Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly

New England Journal of Medicine

Volumn 341, Issue 3, 1999, Pages 142-147

  Otto, Catherine M ^a,b   Lind, Bonnie K ^a   Kitzman, Dalane W ^a,c   Gersh, Bernard J ^d   Siscovick, David S ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ANGINA PECTORIS; AORTA ATHEROSCLEROSIS; AORTA VALVE STENOSIS; ARTICLE; CARDIOVASCULAR RISK; CONGESTIVE HEART FAILURE; ECHOCARDIOGRAPHY; FEMALE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STROKE;

AGED; ANGINA PECTORIS; AORTIC VALVE; CALCINOSIS; CARDIOVASCULAR DISEASES; CEREBROVASCULAR DISORDERS; FEMALE; HEART FAILURE, CONGESTIVE; HEART VALVE DISEASES; HUMANS; MALE; MORTALITY; MYOCARDIAL INFARCTION; PROSPECTIVE STUDIES; RISK; RISK FACTORS; UNITED STATES; VENTRICULAR OUTFLOW OBSTRUCTION;

EID: 0033565955     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199907153410302     Document Type: Article

References (36)

1. Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease: Cardiovascular Health Study. J Am Coll Cardiol 1997;29:630-4.
2. Lindroos M, Kupari M, Heikkila J, Tilvis R. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol 1993;21:1220-5.
3. Frank S, Johnson A, Ross J Jr. Natural history of valvular aortic stenosis. Br Heart J 1973;35:41-6.
4. Chizner MA, Pearle DL, deLeon AC Jr. The natural history of aortic stenosis in adults. Am Heart J 1980;99:419-24.
5. O'Keefe JH Jr, Vlietstra RE, Bailey KR, Holmes DR Jr. Natural history of candidates for balloon aortic valvuloplasty. Mayo Clin Proc 1987;62: 986-91.
6. Turina J, Hess O, Sepulcri F, Krayenbuehl HP. Spontaneous course of aortic valve disease. Eur Heart J 1987;8:471-83.
7. Horstkotte D, Loogen F. The natural history of aortic valve stenosis. Eur Heart J 1988;9:Suppl E:57-64.
8. Otto CM, Burwash IG, Legget ME, et al. Prospective study of asymptomatic valvular aortic stenosis: clinical, echocardiographic, and exercise predictors of outcome. Circulation 1997;95:2262-70.
9. Otto CM, Pearlman AS, Gardner CL. Hemodynamic progression of aortic stenosis in adults assessed by Doppler echocardiography. J Am Coll Cardiol 1989;13:545-50.
10. Roger VL, Tajik AJ, Bailey KR, Oh JK, Taylor CL, Seward JB. Progression of aortic stenosis in adults: new appraisal using Doppler echocardiography. Am Heart J 1990;119:331-8.
11. Faggiano P, Ghizzoni G, Sorgato A, et al. Rate of progression of valvular aortic stenosis in adults. Am J Cardiol 1992;70:229-33.
12. Peter M, Hoffmann A, Parker C, Luscher T, Burckhardt D. Progression of aortic stenosis: role of age and concomitant coronary artery disease. Chest 1993;103:1715-9.
13. Brener SJ, Duffy CI, Thomas JD, Stewart WJ. Progression of aortic stenosis in 394 patients: relation to changes in myocardial and m7itral valve dysfunction. J Am Coll Cardiol 1995;25:305-10.
14. Fried LP, Borhani NO, Enright P, et al. The Cardiovascular Health Study: design and rationale. Ann Epidemiol 1991;1:263-76.
15. Gardin JM, Wong ND, Bommer W, et al. Echocardiographic design of a multicenter investigation of free-living elderly subjects: the Cardiovascular Health Study. J Am Soc Echocardiogr 1992;5:63-72. [Erratum, J Am Soc Echocardiogr 1992;5:550.]
16. Gardin JM, Wong ND, Bommer W, et al. Echocardiographic design of a multicenter investigation of free-living elderly subjects: the Cardiovascular Health Study. J Am Soc Echocardiogr 1992;5:63-72. [Erratum, J Am Soc Echocardiogr 1992;5:550.]
17. Ives DG, Fitzpatrick AL, Bild DE, et al. Surveillance and ascertainment of cardiovascular events: the Cardiovascular Health Study. Ann Epidemiol 1995;5:278-85.
18. Teerlink JR, Newman TB, Schiller NB, Foster E. Aortic sclerosis, as well as aortic stenosis, is a significant predictor of mortality. Circulation 1997;96:Suppl I:I-82. abstract.
