Hypertrophy and fibrosis in the cardiomyopathy of uremia - Beyond coronary heart disease

Seminars in Dialysis

Volumn 21, Issue 4, 2008, Pages 308-318

  Gross, Marie Luise ^a   Ritz, Eberhard ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; CORONARY ARTERY DISEASE; DISEASE COURSE; FIBROSIS; HEART MUSCLE; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; INCIDENCE; PATHOLOGY; SUDDEN DEATH; SURVIVAL RATE; UNITED STATES; UREMIA;

ANIMALS; CARDIOMYOPATHY, HYPERTROPHIC; CORONARY DISEASE; DEATH, SUDDEN, CARDIAC; DISEASE PROGRESSION; FIBROSIS; HUMANS; INCIDENCE; MYOCARDIUM; SURVIVAL RATE; UNITED STATES; UREMIA;

EID: 48049101411     PISSN: 08940959     EISSN: 1525139X     Source Type: Journal    
DOI: 10.1111/j.1525-139X.2008.00454.x     Document Type: Article

References (180)

1. Foley RN, Parfrey PS, Harnett JD, Kent GM, Martin CJ, Murray DC, Barre PE : Clinical and echocardiographic disease in patients starting end-stage renal disease therapy. Kidney Int 47 : 186 192, 1995
2. Silberberg JS, Barre PE, Prichard SS, Sniderman AD : Impact of left ventricular hypertrophy on survival in end-stage renal disease. Kidney Int 36 : 286 290, 1989
3. Rasic S, Kulenovic I, Haracic A, Catovic A : Left ventricular hypertrophy and risk factors for its development in uraemic patients. Bosn J Basic Med Sci 4 : 34 40, 2004
4. Levin A, Singer J, Thompson CR, Ross H, Lewis M : Prevalent left ventricular hypertrophy in the predialysis population: identifying opportunities for intervention. Am J Kidney Dis 27 : 347 354, 1996
5. Johnstone LM, Jones CL, Grigg LE, Wilkinson JL, Walker RG, Powell HR : Left ventricular abnormalities in children, adolescents and young adults with renal disease. Kidney Int 50 : 998 1006, 1996
6. Mitsnefes MM, Daniels SR, Schwartz SM, Meyer RA, Khoury P, Strife CF : Severe left ventricular hypertrophy in pediatric dialysis: prevalence and predictors. Pediatric Nephrol 14 : 898 902, 2000
7. Shin SJ, Kim HW, Chung S, Chung HW, Lee SJ, Kim YS, Bang BK, Chang YS, Park CW : Late referral to a nephrologist increases the risk of uremia-related cardiac hypertrophy in patients on hemodialysis. Nephron Clin Pract 107 : c139 c146, 2007
8. Stefanski A, Schmidt KG, Waldherr R, Ritz E : Early increase in blood pressure and diastolic left ventricular malfunction in patients with glomerulonephritis. Kidney Int 50 : 1321 1326, 1996
9. Levin A, Thompson CR, Ethier J, Carlisle EJ, Tobe S, Mendelssohn D, Burgess E, Jindal K, Barrett B, Singer J, Djurdjev O : Left ventricular mass index increase in early renal disease: impact of decline in hemoglobin. Am J Kidney Dis 34 : 125 134, 1999
10. Chaignon M, Chen WT, Tarazi RC, Bravo EL, Nakamoto S : Effect of hemodialysis on blood volume distribution and cardiac output. Hypertension 3 : 327 332, 1981
11. Harnett JD, Murphy B, Collingwood P, Purchase L, Kent G, Parfrey PS : The reliability and validity of echocardiographic measurement of left ventricular mass index in hemodialysis patients. Nephron 65 : 212 214, 1993
12. London GM : Cardiovascular disease in chronic renal failure: pathophysiologic aspects. Semin Dial 16 : 85 94, 2003
13. McGregor E, Stewart G, Rodger RS, Jardine AG : Early echocardiographic changes and survival following renal transplantation. Nephrol Dial Transplant 15 : 93 98, 2000
14. Stewart GA, Gansevoort RT, Mark PB, Rooney E, McDonagh TA, Dargie HJ, Stuart R, Rodger C, Jardine AG : Electrocardiographic abnormalities and uremic cardiomyopathy. Kidney Int 67 : 217 226, 2005
15. Mark PB, Johnston N, Groenning BA, Foster JE, Blyth KG, Martin TN, Steedman T, Dargie HJ, Jardine AG : Redefinition of uremic cardiomyopathy by contrast-enhanced cardiac magnetic resonance imaging. Kidney Int 69 : 1839 1845, 2006
16. Mall G, Huther W, Schneider J, Lundin P, Ritz E : Diffuse intermyocardiocytic fibrosis in uraemic patients. Nephrol Dial Transplant 5 : 39 44, 1990
17. Aoki J, Ikari Y, Nakajima H, Mori M, Sugimoto T, Hatori M, Tanimoto S, Amiya E, Hara K : Clinical and pathologic characteristics of dilated cardiomyopathy in hemodialysis patients. Kidney Int 67 : 333 340, 2005
18. Bellenger NG, Burgess MI, Ray SG, Lahiri A, Coats AJ, Cleland JG, Pennell DJ : Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur Heart J 21 : 1387 1396, 2000
