메뉴 건너뛰기




Volumn 198, Issue 1, 2008, Pages 17-28

Mechanisms underlying proglucagon gene expression

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HOMEODOMAIN PROTEIN; INSULIN; LIM PROTEIN; MESSENGER RNA; PROEIN ISL 1; PROGLUCAGON; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 7 LIKE 2; TRANSCRIPTION FACTOR BRN 4; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR NKX6.2; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PBX1; WNT PROTEIN;

EID: 47849093381     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0085     Document Type: Review
Times cited : (64)

References (133)
  • 1
    • 0036323269 scopus 로고    scopus 로고
    • Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells
    • Abraham EJ, Leech CA, Lin JC, Zulewski H & Habener JF 2002 Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology 143 3152-3161.
    • (2002) Endocrinology , vol.143 , pp. 3152-3161
    • Abraham, E.J.1    Leech, C.A.2    Lin, J.C.3    Zulewski, H.4    Habener, J.F.5
  • 2
  • 3
    • 0020596734 scopus 로고    scopus 로고
    • \kern-2ptBell GI, Santerre RF & Mullenbach GT 1983b Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature 302 716-718.
    • \kern-2ptBell GI, Santerre RF & Mullenbach GT 1983b Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature 302 716-718.
  • 4
    • 0033561377 scopus 로고    scopus 로고
    • The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH
    • Berthelsen J, Kilstrup-Nielsen C, Blasi F, Mavilio F & Zappavigna V 1999 The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes and Development 13 946-953.
    • (1999) Genes and Development , vol.13 , pp. 946-953
    • Berthelsen, J.1    Kilstrup-Nielsen, C.2    Blasi, F.3    Mavilio, F.4    Zappavigna, V.5
  • 6
    • 0023711886 scopus 로고
    • Control of glucagon-like immunoreactive peptide secretion from fetal rat intestinal cultures
    • Brubaker PL 1988 Control of glucagon-like immunoreactive peptide secretion from fetal rat intestinal cultures. Endocrinology 123 220-226.
    • (1988) Endocrinology , vol.123 , pp. 220-226
    • Brubaker, P.L.1
  • 7
    • 2542479899 scopus 로고    scopus 로고
    • Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
    • Brubaker PL & Drucker DJ 2004 Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 145 2653-2659.
    • (2004) Endocrinology , vol.145 , pp. 2653-2659
    • Brubaker, P.L.1    Drucker, D.J.2
  • 8
    • 0031765091 scopus 로고    scopus 로고
    • Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line
    • Brubaker PL, Schloos J & Drucker DJ 1998 Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line. Endocrinology 139 4108-4114.
    • (1998) Endocrinology , vol.139 , pp. 4108-4114
    • Brubaker, P.L.1    Schloos, J.2    Drucker, D.J.3
  • 9
    • 0029840285 scopus 로고    scopus 로고
    • Molecular and cellular aspects of the glucagon receptor: Role in diabetes and metabolism
    • Burcelin R, Katz EB & Charron MJ 1996 Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism. Diabetes and Metabolism 22 373-396.
    • (1996) Diabetes and Metabolism , vol.22 , pp. 373-396
    • Burcelin, R.1    Katz, E.B.2    Charron, M.J.3
  • 10
    • 0034973592 scopus 로고    scopus 로고
    • Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally
    • Cai J, Qi Y, Wu R, Modderman G, Fu H, Liu R & Qiu M 2001 Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally. Molecular and Cellular Biology 21 4399-4403.
    • (2001) Molecular and Cellular Biology , vol.21 , pp. 4399-4403
    • Cai, J.1    Qi, Y.2    Wu, R.3    Modderman, G.4    Fu, H.5    Liu, R.6    Qiu, M.7
  • 11
    • 0028325376 scopus 로고
    • Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse
    • Campos RV, Lee YC & Drucker DJ 1994 Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology 134 2156-2164.
    • (1994) Endocrinology , vol.134 , pp. 2156-2164
    • Campos, R.V.1    Lee, Y.C.2    Drucker, D.J.3
  • 13
    • 20444444322 scopus 로고    scopus 로고
    • PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP
    • Chen L, Wang P, Andrade CF, Zhao IY, Dube PE, Brubaker PL, Liu M & Jin T 2005 PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP. FEBS Journal 272 2746-2759.