19. Georgeson S, Meyer KB, Pauker SG. Decision analysis in clinical cardiology: when is coronary angiography required in aortic stenosis? J Am Coll Cardiol 1990;15:751-62.
20. Kaufmann P, Vassalli G, Lupi-Wagner S, Jenni R, Hess OM. Coronary artery dimensions in primary and secondary left ventricular hypertrophy. J Am Coll Cardiol 1996;28:745-50.
21. Marcus ML, Doty DB, Hiratzka LF, Wright CB, Eastham CL. Decreased coronary reserve: a mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries. N Engl J Med 1982;307: 1362-7.
22. Nadell R, DePace NL, Ren JF, Hakki AH, Iskandrian AS, Morganroth J. Myocardial oxygen supply/demand ratio in aortic stenosis: hemodynamic and echocardiographic evaluation of patients with and without angina pectoris. J Am Coll Cardiol 1983;2:258-62.
23. Julius BK, Spillmann M, Vassal G, Villari B, Eberli FR, Hess OM. Angina pectoris in patients with aortic stenosis and normal coronary arteries: mechanisms and pathophysiological concepts. Circulation 1997;95: 892-8.
24. Omran H, Fehske W, Rabahieh R, Hagendorff A, Luderitz B. Relation between symptoms and profiles of coronary artery blood flow velocities in patients with aortic valve stenosis: a study using transoesophageal Doppler echocardiography. Heart 1996;75:377-83.
25. Petropoulakis PN, Kyriakidis MK, Tentolouris CA, Kourouclis CV, Toutouzas PK. Changes in phasic coronary blood Bow velocity profile in relation to changes in hemodynamic parameters during stress in patients with aortic valve stenosis. Circulation 1995;92:1437-47.
26. Mohler ER, Sheridan MJ, Nichols R, Harvey WP, Waller BF. Development and progression of aortic valve stenosis: atherosclerosis risk factors - a causal relationship? A clinical morphologic study. Clin Cardiol 1991; 14:995-9.
27. Boon A, Cheriex E, Lodder J, Kessels F. Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve. Heart 1997;78:472-4.
28. Gotoh T, Kuroda T, Yamasawa M, et al. Correlation between lipoprotein(a) and aortic valve sclerosis assessed by echocardiography (the JMS Cardiac Echo and Cohort Study). Am J Cardiol 1995;76:928-32.
29. Aronow WS, Schwartz KS, Koenigsberg M. Correlation of serum lipids, calcium, and phosphorus, diabetes mellitus and history of systemic hypertension with presence or absence of calcified or thickened aortic cusps or root in elderly patients. Am J Cardiol 1987;59:998-9.
30. Hoagland PM, Cook EF, Flatley M, Walker C, Goldman L. Case-control analysis of risk factors for presence of aortic stenosis in adults (age 50 years or older). Am J Cardiol 1985;55:744-7.
31. Deutscher S, Rockette HE, Krishnaswami V. Diabetes and hypercholesterolemia among patients with calcific aortic stenosis. J Chronic Dis 1984;37:407-15.
32. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD. Characterization of the early lesion of 'degenerative' valvular aortic stenosis: histological and immunohistochemical studies. Circulation 1994;90. 844-53.
33. Olsson M, Dalsgaard CJ, Haegerstrand A, Rosenqvist M, Ryden L, Nilsson J. Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves. J Am Coll Cardiol 1994; 23:1162-70.
34. Olsson M, Rosenqvist M, Nilsson J. Expression of HLA-DR antigen and smooth muscle cell differentiation markers by valvular fibroblasts in degenerative aortic stenosis. J Am Coll Cardiol 1994;24:1664-71.
35. O'Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM. Apolipoprotcins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis. Arterioscler Thromb Vasc Biol 1996;16:523-32.
36. O'Brien KD, Kuusisto J, Reichenbach DD, et al. Osteopontin is expressed in human aortic valvular lesions. Circulation 1995;92:2163-8.