19. Grobner T, Prischl FC : Gadolinium and nephrogenic systemic fibrosis. Kidney Int 72 : 260 264, 2007
20. Zoccali C, Benedetto FA, Mallamaci F, Tripepi G, Giacone G, Cataliotti A, Seminara G, Stancanelli B, Malatino LS : Prognostic impact of the indexation of left ventricular mass in patients undergoing dialysis. J Am Soc Nephrol 12 : 2768 2774, 2001
21. London GM : Cardiovascular calcifications in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 14 : S305 S309, 2003
22. Demuth K, Blacher J, Guerin AP, Benoit MO, Moatti N, Safar ME, London GM : Endothelin and cardiovascular remodelling in end-stage renal disease. Nephrol Dial Transplant 13 : 375 383, 1998
23. Blacher J, Demuth K, Guerin AP, Vadez C, Moatti N, Safar ME, London GM : Association between plasma homocysteine concentrations and cardiac hypertrophy in end-stage renal disease. J Nephrol 12 : 248 255, 1999
24. Zoccali C, Mallamaci F, Benedetto FA, Tripepi G, Parlongo S, Cataliotti A, Cutrupi S, Giacone G, Bellanuova I, Cottini E, Malatino LS : Cardiac natriuretic peptides are related to left ventricular mass and function and predict mortality in dialysis patients. J Am Soc Nephrol 12 : 1508 1515, 2001
25. Zoccali C, Mallamaci F, Maas R, Benedetto FA, Tripepi G, Malatino LS, Cataliotti A, Bellanuova I, Boger R : Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients. Kidney Int 62 : 339 345, 2002
26. Mallamaci F, Zoccali C, Parlongo S, Tripepi G, Benedetto FA, Cutrupi S, Bonanno G, Fatuzzo P, Rapisarda F, Seminara G, Stancanelli B, Bellanuova I, Cataliotti A, Malatino LS : Troponin is related to left ventricular mass and predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis 40 : 68 75, 2002
27. Ozkahya M, Ok E, Cirit M, Aydin S, Akcicek F, Basci A, Dorhout Mees EJ : Regression of left ventricular hypertrophy in haemodialysis patients by ultrafiltration and reduced salt intake without antihypertensive drugs. Nephrol Dial Transplant 13 : 1489 1493, 1998
28. Fagugli RM, Reboldi G, Quintaliani G, Pasini P, Ciao G, Cicconi B, Pasticci F, Kaufman JM, Buoncristiani U : Short daily hemodialysis: blood pressure control and left ventricular mass reduction in hypertensive hemodialysis patients. Am J Kidney Dis 38 : 371 376, 2001
29. Rosenthal DS BE : Hematological-Oncological Disorders and Heart Disease. Hearts Disease: Textbook of Cardiovascular Medicine. Philadelphia, PA : WB Saunders, 1992 : 1786 1808
30. London GM, Parfrey PS : Cardiac disease in chronic uremia: pathogenesis. Adv Ren Replace Ther 4 : 194 211, 1997
31. Silberberg J, Racine N, Barre P, Sniderman AD : Regression of left ventricular hypertrophy in dialysis patients following correction of anemia with recombinant human erythropoietin. Can J Cardiol 6 : 1 4, 1990
32. Cannella G, La Canna G, Sandrini M, Gaggiotti M, Nordio G, Movilli E, Mombelloni S, Visioli O, Maiorca R : Reversal of left ventricular hypertrophy following recombinant human erythropoietin treatment of anaemic dialysed uraemic patients. Nephrol Dial Transplant 6 : 31 37, 1991
33. Portoles J, Torralbo A, Martin P, Rodrigo J, Herrero JA, Barrientos A : Cardiovascular effects of recombinant human erythropoietin in predialysis patients. Am J Kidney Dis 29 : 541 548, 1997
34. Hayashi T, Suzuki A, Shoji T, Togawa M, Okada N, Tsubakihara Y, Imai E, Hori M : Cardiovascular effect of normalizing the hematocrit level during erythropoietin therapy in predialysis patients with chronic renal failure. Am J Kidney Dis 35 : 250 256, 2000
35. Parfrey PS, Foley RN, Wittreich BH, Sullivan DJ, Zagari MJ, Frei D : Double-blind comparison of full and partial anemia correction in incident hemodialysis patients without symptomatic heart disease. J Am Soc Nephrol 16 : 2180 2189, 2005
36. Vlahakos DV, Hahalis G, Vassilakos P, Marathias KP, Geroulanos S : Relationship between left ventricular hypertrophy and plasma renin activity in chronic hemodialysis patients. J Am Soc Nephrol 8 : 1764 1770, 1997
37. Sato A, Funder JW, Saruta T : Involvement of aldosterone in left ventricular hypertrophy of patients with end-stage renal failure treated with hemodialysis. Am J Hypertens 12 : 867 873, 1999
38. Bader M : Molecular interactions of vasoactive systems in cardiovascular damage. J Cardiovasc Pharmacol 38 (Suppl. 2 S7 S9, 2001