    • (2005) FEBS Journal , vol.272 , pp. 2746-2759
    • Chen, L.1    Wang, P.2    Andrade, C.F.3    Zhao, I.Y.4    Dube, P.E.5    Brubaker, P.L.6    Liu, M.7    Jin, T.8
  • 14
    • 0030469432 scopus 로고    scopus 로고
    • Glucagon and its receptor in various tissues
    • discussion 42-33
    • Christophe J 1996 Glucagon and its receptor in various tissues. Annals of the New York Academy of Sciences 805 31-42 discussion 42-33.
    • (1996) Annals of the New York Academy of Sciences , vol.805 , pp. 31-42
    • Christophe, J.1
  • 15
    • 0029169645 scopus 로고
    • Interaction of the transcription factor CREB with pancreatic islet cell-specific enhancer elements
    • Diedrich T & Knepel W 1995 Interaction of the transcription factor CREB with pancreatic islet cell-specific enhancer elements. Biological Chemistry Hoppe-Seyler 376 39-44.
    • (1995) Biological Chemistry Hoppe-Seyler , vol.376 , pp. 39-44
    • Diedrich, T.1    Knepel, W.2
  • 17
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble BW & Woodgett JR 2003 GSK-3: tricks of the trade for a multi-tasking kinase. Journal of Cell Science 116 1175-1186.
    • (2003) Journal of Cell Science , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 18
    • 0025794399 scopus 로고
    • Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1
    • Dong J, Asa SL & Drucker DJ 1991 Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1. Molecular Endocrinology 5 1633-1641.
    • (1991) Molecular Endocrinology , vol.5 , pp. 1633-1641
    • Dong, J.1    Asa, S.L.2    Drucker, D.J.3
  • 19
    • 33847617011 scopus 로고    scopus 로고
    • Mechanisms of action of glucagon-like peptide 1 in the pancreas
    • Doyle ME & Egan JM 2007 Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacology and Therapeutics 113 546-593.
    • (2007) Pharmacology and Therapeutics , vol.113 , pp. 546-593
    • Doyle, M.E.1    Egan, J.M.2
  • 20
    • 0035106978 scopus 로고    scopus 로고
    • Minireview: The glucagon-like peptides
    • Drucker DJ 2001 Minireview: the glucagon-like peptides. Endocrinology 142 521-527.
    • (2001) Endocrinology , vol.142 , pp. 521-527
    • Drucker, D.J.1
  • 21
    • 0036158954 scopus 로고    scopus 로고
    • Biological actions and therapeutic potential of the glucagon-like peptides
    • Drucker DJ 2002 Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122 531-544.
    • (2002) Gastroenterology , vol.122 , pp. 531-544
    • Drucker, D.J.1
  • 22
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ 2006 The biology of incretin hormones. Cell Metabolism 3 153-165.
    • (2006) Cell Metabolism , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 23
    • 0024332336 scopus 로고
    • Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine
    • Drucker DJ & Brubaker PL 1989 Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine. PNAS 86 3953-3957.
    • (1989) PNAS , vol.86 , pp. 3953-3957
    • Drucker, D.J.1    Brubaker, P.L.2
  • 24
    • 0026093003 scopus 로고
    • The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells
    • Drucker DJ, Campos R, Reynolds R, Stobie K & Brubaker PL 1991 The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells. Endocrinology 128 394-400.
    • (1991) Endocrinology , vol.128 , pp. 394-400
    • Drucker, D.J.1    Campos, R.2    Reynolds, R.3    Stobie, K.4    Brubaker, P.L.5
  • 25
    • 0028575660 scopus 로고
    • Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line
    • Drucker DJ, Jin T, Asa SL, Young TA & Brubaker PL 1994 Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line. Molecular Endocrinology 8 1646-1655.
