IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma

Cancer Immunology, Immunotherapy

Volumn 57, Issue 10, 2008, Pages 1439-1449

  Frederiksen, Klaus Stensgaard ^a   Lundsgaard, Dorthe ^a   Freeman, Jeremy A ^b   Hughes, Steven D ^b   Holm, Thomas L ^a   Skrumsager, Birte K ^a   Petri, Andreas ^a   Hansen, Lasse T ^a   McArthur, Grant A ^c   Davis, Ian D ^d   Skak, Kresten ^a  

^a NOVO NORDISK A S   (Denmark)

^b ZYMOGENETICS INC   (United States)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

^d AUSTIN HEALTH   (Australia)

Author keywords

Cytokines; IL 21; Immune activation; Immunotherapy

Indexed keywords

CD56 ANTIGEN; GRANZYME B; MESSENGER RNA; PERFORIN; RECOMBINANT INTERLEUKIN 21; RECOMBINANT PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CD8+ T LYMPHOCYTE; CELL CYCLE PROGRESSION; CELL KILLING; CELL MOTILITY; CELL POPULATION; CLINICAL TRIAL; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ENZYME PHOSPHORYLATION; EX VIVO STUDY; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IMMUNE SYSTEM; IMMUNOREACTIVITY; KIDNEY CARCINOMA; LEUKOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MELANOMA; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SYSTEMIC THERAPY; T LYMPHOCYTE; TRANSCRIPTOMICS; UPREGULATION;

CARCINOMA, RENAL CELL; CD8-POSITIVE T-LYMPHOCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; INTERLEUKINS; KIDNEY NEOPLASMS; KILLER CELLS, NATURAL; MAXIMUM TOLERATED DOSE; MELANOMA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTE SUBSETS;

EID: 48149096869     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-008-0479-4     Document Type: Article

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