoki, T.2    Ayabe, S.3
  • 6
    • 18144363888 scopus 로고    scopus 로고
    • Molecular and biochemical characterization of 2-hydroxyisoflavanone dehydratase. Involvement of carboxylesterase-like proteins in leguminous isoflavone biosynthesis
    • T Akashi T Aoki S Ayabe 2005 Molecular and biochemical characterization of 2-hydroxyisoflavanone dehydratase. Involvement of carboxylesterase-like proteins in leguminous isoflavone biosynthesis Plant Physiol 137 882 891
    • (2005) Plant Physiol , vol.137 , pp. 882-891
    • Akashi, T.1    Aoki, T.2    Ayabe, S.3
  • 7
    • 0033228156 scopus 로고    scopus 로고
    • Molecular cloning and biochemical characterization of a novel cytochrome P450, flavone synthase II, that catalyzes direct conversion of flavanones to flavones
    • T Akashi M Fukuchi-Mizutani T Aoki 1999 Molecular cloning and biochemical characterization of a novel cytochrome P450, flavone synthase II, that catalyzes direct conversion of flavanones to flavones Plant Cell Physiol 40 1182 1186
    • (1999) Plant Cell Physiol , vol.40 , pp. 1182-1186
    • Akashi, T.1    Fukuchi-Mizutani, M.2    Aoki, T.3
  • 8
    • 0037328464 scopus 로고    scopus 로고
    • CDNA cloning and biochemical characterization of S-adenosyl-l-methionine: 2,7,4′-trihydroxyisoflavnone 4′-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway
    • T Akashi Y Sawada N Shimada 2003 cDNA cloning and biochemical characterization of S-adenosyl-l-methionine: 2,7,4′-trihydroxyisoflavnone 4′-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway Plant Cell Physiol 44 103 112
    • (2003) Plant Cell Physiol , vol.44 , pp. 103-112
    • Akashi, T.1    Sawada, Y.2    Shimada, N.3
  • 9
    • 33750741065 scopus 로고    scopus 로고
    • Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis
    • T Akashi HD VanEtten Y Sawada 2006 Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis Phytochemistry 67 2525 2530
    • (2006) Phytochemistry , vol.67 , pp. 2525-2530
    • Akashi, T.1    Vanetten, H.D.2    Sawada, Y.3
  • 10
    • 0023664272 scopus 로고
    • Genistein, a specific inhibitor of tyrosine-specific protein kinases
    • T Akiyama J Ishida S Nakagawa 1987 Genistein, a specific inhibitor of tyrosine-specific protein kinases J Biol Chem 262 5592 5595
    • (1987) J Biol Chem , vol.262 , pp. 5592-5595
    • Akiyama, T.1    Ishida, J.2    Nakagawa, S.3
  • 11
    • 0034668117 scopus 로고    scopus 로고
    • Novel flavonol 2-oxoglutarate dependent dioxygenase: Affinity purification, characterization, and kinetic properties
    • D Anzellotti RK Ibrahim 2000 Novel flavonol 2-oxoglutarate dependent dioxygenase: affinity purification, characterization, and kinetic properties Arch Biochem Biophys 382 161 172
    • (2000) Arch Biochem Biophys , vol.382 , pp. 161-172
    • Anzellotti, D.1    Ibrahim, R.K.2
  • 12
    • 0034617986 scopus 로고    scopus 로고
    • Free radicals and grape seed proanthocyanidn extract: Importance in human health and disease prevention
    • D Bagchi M Bagchi SJ Stohs 2000 Free radicals and grape seed proanthocyanidn extract: importance in human health and disease prevention Toxicol 148 187 197
    • (2000) Toxicol , vol.148 , pp. 187-197
    • Bagchi, D.1    Bagchi, M.2    Stohs, S.J.3
  • 13
    • 0029013369 scopus 로고
    • Dietary intervention study to assess estrogenicity of dietary soy, among postmenopausal women
    • D Baird D Umbach 1995 Dietary intervention study to assess estrogenicity of dietary soy, among postmenopausal women Clin Endocrinol 80 1685 1690
    • (1995) Clin Endocrinol , vol.80 , pp. 1685-1690
    • Baird, D.1    Umbach, D.2
  • 14
    • 0030295152 scopus 로고    scopus 로고
    • Isoprenylated flavonoids-a survey
    • D Barron R Ibrahim 1996 Isoprenylated flavonoids-a survey Phytochemistry 43 921 982
    • (1996) Phytochemistry , vol.43 , pp. 921-982
    • Barron, D.1    Ibrahim, R.2
  • 15
    • 0033066444 scopus 로고    scopus 로고
    • The implications of condensed tannins on the nutritive value of temperate forages fed to ruminants
    • TN Barry WC McNabb 1999 The implications of condensed tannins on the nutritive value of temperate forages fed to ruminants Br J Nutr 81 263 272
    • (1999) Br J Nutr , vol.81 , pp. 263-272
    • Barry, T.N.1    McNabb, W.C.2
  • 16
    • 3843067588 scopus 로고    scopus 로고
    • TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana
    • A Baudry MA Heim B Dubreucq 2004 TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana Plant J 39 366 380
    • (2004) Plant J , vol.39 , pp. 366-380
    • Baudry, A.1    Heim, M.A.2    Dubreucq, B.3
  • 17
    • 20044390564 scopus 로고    scopus 로고
    • A plasma membrane H+-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana
    • IR Baxter JC Young G Armstrong 2005 A plasma membrane H+-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana Proc Natl Acad Sci USA 102 2649 2654
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2649-2654
    • Baxter, I.R.1    Young, J.C.2    Armstrong, G.3
  • 18
    • 0035451343 scopus 로고    scopus 로고
    • Soy isoflavonoids and cancer-metabolism at the target site
    • BJ Boersma S Barnes M Kirk 2001 Soy isoflavonoids and cancer-metabolism at the target site Mut Res 480-481 121 127
    • (2001) Mut Res , vol.480-481 , pp. 121-127
    • Boersma, B.J.1    Barnes, S.2    Kirk, M.3
  • 19
    • 33644645555 scopus 로고    scopus 로고
    • Proanthocyanidin synthesis and expression of genes encoding leucoanthocyanidin reductase and anthocyanidin reductase in developing grape berries and grapevine leaves
    • J Bogs MO Downey JS Harvey 2005 Proanthocyanidin synthesis and expression of genes encoding leucoanthocyanidin reductase and anthocyanidin reductase in developing grape berries and grapevine leaves Plant Physiol 139 652 663
    • (2005) Plant Physiol , vol.139 , pp. 652-663
    • Bogs, J.1    Downey, M.O.2    Harvey, J.S.3
  • 20
    • 33645834129 scopus 로고    scopus 로고
    • Identification of the flavonoid hydroxylases from grapevine and their regulation during fruit development
    • J Bogs A Ebadi D McDavid 2006 Identification of the flavonoid hydroxylases from grapevine and their regulation during fruit development Plant Physiol 140 279 291
    • (2006) Plant Physiol , vol.140 , pp. 279-291
    • Bogs, J.1    Ebadi, A.2    McDavid, D.3
  • 21
    • 34250651222 scopus 로고    scopus 로고
    • The grapevine transcription factor VvMYBPA1 regulates proanthocyanidin synthesis during fruit development
    • J Bogs FW Jaffé AM Takos 2007 The grapevine transcription factor VvMYBPA1 regulates proanthocyanidin synthesis during fruit development Plant Physiol 143 1347 1361
    • (2007) Plant Physiol , vol.143 , pp. 1347-1361