39. Rambausek M, Amann K, Mall G, Ritz E : Structural causes of cardiac dysfunction in uremia. Ren Fail 15 : 421 428, 1993
40. Cannella G, Paoletti E, Delfino R, Peloso G, Rolla D, Molinari S : Prolonged therapy with ACE inhibitors induces a regression of left ventricular hypertrophy of dialyzed uremic patients independently from hypotensive effects. Am J Kidney Dis 30 : 659 664, 1997
41. Tornig J, Amann K, Ritz E, Nichols C, Zeier M, Mall G : Arteriolar wall thickening, capillary rarefaction and interstitial fibrosis in the heart of rats with renal failure: the effects of ramipril, nifedipine and moxonidine. J Am Soc Nephrol 7 : 667 675, 1996
42. Gohlke P, Lamberty V, Kuwer I, Bartenbach S, Schnell A, Unger T : Vascular remodeling in systemic hypertension. Am J Cardiol 71 : 2E 7E, 1993
43. Gohlke P, Kuwer I, Bartenbach S, Schnell A, Unger T : Effect of low-dose treatment with perindopril on cardiac function in stroke-prone spontaneously hypertensive rats: role of bradykinin. J Cardiovasc Pharmacol 24 : 462 469, 1994
44. Linz W, Wiemer G, Schaper J, Zimmermann R, Nagasawa K, Gohlke P, Unger T, Scholkens BA : Angiotensin converting enzyme inhibitors, left ventricular hypertrophy and fibrosis. Mol Cell Biochem 147 : 89 97, 1995
45. London G, Guerin A, Pannier B, Marchais S, Benetos A, Safar M : Increased systolic pressure in chronic uremia. Role of arterial wave reflections. Hypertension 20 : 10 19, 1992
46. Klassen PS, Lowrie EG, Reddan DN, DeLong ER, Coladonato JA, Szczech LA, Lazarus JM, Owen WF Jr : Association between pulse pressure and mortality in patients undergoing maintenance hemodialysis. JAMA 287 : 1548 1555, 2002
47. London GM, Marchais SJ, Safar ME, Genest AF, Guerin AP, Metivier F, Chedid K, London AM : Aortic and large artery compliance in end-stage renal failure. Kidney Int 37 : 137 142, 1990
48. Mourad JJ, Pannier B, Blacher J, Rudnichi A, Benetos A, London GM, Safar ME : Creatinine clearance, pulse wave velocity, carotid compliance and essential hypertension. Kidney Int 59 : 1834 1841, 2001
49. Konings CJ, Dammers R, Rensma PL, Kooman JP, Hoeks AP, Kornet L, Gladziwa U, van der Sande FM, Leunissen KM : Arterial wall properties in patients with renal failure. Am J Kidney Dis 39 : 1206 1212, 2002
50. Matsumoto Y, Hamada M, Hiwada K : Aortic distensibility is closely related to the progression of left ventricular hypertrophy in patients receiving hemodialysis. Angiology 51 : 933 941, 2000
51. Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME, London GM : Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension 32 : 570 574, 1998
52. Amann K, Neususs R, Ritz E, Irzyniec T, Wiest G, Mall G : Changes of vascular architecture independent of blood pressure in experimental uremia. Am J Hypertens 8 : 409 417, 1995
53. Goodman WG, Goldin J, Kuizon BD, Yoon C, Gales B, Sider D, Wang Y, Chung J, Emerick A, Greaser L, Elashoff RM, Salusky IB : Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342 : 1478 1483, 2000
54. Gibbons GH, Dzau VJ : The emerging concept of vascular remodeling. N Engl J Med 330 : 1431 1438, 1994
55. London GM, Pannier B, Guerin AP, Blacher J, Marchais SJ, Darne B, Metivier F, Adda H, Safar ME : Alterations of left ventricular hypertrophy in and survival of patients receiving hemodialysis: follow-up of an interventional study. J Am Soc Nephrol 12 : 2759 2767, 2001
56. Orth SR, Amann K, Strojek K, Ritz E : Sympathetic overactivity and arterial hypertension in renal failure. Nephrol Dial Transplant 16 (Suppl. 1 67 69, 2001
57. Converse RL Jr, Jacobsen TN, Toto RD, Jost CM, Cosentino F, Fouad-Tarazi F, Victor RG : Sympathetic overactivity in patients with chronic renal failure. N Engl J Med 327 : 1912 1918, 1992
58. Ligtenberg G, Blankestijn PJ, Oey PL, Klein IH, Dijkhorst-Oei LT, Boomsma F, Wieneke GH, van Huffelen AC, Koomans HA : Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure. N Engl J Med 340 : 1321 1328, 1999
59. Harnett JD, Foley RN, Kent GM, Barre PE, Murray D, Parfrey PS : Congestive heart failure in dialysis patients: prevalence, incidence, prognosis and risk factors. Kidney Int 47 : 884 890, 1995
