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Volumn 85, Issue 4, 2003, Pages 957-968

Co-ordinate transcriptional regulation of dopamine synthesis genes by α-synuclein in human neuroblastoma cell lines

Author keywords

Oligonucleotide expression array; Parkinson's disease; Quantitative real time RT PCR; synuclein

Indexed keywords

ALPHA SYNUCLEIN; AROMATIC ACID DECARBOXYLASE; CARBOXYLYASE; DIHYDROPTERIDINE REDUCTASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MESSENGER RNA; SEPIAPTERIN REDUCTASE; TRANSCRIPTION FACTOR; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

EID: 0038701729     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01742.x     Document Type: Article
Times cited : (137)

References (58)
  • 5
    • 0034007822 scopus 로고    scopus 로고
    • Pathoanatomy of Parkinson's disease
    • Braak H. and Braak E. (2000) Pathoanatomy of Parkinson's disease. J. Neurol. 247, 3-10.
    • (2000) J. Neurol. , vol.247 , pp. 3-10
    • Braak, H.1    Braak, E.2
  • 6
    • 0035871859 scopus 로고    scopus 로고
    • Physiological patterns of electrical stimulation can induce neuronal gene expression by activating N-type calcium channels
    • Brosenitsch T. A. and Katz D. M. (2001) Physiological patterns of electrical stimulation can induce neuronal gene expression by activating N-type calcium channels. J. Neurosci. 21, 2571-2579.
    • (2001) J. Neurosci. , vol.21 , pp. 2571-2579
    • Brosenitsch, T.A.1    Katz, D.M.2
  • 8
    • 0037179121 scopus 로고    scopus 로고
    • Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra
    • Chu Y., Kompoliti K., Cochran E. J., Mufson E. J. and Kordower J. H. (2002) Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra. J. Comp. Neurol. 450, 203-214.
    • (2002) J. Comp. Neurol. , vol.450 , pp. 203-214
    • Chu, Y.1    Kompoliti, K.2    Cochran, E.J.3    Mufson, E.J.4    Kordower, J.H.5
  • 9
    • 0024492340 scopus 로고
    • Phenotypic diversification in human neuroblastoma cells: Expression of distinct neural crest lineages
    • Ciccarone V., Spengler B., Meyers J., Biedler J. and Ross R. (1989) Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages. Cancer Res. 49, 219-225.
    • (1989) Cancer Res. , vol.49 , pp. 219-225
    • Ciccarone, V.1    Spengler, B.2    Meyers, J.3    Biedler, J.4    Ross, R.5
  • 10
    • 0034646391 scopus 로고    scopus 로고
    • Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
    • Conway K. A., Harper J. D. and Lansbury P. T. (2000) Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry 39, 2552-2563.
    • (2000) Biochemistry , vol.39 , pp. 2552-2563
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 11
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
    • Conway K. A., Rochet J. C., Bieganski R. M. and Lansbury P. T. Jr (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294, 1346-1349.
    • (2001) Science , vol.294 , pp. 1346-1349
    • Conway, K.A.1    Rochet, J.C.2    Bieganski, R.M.3    Lansbury P.T., Jr.4
  • 12
    • 84940364788 scopus 로고    scopus 로고
    • Alpha-synuclein and the Lewy body disorders
    • Dickson D. W. (2001) alpha-Synuclein and the Lewy body disorders. Curr. Opin. Neurol. 14, 423-432.
    • (2001) Curr. Opin. Neurol. , vol.14 , pp. 423-432
    • Dickson, D.W.1
  • 14
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany M. B. and Bender W. W. (2000) A Drosophila model of Parkinson's disease. Nature 404, 394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 15
    • 0037052633 scopus 로고    scopus 로고
    • MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells
    • Gomez-Santos C., Ferrer I., Reiriz J., Vinals F., Barrachina M. and Ambrosio S. (2002) MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells. Brain Res. 935, 32-39.
    • (2002) Brain Res. , vol.935 , pp. 32-39
    • Gomez-Santos, C.1    Ferrer, I.2    Reiriz, J.3    Vinals, F.4    Barrachina, M.5    Ambrosio, S.6
  • 16
    • 0034941949 scopus 로고    scopus 로고
    • Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: Effect of R-apomorphine
    • Grunblatt E., Mandel S., Maor G. and Youdim M. B. (2001) Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: effect of R-apomorphine. J. Neurochem. 78, 1-12.