    • (1994) Molecular Endocrinology , vol.8 , pp. 1646-1655
    • Drucker, D.J.1    Jin, T.2    Asa, S.L.3    Young, T.A.4    Brubaker, P.L.5
  • 26
    • 0029795016 scopus 로고    scopus 로고
    • Induction of intestinal epithelial proliferation by glucagon-like peptide 2
    • Drucker DJ, Erlich P, Asa SL & Brubaker PL 1996 Induction of intestinal epithelial proliferation by glucagon-like peptide 2. PNAS 93 7911-7916.
    • (1996) PNAS , vol.93 , pp. 7911-7916
    • Drucker, D.J.1    Erlich, P.2    Asa, S.L.3    Brubaker, P.L.4
  • 27
    • 0024074541 scopus 로고
    • Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic alpha cells
    • Efrat S, Teitelman G, Anwar M, Ruggiero D & Hanahan D 1988 Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic alpha cells. Neuron 1 605-613.
    • (1988) Neuron , vol.1 , pp. 605-613
    • Efrat, S.1    Teitelman, G.2    Anwar, M.3    Ruggiero, D.4    Hanahan, D.5
  • 28
    • 34250639383 scopus 로고    scopus 로고
    • Evaluation of polymorphisms known to contribute to risk for diabetes in African and African-American populations
    • Elbein SC 2007 Evaluation of polymorphisms known to contribute to risk for diabetes in African and African-American populations. Current Opinion in Clinical Nutrition and Metabolic Care 10 415-419.
    • (2007) Current Opinion in Clinical Nutrition and Metabolic Care , vol.10 , pp. 415-419
    • Elbein, S.C.1
  • 29
    • 0026638915 scopus 로고
    • Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1
    • Ericson J, Thor S, Edlund T, Jessell TM & Yamada T 1992 Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science 256 1555-1560.
    • (1992) Science , vol.256 , pp. 1555-1560
    • Ericson, J.1    Thor, S.2    Edlund, T.3    Jessell, T.M.4    Yamada, T.5
  • 30
    • 0036795454 scopus 로고    scopus 로고
    • Pax-2 activates the proglucagon gene promoter but is not essential for proglucagon gene expression or development of proglucagon-producing cell lineages in the murine pancreas or intestine
    • Flock G & Drucker DJ 2002 Pax-2 activates the proglucagon gene promoter but is not essential for proglucagon gene expression or development of proglucagon-producing cell lineages in the murine pancreas or intestine. Molecular Endocrinology 16 2349-2359.
    • (2002) Molecular Endocrinology , vol.16 , pp. 2349-2359
    • Flock, G.1    Drucker, D.J.2
  • 32
    • 34548422439 scopus 로고    scopus 로고
    • Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane-domain receptor signaling pathways
    • Force T, Woulfe K, Koch WJ & Kerkela R 2007 Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane-domain receptor signaling pathways. Science's STKE pe41.
    • (2007) Science's STKE pe41
    • Force, T.1    Woulfe, K.2    Koch, W.J.3    Kerkela, R.4
  • 33
    • 34347327199 scopus 로고    scopus 로고
    • A new era in finding type 2 diabetes genes-the unusual suspects
    • Frayling TM 2007 A new era in finding type 2 diabetes genes-the unusual suspects. Diabetic Medicine 24 696-701.
    • (2007) Diabetic Medicine , vol.24 , pp. 696-701
    • Frayling, T.M.1
  • 35
    • 0027411690 scopus 로고
    • Multiple cis-acting domains mediate basal and adenosine 3′,5′-monophosphate-dependent glucagon gene transcription in a mouse neuroendocrine cell line
    • Gajic D & Drucker DJ 1993 Multiple cis-acting domains mediate basal and adenosine 3′,5′-monophosphate-dependent glucagon gene transcription in a mouse neuroendocrine cell line. Endocrinology 132 1055-1062.
    • (1993) Endocrinology , vol.132 , pp. 1055-1062
    • Gajic, D.1    Drucker, D.J.2
  • 36
    • 0026471057 scopus 로고
    • Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
    • German MS, Wang J, Chadwick RB & Rutter WJ 1992 Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes and Development 6 2165-2176.