60. Parfrey PS, Foley RN, Harnett JD, Kent GM, Murray DC, Barre PE : Outcome and risk factors for left ventricular disorders in chronic uraemia. Nephrol Dial Transplant 11 : 1277 1285, 1996
61. Foley RN, Parfrey PS, Kent GM, Harnett JD, Murray DC, Barre PE : Long-term evolution of cardiomyopathy in dialysis patients. Kidney Int 54 : 1720 1725, 1998
62. Periyasamy SM, Chen J, Cooney D, Carter P, Omran E, Tian J, Priyadarshi S, Bagrov A, Fedorova O, Malhotra D, Xie Z, Shapiro JI : Effects of uremic serum on isolated cardiac myocyte calcium cycling and contractile function. Kidney Int 60 : 2367 2376, 2001
63. Foley RN, Parfrey PS, Morgan J, Barre PE, Campbell P, Cartier P, Coyle D, Fine A, Handa P, Kingma I, Lau CY, Levin A, Mendelssohn D, Muirhead N, Murphy B, Plante RK, Posen G, Wells GA : Effect of hemoglobin levels in hemodialysis patients with asymptomatic cardiomyopathy. Kidney Int 58 : 1325 1335, 2000
64. London GM, Pannier B, Guerin AP, Marchais SJ, Safar ME, Cuche JL : Cardiac hypertrophy, aortic compliance, peripheral resistance, and wave reflection in end-stage renal disease. Comparative effects of ACE inhibition and calcium channel blockade. Circulation 90 : 2786 2796, 1994
65. Ritz E, Rambausek M, Mall G, Ruffmann K, Mandelbaum A : Cardiac changes in uraemia and their possible relationship to cardiovascular instability on dialysis. Nephrol Dial Transplant 5 (Suppl. 1 93 97, 1990
66. Ahmed A, Rich MW, Sanders PW, Perry GJ, Bakris GL, Zile MR, Love TE, Aban IB, Shlipak MG : Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched study. Am J Cardiol 99 : 393 398, 2007
67. Diez J : Mechanisms of cardiac fibrosis in hypertension. J Clin Hypertens (Greenwich, Conn) 9 : 546 550, 2007
68. Mall G, Rambausek M, Neumeister A, Kollmar S, Vetterlein F, Ritz E : Myocardial interstitial fibrosis in experimental uremia - implications for cardiac compliance. Kidney Int 33 : 804 811, 1988
69. Bakth S, Arena J, Lee W, Torres R, Haider B, Patel BC, Lyons MM, Regan TJ : Arrhythmia susceptibility and myocardial composition in diabetes. Influence of physical conditioning. J Clin Invest 77 : 382 395, 1986
70. Diez J : Profibrotic effects of angiotensin II in the heart: a matter of mediators. Hypertension 43 : 1164 1165, 2004
71. La Vecchia L, Ometto R, Bedogni F, Finocchi G, Mosele GM, Bozzola L, Bevilacqua P, Vincenzi M : Ventricular late potentials, interstitial fibrosis, and right ventricular function in patients with ventricular tachycardia and normal left ventricular function. Am J Cardiol 81 : 790 792, 1998
72. Amann K, Ritz E : Cardiac disease in chronic uremia: pathophysiology. Adv Ren Replace Ther 4 : 212 224, 1997
73. Amann K, Ritz E, Wiest G, Klaus G, Mall G : A role of parathyroid hormone for the activation of cardiac fibroblasts in uremia. J Am Soc Nephrol 4 : 1814 1819, 1994
74. Diez J, Lopez B, Gonzalez A, Querejeta R : Clinical aspects of hypertensive myocardial fibrosis. Curr Opin Cardiol 16 : 328 335, 2001
75. Gonzalez A, Lopez B, Diez J : Fibrosis in hypertensive heart disease: role of the renin-angiotensin-aldosterone system. Med Clin North Am 88 : 83 97, 2004
76. Amann K, Simonaviciene A, Medwedewa T, Koch A, Orth S, Gross ML, Haas C, Kuhlmann A, Linz W, Scholkens B, Ritz E : Blood pressure-independent additive effects of pharmacologic blockade of the renin-angiotensin and endothelin systems on progression in a low-renin model of renal damage. J Am Soc Nephrol 12 : 2572 2584, 2001
77. Block GA, Port FK : Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: recommendations for a change in management. Am J Kidney Dis 35 : 1226 1237, 2000
78. Amann K, Tornig J, Kugel B, Gross ML, Tyralla K, El-Shakmak A, Szabo A, Ritz E : Hyperphosphatemia aggravates cardiac fibrosis and microvascular disease in experimental uremia. Kidney Int 63 : 1296 1301, 2003
79. Braun J, Oldendorf M, Moshage W, Heidler R, Zeitler E, Luft FC : Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients. Am J Kidney Dis 27 : 394 401, 1996
80. Schwarz U, Buzello M, Ritz E, Stein G, Raabe G, Wiest G, Mall G, Amann K : Morphology of coronary atherosclerotic lesions in patients with end-stage renal failure. Nephrol Dial Transplant 15 : 218 223, 2000
81. Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K, Morii H, Giachelli CM : Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 87 : E10 E17, 2000
82. Steitz SA, Speer MY, Curinga G, Yang HY, Haynes P, Aebersold R, Schinke T, Karsenty G, Giachelli CM : Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res 89 : 1147 1154, 2001
83. Marchais SJ, Metivier F, Guerin AP, London GM : Association of hyperphosphataemia with haemodynamic disturbances in end-stage renal disease. Nephrol Dial Transplant 14 : 2178 2183, 1999
84. London GM, Fabiani F, Marchais SJ, de Vernejoul MC, Guerin AP, Safar ME, Metivier F, Llach F : Uremic cardiomyopathy: an inadequate left ventricular hypertrophy. Kidney Int 31 : 973 980, 1987
85. Smogorzewski M, Zayed M, Zhang YB, Roe J, Massry SG : Parathyroid hormone increases cytosolic calcium concentration in adult rat cardiac myocytes. Am J Physiol 264 : H1998 H2006, 1993
86. Amann K, Tornig J, Flechtenmacher C, Nabokov A, Mall G, Ritz E : Blood-pressure-independent wall thickening of intramyocardial arterioles in experimental uraemia: evidence for a permissive action of PTH. Nephrol Dial Transplant 10 : 2043 2048, 1995
87. Pirola CJ, Wang HM, Kamyar A, Wu S, Enomoto H, Sharifi B, Forrester JS, Clemens TL, Fagin JA : Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms. J Biol Chem 268 : 1987 1994, 1993
88. Okano K, Wu S, Huang X, Pirola CJ, Juppner H, Abou-Samra AB, Segre GV, Iwasaki K, Fagin JA, Clemens TL : Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor and its messenger ribonucleic acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells: cell-specific regulation by angiotensin-II and PTHrP. Endocrinology 135 : 1093 1099, 1994
89. Kuczera M, Hilgers KF, Lisson C, Ganten D, Hilgenfeldt U, Ritz E, Mann JF : Local angiotensin formation in hindlimbs of uremic hypertensive and renovascular hypertensive rats. J Hypertens 9 : 41 48, 1991
90. Fiorillo C, Oliviero C, Rizzuti G, Nediani C, Pacini A, Nassi P : Oxidative stress and antioxidant defenses in renal patients receiving regular haemodialysis. Clin Chem Lab Med 36 : 149 153, 1998
91. Tetta C, Biasioli S, Schiavon R, Inguaggiato P, David S, Panichi V, Wratten ML : An overview of haemodialysis and oxidant stress. Blood Purif 17 : 118 126, 1999
92. Zanzinger J, Czachurski J : Chronic oxidative stress in the RVLM modulates sympathetic control of circulation in pigs. Pflugers Arch 439 : 489 494, 2000
93. Miyazaki H, Matsuoka H, Itabe H, Usui M, Ueda S, Okuda S, Imaizumi T : Hemodialysis impairs endothelial function via oxidative stress: effects of vitamin E-coated dialyzer. Circulation 101 : 1002 1006, 2000
94. Wolf G : Free radical production and angiotensin. Curr Hypertens Rep 2 : 167 173, 2000
95. Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM : The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int 62 : 1524 1538, 2002
96. Daugherty A, Dunn JL, Rateri DL, Heinecke JW : Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J Clin Invest 94 : 437 444, 1994
97. Gross ML, Meyer HP, Ziebart H, Rieger P, Wenzel U, Amann K, Berger I, Adamczak M, Schirmacher P, Ritz E : Calcification of coronary intima and media: immunohistochemistry, backscatter imaging, and x-ray analysis in renal and nonrenal patients. Clin J Am Soc Nephrol 2 : 121 134, 2007
98. Heinecke JW : Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall. FASEB J 13 : 1113 1120, 1999
99. Hazen SL, Heinecke JW : 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. J Clin Invest 99 : 2075 2081, 1997
100. Uchida K : Role of reactive aldehyde in cardiovascular diseases. Free Radic Biol Med 28 : 1685 1696, 2000
101. Himmelfarb J, McMonagle E, McMenamin E : Plasma protein thiol oxidation and carbonyl formation in chronic renal failure. Kidney Int 58 : 2571 2578, 2000
102. Himmelfarb J, McMonagle E : Manifestations of oxidant stress in uremia. Blood Purif 19 : 200 205, 2001
103. Miyata T, van Ypersele de Strihou C, Kurokawa K, Baynes JW : Alterations in nonenzymatic biochemistry in uremia: origin and significance of "carbonyl stress" in long-term uremic complications. Kidney Int 55 : 389 399, 1999
104. Amann K, Tornig J, Buzello M, Kuhlmann A, Gross ML, Adamczak M, Buzello M, Ritz E : Effect of antioxidant therapy with dl-alpha-tocopherol on cardiovascular structure in experimental renal failure. Kidney Int 62 : 877 884, 2002