    • Bogs, J.1    Jaffé, F.W.2    Takos, A.M.3
  • 22
    • 0034489893 scopus 로고    scopus 로고
    • Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis
    • J Borevitz Y Xia JW Blount 2000 Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis Plant Cell 12 2383 2393
    • (2000) Plant Cell , vol.12 , pp. 2383-2393
    • Borevitz, J.1    Xia, Y.2    Blount, J.W.3
  • 23
    • 33645655917 scopus 로고    scopus 로고
    • Glycosyltransferases of lipophilic small molecules
    • D Bowles E Lim B Poppenberger 2006 Glycosyltransferases of lipophilic small molecules Annu Rev Plant Biol 57 567 597
    • (2006) Annu Rev Plant Biol , vol.57 , pp. 567-597
    • Bowles, D.1    Lim, E.2    Poppenberger, B.3
  • 24
    • 0029786235 scopus 로고    scopus 로고
    • Quantitative trait loci and metabolic pathways: Genetic control of the concentration of maysin, a corn earworm resistance factor, in maize silks
    • PF Byrne MD McMullen ME Snook 1996 Quantitative trait loci and metabolic pathways: Genetic control of the concentration of maysin, a corn earworm resistance factor, in maize silks Proc Natl Acad Sci USA 93 8820 8825
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8820-8825
    • Byrne, P.F.1    McMullen, M.D.2    Snook, M.E.3
  • 25
    • 0030020915 scopus 로고    scopus 로고
    • Cytochrome P450-dependent methylenedioxy bridge formation in Cicer arietinum
    • S Clemens W Barz 1996 Cytochrome P450-dependent methylenedioxy bridge formation in Cicer arietinum Phytochemistry 41 457 460
    • (1996) Phytochemistry , vol.41 , pp. 457-460
    • Clemens, S.1    Barz, W.2
  • 27
    • 33644700143 scopus 로고    scopus 로고
    • Metabolic engineering of isoflavonoid biosynthesis in alfalfa (Medicago sativa L.)
    • BE Deavours RA Dixon 2005 Metabolic engineering of isoflavonoid biosynthesis in alfalfa (Medicago sativa L.) Plant Physiol 138 2245 2259
    • (2005) Plant Physiol , vol.138 , pp. 2245-2259
    • Deavours, B.E.1    Dixon, R.A.2
  • 28
    • 33750428586 scopus 로고    scopus 로고
    • Functional analysis of members of the isoflavone- and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula
    • BE Deavours C-J Liu M Naoumkina 2006 Functional analysis of members of the isoflavone- and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula Plant Mol Biol 62 715 733
    • (2006) Plant Mol Biol , vol.62 , pp. 715-733
    • Deavours, B.E.1    Liu, C.-J.2    Naoumkina, M.3
  • 29
    • 0035037365 scopus 로고    scopus 로고
    • The TRANSPARENT TESTA 12 gene of Arabidopsis encodes a multidrug secondary transporter-like protein required for flavonoid sequestration in vacuoles of the seed coat endothelium
    • I Debeaujon AJM Peeters KM Leon-Kloosterziel 2001 The TRANSPARENT TESTA 12 gene of Arabidopsis encodes a multidrug secondary transporter-like protein required for flavonoid sequestration in vacuoles of the seed coat endothelium Plant Cell 13 853 871
    • (2001) Plant Cell , vol.13 , pp. 853-871
    • Debeaujon, I.1    Peeters, A.J.M.2    Leon-Kloosterziel, K.M.3
  • 30
    • 33646837363 scopus 로고    scopus 로고
    • Characterization of a grapevine R2R3-MYB transcription factor that regulates the phenylpropanoid pathway
    • L Deluc F Barrieu C Marchive 2006 Characterization of a grapevine R2R3-MYB transcription factor that regulates the phenylpropanoid pathway Plant Physiol 140 499 511
    • (2006) Plant Physiol , vol.140 , pp. 499-511
    • Deluc, L.1    Barrieu, F.2    Marchive, C.3
  • 31
    • 0032894527 scopus 로고    scopus 로고
    • Diet and its preventive role in prostatic disease
    • L Denis M Morton K Griffiths 1999 Diet and its preventive role in prostatic disease Eur Urol 35 377 387
    • (1999) Eur Urol , vol.35 , pp. 377-387
    • Denis, L.1    Morton, M.2    Griffiths, K.3
  • 34
    • 11144274431 scopus 로고    scopus 로고
    • Proanthocyanidins-a final frontier in flavonoid research?
    • RA Dixon DY Xie SB Sharma 2005 Proanthocyanidins-a final frontier in flavonoid research? New Phytol 165 9 28
    • (2005) New Phytol , vol.165 , pp. 9-28
    • Dixon, R.A.1    Xie, D.Y.2    Sharma, S.B.3
  • 35
    • 0034941792 scopus 로고    scopus 로고
    • A review of latest research findings on the health promotion properties of tea
    • CJ Dufresne ER Farnworth 2001 A review of latest research findings on the health promotion properties of tea J Nutr Biochem 12 404 421
    • (2001) J Nutr Biochem , vol.12 , pp. 404-421
    • Dufresne, C.J.1    Farnworth, E.R.2
  • 36
    • 33947123585 scopus 로고    scopus 로고
    • Chemistry and pharmacology of oxyprenylated secondary plant metabolites
    • F Epifano S Genovese L Menghini 2007 Chemistry and pharmacology of oxyprenylated secondary plant metabolites Phytochemistry 68 939 953
    • (2007) Phytochemistry , vol.68 , pp. 939-953
    • Epifano, F.1    Genovese, S.2    Menghini, L.3
  • 37
    • 0001585772 scopus 로고    scopus 로고
    • The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro
    • LY Foo Y Lu AB Howell 2000 The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro Phytochemistry 54 173 181
    • (2000) Phytochemistry , vol.54 , pp. 173-181
    • Foo, L.Y.1    Lu, Y.2    Howell, A.B.3
  • 38
    • 0030043463 scopus 로고    scopus 로고
    • Proanthocyanidins from Lotus corniculatus
    • LY Foo R Newman G Waghorn 1996 Proanthocyanidins from Lotus corniculatus Phytochemistry 41 617 624
    • (1996) Phytochemistry , vol.41 , pp. 617-624
    • Foo, L.Y.1    Newman, R.2    Waghorn, G.3
  • 39
    • 0029610477 scopus 로고
    • Review of the biology of quercetin and related bioflavonoids
    • JV Formica W Regelson 1995 Review of the biology of quercetin and related bioflavonoids Food Chem Toxicol 33 1061 1080
    • (1995) Food Chem Toxicol , vol.33 , pp. 1061-1080
    • Formica, J.V.1    Regelson, W.2
  • 40
    • 0037403591 scopus 로고    scopus 로고
    • A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3′,5′-hydroxylase gene
    • Y Fukui Y Tanaka T Kusumi 2003 A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3′,5′-hydroxylase gene Phytochemistry 63 15 23
    • (2003) Phytochemistry , vol.63 , pp. 15-23
    • Fukui, Y.1    Tanaka, Y.2    Kusumi, T.3
  • 41
    • 33845615515 scopus 로고    scopus 로고
    • The Rc and Rd genes are involved in proanthocyanidin synthesis in rice pericarp
    • T Furukawa M Maekawa T Oki 2007 The Rc and Rd genes are involved in proanthocyanidin synthesis in rice pericarp Plant J 49 91 102
    • (2007) Plant J , vol.49 , pp. 91-102
    • Furukawa, T.1    Maekawa, M.2    Oki, T.3
  • 42
    • 0028891259 scopus 로고
    • Biosynthesis, accumulation and secretion of isoflavonoids during germination and development of white lupin (Lupinus albus L.)
