메뉴 건너뛰기




Volumn 66, Issue 21, 2006, Pages 10233-10237

Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSAMINOGLYCAN; HEPARAN SULFATE; HEPARANASE; HERMES ANTIGEN; HYALURONIC ACID;

EID: 33751270222     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-1464     Document Type: Review
Times cited : (325)

References (57)
  • 1
    • 30544441820 scopus 로고    scopus 로고
    • The global breast cancer burden: Variations in epidemiology and survival
    • Hortobagyi GN, de la Garza SJ, Pritchard K, et al. The global breast cancer burden: variations in epidemiology and survival. Clin Breast Cancer 2005;6:391-401.
    • (2005) Clin Breast Cancer , vol.6 , pp. 391-401
    • Hortobagyi, G.N.1    De La Garza, S.J.2    Pritchard, K.3
  • 2
    • 0033057962 scopus 로고    scopus 로고
    • Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis
    • Vlodavsky I, Friedmann Y, Elkin M, et al. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat Med 1999;5:793-802.
    • (1999) Nat Med , vol.5 , pp. 793-802
    • Vlodavsky, I.1    Friedmann, Y.2    Elkin, M.3
  • 3
    • 0033569922 scopus 로고    scopus 로고
    • Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer
    • Fairbanks MB, Mildner AM, Leone JW, et al. Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer. J Biol Chem 1999;274:29587-90.
    • (1999) J Biol Chem , vol.274 , pp. 29587-29590
    • Fairbanks, M.B.1    Mildner, A.M.2    Leone, J.W.3
  • 4
    • 33644863802 scopus 로고    scopus 로고
    • Heparanase promotes growth, angiogenesis, and survival of primary breast tumors
    • Cohen I, Pappo O, Elkin M, et al. Heparanase promotes growth, angiogenesis, and survival of primary breast tumors. Int J Cancer 2006;118:1609-17.
    • (2006) Int J Cancer , vol.118 , pp. 1609-1617
    • Cohen, I.1    Pappo, O.2    Elkin, M.3
  • 6
    • 0036672885 scopus 로고    scopus 로고
    • Heparanase-1 expression is associated with the metastatic potential of breast cancer
    • Maxhimer JB, Quiros RM, Stewart R, et al. Heparanase-1 expression is associated with the metastatic potential of breast cancer. Surgery 2002;132:326-33.
    • (2002) Surgery , vol.132 , pp. 326-333
    • Maxhimer, J.B.1    Quiros, R.M.2    Stewart, R.3
  • 7
    • 33644854118 scopus 로고    scopus 로고
    • COX-2 induction by heparanase in the progression of breast cancer
    • Imada T, Matsuoka J, Nobuhisa T, et al. COX-2 induction by heparanase in the progression of breast cancer. Int J Mol Med 2006;17:221-8.
    • (2006) Int J Mol Med , vol.17 , pp. 221-228
    • Imada, T.1    Matsuoka, J.2    Nobuhisa, T.3
  • 8
    • 14544296126 scopus 로고    scopus 로고
    • Ductal carcinoma in situ of the breast and heparanase-1 expression: A molecular explanation for more aggressive subtypes
    • Maxhimer JB, Pesce CE, Stewart RA, Gattuso P, Prinz RA, Xu X. Ductal carcinoma in situ of the breast and heparanase-1 expression: a molecular explanation for more aggressive subtypes. J Am Coll Surg 2005;200:328-35.
    • (2005) J Am Coll Surg , vol.200 , pp. 328-335
    • Maxhimer, J.B.1    Pesce, C.E.2    Stewart, R.A.3    Gattuso, P.4    Prinz, R.A.5    Xu, X.6
  • 9
    • 0035405257 scopus 로고    scopus 로고
    • Proteoglycans: Pericellular and cell surface multireceptors that integrate external stimuli in the mammary gland
    • Delehedde M, Lyon M, Sergeant N, Rahmoune H, Fernig DG. Proteoglycans: pericellular and cell surface multireceptors that integrate external stimuli in the mammary gland. J Mammary Gland Biol Neoplasia 2001;6:253-73.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , pp. 253-273
    • Delehedde, M.1    Lyon, M.2    Sergeant, N.3    Rahmoune, H.4    Fernig, D.G.5
  • 10
    • 0024600971 scopus 로고
    • Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules
    • Bashkin P, Doctrow S, Klagsbrun M, Svahn CM, Folkman J, Vlodavsky I. Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry 1989;28:1737-43.