105. Stenvinkel P : Inflammatory and atherosclerotic interactions in the depleted uremic patient. Blood Purif 19 : 53 61, 2001
106. Arici M, Walls J : End-stage renal disease, atherosclerosis, and cardiovascular mortality: is C-reactive protein the missing link? Kidney Int 59 : 407 414, 2001
107. Nguyen-Khoa T, Massy ZA, De Bandt JP, Kebede M, Salama L, Lambrey G, Witko-Sarsat V, Drueke TB, Lacour B, Thevenin M : Oxidative stress and haemodialysis: role of inflammation and duration of dialysis treatment. Nephrol Dial Transplant 16 : 335 340, 2001
108. Elkareh J, Kennedy DJ, Yashaswi B, Vetteth S, Shidyak A, Kim EG, Smaili S, Periyasamy SM, Hariri IM, Fedorova L, Liu J, Wu L, Kahaleh MB, Xie Z, Malhotra D, Fedorova OV, Kashkin VA, Bagrov AY, Shapiro JI : Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Hypertension 49 : 215 224, 2007
109. Kennedy DJ, Vetteth S, Periyasamy SM, Kanj M, Fedorova L, Khouri S, Kahaleh MB, Xie Z, Malhotra D, Kolodkin NI, Lakatta EG, Fedorova OV, Bagrov AY, Shapiro JI : Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension 47 : 488 495, 2006
110. Kennedy DJ, Elkareh J, Shidyak A, Shapiro AP, Smaili S, Mutgi K, Gupta S, Tian J, Morgan E, Khouri S, Cooper CJ, Periyasamy SM, Xie Z, Malhotra D, Fedorova OV, Bagrov AY, Shapiro JI : Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. Am J Physiol 294 : F450 F454, 2008
111. Komiyama Y, Dong XH, Nishimura N, Masaki H, Yoshika M, Masuda M, Takahashi H : A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure. Clin Biochem 38 : 36 45, 2005
112. Priyadarshi S, Valentine B, Han C, Fedorova OV, Bagrov AY, Liu J, Periyasamy SM, Kennedy D, Malhotra D, Xie Z, Shapiro JI : Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat. Kidney Int 63 : 1785 1790, 2003
113. Ritz E, Dikow R, Morath C, Schwenger V : Salt - a potential 'uremic toxin'? Blood Purif 24 : 63 66, 2006
114. Sanders PW : Assessment and treatment of hypertension in dialysis: the case for salt restriction. Semin Dial 20 : 408 411, 2007
115. Bauer N, Muller-Ehmsen J, Kramer U, Hambarchian N, Zobel C, Schwinger RH, Neu H, Kirch U, Grunbaum EG, Schoner W : Ouabain-like compound changes rapidly on physical exercise in humans and dogs: effects of beta-blockade and angiotensin-converting enzyme inhibition. Hypertension 45 : 1024 1028, 2005
116. Fedorova OV, Bagrov AY : Inhibition of Na/K ATPase from rat aorta by two Na/K pump inhibitors, ouabain and marinobufagenin: evidence of interaction with different alpha-subunit isoforms. Am J Hypertens 10 : 929 935, 1997
117. Fedorova OV, Lakatta EG, Bagrov AY : Endogenous Na,K pump ligands are differentially regulated during acute NaCl loading of Dahl rats. Circulation 102 : 3009 3014, 2000
118. Herrera VL, Xie HX, Lopez LV, Schork NJ, Ruiz-Opazo N : The alpha1 Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitiveHSD rat. J Clin Invest 102 : 1102 1111, 1998
119. Fedorova OV, Agalakova NI, Talan MI, Lakatta EG, Bagrov AY : Brain ouabain stimulates peripheral marinobufagenin via angiotensin II signalling in NaCl-loaded Dahl-S rats. J Hypertens 23 : 1515 1523, 2005
120. Liu J, Liang M, Liu L, Malhotra D, Xie Z, Shapiro JI : Ouabain-induced endocytosis of the plasmalemmal Na/K-ATPase in LLC-PK1 cells requires caveolin-1. Kidney Int 67 : 1844 1854, 2005
121. Liu L, Mohammadi K, Aynafshar B, Wang H, Li D, Liu J, Ivanov AV, Xie Z, Askari A : Role of caveolae in signal-transducing function of cardiac Na+/K+-ATPase. Am J Physiol Cell Physiol 284 : C1550 C1560, 2003
122. Kometiani P, Li J, Gnudi L, Kahn BB, Askari A, Xie Z : Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. J Biol Chem 273 : 15249 15256, 1998
123. Haas M, Askari A, Xie Z : Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase. J Biol Chem 275 : 27832 27837, 2000
124. Huang L, Li H, Xie Z : Ouabain-induced hypertrophy in cultured cardiac myocytes is accompanied by changes in expression of several late response genes. J Mol Cell Cardiol 29 : 429 437, 1997
125. Xie Z, Kometiani P, Liu J, Li J, Shapiro JI, Askari A : Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes. J Biol Chem 274 : 19323 19328, 1999
