메뉴 건너뛰기




Volumn 9, Issue 1, 2007, Pages 1-7

Production of soybean isoflavone genistein in non-legume plants via genetically modified secondary metabolism pathway

Author keywords

Flavanone 3 hydroxylase; Genistein; Isoflavone synthase; Metabolic engineering; Phenylalanine ammonia lyase

Indexed keywords

AGRICULTURAL PRODUCTS; AMMONIA; BIOSYNTHESIS; ENZYMES; GENES; METABOLISM; PLANTS (BOTANY);

EID: 33845663674     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2006.08.003     Document Type: Article
Times cited : (75)

References (35)
  • 1
    • 0033230703 scopus 로고    scopus 로고
    • Cloning and functional expression of a cytochrome P450 cDNA encoding 2-hydroxyisoflavanone synthase involved in biosynthesis of the isoflavonoid skeleton in Licorice
    • Akashi T., Aoki T., and Ayabe S. Cloning and functional expression of a cytochrome P450 cDNA encoding 2-hydroxyisoflavanone synthase involved in biosynthesis of the isoflavonoid skeleton in Licorice. Plant Physiol. 121 (1999) 821-828
    • (1999) Plant Physiol. , vol.121 , pp. 821-828
    • Akashi, T.1    Aoki, T.2    Ayabe, S.3
  • 2
    • 0034349180 scopus 로고    scopus 로고
    • Flavonoids of leguminous plants: structure, biological activity, and biosynthesis
    • Aoki T., Akashi T., and Ayabe S. Flavonoids of leguminous plants: structure, biological activity, and biosynthesis. J. Plant Res. 113 (2000) 475-488
    • (2000) J. Plant Res. , vol.113 , pp. 475-488
    • Aoki, T.1    Akashi, T.2    Ayabe, S.3
  • 3
    • 0028018107 scopus 로고
    • Quantitative relationship between phenylalanine ammonia-lyase levels and phenylpropanoid accumulation in transgenic tobacco identifies a rate-determining step in natural product synthesis
    • Bate N.J., Orr J., Ni W., Meromi A., Nadler-Hassar T., Doerner P.W., Dixon R.A., Lamb C.J., and Elkind Y. Quantitative relationship between phenylalanine ammonia-lyase levels and phenylpropanoid accumulation in transgenic tobacco identifies a rate-determining step in natural product synthesis. Proc. Natl. Acad. Sci. USA 91 (1994) 7608-7612
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7608-7612
    • Bate, N.J.1    Orr, J.2    Ni, W.3    Meromi, A.4    Nadler-Hassar, T.5    Doerner, P.W.6    Dixon, R.A.7    Lamb, C.J.8    Elkind, Y.9
  • 4
    • 20544469985 scopus 로고    scopus 로고
    • Health effects of phytoestrogens
    • Branca F., and Lorenzetti S. Health effects of phytoestrogens. Forum. Nutr. 57 (2005) 100-111
    • (2005) Forum. Nutr. , vol.57 , pp. 100-111
    • Branca, F.1    Lorenzetti, S.2
  • 5
    • 0033966729 scopus 로고    scopus 로고
    • Expression profiling of the maize flavonoid pathway genes controlled by estradiol-inducible transcription factors CRC and P
    • Bruce W., Folkerts O., Garnaat C., Crasta O., Roth B., and Bowen B. Expression profiling of the maize flavonoid pathway genes controlled by estradiol-inducible transcription factors CRC and P. Plant Cell 12 (2000) 65-79
    • (2000) Plant Cell , vol.12 , pp. 65-79
    • Bruce, W.1    Folkerts, O.2    Garnaat, C.3    Crasta, O.4    Roth, B.5    Bowen, B.6
  • 6
    • 0033607282 scopus 로고    scopus 로고
    • Interaction among enzymes of the Arabidopsis flavonoid biosynthetic pathway
    • Burbulis I.E., and Winkel-Shirley B. Interaction among enzymes of the Arabidopsis flavonoid biosynthetic pathway. Proc. Natl. Acad. Sci. USA 96 (1999) 12929-12934