    • H Gagnon S Tahara RK Ibrahim 1995 Biosynthesis, accumulation and secretion of isoflavonoids during germination and development of white lupin (Lupinus albus L.) J Exp Bot 46 609 616
    • (1995) J Exp Bot , vol.46 , pp. 609-616
    • Gagnon, H.1    Tahara, S.2    Ibrahim, R.K.3
  • 43
    • 0028901336 scopus 로고
    • Antithyroid effects in vivo and in vitro of vitexin: A C-glucosylflavone in millet
    • E Gaitan R Cooksey J Legan 1995 Antithyroid effects in vivo and in vitro of vitexin: a C-glucosylflavone in millet J Clin Endocrinol Metabol 80 1144 1147
    • (1995) J Clin Endocrinol Metabol , vol.80 , pp. 1144-1147
    • Gaitan, E.1    Cooksey, R.2    Legan, J.3
  • 44
    • 34250208085 scopus 로고    scopus 로고
    • A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates
    • Y Haagen I Unsöld L Westrich 2007 A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates FEBS Lett 581 2889 2893
    • (2007) FEBS Lett , vol.581 , pp. 2889-2893
    • Haagen, Y.1    Unsöld, I.2    Westrich, L.3
  • 45
    • 0034736046 scopus 로고    scopus 로고
    • Advances in flavonoid research since 1992
    • JB Harborne CA Williams 2000 Advances in flavonoid research since 1992 Phytochemistry 55 481 504
    • (2000) Phytochemistry , vol.55 , pp. 481-504
    • Harborne, J.B.1    Williams, C.A.2
  • 46
    • 0033791938 scopus 로고    scopus 로고
    • Genetic manipulation of isoflavone 7-O-methyltransferase enhances the biosynthesis of 4′-O-methylated isoflavonoid phytoalexins and disease resistance in alfalfa
    • XZ He R Dixon 2000 Genetic manipulation of isoflavone 7-O-methyltransferase enhances the biosynthesis of 4′-O-methylated isoflavonoid phytoalexins and disease resistance in alfalfa Plant Cell 12 1689 1702
    • (2000) Plant Cell , vol.12 , pp. 1689-1702
    • He, X.Z.1    Dixon, R.2
  • 47
    • 0031881338 scopus 로고    scopus 로고
    • Stress responses in alfalfa (Medicago sativa L.) XXII. cDNA cloning and characterization of an elicitor-inducible isoflavone 7-O-methyltransferase
    • XZ He JT Reddy RA Dixon 1998 Stress responses in alfalfa (Medicago sativa L.) XXII. cDNA cloning and characterization of an elicitor-inducible isoflavone 7-O-methyltransferase Plant Mol Biol 36 43 54
    • (1998) Plant Mol Biol , vol.36 , pp. 43-54
    • He, X.Z.1    Reddy, J.T.2    Dixon, R.A.3
  • 48
    • 33845928213 scopus 로고    scopus 로고
    • Mutational analysis of the Medicago glycosyltransferase UGT71G1 reveals residues that control regioselectivity for (iso)flavonoid glycosylation
    • XZ He XQ Wang RA Dixon 2006 Mutational analysis of the Medicago glycosyltransferase UGT71G1 reveals residues that control regioselectivity for (iso)flavonoid glycosylation J Biol Chem 281 34441 34447
    • (2006) J Biol Chem , vol.281 , pp. 34441-34447
    • He, X.Z.1    Wang, X.Q.2    Dixon, R.A.3
  • 49
    • 0033951110 scopus 로고    scopus 로고
    • Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes
    • W Jung O Yu S-M Lau 2000 Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes Nat Biotech 18 208 212
    • (2000) Nat Biotech , vol.18 , pp. 208-212
    • Jung, W.1    Yu, O.2    Lau, S.-M.3
  • 50
  • 52
    • 2142799601 scopus 로고    scopus 로고
    • Cloning and expression of the isoflavone synthase gene (IFS-Tp) from Trifolium pratense
    • BG Kim SY Kim HS Song 2003 Cloning and expression of the isoflavone synthase gene (IFS-Tp) from Trifolium pratense Mol Cells 15 301 306
    • (2003) Mol Cells , vol.15 , pp. 301-306
    • Kim, B.G.1    Kim, S.Y.2    Song, H.S.3
  • 53
    • 0345874786 scopus 로고    scopus 로고
    • TRANSPARENT TESTA 19 is involved in the accumulation of both anthocyanins and proanthocyanidins in Arabidopsis
    • S Kitamura N Shikazono A Tanaka 2004 TRANSPARENT TESTA 19 is involved in the accumulation of both anthocyanins and proanthocyanidins in Arabidopsis Plant J 37 104 114
    • (2004) Plant J , vol.37 , pp. 104-114
    • Kitamura, S.1    Shikazono, N.2    Tanaka, A.3
  • 54
    • 0031830517 scopus 로고    scopus 로고
    • Prenylflavonoids: A new class of non-steroidal phytoestrogen. 1. Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship
    • M Kitaoka H Kadokawa M Sugano 1998 Prenylflavonoids: a new class of non-steroidal phytoestrogen. 1. Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship Planta Med 64 511 515
    • (1998) Planta Med , vol.64 , pp. 511-515
    • Kitaoka, M.1    Kadokawa, H.2    Sugano, M.3
  • 55
    • 20544457539 scopus 로고    scopus 로고
    • Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products
    • T Kuzuyama JP Noel SB Richard 2005 Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products Nature 435 983 987
    • (2005) Nature , vol.435 , pp. 983-987
    • Kuzuyama, T.1    Noel, J.P.2    Richard, S.B.3
  • 56
    • 0000196973 scopus 로고
    • Enzymatic prenylation of isoflavones in white lupin
    • P LaFlamme H Khouri P Gulick 1993 Enzymatic prenylation of isoflavones in white lupin Phytochemistry 34 147 151
    • (1993) Phytochemistry , vol.34 , pp. 147-151
    • Laflamme, P.1    Khouri, H.2    Gulick, P.3
  • 57
    • 0026095778 scopus 로고
    • Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives: Relationship to antioxidant activity and to iron ion-reducing ability
    • MJ Laughton PJ Evans MA Moroney 1991 Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives: relationship to antioxidant activity and to iron ion-reducing ability Biochem Pharmacol 42 1673 1681
    • (1991) Biochem Pharmacol , vol.42 , pp. 1673-1681
    • Laughton, M.J.1    Evans, P.J.2    Moroney, M.A.3
  • 58
    • 0025761501 scopus 로고
    • Dietary effects on breast-cancer risk in Singapore
    • HP Lee L Gourley SW Duffy 1991 Dietary effects on breast-cancer risk in Singapore Lancet 337 1197 1200
    • (1991) Lancet , vol.337 , pp. 1197-1200
    • Lee, H.P.1    Gourley, L.2    Duffy, S.W.3
  • 59
    • 24044445872 scopus 로고    scopus 로고
    • Purified high-dose anthocyanoside oligomer administration improves nocturnal vision and clinical symptoms in myopis subjects
    • JM Lee HK Lee CY Kim 2005 Purified high-dose anthocyanoside oligomer administration improves nocturnal vision and clinical symptoms in myopis subjects Br J Nutr 93 895 800
    • (2005) Br J Nutr , vol.93 , pp. 895-800
    • Lee, J.M.1    Lee, H.K.2    Kim, C.Y.3
  • 60
    • 0026677159 scopus 로고
    • Condensed tannins in some forage legumes: Their role in the prevention of ruminant pasture bloat
    • GL Lees 1992 Condensed tannins in some forage legumes: their role in the prevention of ruminant pasture bloat Basic Life Sci 59 915 934
    • (1992) Basic Life Sci , vol.59 , pp. 915-934
    • Lees, G.L.1
  • 61
    • 34548536586 scopus 로고    scopus 로고
    • Maize Lc transcription factor enhances biosynthesis of anthocyanins, distinct proanthocyanidins and phenylpropanoids in apple (Malus domestica Borkh.)