126. Mohammadi K, Kometiani P, Xie Z, Askari A : Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. J Biol Chem 276 : 42050 42056, 2001
127. Saunders R, Scheiner-Bobis G : Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump. Eur J Biochem 271 : 1054 1062, 2004
128. Hayflick L, Moorhead PS : The serial cultivation of human diploid cell strains. Exp Cell Res 25 : 585 621, 1961
129. Hayflick L : Living forever and dying in the attempt. Exp Gerontol 38 : 1231 1241, 2003
130. Harley CB, Futcher AB, Greider CW : Telomeres shorten during ageing of human fibroblasts. Nature 345 : 458 460, 1990
131. Trivier E, Kurz DJ, Hong Y, Huang HL, Erusalimsky JD : Differential regulation of telomerase in endothelial cells by fibroblast growth factor-2 and vascular endothelial growth factor-a: association with replicative life span. Ann N Y Acad Sci 1019 : 111 115, 2004
132. Zheng W, Wang H, Xue L, Zhang Z, Tong T : Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast. J Biol Chem 279 : 31524 31532, 2004
133. Kashino G, Kodama S, Nakayama Y, Suzuki K, Fukase K, Goto M, Watanabe M : Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells. Free Radic Biol Med 35 : 438 443, 2003
134. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE : Extension of life-span by introduction of telomerase into normal human cells. Science 279 : 349 352, 1998
135. Martens UM, Chavez EA, Poon SS, Schmoor C, Lansdorp PM:Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp Cell Res 256:291 299, 2000
136. Taylor LM, James A, Schuller CE, Brce J, Lock RB, Mackenzie KL:Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization. J Biol Chem 279:43634 43645, 2004
137. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA:Role of the INK4a locus in tumor suppression and cell mortality. Cell 85:27 37, 1996
138. Wright WE, Shay JW:Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med 6:849 851, 2000
139. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW:Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25 34, 1997
140. Lee HW, Blasco MA, Gottlieb GJ, Horner JW 2nd, Greider CW, DePinho RA:Essential role of mouse telomerase in highly proliferative organs. Nature 392:569 574, 1998
141. Wright WE, Shay JW:Historical claims and current interpretations of replicative aging. Nat Biotechnol 20:682 688, 2002
142. Shay JW, Roninson IB:Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23:2919 2933, 2004
143. Darbro BW, Schneider GB, Klingelhutz AJ:Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes. J Invest Dermatol 125:499 509, 2005
144. Ramirez RD, Morales CP, Herbert BS, Rohde JM, Passons C, Shay JW, Wright WE:Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev 15:398 403, 2001
145. Weinberg RA:The retinoblastoma protein and cell cycle control. Cell 81:323 330, 1995
146. Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R:Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev 19:1432 1437, 2005
147. Zhu D, Xu G, Ghandhi S, Hubbard K:Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: implications for cellular senescence. J Cell Physiol 193:19 25, 2002
148. Carnero A, Hudson JD, Price CM, Beach DH:p16INK4A and p19ARF act in overlapping pathways in cellular immortalization. Nat Cell Biol 2:148 155, 2000
149. Haber DA:Splicing into senescence: the curious case of p16 and p19ARF. Cell 91:555 558, 1997
150. Jacobs JJ, de Lange T:Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr Biol 14:2302 2308, 2004
151. Melk A, Mansfield ES, Hsieh SC, Hernandez-Boussard T, Grimm P, Rayner DC, Halloran PF, Sarwal MM:Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling. Kidney Int 68:2667 2679, 2005
152. Melk A, Schmidt BM, Takeuchi O, Sawitzki B, Rayner DC, Halloran PF:Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney. Kidney Int 65:510 520, 2004
153. Melk A, Kittikowit W, Sandhu I, Halloran KM, Grimm P, Schmidt BM, Halloran PF:Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening. Kidney Int 63:2134 2143, 2003
154. Melk A:Senescence of renal cells: molecular basis and clinical implications. Nephrol Dial Transplant 18:2474 2478, 2003
155. Rostand SG, Kirk KA, Rutsky EA:The epidemiology of coronary artery disease in patients on maintenance hemodialysis: implications for management. Contrib Nephrol 52:34 41, 1986