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12929-12934
    • Burbulis, I.E.1    Winkel-Shirley, B.2
  • 7
  • 8
    • 33644700143 scopus 로고    scopus 로고
    • Metabolic engineering of isoflavonoid biosynthesis in Alfalfa
    • Deavours B.E., and Dixon R.A. Metabolic engineering of isoflavonoid biosynthesis in Alfalfa. Plant Physiol. 138 (2005) 2245-2259
    • (2005) Plant Physiol. , vol.138 , pp. 2245-2259
    • Deavours, B.E.1    Dixon, R.A.2
  • 10
    • 0037355426 scopus 로고    scopus 로고
    • Legume natural products: understanding and manipulating complex pathways for human and animal health
    • Dixon R.A., and Sumner L.W. Legume natural products: understanding and manipulating complex pathways for human and animal health. Plant Physiol. 131 (2003) 878-885
    • (2003) Plant Physiol. , vol.131 , pp. 878-885
    • Dixon, R.A.1    Sumner, L.W.2
  • 11
    • 20444422841 scopus 로고    scopus 로고
    • Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae
    • Jiang H., Wood K.V., and Morgan J.A. Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 71 (2005) 2962-2969
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 2962-2969
    • Jiang, H.1    Wood, K.V.2    Morgan, J.A.3
  • 13
    • 0033951110 scopus 로고    scopus 로고
    • Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes
    • Jung W., Yu O., Lau S.C., O'Keefe D.P., Odell J., Fader G.., and McGonigle B. Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes. Nat. Biotechnol. 18 (2000) 208-212
    • (2000) Nat. Biotechnol. , vol.18 , pp. 208-212
    • Jung, W.1    Yu, O.2    Lau, S.C.3    O'Keefe, D.P.4    Odell, J.5    Fader, G..6    McGonigle, B.7
  • 14
    • 2142799601 scopus 로고    scopus 로고
    • Cloning and expression of the isoflavone synthase gene (IFS-Tp) from Trifolium pratense
    • Kim B.G., Kim S., Song H.S., Lee C., Hur H., Kim S., and Ahn J. Cloning and expression of the isoflavone synthase gene (IFS-Tp) from Trifolium pratense. Mol. Cells 15 (2003) 301-306
    • (2003) Mol. Cells , vol.15 , pp. 301-306
    • Kim, B.G.1    Kim, S.2    Song, H.S.3    Lee, C.4    Hur, H.5    Kim, S.6    Ahn, J.7
  • 15
    • 0034086069 scopus 로고    scopus 로고
    • Protection against breast cancer with genistein: a component of soy
    • Lamartiniere C.A. Protection against breast cancer with genistein: a component of soy. Am. J. Clin. Nutr. 71 (2000) 1705S-1707S
    • (2000) Am. J. Clin. Nutr. , vol.71
    • Lamartiniere, C.A.1
  • 16
    • 29144455444 scopus 로고    scopus 로고
    • Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae
    • Leonard E., Yan Y., Lim K.H., and Koffas M.A.G. Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 71 (2005) 8241-8248
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 8241-8248
    • Leonard, E.1    Yan, Y.2    Lim, K.H.3    Koffas, M.A.G.4
  • 17
    • 33644816925 scopus 로고    scopus 로고
    • Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in E. coli
    • Leonard E., Yan Y., and Koffas M.A.G. Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in E. coli. Metab. Eng. 8 (2006) 172-181
    • (2006) Metab. Eng. , vol.8 , pp. 172-181
    • Leonard, E.1    Yan, Y.2    Koffas, M.A.G.3
  • 18
    • 32544447552 scopus 로고    scopus 로고
    • Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in E. coli