    • (1989) Biochemistry , vol.28 , pp. 1737-1743
    • Bashkin, P.1    Doctrow, S.2    Klagsbrun, M.3    Svahn, C.M.4    Folkman, J.5    Vlodavsky, I.6
  • 11
    • 0031749471 scopus 로고    scopus 로고
    • Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2
    • Kato M, Wang H, Kainulainen V, et al. Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat Med 1998;4:691-7.
    • (1998) Nat Med , vol.4 , pp. 691-697
    • Kato, M.1    Wang, H.2    Kainulainen, V.3
  • 13
    • 21344452789 scopus 로고    scopus 로고
    • Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases
    • Kelly T, Suva LJ, Huang Y, et al. Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases. Cancer Res 2005;65:5778-84.
    • (2005) Cancer Res , vol.65 , pp. 5778-5784
    • Kelly, T.1    Suva, L.J.2    Huang, Y.3
  • 15
    • 32944479184 scopus 로고    scopus 로고
    • Heparanase induces vascular endothelial growth factor expression: Correlation with p38 phosphorylation levels and Src activation
    • Zetser A, Bashenko Y, Edovitsky E, Levy-Adam F, Vlodavsky I, Ilan N. Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res 2006;66:1455-63.
    • (2006) Cancer Res , vol.66 , pp. 1455-1463
    • Zetser, A.1    Bashenko, Y.2    Edovitsky, E.3    Levy-Adam, F.4    Vlodavsky, I.5    Ilan, N.6
  • 17
    • 33745606964 scopus 로고    scopus 로고
    • Tumor suppressor p53 regulates heparanase gene expression
    • Baraz L, Haupt Y, Elkin M, Peretz T, Vlodavsky I. Tumor suppressor p53 regulates heparanase gene expression. Oncogene 2006;25:3939-47.
    • (2006) Oncogene , vol.25 , pp. 3939-3947
    • Baraz, L.1    Haupt, Y.2    Elkin, M.3    Peretz, T.4    Vlodavsky, I.5
  • 18
    • 0032475456 scopus 로고    scopus 로고
    • Immunohistochemical detection of c-erbB-2 and p53 in benign breast disease and breast cancer risk
    • Rohan TE, Hartwick W, Miller AB, Kandel RA. Immunohistochemical detection of c-erbB-2 and p53 in benign breast disease and breast cancer risk. J Natl Cancer Inst 1998;90:1262-9.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1262-1269
    • Rohan, T.E.1    Hartwick, W.2    Miller, A.B.3    Kandel, R.A.4
  • 19
    • 0037434721 scopus 로고    scopus 로고
    • Trans-activation of heparanase promoter by ETS transcription factors
    • Lu WC, Liu YN, Kang BB, Chen JH. Trans-activation of heparanase promoter by ETS transcription factors. Oncogene 2003;22:919-23.
    • (2003) Oncogene , vol.22 , pp. 919-923
    • Lu, W.C.1    Liu, Y.N.2    Kang, B.B.3    Chen, J.H.4
  • 20
    • 0032479139 scopus 로고    scopus 로고
    • The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factor
    • Watabe T, Yoshida K, Shindoh M, et al. The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factor. Int J Cancer 1998;77:128-37.
    • (1998) Int J Cancer , vol.77 , pp. 128-137
    • Watabe, T.1    Yoshida, K.2    Shindoh, M.3
  • 21
    • 0347320783 scopus 로고    scopus 로고
    • Regulation of heparanase gene expression by estrogen in breast cancer
    • Elkin M, Cohen I, Zcharia E, et al. Regulation of heparanase gene expression by estrogen in breast cancer. Cancer Res 2003;63:8821-6.
    • (2003) Cancer Res , vol.63 , pp. 8821-8826
    • Elkin, M.1    Cohen, I.2    Zcharia, E.3
  • 23
    • 0033565247 scopus 로고    scopus 로고
    • Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity
    • Parish CR, Freeman C, Brown KJ, Francis DJ, Cowden WB. Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity. Cancer Res 1999;59:3433-41.
    • (1999) Cancer Res , vol.59 , pp. 3433-3441
    • Parish, C.R.1    Freeman, C.2    Brown, K.J.3    Francis, D.J.4    Cowden, W.B.5
  • 24
    • 0032879625 scopus 로고    scopus 로고
    • Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides
    • Miao HQ, Elkin M, Aingorn E, Ishai-Michaeli R, Stein CA, Vlodavsky I. Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides. Int J Cancer 1999;83:424-31.