    • H Li H Flachowsky TC Fischer 2007 Maize Lc transcription factor enhances biosynthesis of anthocyanins, distinct proanthocyanidins and phenylpropanoids in apple (Malus domestica Borkh.) Planta 226 1243 1254
    • (2007) Planta , vol.226 , pp. 1243-1254
    • Li, H.1    Flachowsky, H.2    Fischer, T.C.3
  • 62
    • 34250172749 scopus 로고    scopus 로고
    • Crystal structure of Medicago truncatula UGT85H2-insights into the structural basis of a multifunctional (iso)flavonoid glycosyltransferase
    • L Li L Modolo L Escamilla-Trevino 2007 Crystal structure of Medicago truncatula UGT85H2-insights into the structural basis of a multifunctional (iso)flavonoid glycosyltransferase J Mol Biol 370 951 963
    • (2007) J Mol Biol , vol.370 , pp. 951-963
    • Li, L.1    Modolo, L.2    Escamilla-Trevino, L.3
  • 63
    • 4143140277 scopus 로고    scopus 로고
    • Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides
    • EK Lim DA Ashford B Hou RG Jackson DJ Bowles 2004 Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides Biotechnol Bioeng 87 623 631
    • (2004) Biotechnol Bioeng , vol.87 , pp. 623-631
    • Lim, E.K.1    Ashford, D.A.2    Hou, B.3    Jackson, R.G.4    Bowles, D.J.5
  • 64
    • 0031797349 scopus 로고    scopus 로고
    • Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats
    • R Lin T Li 1998 Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats Am J Clin Nutr 68 1512S 1515S
    • (1998) Am J Clin Nutr , vol.68
    • Lin, R.1    Li, T.2
  • 65
    • 0037195078 scopus 로고    scopus 로고
    • Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis
    • CJ Liu JW Blount CL Steele 2002 Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis Proc Natl Acad Sci USA 99 14578 14583
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14578-14583
    • Liu, C.J.1    Blount, J.W.2    Steele, C.L.3
  • 66
    • 33947534869 scopus 로고    scopus 로고
    • Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses
    • CJ Liu BE Deavours SB Richard 2006 Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses Plant Cell 18 3656 3669
    • (2006) Plant Cell , vol.18 , pp. 3656-3669
    • Liu, C.J.1    Deavours, B.E.2    Richard, S.B.3
  • 67
    • 0035542775 scopus 로고    scopus 로고
    • Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis
    • CJ Liu RA Dixon 2001 Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis Plant Cell 13 2643 2658
    • (2001) Plant Cell , vol.13 , pp. 2643-2658
    • Liu, C.J.1    Dixon, R.A.2
  • 68
    • 0344961689 scopus 로고    scopus 로고
    • Regiospecific hydroxylation of isoflavones by cytochrome P450 81E enzymes from Medicago truncatula
    • CJ Liu DV Huhman LW Sumner 2003 Regiospecific hydroxylation of isoflavones by cytochrome P450 81E enzymes from Medicago truncatula Plant J 36 471 484
    • (2003) Plant J , vol.36 , pp. 471-484
    • Liu, C.J.1    Huhman, D.V.2    Sumner, L.W.3
  • 69
    • 33845663674 scopus 로고    scopus 로고
    • Production of soybean isoflavone genistein in non-legume plants via genetically modified secondary metabolism pathway
    • R Liu Y Hu J Li 2007 Production of soybean isoflavone genistein in non-legume plants via genetically modified secondary metabolism pathway Metab Eng 9 1 7
    • (2007) Metab Eng , vol.9 , pp. 1-7
    • Liu, R.1    Hu, Y.2    Li, J.3
  • 70
    • 34547675748 scopus 로고    scopus 로고
    • +-antiporter active in proanthocyanidin-accumulating cells of the seed coat
    • +-antiporter active in proanthocyanidin-accumulating cells of the seed coat Plant Cell 19 2023 2038
    • (2007) Plant Cell , vol.19 , pp. 2023-2038
    • Marinova, K.1    Pourcel, L.2    Weder, B.3
  • 71
    • 0033375553 scopus 로고    scopus 로고
    • Cloning and expression of flavone synthease II from Gerbera hybrids
    • S Martens G Forkmann 1999 Cloning and expression of flavone synthease II from Gerbera hybrids Plant J 20 611 618
    • (1999) Plant J , vol.20 , pp. 611-618
    • Martens, S.1    Forkmann, G.2
  • 72
    • 0032708789 scopus 로고    scopus 로고
    • In vitro and in vivo antioxidant properties of Vacinnum myrtillus
    • S Martin-Aragon B Basabe JM Benedi 1999 In vitro and in vivo antioxidant properties of Vacinnum myrtillus Pharm Biol 37 109 113
    • (1999) Pharm Biol , vol.37 , pp. 109-113
    • Martin-Aragon, S.1    Basabe, B.2    Benedi, J.M.3
  • 73
    • 0026583736 scopus 로고
    • Effects of flavonoids on immune and inflammatory cell functions
    • E Middleton C Kandaswami 1992 Effects of flavonoids on immune and inflammatory cell functions Biochem Pharmacol 43 1167 1179
    • (1992) Biochem Pharmacol , vol.43 , pp. 1167-1179
    • Middleton, E.1    Kandaswami, C.2
  • 74
    • 0036160624 scopus 로고    scopus 로고
    • Oestrogenic activity of the hop phyto-oestrogen, 8-prenylnaringenin
    • S Milligan J Kalita V Pocock 2002 Oestrogenic activity of the hop phyto-oestrogen, 8-prenylnaringenin Reproduction (Cambridge) 123 235 242
    • (2002) Reproduction (Cambridge) , vol.123 , pp. 235-242
    • Milligan, S.1    Kalita, J.2    Pocock, V.3
  • 75
    • 0033304530 scopus 로고    scopus 로고
    • Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer
    • SR Milligan JC Kalita A Heyerick 1999 Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer J Clin Endocrinol Metab 84 2249 2252