    • (1992) Genes and Development , vol.6 , pp. 2165-2176
    • German, M.S.1    Wang, J.2    Chadwick, R.B.3    Rutter, W.J.4
  • 37
    • 2942624436 scopus 로고    scopus 로고
    • Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two elements related to cyclic AMP response element
    • Gevrey JC, Malapel M, Philippe J, Mithieux G, Chayvialle JA, Abello J & Cordier-Bussat M 2004 Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two elements related to cyclic AMP response element. Diabetologia 47 926-936.
    • (2004) Diabetologia , vol.47 , pp. 926-936
    • Gevrey, J.C.1    Malapel, M.2    Philippe, J.3    Mithieux, G.4    Chayvialle, J.A.5    Abello, J.6    Cordier-Bussat, M.7
  • 41
    • 14244266611 scopus 로고    scopus 로고
    • Minireview: Transcriptional regulation in pancreatic development
    • Habener JF, Kemp DM & Thomas MK 2005 Minireview: transcriptional regulation in pancreatic development. Endocrinology 146 1025-1034.
    • (2005) Endocrinology , vol.146 , pp. 1025-1034
    • Habener, J.F.1    Kemp, D.M.2    Thomas, M.K.3
  • 43
    • 0021719480 scopus 로고
    • Pre-proglucagon messenger ribonucleic acid: Nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid
    • Heinrich G, Gros P, Lund PK, Bentley RC & Habener JF 1984 Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid. Endocrinology 115 2176-2181.
    • (1984) Endocrinology , vol.115 , pp. 2176-2181
    • Heinrich, G.1    Gros, P.2    Lund, P.K.3    Bentley, R.C.4    Habener, J.F.5
  • 46
    • 23144437373 scopus 로고    scopus 로고
    • NKX6 transcription factor activity is required for α- and β-cell development in the pancreas
    • Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J & Sander M 2005 NKX6 transcription factor activity is required for α- and β-cell development in the pancreas. Development 132 3139-3149.
    • (2005) Development , vol.132 , pp. 3139-3149
    • Henseleit, K.D.1    Nelson, S.B.2    Kuhlbrodt, K.3    Hennings, J.C.4    Ericson, J.5    Sander, M.6
  • 47
    • 0034623077 scopus 로고    scopus 로고
    • Heterodimeric Pbx-Prep1 homeodomain protein binding to the glucagon gene restricting transcription in a cell type-dependent manner
    • Herzig S, Fuzesi L & Knepel W 2000 Heterodimeric Pbx-Prep1 homeodomain protein binding to the glucagon gene restricting transcription in a cell type-dependent manner. Journal of Biological Chemistry 275 27989-27999.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 27989-27999
    • Herzig, S.1    Fuzesi, L.2    Knepel, W.3
  • 48
    • 31844443202 scopus 로고    scopus 로고
    • Glucagon-like peptide-1: From extract to agent. The Claude Bernard Lecture, 2005
    • Holst JJ 2006 Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005. Diabetologia 49 253-260.
    • (2006) Diabetologia , vol.49 , pp. 253-260
    • Holst, J.J.1
  • 49
    • 12244305595 scopus 로고    scopus 로고
    • New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic β-cells
    • Holz GG 2004 New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic β-cells. Hormone and Metabolic Research 36 787-794.
    • (2004) Hormone and Metabolic Research , vol.36 , pp. 787-794
    • Holz, G.G.1
  • 50
    • 0032877154 scopus 로고    scopus 로고
    • Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator
    • Hussain MA & Habener JF 1999 Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator. Journal of Biological Chemistry 274 28950-28957.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 28950-28957
    • Hussain, M.A.1    Habener, J.F.2
  • 51
    • 0030712878 scopus 로고    scopus 로고
    • POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element
    • Hussain MA, Lee J, Miller CP & Habener JF 1997 POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element. Molecular and Cellular Biology 17 7186-7194.
    • (1997) Molecular and Cellular Biology , vol.17 , pp. 7186-7194
    • Hussain, M.A.1    Lee, J.2    Miller, C.P.3    Habener, J.F.4
  • 52
    • 0037013298 scopus 로고    scopus 로고
    • Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells
    • Hussain MA, Miller CP & Habener JF 2002 Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells. Journal of Biological Chemistry 277 16028-16032.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 16028-16032
    • Hussain, M.A.1    Miller, C.P.2    Habener, J.F.3
  • 53
    • 0035795227 scopus 로고    scopus 로고
    • Molecular evolution of proglucagon
    • Irwin DM 2001 Molecular evolution of proglucagon. Regulatory Peptides 98 1-12.