    • (2001) J. Neurochem. , vol.78 , pp. 1-12
    • Grunblatt, E.1    Mandel, S.2    Maor, G.3    Youdim, M.B.4
  • 17
    • 0035976959 scopus 로고    scopus 로고
    • Alpha-synuclein affects the MAPK pathway and accelerates cell death
    • Iwata A., Maruyama M., Kanazawa I. and Nukina N. (2001a) alpha-Synuclein affects the MAPK pathway and accelerates cell death. J. Biol. Chem. 276, 45320-45329.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45320-45329
    • Iwata, A.1    Maruyama, M.2    Kanazawa, I.3    Nukina, N.4
  • 18
    • 0035076647 scopus 로고    scopus 로고
    • Alpha-synuclein forms a complex with transcription factor Elk-1
    • Iwata A., Miura S., Kanazawa I., Sawada M. and Nukina N. (2001b) alpha-Synuclein forms a complex with transcription factor Elk-1. J. Neurochem. 77, 239-252.
    • (2001) J. Neurochem. , vol.77 , pp. 239-252
    • Iwata, A.1    Miura, S.2    Kanazawa, I.3    Sawada, M.4    Nukina, N.5
  • 19
    • 0036501462 scopus 로고    scopus 로고
    • Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho-/- mice
    • Kennan A., Aherne A., Palfi A., Humphries M., McKee A., Stitt A., Simpson D. A., Demtroder K., Omtoft T., Ayuso C., Kenna P. F., Farrar G. J. and Humphries P. (2002) Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho-/- mice. Hum. Mol. Genet. 11, 547-557.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 547-557
    • Kennan, A.1    Aherne, A.2    Palfi, A.3    Humphries, M.4    McKee, A.5    Stitt, A.6    Simpson, D.A.7    Demtroder, K.8    Omtoft, T.9    Ayuso, C.10    Kenna, P.F.11    Farrar, G.J.12    Humphries, P.13
  • 21
    • 0033773403 scopus 로고    scopus 로고
    • Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein
    • Ko L., Mehta N. D., Farrer M., Easson C., Hussey J., Yen S., Hardy J. and Yen S. H. (2000) Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein. J. Neurochem. 75, 2546-2554.
    • (2000) J. Neurochem. , vol.75 , pp. 2546-2554
    • Ko, L.1    Mehta, N.D.2    Farrer, M.3    Easson, C.4    Hussey, J.5    Yen, S.6    Hardy, J.7    Yen, S.H.8
  • 26
    • 0035066885 scopus 로고    scopus 로고
    • Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
    • Lee F. J., Liu F., Pristupa Z. B. and Niznik H. B. (2001a) Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB J. 15, 916-926.
    • (2001) FASEB J. , vol.15 , pp. 916-926
    • Lee, F.J.1    Liu, F.2    Pristupa, Z.B.3    Niznik, H.B.4
  • 27
    • 0037085288 scopus 로고    scopus 로고
    • Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors
    • Lee H. J., Shin S. Y., Choi C., Lee Y. H. and Lee S. J. (2001b) Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J. Biol. Chem. 277, 5411-5417.
    • (2001) J. Biol. Chem. , vol.277 , pp. 5411-5417
    • Lee, H.J.1    Shin, S.Y.2    Choi, C.3    Lee, Y.H.4    Lee, S.J.5
  • 28
    • 0037135193 scopus 로고    scopus 로고
    • Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro
    • Lehmensiek V., Tan E. M., Schwarz J. and Storch A. (2002) Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro. Neuroreport 13, 1279-1283.
    • (2002) Neuroreport , vol.13 , pp. 1279-1283
    • Lehmensiek, V.1    Tan, E.M.2    Schwarz, J.3    Storch, A.4
  • 29
    • 0037064078 scopus 로고    scopus 로고
    • Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line
    • Lotharius J., Barg S., Wiekop P., Lundberg C., Raymon H. K. and Brundin P. (2002) Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J. Biol. Chem. 277, 38884-38894.
    • (2002) J. Biol. Chem. , vol.277 , pp. 38884-38894
    • Lotharius, J.1    Barg, S.2    Wiekop, P.3    Lundberg, C.4    Raymon, H.K.5    Brundin, P.6
  • 31
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders
    • Masliah E., Rockenstein E., Veinbergs I., Mallory M., Hashimoto M., Takeda A., Sagara Y., Sisk A. and Mucke L. (2000) Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 287, 1265-1269.
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Mallory, M.4    Hashimoto, M.5    Takeda, A.6    Sagara, Y.7    Sisk, A.8    Mucke, L.9
  • 33
    • 0034023082 scopus 로고    scopus 로고
    • Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from parkinsonian brain