    • (1999) Int J Cancer , vol.83 , pp. 424-431
    • Miao, H.Q.1    Elkin, M.2    Aingorn, E.3    Ishai-Michaeli, R.4    Stein, C.A.5    Vlodavsky, I.6
  • 25
    • 0038206935 scopus 로고    scopus 로고
    • An expanding role for antithrombotic therapy in cancer patients
    • Kakkar AK. An expanding role for antithrombotic therapy in cancer patients. Cancer Treat Rev 2003;29 Suppl 2:23-6.
    • (2003) Cancer Treat Rev , vol.29 , Issue.SUPPL. 2 , pp. 23-26
    • Kakkar, A.K.1
  • 26
    • 0037457306 scopus 로고    scopus 로고
    • Inhibition of heparanase activity and heparanase-induced angiogenesis by suramin analogues
    • Marchetti D, Reiland J, Erwin B, Roy M. Inhibition of heparanase activity and heparanase-induced angiogenesis by suramin analogues. Int J Cancer 2003;104:167-74.
    • (2003) Int J Cancer , vol.104 , pp. 167-174
    • Marchetti, D.1    Reiland, J.2    Erwin, B.3    Roy, M.4
  • 27
    • 3042697038 scopus 로고    scopus 로고
    • Hyaluronan: From extracellular glue to pericellular cue
    • Toole BP. Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer 2004;4:528-39.
    • (2004) Nat Rev Cancer , vol.4 , pp. 528-539
    • Toole, B.P.1
  • 28
    • 22844436226 scopus 로고    scopus 로고
    • Recent advances in tumor-targeting anticancer drug conjugates
    • Jaracz S, Chen J, Kuznetsova LV, Ojima I. Recent advances in tumor-targeting anticancer drug conjugates. Bioorg Med Chem 2005;13:5043-54.
    • (2005) Bioorg Med Chem , vol.13 , pp. 5043-5054
    • Jaracz, S.1    Chen, J.2    Kuznetsova, L.V.3    Ojima, I.4
  • 29
    • 25844473391 scopus 로고    scopus 로고
    • The over-expression of HAS2, Hyal-2, and CD44 is implicated in the invasiveness of breast cancer
    • Udabage L, Brownlee GR, Nilsson SK, Brown TJ. The over-expression of HAS2, Hyal-2, and CD44 is implicated in the invasiveness of breast cancer. Exp Cell Res 2005;310:205-17.
    • (2005) Exp Cell Res , vol.310 , pp. 205-217
    • Udabage, L.1    Brownlee, G.R.2    Nilsson, S.K.3    Brown, T.J.4
  • 30
    • 22244442728 scopus 로고    scopus 로고
    • Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer
    • Udabage L, Brownlee GR, Waltham M, et al. Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer. Cancer Res 2005;65:6139-50.
    • (2005) Cancer Res , vol.65 , pp. 6139-6150
    • Udabage, L.1    Brownlee, G.R.2    Waltham, M.3
  • 31
    • 0037058318 scopus 로고    scopus 로고
    • Hyaluronidase reduces human breast cancer xenografts in SCID mice
    • Shuster S, Frost GI, Csoka AB, Formby B, Stern R. Hyaluronidase reduces human breast cancer xenografts in SCID mice. Int J Cancer 2002;102:192-7.
    • (2002) Int J Cancer , vol.102 , pp. 192-197
    • Shuster, S.1    Frost, G.I.2    Csoka, A.B.3    Formby, B.4    Stern, R.5
  • 32
    • 23444445895 scopus 로고    scopus 로고
    • Hyaluronan metabolism: A major paradox in cancer biology
    • Stern R. Hyaluronan metabolism: a major paradox in cancer biology. Pathol Biol (Paris) 2005;53:372-82.
    • (2005) Pathol Biol (Paris) , vol.53 , pp. 372-382
    • Stern, R.1
  • 33
    • 20144385541 scopus 로고    scopus 로고
    • Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2
    • Misra S, Ghatak S, Toole BP. Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2. J Biol Chem 2005;280:20310-5.
    • (2005) J Biol Chem , vol.280 , pp. 20310-20315
    • Misra, S.1    Ghatak, S.2    Toole, B.P.3
  • 34
    • 0033889231 scopus 로고    scopus 로고
    • Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival
    • Auvinen P, Tammi R, Parkkinen J, et al. Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival. Am J Pathol 2000;156:529-36.