    • (2001) Regulatory Peptides , vol.98 , pp. 1-12
    • Irwin, D.M.1
  • 55
    • 0242409214 scopus 로고    scopus 로고
    • Clinical significance of GLP-2 in short-bowel syndrome
    • Jeppesen PB 2003 Clinical significance of GLP-2 in short-bowel syndrome. Journal of Nutrition 133 3721-3724.
    • (2003) Journal of Nutrition , vol.133 , pp. 3721-3724
    • Jeppesen, P.B.1
  • 56
    • 0029095180 scopus 로고
    • The proglucagon gene upstream enhancer contains positive and negative domains important for tissue-specific proglucagon gene transcription
    • Jin T & Drucker DJ 1995 The proglucagon gene upstream enhancer contains positive and negative domains important for tissue-specific proglucagon gene transcription. Molecular Endocrinology 9 1306-1320.
    • (1995) Molecular Endocrinology , vol.9 , pp. 1306-1320
    • Jin, T.1    Drucker, D.J.2
  • 57
    • 0029655778 scopus 로고    scopus 로고
    • Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3
    • Jin T & Drucker DJ 1996 Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3. Molecular and Cellular Biology 16 19-28.
    • (1996) Molecular and Cellular Biology , vol.16 , pp. 19-28
    • Jin, T.1    Drucker, D.J.2
  • 58
    • 0031016385 scopus 로고    scopus 로고
    • The caudal homeobox protein cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells
    • Jin T, Trinh DK, Wang F & Drucker DJ 1997 The caudal homeobox protein cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells. Molecular Endocrinology 11 203-209.
    • (1997) Molecular Endocrinology , vol.11 , pp. 203-209
    • Jin, T.1    Trinh, D.K.2    Wang, F.3    Drucker, D.J.4
  • 59
    • 0025280050 scopus 로고
    • Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain
    • Karlsson O, Thor S, Norberg T, Ohlsson H & Edlund T 1990 Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature 344 879-882.
    • (1990) Nature , vol.344 , pp. 879-882
    • Karlsson, O.1    Thor, S.2    Norberg, T.3    Ohlsson, H.4    Edlund, T.5
  • 61
    • 2342626059 scopus 로고    scopus 로고
    • Gastro-intestinal hormones GIP and GLP-1
    • Kieffer TJ 2004 Gastro-intestinal hormones GIP and GLP-1. Annales d'Endocrinologie 65 13-21.
    • (2004) Annales d'Endocrinologie , vol.65 , pp. 13-21
    • Kieffer, T.J.1
  • 62
    • 0036544854 scopus 로고    scopus 로고
    • Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
    • Kim SK, Selleri L, Lee JS, Zhang AY, Gu X, Jacobs Y & Cleary ML 2002 Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nature Genetics 30 430-435.
    • (2002) Nature Genetics , vol.30 , pp. 430-435
    • Kim, S.K.1    Selleri, L.2    Lee, J.S.3    Zhang, A.Y.4    Gu, X.5    Jacobs, Y.6    Cleary, M.L.7
  • 63
    • 0025221222 scopus 로고
    • Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells
    • Knepel W, Chafitz J & Habener JF 1990 Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells. Molecular and Cellular Biology 10 6799-6804.