    • Mogi M., Togari A., Kondo T., Mizuno Y., Komure O., Kuno S., Ichinose H. and Nagatsu T. (2000) Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from parkinsonian brain. J. Neural Transm. 107, 335-341.
    • (2000) J. Neural Transm. , vol.107 , pp. 335-341
    • Mogi, M.1    Togari, A.2    Kondo, T.3    Mizuno, Y.4    Komure, O.5    Kuno, S.6    Ichinose, H.7    Nagatsu, T.8
  • 34
    • 0037154184 scopus 로고    scopus 로고
    • Recent advances in the genetics and pathogenesis of Parkinson disease
    • Mouradian M. M. (2002) Recent advances in the genetics and pathogenesis of Parkinson disease. Neurology 58, 179-185.
    • (2002) Neurology , vol.58 , pp. 179-185
    • Mouradian, M.M.1
  • 35
    • 0034193399 scopus 로고    scopus 로고
    • Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
    • Murphy D. D., Rueter S. M., Trojanowski J. Q. and Lee V. M. (2000) Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J. Neurosci. 20, 3214-3220.
    • (2000) J. Neurosci. , vol.20 , pp. 3214-3220
    • Murphy, D.D.1    Rueter, S.M.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 37
    • 0037092442 scopus 로고    scopus 로고
    • A role for alpha-synuclein in the regulation of dopamine biosynthesis
    • Perez R. G., Waymire J. C., Lin E., Liu J. J., Guo F. and Zigmond M. J. (2002) A role for alpha-synuclein in the regulation of dopamine biosynthesis. J. Neurosci. 22, 3090-3099.
    • (2002) J. Neurosci. , vol.22 , pp. 3090-3099
    • Perez, R.G.1    Waymire, J.C.2    Lin, E.3    Liu, J.J.4    Guo, F.5    Zigmond, M.J.6
  • 38
    • 0037137702 scopus 로고    scopus 로고
    • Parkin protects against the toxicity associated with overexpression of mutant α-synuclein: Proteasome dysfunction selectively affects catecholaminergic neurons
    • Petrucelli L., O'Farrell C., Lockhart P. J., Baptista M., Kehoe K., Vink L., Choi P., Wolozin B., Farrer M., Hardy J. and Cookson M. R. (2002) Parkin protects against the toxicity associated with overexpression of mutant α-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron 36, 1007-1019.
    • (2002) Neuron , vol.36 , pp. 1007-1019
    • Petrucelli, L.1    O'Farrell, C.2    Lockhart, P.J.3    Baptista, M.4    Kehoe, K.5    Vink, L.6    Choi, P.7    Wolozin, B.8    Farrer, M.9    Hardy, J.10    Cookson, M.R.11
  • 42
    • 0035714069 scopus 로고    scopus 로고
    • Use of real-time quantitative PCR to validate the results of cDNA array and differential display PCR technologies
    • Rajeevan M. S., Ranamukhaarachchi D. G., Vernon S. D. and Unger E. R. (2001) Use of real-time quantitative PCR to validate the results of cDNA array and differential display PCR technologies. Methods Dec 25(4), 443-451.
    • (2001) Methods , vol.DEC 25 , Issue.4 , pp. 443-451
    • Rajeevan, M.S.1    Ranamukhaarachchi, D.G.2    Vernon, S.D.3    Unger, E.R.4
  • 44
    • 0032874648 scopus 로고    scopus 로고
    • Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain
    • Sakurada K., Ohshima-Sakurada M., Palmer T. D. and Gage F. H. (1999) Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development 126, 4017-4026.
    • (1999) Development , vol.126 , pp. 4017-4026
    • Sakurada, K.1    Ohshima-Sakurada, M.2    Palmer, T.D.3    Gage, F.H.4
  • 45
    • 0027207188 scopus 로고
    • Secretoneurin releases dopamine from rat striatal slices: A biological effect of a peptide derived from secretogranin II (chromogranin C)
    • Saria A., Troger J., Kirchmair R., Fischer-Colbrie R., Hogue-Angeletti R. and Winkler H. (1993) Secretoneurin releases dopamine from rat striatal slices: a biological effect of a peptide derived from secretogranin II (chromogranin C). Neuroscience 54, 1-4.
    • (1993) Neuroscience , vol.54 , pp. 1-4
    • Saria, A.1    Troger, J.2    Kirchmair, R.3    Fischer-Colbrie, R.4    Hogue-Angeletti, R.5    Winkler, H.6
  • 46
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer T. B., Betarbet R., Stout A. K., Lund S., Baptista M., Panov A. V., Cookson M. R. and Greenamyre J. T. (2002) An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J. Neurosci. 22, 7006-7015.
    • (2002) J. Neurosci. , vol.22 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6    Cookson, M.R.7    Greenamyre, J.T.8
  • 47
    • 0036777846 scopus 로고    scopus 로고