    • (2000) Am J Pathol , vol.156 , pp. 529-536
    • Auvinen, P.1    Tammi, R.2    Parkkinen, J.3
  • 35
    • 0037325180 scopus 로고    scopus 로고
    • Breast cancer stromal myxoid changes are associated with tumor invasion and metastasis: A central role for hyaluronan
    • Wernicke M, Pineiro LC, Caramutti D, et al. Breast cancer stromal myxoid changes are associated with tumor invasion and metastasis: a central role for hyaluronan. Mod Pathol 2003;16:99-107.
    • (2003) Mod Pathol , vol.16 , pp. 99-107
    • Wernicke, M.1    Pineiro, L.C.2    Caramutti, D.3
  • 36
    • 0036233581 scopus 로고    scopus 로고
    • Sonographic morphology of infiltrating breast carcinoma: Relationship with the shape of the hyaluronan extracellular matrix
    • Vignal P, Meslet MR, Romeo JM, Feuilhade F. Sonographic morphology of infiltrating breast carcinoma: relationship with the shape of the hyaluronan extracellular matrix. J Ultrasound Med 2002;21:532-8.
    • (2002) J Ultrasound Med , vol.21 , pp. 532-538
    • Vignal, P.1    Meslet, M.R.2    Romeo, J.M.3    Feuilhade, F.4
  • 37
    • 0025120954 scopus 로고
    • Serum hyaluronan (hyaluronic acid) in breast cancer patients
    • Delpech B, Chevallier B, Reinhardt N, et al. Serum hyaluronan (hyaluronic acid) in breast cancer patients. Int J Cancer 1990;46:388-90.
    • (1990) Int J Cancer , vol.46 , pp. 388-390
    • Delpech, B.1    Chevallier, B.2    Reinhardt, N.3
  • 38
    • 0027065573 scopus 로고
    • Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons
    • Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci USA 1992;89:12160-4.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 12160-12164
    • Screaton, G.R.1    Bell, M.V.2    Jackson, D.G.3    Cornelis, F.B.4    Gerth, U.5    Bell, J.I.6
  • 39
    • 26444490562 scopus 로고    scopus 로고
    • Expression of CD44s, CD44v3, and CD44v6 in benign and malignant breast lesions: Correlation and colocalization with hyaluronan
    • Auvinen P, Tammi R, Tammi M, Johansson R, Kosma VM. Expression of CD44s, CD44v3, and CD44v6 in benign and malignant breast lesions: correlation and colocalization with hyaluronan. Histopathology 2005;47:420-8.
    • (2005) Histopathology , vol.47 , pp. 420-428
    • Auvinen, P.1    Tammi, R.2    Tammi, M.3    Johansson, R.4    Kosma, V.M.5
  • 40
    • 18244387224 scopus 로고    scopus 로고
    • CD44 expression is associated with increased survival in node-negative invasive breast carcinoma
    • Diaz LK, Zhou X, Wright ET, et al. CD44 expression is associated with increased survival in node-negative invasive breast carcinoma. Clin Cancer Res 2005;11:3309-14.
    • (2005) Clin Cancer Res , vol.11 , pp. 3309-3314
    • Diaz, L.K.1    Zhou, X.2    Wright, E.T.3
  • 41
    • 0037495268 scopus 로고    scopus 로고
    • Clinicopathological associations of CD44 mRNA and protein expression in primary breast carcinomas
    • Berner HS, Suo Z, Risberg B, Villman K, Karlsson MG, Nesland JM. Clinicopathological associations of CD44 mRNA and protein expression in primary breast carcinomas. Histopathology 2003;42:546-54.
    • (2003) Histopathology , vol.42 , pp. 546-554
    • Berner, H.S.1    Suo, Z.2    Risberg, B.3    Villman, K.4    Karlsson, M.G.5    Nesland, J.M.6
  • 42
    • 13244261126 scopus 로고    scopus 로고
    • Expression of cell adhesion molecules, CD44s and E-cadherin, and microvessel density in invasive micropapillary carcinoma of the breast
    • Gong Y, Sun X, Huo L, Wiley EL, Rao MS. Expression of cell adhesion molecules, CD44s and E-cadherin, and microvessel density in invasive micropapillary carcinoma of the breast. Histopathology 2005;46:24-30.
    • (2005) Histopathology , vol.46 , pp. 24-30
    • Gong, Y.1    Sun, X.2    Huo, L.3    Wiley, E.L.4    Rao, M.S.5
  • 44
    • 1242285621 scopus 로고    scopus 로고
    • The role of CD44v3 expression in female breast carcinomas
    • Rys J, Kruczak A, Lackowska B, et al. The role of CD44v3 expression in female breast carcinomas. Pol J Pathol 2003;54:243-7.