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2249-2252
    • Milligan, S.R.1    Kalita, J.C.2    Heyerick, A.3
  • 76
    • 0034485521 scopus 로고    scopus 로고
    • The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids
    • SR Milligan JC Kalita V Pocock 2000 The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids J Clin Endocrinol Metab 85 4912 4915
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4912-4915
    • Milligan, S.R.1    Kalita, J.C.2    Pocock, V.3
  • 77
    • 3042729283 scopus 로고    scopus 로고
    • Evaluation of post transcriptional gene silencing methods using flower color as the indicator
    • M Mizutani S Tsuda K Suzuki 2003 Evaluation of post transcriptional gene silencing methods using flower color as the indicator Plant Cell Physiol 44 s122
    • (2003) Plant Cell Physiol , vol.44 , pp. 122
    • Mizutani, M.1    Tsuda, S.2    Suzuki, K.3
  • 78
    • 34250179856 scopus 로고    scopus 로고
    • A functional genomics approach to (iso)flavonoid glycosylation in the model legume Medicago truncatula
    • L Modolo JW Blount L Achnine 2007 A functional genomics approach to (iso)flavonoid glycosylation in the model legume Medicago truncatula Plant Mol Biol 64 499 518
    • (2007) Plant Mol Biol , vol.64 , pp. 499-518
    • Modolo, L.1    Blount, J.W.2    Achnine, L.3
  • 79
    • 0742285083 scopus 로고    scopus 로고
    • CDNA cloning and expression of isoflavonoid-specific glucosyltransferase from Glycyrrhiza echinata cell-suspension cultures
    • S Nagashima R Inagaki A Kubo 2004 cDNA cloning and expression of isoflavonoid-specific glucosyltransferase from Glycyrrhiza echinata cell-suspension cultures Planta 218 456 459
    • (2004) Planta , vol.218 , pp. 456-459
    • Nagashima, S.1    Inagaki, R.2    Kubo, A.3
  • 80
    • 0033192101 scopus 로고    scopus 로고
    • Induction of isoflavonoid and retrochalcone branches of the flavonoid pathway in cultured Glycyrrhiza echinata cells treated with yeast extract
    • K Nakamura T Akashi T Aoki 1999 Induction of isoflavonoid and retrochalcone branches of the flavonoid pathway in cultured Glycyrrhiza echinata cells treated with yeast extract Biosci Biotechnol Biochem 63 1618 1620
    • (1999) Biosci Biotechnol Biochem , vol.63 , pp. 1618-1620
    • Nakamura, K.1    Akashi, T.2    Aoki, T.3
  • 81
    • 0033768615 scopus 로고    scopus 로고
    • The TT8 gene encodes a basic helix-loop-helix domain protein required for expression of DFR and BAN genes in Arabidopsis siliques
    • N Nesi I Debeaujon C Jond 2000 The TT8 gene encodes a basic helix-loop-helix domain protein required for expression of DFR and BAN genes in Arabidopsis siliques Plant Cell 12 1863 1878
    • (2000) Plant Cell , vol.12 , pp. 1863-1878
    • Nesi, N.1    Debeaujon, I.2    Jond, C.3
  • 82
    • 0034816095 scopus 로고    scopus 로고
    • The Arabidopsis TT2 gene encodes an R2R3 MYB domain protein that acts as a key determinant for proanthocyanidin accumulation in developing seed
    • N Nesi C Jond I Debeaujon 2001 The Arabidopsis TT2 gene encodes an R2R3 MYB domain protein that acts as a key determinant for proanthocyanidin accumulation in developing seed Plant Cell 13 2099 2114
    • (2001) Plant Cell , vol.13 , pp. 2099-2114
    • Nesi, N.1    Jond, C.2    Debeaujon, I.3
  • 83
    • 33645290775 scopus 로고    scopus 로고
    • Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification
    • W Offen C Martinez-Fleites M Yang 2006 Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification EMBO J 25 1396 1405
    • (2006) EMBO J , vol.25 , pp. 1396-1405
    • Offen, W.1    Martinez-Fleites, C.2    Yang, M.3
  • 84
    • 0024238244 scopus 로고
    • Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha-ras-transformed NIH 3T3 cells
    • A Okura H Arakawa H Oka 1988 Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha-ras-transformed NIH 3T3 cells Biochem Biophys Res Commun 157 183 189
    • (1988) Biochem Biophys Res Commun , vol.157 , pp. 183-189
    • Okura, A.1    Arakawa, H.2    Oka, H.3
  • 85
    • 33746611926 scopus 로고    scopus 로고
    • Yellow flowers generated by expression of the aurone biosynthetic pathway
    • E Ono M Fukuchi-Mizutani N Nakamura 2006 Yellow flowers generated by expression of the aurone biosynthetic pathway Proc Natl Acad Sci USA 103 11075 11080
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11075-11080
    • Ono, E.1    Fukuchi-Mizutani, M.2    Nakamura, N.3
  • 86
    • 36248986142 scopus 로고    scopus 로고
    • Early steps in proanthocyanidin biosynthesis in the model legume Medicago truncatula
    • (in press)
    • Pang Y, Peel GJ, Wright E et al (2007) Early steps in proanthocyanidin biosynthesis in the model legume Medicago truncatula. Plant Physiol (in press)
    • (2007) Plant Physiol
    • Pang, Y.1    Peel, G.J.2    Wright, E.3
  • 87
    • 17144387562 scopus 로고    scopus 로고
    • Light and an exogenous transcription factor qualitatively and quantitatively affect the biosynthetic pathway of condensed tannins in Lotus corniculatus leaves
    • F Paolocci T Bovone N Tosti 2005 Light and an exogenous transcription factor qualitatively and quantitatively affect the biosynthetic pathway of condensed tannins in Lotus corniculatus leaves J Exp Bot 56 1093 1103