156. Marcus ML, Harrison DG, Chilian WM, Koyanagi S, Inou T, Tomanek RJ, Martins JB, Eastham CL, Hiratzka LF:Alterations in the coronary circulation in hypertrophied ventricles. Circulation 75:I19 I25, 1987
157. Delano BG, Nacht R, Friedman EA, Krasow N:Myocardial anaerobiosis in anemia in uremic man. Am J Cardiol 29:39 46, 1972
158. Amann K, Wiest G, Zimmer G, Gretz N, Ritz E, Mall G:Reduced capillary density in the myocardium of uremic rats - a stereological study. Kidney Int 42:1079 1085, 1992
159. Amann K, Neimeier KA, Schwarz U, Tornig J, Matthias S, Orth SR, Mall G, Ritz E:Rats with moderate renal failure show capillary deficit in heart but not skeletal muscle. Am J Kidney Dis 30:382 388, 1997
160. Opherk D, Mall G, Zebe H, Schwarz F, Weihe E, Manthey J, Kubler W:Reduction of coronary reserve: a mechanism for angina pectoris in patients with arterial hypertension and normal coronary arteries. Circulation 69:1 7, 1984
161. Schwartzkopff B, Motz W, Frenzel H, Vogt M, Knauer S, Strauer BE:Structural and functional alterations of the intramyocardial coronary arterioles in patients with arterial hypertension. Circulation 88:993 1003, 1993
162. Zebe H RB, Ritz E, Hasselbach W, Goy W:Myocardial metabolism in experimental uremia. In:A Heidland (ed). Renal Insufficiency. Stuttgart:Georg
163. Raine AE, Seymour AM, Roberts AF, Radda GK, Ledingham JG:Impairment of cardiac function and energetics in experimental renal failure. J Clin Invest 92:2934 2940, 1993
164. Allard MF, Schonekess BO, Henning SL, English DR, Lopaschuk GD:Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts. Am J Physiol 267:H742 H750, 1994
165. Lopaschuk GD, Belke DD, Gamble J, Itoi T, Schonekess BO:Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta 1213:263 276, 1994
166. van der Vusse GJ, van Bilsen M, Glatz JF:Cardiac fatty acid uptake and transport in health and disease. Cardiovasc Res 45:279 293, 2000
167. Taegtmeyer H, Overturf ML:Effects of moderate hypertension on cardiac function and metabolism in the rabbit. Hypertension 11:416 426, 1988
168. Christe ME, Rodgers RL:Altered glucose and fatty acid oxidation in hearts of the spontaneously hypertensive rat. J Mol Cell Cardiol 26:1371 1375, 1994
169. Stewart BF, Siscovick D, Lind BK, Gardin JM, Gottdiener JS, Smith VE, Kitzman DW, Otto CM:Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol 29:630 634, 1997
170. Fulkerson PK, Beaver BM, Auseon JC, Graber HL:Calcification of the mitral annulus: etiology, clinical associations, complications and therapy. Am J Med 66:967 977, 1979
171. Roberts WC:The senile cardiac calcification syndrome. Am J Cardiol 58:572 574, 1986
172. Wang AY, Woo J, Wang M, Sea MM, Ip R, Li PK, Lui SF, Sanderson JE:Association of inflammation and malnutrition with cardiac valve calcification in continuous ambulatory peritoneal dialysis patients. J Am Soc Nephrol 12:1927 1936, 2001
173. Raggi P, Boulay A, Chasan-Taber S, Amin N, Dillon M, Burke SK, Chertow GM:Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 39:695 701, 2002
174. Otto CM, Lind BK, Kitzman DW, Gersh BJ, Siscovick DS:Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med 341:142 147, 1999
175. Kamensky G, Lisy L, Polak E, Piknova E, Plevova N:Mitral annular calcifications and aortic plaques as predictors of increased cardiovascular mortality. J Cardiol 37 (Suppl. 1 21 26, 2001
176. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD:Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 90:844 853, 1994
177. Boon A, Cheriex E, Lodder J, Kessels F:Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve. Heart 78:472 474, 1997
178. Nair CK, Sudhakaran C, Aronow WS, Thomson W, Woodruff MP, Sketch MH:Clinical characteristics of patients younger than 60 years with mitral anular calcium: comparison with age- and sex-matched control subjects. Am J Cardiol 54:1286 1287, 1984
179. Drolet MC, Arsenault M, Couet J:Experimental aortic valve stenosis in rabbits. J Am Coll Cardiol 41:1211 1217, 2003
180. Wang AY, Wang M, Woo J, Lam CW, Li PK, Lui SF, Sanderson JE:Cardiac valve calcification as an important predictor for all-cause mortality and cardiovascular mortality in long-term peritoneal dialysis patients: a prospective study. J Am Soc Nephrol 14:159 168, 2003