    • Parkinson's genetics: Molecular insights for the new millenium
    • Skipper L. and Farrer M. (2002) Parkinson's genetics: Molecular insights for the new millenium. Neurotoxicology Oct; 23(4-5), 503-514.
    • (2002) Neurotoxicology , vol.OCT 23 , Issue.4-5 , pp. 503-514
    • Skipper, L.1    Farrer, M.2
  • 49
    • 0035097503 scopus 로고    scopus 로고
    • Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation
    • Spira P. J., Sharpe D. M., Halliday G., Cavanagh J. and Nicholson G. A. (2001) Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation. Ann. Neurol. 49, 313-319.
    • (2001) Ann. Neurol. , vol.49 , pp. 313-319
    • Spira, P.J.1    Sharpe, D.M.2    Halliday, G.3    Cavanagh, J.4    Nicholson, G.A.5
  • 50
    • 0035894855 scopus 로고    scopus 로고
    • Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
    • Stefanis L., Larsen K. E., Rideout H. J., Sulzer D. and Greene L. A. (2001) Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J. Neurosci. 21, 9549-9560.
    • (2001) J. Neurosci. , vol.21 , pp. 9549-9560
    • Stefanis, L.1    Larsen, K.E.2    Rideout, H.J.3    Sulzer, D.4    Greene, L.A.5
  • 52
    • 0033198680 scopus 로고    scopus 로고
    • Tripeptidyl peptidases: Enzymes that count
    • Tomkinson B. (1999) Tripeptidyl peptidases: enzymes that count. Trends Biochem. Sci. 24, 355-359.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 355-359
    • Tomkinson, B.1
  • 53
    • 0033966487 scopus 로고    scopus 로고
    • Alpha-synuclein up-regulation in substantia nigra dopammergic neurons following administration of the parkinsonian toxin MPTP
    • Vila M., Vukosavic S., Jackson-Lewis V., Neystat M., Jakowec M. and Przedborski S. (2000) alpha-Synuclein up-regulation in substantia nigra dopammergic neurons following administration of the parkinsonian toxin MPTP. J. Neurochem. 74, 721-729.
    • (2000) J. Neurochem. , vol.74 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 54
    • 0033525771 scopus 로고    scopus 로고
    • The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease
    • Westphal C. H., Muller L., Zhou A., Zhu X., Bonner-Weir S., Schambelan M., Steiner D. F., Lindberg I. and Leder P. (1999) The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease. Cell 96, 689-700.
    • (1999) Cell , vol.96 , pp. 689-700
    • Westphal, C.H.1    Muller, L.2    Zhou, A.3    Zhu, X.4    Bonner-Weir, S.5    Schambelan, M.6    Steiner, D.F.7    Lindberg, I.8    Leder, P.9
  • 55
    • 0036278335 scopus 로고    scopus 로고
    • Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
    • Xu J., Kao S.-Y., Lee F. J. S., Song W., Jin L.-W. and Yankner B. A. (2002) Dopamine-dependent neurotoxicity of α-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat. Med. 8, 600-606.
    • (2002) Nat. Med. , vol.8 , pp. 600-606
    • Xu, J.1    Kao, S.-Y.2    Lee, F.J.S.3    Song, W.4    Jin, L.-W.5    Yankner, B.A.6
  • 56
    • 0036269810 scopus 로고    scopus 로고
    • Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis
    • Yoshihara T., Ishigaki S., Yamamoto M., Liang Y., Niwa J., Takeuchi H., Doyu M. and Sobue G. (2002) Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 80, 158-167.
    • (2002) J. Neurochem. , vol.80 , pp. 158-167
    • Yoshihara, T.1    Ishigaki, S.2    Yamamoto, M.3    Liang, Y.4    Niwa, J.5    Takeuchi, H.6    Doyu, M.7    Sobue, G.8
  • 57
    • 0034595728 scopus 로고    scopus 로고
    • Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells
    • Zhou W., Hurlbert M. S., Schaack J., Prasad K. N. and Freed C. R. (2000) Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells. Brain Res. 866, 33-43.
    • (2000) Brain Res. , vol.866 , pp. 33-43
    • Zhou, W.1    Hurlbert, M.S.2    Schaack, J.3    Prasad, K.N.4    Freed, C.R.5
  • 58
    • 0035942240 scopus 로고    scopus 로고
    • Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei
    • Zirlinger M., Kreiman G. and Anderson D. J. (2001) Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei. Proc. Natl Acad. Sci. USA 98, 5270-5275.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 5270-5275
    • Zirlinger, M.1    Kreiman, G.2    Anderson, D.J.3


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