    • (2005) J Exp Bot , vol.56 , pp. 1093-1103
    • Paolocci, F.1    Bovone, T.2    Tosti, N.3
  • 88
    • 33846381025 scopus 로고    scopus 로고
    • Ectopic expression of a basic helix-loop-helix gene transactivates parallel pathways of proanthocyanidin biosynthesis. Structure, expression, analysis, and genetic control of leucoanthocyanidin 4-reductase and anthocyanidin reductase genes in Lotus corniculatus
    • F Paolocci MP Robbins L Madeo 2007 Ectopic expression of a basic helix-loop-helix gene transactivates parallel pathways of proanthocyanidin biosynthesis. Structure, expression, analysis, and genetic control of leucoanthocyanidin 4-reductase and anthocyanidin reductase genes in Lotus corniculatus Plant Physiol 143 504 516
    • (2007) Plant Physiol , vol.143 , pp. 504-516
    • Paolocci, F.1    Robbins, M.P.2    Madeo, L.3
  • 89
    • 0037418178 scopus 로고    scopus 로고
    • CloQ, a prenyltransferase involved in clorobiocin biosynthesis
    • F Pojer E Wemakor B Kammerer 2003 CloQ, a prenyltransferase involved in clorobiocin biosynthesis Proc Natl Acad Sci USA 100 2316 2321
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2316-2321
    • Pojer, F.1    Wemakor, E.2    Kammerer, B.3
  • 90
    • 0031772172 scopus 로고    scopus 로고
    • Soy protein and isoflavones: Their effects on blood lipids and bone density in postmenopausal women
    • S Potter J Baum H Teng 1998 Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women Am J Clin Nutr 68 1375S 1379S
    • (1998) Am J Clin Nutr , vol.68
    • Potter, S.1    Baum, J.2    Teng, H.3
  • 91
    • 33344460777 scopus 로고    scopus 로고
    • TRANSPARENT TESTA10 encodes a laccase-like enzyme involved in oxidative polymerization of flavonoids in Arabidopsis seed coat
    • L Pourcel JM Routaboul L Kerhoas 2005 TRANSPARENT TESTA10 encodes a laccase-like enzyme involved in oxidative polymerization of flavonoids in Arabidopsis seed coat Plant Cell 17 2966 2980
    • (2005) Plant Cell , vol.17 , pp. 2966-2980
    • Pourcel, L.1    Routaboul, J.M.2    Kerhoas, L.3
  • 92
    • 0038715050 scopus 로고    scopus 로고
    • Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc
    • H Ray M Yu P Auser 2003 Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc Plant Physiol 132 1448 1463
    • (2003) Plant Physiol , vol.132 , pp. 1448-1463
    • Ray, H.1    Yu, M.2    Auser, P.3
  • 93
    • 0346034859 scopus 로고    scopus 로고
    • Sn, a maize bHLH gene, modulates anthocyanin and condensed tannin pathways in Lotus corniculatus
    • MP Robbins F Paolocci J-W Hughes 2003 Sn, a maize bHLH gene, modulates anthocyanin and condensed tannin pathways in Lotus corniculatus J Exp Bot 54 239 248
    • (2003) J Exp Bot , vol.54 , pp. 239-248
    • Robbins, M.P.1    Paolocci, F.2    Hughes, J.-W.3
  • 94
    • 0035113472 scopus 로고    scopus 로고
    • Higher plant glycosyltransferases
    • JR Ross Y Li EK Lim 2001 Higher plant glycosyltransferases Genome Biol 2 30041 30046
    • (2001) Genome Biol , vol.2 , pp. 30041-30046
    • Ross, J.R.1    Li, Y.2    Lim, E.K.3
  • 95
    • 33744491283 scopus 로고    scopus 로고
    • Flavonoid diversity and biosynthesis in seed of Arabidopsis thaliana
    • J-M Routaboul L Kerhoas I Debeaujon 2006 Flavonoid diversity and biosynthesis in seed of Arabidopsis thaliana Planta 224 96 107
    • (2006) Planta , vol.224 , pp. 96-107
    • Routaboul, J.-M.1    Kerhoas, L.2    Debeaujon, I.3
  • 96
    • 33646512624 scopus 로고    scopus 로고
    • Antioxidant activity of isoflavones and their major metabolites using different in vitro assays
    • CE Rufer SE Kulling 2006 Antioxidant activity of isoflavones and their major metabolites using different in vitro assays J Agric Food Chem 54 2926 2931
    • (2006) J Agric Food Chem , vol.54 , pp. 2926-2931
    • Rufer, C.E.1    Kulling, S.E.2
  • 97
    • 0041559957 scopus 로고    scopus 로고
    • Anthocyanin and proanthocyanidin content in selected white and red wines. Oxygen radical absorbance capacity compairson with nontraditional wines obtained from highbush blueberry
    • MC Sanchez G Cao B Ou 2003 Anthocyanin and proanthocyanidin content in selected white and red wines. Oxygen radical absorbance capacity compairson with nontraditional wines obtained from highbush blueberry J Agric Food Chem 51 4889 4896
    • (2003) J Agric Food Chem , vol.51 , pp. 4889-4896
    • Sanchez, M.C.1    Cao, G.2    Ou, B.3
  • 98
    • 16244404948 scopus 로고    scopus 로고
    • Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue
    • Y Sawada S Ayabe 2005 Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue Biochem Biophy Res Commun 330 907 913
    • (2005) Biochem Biophy Res Commun , vol.330 , pp. 907-913
    • Sawada, Y.1    Ayabe, S.2
  • 99
    • 0036735095 scopus 로고    scopus 로고
    • Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase
    • Y Sawada K Kinoshita T Akashi 2002 Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase Plant J 31 555 564
    • (2002) Plant J , vol.31 , pp. 555-564
    • Sawada, Y.1    Kinoshita, K.2    Akashi, T.3
  • 100
    • 0031660180 scopus 로고    scopus 로고
    • Molecular characterization and functional expression of dihydroxypterocarpan 6a-hydroxylase, an enzyme specific for pterocarpanoid phytoalexin biosynthesis in soybean (Glycine max L.)