    • Leonard E., Chemler J., Lim K.H., and Koffas M.A.G. Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in E. coli. Appl. Microbiol. Biotechnol. 70 (2006) 85-91
    • (2006) Appl. Microbiol. Biotechnol. , vol.70 , pp. 85-91
    • Leonard, E.1    Chemler, J.2    Lim, K.H.3    Koffas, M.A.G.4
  • 19
    • 0037195078 scopus 로고    scopus 로고
    • Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis
    • Liu C., Blount J.W., Steele C.L., and Dixon R.A. Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis. Proc. Natl. Acad. Sci. USA 99 (2002) 14578-14583
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14578-14583
    • Liu, C.1    Blount, J.W.2    Steele, C.L.3    Dixon, R.A.4
  • 20
    • 33746402832 scopus 로고    scopus 로고
    • Expression profile of a PAL gene from A. membranaceus var. Mongholicus and its crucial role in flux into flavonoid biosynthesis
    • Liu R., Xu S., Li J., Hu Y., and Lin Z. Expression profile of a PAL gene from A. membranaceus var. Mongholicus and its crucial role in flux into flavonoid biosynthesis. Plant Cell Rep. 25 (2006) 705-710
    • (2006) Plant Cell Rep. , vol.25 , pp. 705-710
    • Liu, R.1    Xu, S.2    Li, J.3    Hu, Y.4    Lin, Z.5
  • 21
    • 0002215828 scopus 로고
    • Phenolic biosynthesis during grain development in wheat changes in phenylalanine ammonia lyase activity and soluble phenolic content
    • McCallum J.A., and Walker J.R.L. Phenolic biosynthesis during grain development in wheat changes in phenylalanine ammonia lyase activity and soluble phenolic content. J. Cereal Sci. 11 (1990) 35-49
    • (1990) J. Cereal Sci. , vol.11 , pp. 35-49
    • McCallum, J.A.1    Walker, J.R.L.2
  • 22
    • 5444258710 scopus 로고    scopus 로고
    • Health benefits of soy isoflavonoids and strategies for enhancement: a review
    • McCue P., and Shetty K. Health benefits of soy isoflavonoids and strategies for enhancement: a review. Crit. Rev. Food Sci. Nutr. 44 (2004) 361-367
    • (2004) Crit. Rev. Food Sci. Nutr. , vol.44 , pp. 361-367
    • McCue, P.1    Shetty, K.2
  • 23
    • 0032839807 scopus 로고    scopus 로고
    • Legumes and soybeans: overview of their nutritional profiles and health effects
    • Messina M.J. Legumes and soybeans: overview of their nutritional profiles and health effects. Am. J. Clin. Nutr. 70 (1999) 439S-450S
    • (1999) Am. J. Clin. Nutr. , vol.70
    • Messina, M.J.1
  • 24
    • 0033136864 scopus 로고    scopus 로고
    • Disruption of specific flavonoid genes enhances the accumulation of flavonoid enzymes and end-products in Arabidopsis seedlings
    • Pelletier M.K., Burbulis I.E., and Winkel-Shirley B. Disruption of specific flavonoid genes enhances the accumulation of flavonoid enzymes and end-products in Arabidopsis seedlings. Plant Mol. Biol. 40 (1999) 45-54
    • (1999) Plant Mol. Biol. , vol.40 , pp. 45-54
    • Pelletier, M.K.1    Burbulis, I.E.2    Winkel-Shirley, B.3
  • 25
    • 0037116404 scopus 로고    scopus 로고
    • Flavonoid gene expression and UV photoprotection in transgenic and mutant petunia leaves
    • Ryan K.G., Swinny E.E., Markham K.R., and Winefield C. Flavonoid gene expression and UV photoprotection in transgenic and mutant petunia leaves. Phytochemistry 59 (2002) 23-32
    • (2002) Phytochemistry , vol.59 , pp. 23-32
    • Ryan, K.G.1    Swinny, E.E.2    Markham, K.R.3    Winefield, C.4
  • 26
    • 0033011895 scopus 로고    scopus 로고
    • Dietary isoflavones: biological effects and relevance to human health