    • (1990) Molecular and Cellular Biology , vol.10 , pp. 6799-6804
    • Knepel, W.1    Chafitz, J.2    Habener, J.F.3
  • 65
    • 0029826459 scopus 로고    scopus 로고
    • The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells
    • Laser B, Meda P, Constant I & Philippe J 1996 The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells. Journal of Biological Chemistry 271 28984-28994.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 28984-28994
    • Laser, B.1    Meda, P.2    Constant, I.3    Philippe, J.4
  • 66
    • 0026658127 scopus 로고
    • Glucagon gene 5′-flanking sequences direct expression of sumian virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice
    • Lee YC, Asa SL & Drucker DJ 1992 Glucagon gene 5′-flanking sequences direct expression of sumian virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice. Journal of Biological Chemistry 267 10705-10708.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 10705-10708
    • Lee, Y.C.1    Asa, S.L.2    Drucker, D.J.3
  • 68
    • 43749120731 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic β-cell proliferation
    • Liu Z & Habener JF 2008. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic β-cell proliferation. Journal of Biological Chemistry 283 8723-8735.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 8723-8735
    • Liu, Z.1    Habener, J.F.2
  • 69
    • 33645849844 scopus 로고    scopus 로고
    • Pbx1 is a co-factor for Cdx-2 in regulating proglucagon gene expression in pancreatic A cells
    • Liu T, Branch DR & Jin T 2006 Pbx1 is a co-factor for Cdx-2 in regulating proglucagon gene expression in pancreatic A cells. Molecular and Cellular Endocrinology 249 140-149.
    • (2006) Molecular and Cellular Endocrinology , vol.249 , pp. 140-149
    • Liu, T.1    Branch, D.R.2    Jin, T.3
  • 71
    • 0021032599 scopus 로고
    • Mammalian pancreatic preproglucagon contains three glucagon-related peptides
    • Lopez LC, Frazier ML, Su CJ, Kumar A & Saunders GF 1983 Mammalian pancreatic preproglucagon contains three glucagon-related peptides. PNAS 80 5485-5489.
    • (1983) PNAS , vol.80 , pp. 5485-5489
    • Lopez, L.C.1    Frazier, M.L.2    Su, C.J.3    Kumar, A.4    Saunders, G.F.5
  • 72
    • 33746076698 scopus 로고    scopus 로고
    • Role of the exchange protein directly activated by cyclic adenosine 5′-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells
    • Lotfi S, Li Z, Sun J, Zuo Y, Lain PP, Kang Y, Rahimi M, Islam D, Wang P, Gaisano HY & Jin T 2006 Role of the exchange protein directly activated by cyclic adenosine 5′-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells. Endocrinology 147 3727-3736.
    • (2006) Endocrinology , vol.147 , pp. 3727-3736
    • Lotfi, S.1    Li, Z.2    Sun, J.3    Zuo, Y.4    Lain, P.P.5    Kang, Y.6    Rahimi, M.7    Islam, D.8    Wang, P.9    Gaisano, H.Y.10    Jin, T.11
  • 73
    • 0029844024 scopus 로고    scopus 로고
    • Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line
    • Lu F, Jin T & Drucker DJ 1996 Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line. Endocrinology 137 3710-3716.
    • (1996) Endocrinology , vol.137 , pp. 3710-3716
    • Lu, F.1    Jin, T.2    Drucker, D.J.3
  • 74
    • 0020026919 scopus 로고
    • Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem
    • Lund PK, Goodman RH, Dee PC & Habener JF 1982 Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem. PNAS 79 345-349.
    • (1982) PNAS , vol.79 , pp. 345-349
    • Lund, P.K.1    Goodman, R.H.2    Dee, P.C.3    Habener, J.F.4
  • 77
    • 2442708165 scopus 로고    scopus 로고
    • Frizzleds: New members of the superfamily of G-protein-coupled receptors
    • Malbon CC 2004 Frizzleds: new members of the superfamily of G-protein-coupled receptors. Frontiers in Bioscience 9 1048-1058.
    • (2004) Frontiers in Bioscience , vol.9 , pp. 1048-1058
    • Malbon, C.C.1
  • 78
    • 33845999607 scopus 로고    scopus 로고
    • FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells
    • McKinnon CM, Ravier MA & Rutter GA 2006 FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells. Journal of Biological Chemistry 281 39358-39369.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 39358-39369
    • McKinnon, C.M.1    Ravier, M.A.2    Rutter, G.A.3
  • 80
    • 0031128225 scopus 로고    scopus 로고
    • WNTs modulate cell fate and behavior during vertebrate development
    • Moon RT, Brown JD & Torres M 1997 WNTs modulate cell fate and behavior during vertebrate development. Trends in Genetics 13 157-162.