    • CR Schopfer G Kochs F Lottspeich 1998 Molecular characterization and functional expression of dihydroxypterocarpan 6a-hydroxylase, an enzyme specific for pterocarpanoid phytoalexin biosynthesis in soybean (Glycine max L.) FEBS Lett 432 182 186
    • (1998) FEBS Lett , vol.432 , pp. 182-186
    • Schopfer, C.R.1    Kochs, G.2    Lottspeich, F.3
  • 101
  • 102
    • 33645281589 scopus 로고    scopus 로고
    • Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from Medicago truncatula
    • H Shao X He L Achnine 2005 Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from Medicago truncatula Plant Cell 17 3141 3154
    • (2005) Plant Cell , vol.17 , pp. 3141-3154
    • Shao, H.1    He, X.2    Achnine, L.3
  • 103
    • 33644753233 scopus 로고    scopus 로고
    • Metabolic engineering of proanthocyanidins by ectopic expression of transcription factors in Arabidopsis thaliana
    • SB Sharma RA Dixon 2006 Metabolic engineering of proanthocyanidins by ectopic expression of transcription factors in Arabidopsis thaliana Plant J 44 62 75
    • (2006) Plant J , vol.44 , pp. 62-75
    • Sharma, S.B.1    Dixon, R.A.2
  • 104
    • 0035868353 scopus 로고    scopus 로고
    • Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation
    • JPE Spencer H Schroeter G Kuhnle 2001 Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation Biochem J 354 493 500
    • (2001) Biochem J , vol.354 , pp. 493-500
    • Spencer, J.P.E.1    Schroeter, H.2    Kuhnle, G.3
  • 105
    • 33745621868 scopus 로고    scopus 로고
    • Metabolic engineering of rice with soybean isoflavone synthase for promoting nodulation gene expression in rhizobia
    • V Sreevidya C Srinivasa Rao S Sullia 2006 Metabolic engineering of rice with soybean isoflavone synthase for promoting nodulation gene expression in rhizobia J Exp Bot 57 1957 1969
    • (2006) J Exp Bot , vol.57 , pp. 1957-1969
    • Sreevidya, V.1    Srinivasa Rao, C.2    Sullia, S.3
  • 106
    • 0033167088 scopus 로고    scopus 로고
    • Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean
    • CL Steele M Gijzen D Qutob 1999 Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean Arch Biochem Biophys 367 147 150
    • (1999) Arch Biochem Biophys , vol.367 , pp. 147-150
    • Steele, C.L.1    Gijzen, M.2    Qutob, D.3
  • 107
    • 0032440431 scopus 로고    scopus 로고
    • Dietary phytoestrogens and their role in hormonally dependent disease
    • L Strauss R Santti N Saarinen 1998 Dietary phytoestrogens and their role in hormonally dependent disease Toxicol Lett 103 349 354
    • (1998) Toxicol Lett , vol.103 , pp. 349-354
    • Strauss, L.1    Santti, R.2    Saarinen, N.3
  • 108
    • 33745385623 scopus 로고    scopus 로고
    • Caught red-handed: Rc encodes a basic helix-loop-helix protein conditioning red pericarp in rice
    • MT Sweeney MJ Thomson BE Pfeil 2006 Caught red-handed: Rc encodes a basic helix-loop-helix protein conditioning red pericarp in rice Plant Cell 18 283 294
    • (2006) Plant Cell , vol.18 , pp. 283-294
    • Sweeney, M.T.1    Thomson, M.J.2    Pfeil, B.E.3
  • 109
    • 0029135787 scopus 로고
    • Prenylated isoflavonoids-an update
    • S Tahara RK Ibrahim 1995 Prenylated isoflavonoids-an update Phytochemistry 38 1073 1094
    • (1995) Phytochemistry , vol.38 , pp. 1073-1094
    • Tahara, S.1    Ibrahim, R.K.2
  • 110
    • 0001735423 scopus 로고    scopus 로고
    • Metabolic engineering to modify flower color
    • Y Tanaka S Tsuda T Kusumi 1998 Metabolic engineering to modify flower color Plant Cell Physiol 39 1119 1126
    • (1998) Plant Cell Physiol , vol.39 , pp. 1119-1126
    • Tanaka, Y.1    Tsuda, S.2    Kusumi, T.3
  • 111
    • 0042357171 scopus 로고    scopus 로고
    • Proanthocyanidin biosynthesis in plants. Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA
    • GJ Tanner KT Francki S Abrahams 2003 Proanthocyanidin biosynthesis in plants. Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA J Biol Chem 278 31647 31656
    • (2003) J Biol Chem , vol.278 , pp. 31647-31656
    • Tanner, G.J.1    Francki, K.T.2    Abrahams, S.3
  • 112
    • 33746888659 scopus 로고    scopus 로고
    • Engineering isoflavone metabolism with an artificial bifunctional enzyme
    • L Tian RA Dixon 2006 Engineering isoflavone metabolism with an artificial bifunctional enzyme Planta 224 496 507
    • (2006) Planta , vol.224 , pp. 496-507
    • Tian, L.1    Dixon, R.A.2
  • 113
    • 0034056131 scopus 로고    scopus 로고
    • Dietary soy-derived isoflavone phytoestrogens: Could they have a role in coronary heart disease prevention
    • MJ Tikkanen H Adlercreutz 2000 Dietary soy-derived isoflavone phytoestrogens: could they have a role in coronary heart disease prevention Biochem Pharmacol 60 1 5
    • (2000) Biochem Pharmacol , vol.60 , pp. 1-5
    • Tikkanen, M.J.1    Adlercreutz, H.2
  • 114
    • 17044369876 scopus 로고    scopus 로고
    • Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor
    • T Tohge Y Nishiyama MY Hirai 2005 Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor Plant J 42 218 235
    • (2005) Plant J , vol.42 , pp. 218-235
    • Tohge, T.1    Nishiyama, Y.2    Hirai, M.Y.3
  • 115
    • 0346463040 scopus 로고    scopus 로고
    • Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis
    • JJ Turnbull J Nakajima RD Welford 2004 Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis J Biol Chem 279 1206 1216
    • (2004) J Biol Chem , vol.279 , pp. 1206-1216
    • Turnbull, J.J.1    Nakajima, J.2    Welford, R.D.3
  • 116
    • 0036853770 scopus 로고    scopus 로고
    • Beneficial effects of a novel IH636 grape seed proanthocyanidin extract and a niacin-bound chromium in a hamster aterosclerosis model
    • JA Vinson MA Mandarano DL Shuta 2002 Beneficial effects of a novel IH636 grape seed proanthocyanidin extract and a niacin-bound chromium in a hamster aterosclerosis model Mol Cell Biochem 240 99 103
    • (2002) Mol Cell Biochem , vol.240 , pp. 99-103
    • Vinson, J.A.1    Mandarano, M.A.2    Shuta, D.L.3
  • 117
    • 0033165574 scopus 로고    scopus 로고
    • The TRANSPARENT TESTA GLABRA 1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein
    • AR Walker PA Davison AC Bolognesi-Winfield 1999 The TRANSPARENT TESTA GLABRA 1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein Plant Cell 11 1377 1349
    • (1999) Plant Cell , vol.11 , pp. 1377-1349
    • Walker, A.R.1    Davison, P.A.2    Bolognesi-Winfield, A.C.3
  • 118
    • 0015888576 scopus 로고
    • The in vivo incorporation of a flavanone into C-glycosylflavones
    • JW Wallace H Grisebach 1973 The in vivo incorporation of a flavanone into C-glycosylflavones Biochim Biophys Acta 304 837 841
    • (1973) Biochim Biophys Acta , vol.304 , pp. 837-841