    • (2003) Pol J Pathol , vol.54 , pp. 243-247
    • Rys, J.1    Kruczak, A.2    Lackowska, B.3
  • 45
    • 18544364014 scopus 로고    scopus 로고
    • Expression of a CD44 variant and VEGF-C and the implications for lymphatic metastasis and long-term prognosis of human breast cancer
    • Watanabe O, Kinoshita J, Shimizu T, et al. Expression of a CD44 variant and VEGF-C and the implications for lymphatic metastasis and long-term prognosis of human breast cancer. J Exp Clin Cancer Res 2005;24:75-82.
    • (2005) J Exp Clin Cancer Res , vol.24 , pp. 75-82
    • Watanabe, O.1    Kinoshita, J.2    Shimizu, T.3
  • 46
    • 0043032859 scopus 로고    scopus 로고
    • Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression
    • Bourguignon LY, Singleton PA, Zhu H, Diedrich F. Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. J Biol Chem 2003;278:29420-34.
    • (2003) J Biol Chem , vol.278 , pp. 29420-29434
    • Bourguignon, L.Y.1    Singleton, P.A.2    Zhu, H.3    Diedrich, F.4
  • 47
    • 0035404863 scopus 로고    scopus 로고
    • CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression
    • Bourguignon LY. CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression. J Mammary Gland Biol Neoplasia 2001;6:287-97.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , pp. 287-297
    • Bourguignon, L.Y.1
  • 48
    • 0033593482 scopus 로고    scopus 로고
    • Characterization of the heparan sulfate and chondroitin sulfate assembly sites in CD44
    • Greenfield B, Wang WC, Marquardt H, et al. Characterization of the heparan sulfate and chondroitin sulfate assembly sites in CD44. J Biol Chem 1999;274:2511-7.
    • (1999) J Biol Chem , vol.274 , pp. 2511-2517
    • Greenfield, B.1    Wang, W.C.2    Marquardt, H.3
  • 50
    • 12944288172 scopus 로고    scopus 로고
    • Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis
    • Abraham BK, Fritz P, McClellan M, Hauptvogel P, Athelogou M, Brauch H. Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. Clin Cancer Res 2005;11:1154-9.
    • (2005) Clin Cancer Res , vol.11 , pp. 1154-1159
    • Abraham, B.K.1    Fritz, P.2    McClellan, M.3    Hauptvogel, P.4    Athelogou, M.5    Brauch, H.6
  • 51
    • 18144391946 scopus 로고    scopus 로고
    • A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells
    • Yoshihara S, Kon A, Kudo D, et al. A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells. FEBS Lett 2005;579:2722-6.
    • (2005) FEBS Lett , vol.579 , pp. 2722-2726
    • Yoshihara, S.1    Kon, A.2    Kudo, D.3
  • 53
    • 0037478612 scopus 로고    scopus 로고
    • Regulation of multidrug resistance in cancer cells by hyaluronan
    • Misra S, Ghatak S, Zoltan-Jones A, Toole BP. Regulation of multidrug resistance in cancer cells by hyaluronan. J Biol Chem 2003;278:25285-8.
    • (2003) J Biol Chem , vol.278 , pp. 25285-25288
    • Misra, S.1    Ghatak, S.2    Zoltan-Jones, A.3    Toole, B.P.4
  • 54
    • 0036115512 scopus 로고    scopus 로고
    • Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates
    • Luo Y, Bernshaw NJ, Lu ZR, Kopecek J, Prestwich GD. Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates. Pharm Res 2002;19:396-402.
    • (2002) Pharm Res , vol.19 , pp. 396-402
    • Luo, Y.1    Bernshaw, N.J.2    Lu, Z.R.3    Kopecek, J.4    Prestwich, G.D.5
  • 55
    • 22144488513 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic evaluation of intravenous hyaluronic acid in combination with doxorubicin or 5-fluorouracil
    • Rosenthal MA, Gibbs P, Brown TJ, et al. Phase I and pharmacokinetic evaluation of intravenous hyaluronic acid in combination with doxorubicin or 5-fluorouracil. Chemotherapy 2005;51:132-41.
    • (2005) Chemotherapy , vol.51 , pp. 132-141
    • Rosenthal, M.A.1    Gibbs, P.2    Brown, T.J.3
  • 57
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - An obstacle in cancer therapy
    • Heldin CH, Rubin K, Pietras K, Ostman A. High interstitial fluid pressure-an obstacle in cancer therapy. Nat Rev Cancer 2004;4:806-13.
    • (2004) Nat Rev Cancer , vol.4 , pp. 806-813
    • Heldin, C.H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.