    • (1997) Trends in Genetics , vol.13 , pp. 157-162
    • Moon, R.T.1    Brown, J.D.2    Torres, M.3
  • 82
    • 33845595901 scopus 로고    scopus 로고
    • Gut peptides in the regulation of food intake and energy homeostasis
    • Murphy KG, Dhillo WS & Bloom SR 2006 Gut peptides in the regulation of food intake and energy homeostasis. Endocrine Reviews 27 719-727.
    • (2006) Endocrine Reviews , vol.27 , pp. 719-727
    • Murphy, K.G.1    Dhillo, W.S.2    Bloom, S.R.3
  • 83
    • 34447521981 scopus 로고    scopus 로고
    • The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1 + pancreatic progenitor cells
    • Nelson SB, Schaffer AE & Sander M 2007 The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1 + pancreatic progenitor cells. Development 134 2491-2500.
    • (2007) Development , vol.134 , pp. 2491-2500
    • Nelson, S.B.1    Schaffer, A.E.2    Sander, M.3
  • 84
    • 0037428472 scopus 로고    scopus 로고
    • Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells
    • Ni Z, Anini Y, Fang X, Mills G, Brubaker PL & Jin T 2003 Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells. Journal of Biological Chemistry 278 1380-1387.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 1380-1387
    • Ni, Z.1    Anini, Y.2    Fang, X.3    Mills, G.4    Brubaker, P.L.5    Jin, T.6
  • 85
    • 0032698718 scopus 로고    scopus 로고
    • Divergent regulation of human and rat proglucagon gene promoters in vivo
    • Nian M, Drucker DJ & Irwin D 1999 Divergent regulation of human and rat proglucagon gene promoters in vivo. American Journal of Physiology 277 G829-G837.
    • (1999) American Journal of Physiology , vol.277
    • Nian, M.1    Drucker, D.J.2    Irwin, D.3
  • 89
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus
    • Peifer M & Polakis P 2000 Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 287 1606-1609.
    • (2000) Science , vol.287 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 91
    • 0030051923 scopus 로고    scopus 로고
    • Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation
    • Pfaff SL, Mendelsohn M, Stewart CL, Edlund T & Jessell TM 1996 Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell 84 309-320.
    • (1996) Cell , vol.84 , pp. 309-320
    • Pfaff, S.L.1    Mendelsohn, M.2    Stewart, C.L.3    Edlund, T.4    Jessell, T.M.5
  • 92
    • 0024334030 scopus 로고
    • Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line
    • Philippe J 1989 Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line. Journal of Clinical Investigation 84 672-677.
    • (1989) Journal of Clinical Investigation , vol.84 , pp. 672-677
    • Philippe, J.1
  • 93
    • 0025740672 scopus 로고
    • Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element
    • Philippe J 1991 Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element. PNAS 88 7224-7227.
    • (1991) PNAS , vol.88 , pp. 7224-7227
    • Philippe, J.1
  • 94
    • 0023074776 scopus 로고
    • Transcriptional regulation of genes encoding insulin, glucagon, and angiotensinogen by sodium butyrate in a rat islet cell line
    • Philippe J, Drucker DJ, Chick WL & Habener JF 1987a Transcriptional regulation of genes encoding insulin, glucagon, and angiotensinogen by sodium butyrate in a rat islet cell line. Molecular and Cellular Biology 7 560-563.
    • (1987) Molecular and Cellular Biology , vol.7 , pp. 560-563
    • Philippe, J.1    Drucker, D.J.2    Chick, W.L.3    Habener, J.F.4
  • 95
    • 0023644554 scopus 로고
    • Glucagon gene transcription in an islet cell line is regulated via a protein kinase C-activated pathway
    • Philippe J, Drucker DJ & Habener JF 1987b Glucagon gene transcription in an islet cell line is regulated via a protein kinase C-activated pathway. Journal of Biological Chemistry 262 1823-1828.