    • Setchell K.D.R., and Cassidy A. Dietary isoflavones: biological effects and relevance to human health. J. Nutr. 126 (1999) 758S-767S
    • (1999) J. Nutr. , vol.126
    • Setchell, K.D.R.1    Cassidy, A.2
  • 27
    • 0041320812 scopus 로고    scopus 로고
    • Phenylpropanoid compounds and disease resistance in transgenic tobacco with altered expression of l-phenylalanine ammonia-lyase
    • Shadle G.L., Wesley S.V., Korth K.L., Chen F., Lamb C., and Dixon R.A. Phenylpropanoid compounds and disease resistance in transgenic tobacco with altered expression of l-phenylalanine ammonia-lyase. Phytochemistry 64 (2003) 153-161
    • (2003) Phytochemistry , vol.64 , pp. 153-161
    • Shadle, G.L.1    Wesley, S.V.2    Korth, K.L.3    Chen, F.4    Lamb, C.5    Dixon, R.A.6
  • 28
    • 10844268741 scopus 로고    scopus 로고
    • Fast screening method for the analysis of total flavonoid content in plants and foodstuffs by high-performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry with polarity switching
    • Tolonen A., and Uusitalo J. Fast screening method for the analysis of total flavonoid content in plants and foodstuffs by high-performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry with polarity switching. Rapid Commun. Mass Spectrom. 18 (2004) 3113-3122
    • (2004) Rapid Commun. Mass Spectrom. , vol.18 , pp. 3113-3122
    • Tolonen, A.1    Uusitalo, J.2
  • 30
    • 25144431998 scopus 로고    scopus 로고
    • Biosynthesis of natural flavanones in Saccharomyces cerevisiae
    • Yan Y., Kohli A., and Koffas M.A.G. Biosynthesis of natural flavanones in Saccharomyces cerevisiae. Appl. Environ. Micobiol. 71 (2005) 5610-5613
    • (2005) Appl. Environ. Micobiol. , vol.71 , pp. 5610-5613
    • Yan, Y.1    Kohli, A.2    Koffas, M.A.G.3
  • 31
    • 0033791950 scopus 로고    scopus 로고
    • Production of the isoflavones genistein and daidzein in non-legume dicot and monocot tissues
    • Yu O., Jung W., Shi J., Croes R.A., Fader G.M., McGonigle B., and Odell J.T. Production of the isoflavones genistein and daidzein in non-legume dicot and monocot tissues. Plant Physiol. 124 (2000) 781-793
    • (2000) Plant Physiol. , vol.124 , pp. 781-793
    • Yu, O.1    Jung, W.2    Shi, J.3    Croes, R.A.4    Fader, G.M.5    McGonigle, B.6    Odell, J.T.7
  • 33
    • 0036669527 scopus 로고    scopus 로고
    • Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation
    • Watanabe S., Uesugi S., and Kikuchi Y. Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation. Biomed. Pharmacother. 56 (2002) 302-312
    • (2002) Biomed. Pharmacother. , vol.56 , pp. 302-312
    • Watanabe, S.1    Uesugi, S.2    Kikuchi, Y.3
  • 34
    • 0034979805 scopus 로고    scopus 로고
    • Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology
    • Winkel-Shirley B. Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. Plant Physiol. 126 (2001) 485-493
    • (2001) Plant Physiol. , vol.126 , pp. 485-493
    • Winkel-Shirley, B.1
  • 35
    • 0034937123 scopus 로고    scopus 로고
    • Chemosystematics of taxa from the Leontodon section Oporinia
    • Zidorn C., and Stuppner H. Chemosystematics of taxa from the Leontodon section Oporinia. Biochem. System. Ecol. 29 (2001) 827-837
    • (2001) Biochem. System. Ecol. , vol.29 , pp. 827-837
    • Zidorn, C.1    Stuppner, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.