    • Wallace, J.W.1    Grisebach, H.2
  • 119
    • 0011288088 scopus 로고
    • On the biogenesis of flavone O-glycosides and C-glycosides in the lemnaceae
    • JW Wallace TJ Mabry RE Alston 1969 On the biogenesis of flavone O-glycosides and C-glycosides in the lemnaceae Phytochemistry 8 93 99
    • (1969) Phytochemistry , vol.8 , pp. 93-99
    • Wallace, J.W.1    Mabry, T.J.2    Alston, R.E.3
  • 120
    • 0024287676 scopus 로고
    • Induction of phytoalexin synthesis in soybean: Enzymatic cyclization of prenylated pterocarpans to glyceollin isomers
    • R Welle H Grisebach 1988 Induction of phytoalexin synthesis in soybean: enzymatic cyclization of prenylated pterocarpans to glyceollin isomers Arch Biochem Biophys 263 191 198
    • (1988) Arch Biochem Biophys , vol.263 , pp. 191-198
    • Welle, R.1    Grisebach, H.2
  • 121
    • 0001233414 scopus 로고
    • Properties and solubilization of the prenyltransferase of isoflavonoid phytoalexin biosynthesis in soybean
    • R Welle H Grisebach 1991 Properties and solubilization of the prenyltransferase of isoflavonoid phytoalexin biosynthesis in soybean Phytochemistry 30 479 484
    • (1991) Phytochemistry , vol.30 , pp. 479-484
    • Welle, R.1    Grisebach, H.2
  • 122
    • 0033855504 scopus 로고    scopus 로고
    • Isoflavone phytoestrogens consumed in soy decrease F-2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans
    • H Wiseman JD OReilly H Adlercreutz 2000 Isoflavone phytoestrogens consumed in soy decrease F-2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans Am J Clin Nutr 72 395 400
    • (2000) Am J Clin Nutr , vol.72 , pp. 395-400
    • Wiseman, H.1    Oreilly, J.D.2    Adlercreutz, H.3
  • 123
    • 0031282612 scopus 로고    scopus 로고
    • Isolation of the cDNAs encoding (+)6a-hydroxymaackiain 3-O-methyltransferase, the terminal step for the synthesis of the phytoalexin pisatin in Pisum satium
    • Q Wu CL Presig HD VanEtten 1997 Isolation of the cDNAs encoding (+)6a-hydroxymaackiain 3-O-methyltransferase, the terminal step for the synthesis of the phytoalexin pisatin in Pisum satium Plant Mol Biol 35 551 560
    • (1997) Plant Mol Biol , vol.35 , pp. 551-560
    • Wu, Q.1    Presig, C.L.2    Vanetten, H.D.3
  • 124
    • 0037449585 scopus 로고    scopus 로고
    • Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis
    • D Xie SR Sharma NL Paiva 2003 Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis Science 299 396 399
    • (2003) Science , vol.299 , pp. 396-399
    • Xie, D.1    Sharma, S.R.2    Paiva, N.L.3
  • 125
    • 0346059448 scopus 로고    scopus 로고
    • Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana
    • DY Xie SB Sharma RA Dixon 2004 Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana Arch Biochem Biophys 422 91 102
    • (2004) Arch Biochem Biophys , vol.422 , pp. 91-102
    • Xie, D.Y.1    Sharma, S.B.2    Dixon, R.A.3
  • 126
    • 33644748116 scopus 로고    scopus 로고
    • Metabolic engineering of proanthocyanidins through co-expression of anthocyanidin reductase and the PAP1 MYB transcription factor
    • DY Xie B Sharma E Wright 2006 Metabolic engineering of proanthocyanidins through co-expression of anthocyanidin reductase and the PAP1 MYB transcription factor Plant J 45 895 907
    • (2006) Plant J , vol.45 , pp. 895-907
    • Xie, D.Y.1    Sharma, B.2    Wright, E.3
  • 127
    • 0033791950 scopus 로고    scopus 로고
    • Production of the isoflavones genistein and daidzein in non-legume dicot and monocot tissues
    • O Yu W Jung J Shi 2000 Production of the isoflavones genistein and daidzein in non-legume dicot and monocot tissues Plant Physiol 124 781 794
    • (2000) Plant Physiol , vol.124 , pp. 781-794
    • Yu, O.1    Jung, W.2    Shi, J.3
  • 128
    • 0041367286 scopus 로고    scopus 로고
    • Metabolic engineering to increase isoflavone biosynthesis in soybean seed
    • O Yu J Shi AO Hession 2003 Metabolic engineering to increase isoflavone biosynthesis in soybean seed Phytochemistry 63 753 763
    • (2003) Phytochemistry , vol.63 , pp. 753-763
    • Yu, O.1    Shi, J.2    Hession, A.O.3
  • 129
    • 0342618482 scopus 로고    scopus 로고
    • Inhibitory effects of jasmine green tea epicatechin isomers on free radical-induced lysis of red blood cells
    • AQ Zhan QY Zhu YS Luk 1997 Inhibitory effects of jasmine green tea epicatechin isomers on free radical-induced lysis of red blood cells Life Sci 61 383 394
    • (1997) Life Sci , vol.61 , pp. 383-394
    • Zhan, A.Q.1    Zhu, Q.Y.2    Luk, Y.S.3
  • 130
    • 0142181015 scopus 로고    scopus 로고
    • A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis
    • F Zhang A Gonzalez M Zhao 2003 A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis Development 130 4859 4869
    • (2003) Development , vol.130 , pp. 4859-4869
    • Zhang, F.1    Gonzalez, A.2    Zhao, M.3
  • 131
    • 33646449792 scopus 로고    scopus 로고
    • Puerarin induces angiogenesis in myocardium of rat with myocardial infarction
    • S Zhang S Chen Y Shen 2006 Puerarin induces angiogenesis in myocardium of rat with myocardial infarction Biol Pharm Bull 29 945 950
    • (2006) Biol Pharm Bull , vol.29 , pp. 945-950
    • Zhang, S.1    Chen, S.2    Shen, Y.3
  • 132
    • 0035119588 scopus 로고    scopus 로고
    • Crystal structures of chalcone O-methyltransferase and isoflavone O-methyltransferase reveal the structural basis for substrate specificity in plant O-methyltransferases
    • C Zubieta RA Dixon JP Noel 2001 Crystal structures of chalcone O-methyltransferase and isoflavone O-methyltransferase reveal the structural basis for substrate specificity in plant O-methyltransferases Nat Struct Biol 8 271 279
    • (2001) Nat Struct Biol , vol.8 , pp. 271-279
    • Zubieta, C.1    Dixon, R.A.2    Noel, J.P.3
  • 133
    • 0036314962 scopus 로고    scopus 로고
    • Modification of flower color and fragrance by antisense suppression of the flavanone 3-hydroxylase gene
    • A Zuker T Tzfira H Ben-Meir 2002 Modification of flower color and fragrance by antisense suppression of the flavanone 3-hydroxylase gene Mol Breed 9 33 41
    • (2002) Mol Breed , vol.9 , pp. 33-41
    • Zuker, A.1    Tzfira, T.2    Ben-Meir, H.3
  • 134
    • 0032431931 scopus 로고    scopus 로고
    • In-vitro prenylation of aromatic intermediates in the biosynthesis of bitter acids in Humulus lupulus
    • KWM Zuurbier SY Fung JJC Scheffer 1998 In-vitro prenylation of aromatic intermediates in the biosynthesis of bitter acids in Humulus lupulus Phytochemistry 49 2315 2322
    • (1998) Phytochemistry , vol.49 , pp. 2315-2322
    • Zuurbier, K.W.M.1    Fung, S.Y.2    Scheffer, J.J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.