    • (1987) Journal of Biological Chemistry , vol.262 , pp. 1823-1828
    • Philippe, J.1    Drucker, D.J.2    Habener, J.F.3
  • 96
    • 0035154289 scopus 로고    scopus 로고
    • New signaling pathways for hormones and cyclic adenosine 3′,5′-monophosphate action in endocrine cells
    • Richards JS 2001 New signaling pathways for hormones and cyclic adenosine 3′,5′-monophosphate action in endocrine cells. Molecular Endocrinology 15 209-218.
    • (2001) Molecular Endocrinology , vol.15 , pp. 209-218
    • Richards, J.S.1
  • 98
    • 0034693046 scopus 로고    scopus 로고
    • The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter
    • Ritz-Laser B, Estreicher A, Gauthier B & Philippe J 2000 The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter. Journal of Biological Chemistry 275 32708-32715.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 32708-32715
    • Ritz-Laser, B.1    Estreicher, A.2    Gauthier, B.3    Philippe, J.4
  • 99
    • 0036165598 scopus 로고    scopus 로고
    • The pancreatic β-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6
    • Ritz-Laser B, Estreicher A, Gauthier BR, Mamin A, Edlund H & Philippe J 2002 The pancreatic β-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6. Diabetologia 45 97-107.
    • (2002) Diabetologia , vol.45 , pp. 97-107
    • Ritz-Laser, B.1    Estreicher, A.2    Gauthier, B.R.3    Mamin, A.4    Edlund, H.5    Philippe, J.6
  • 100
    • 14844312096 scopus 로고    scopus 로고
    • The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression
    • Ritz-Laser B, Mamin A, Brun T, Avril I, Schwitzgebel VM & Philippe J 2005 The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Molecular Endocrinology 19 759-770.
    • (2005) Molecular Endocrinology , vol.19 , pp. 759-770
    • Ritz-Laser, B.1    Mamin, A.2    Brun, T.3    Avril, I.4    Schwitzgebel, V.M.5    Philippe, J.6
  • 102
    • 1842330860 scopus 로고    scopus 로고
    • Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
    • Sander M, Neubuser A, Kalamaras J, Ee HC, Martin GR & German MS 1997 Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes and Development 11 1662-1673.
    • (1997) Genes and Development , vol.11 , pp. 1662-1673
    • Sander, M.1    Neubuser, A.2    Kalamaras, J.3    Ee, H.C.4    Martin, G.R.5    German, M.S.6
  • 107
    • 0027416480 scopus 로고
    • Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element
    • Schwaninger M, Lux G, Blume R, Oetjen E, Hidaka H & Knepel W 1993 Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element. Journal of Biological Chemistry 268 5168-5177.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 5168-5177
    • Schwaninger, M.1    Lux, G.2    Blume, R.3    Oetjen, E.4    Hidaka, H.5    Knepel, W.6
  • 110
    • 26844577365 scopus 로고    scopus 로고
    • Proglucagon-derived peptides: Mechanisms of action and therapeutic potential
    • Sinclair EM & Drucker DJ 2005 Proglucagon-derived peptides: mechanisms of action and therapeutic potential. Physiology 20 357-365.
    • (2005) Physiology , vol.20 , pp. 357-365
    • Sinclair, E.M.1    Drucker, D.J.2
  • 111
    • 0030449964 scopus 로고    scopus 로고
    • Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
    • Stambolic V, Ruel L & Woodgett JR 1996 Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Current Biology 6 1664-1668.
    • (1996) Current Biology , vol.6 , pp. 1664-1668
    • Stambolic, V.1    Ruel, L.2    Woodgett, J.R.3
  • 112
    • 0030914931 scopus 로고    scopus 로고
    • Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas
    • St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A & Gruss P 1997 Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature 387 406-409.
    • (1997) Nature , vol.387 , pp. 406-409
    • St-Onge, L.1    Sosa-Pineda, B.2    Chowdhury, K.3    Mansouri, A.4    Gruss, P.5
  • 113
    • 0029855582 scopus 로고    scopus 로고
    • Forebrain patterning defects in small eye mutant mice
    • Stoykova A, Fritsch R, Walther C & Gruss P 1996 Forebrain patterning defects in small eye mutant mice. Development 122 3453-3465.
    • (1996) Development , vol.122 , pp. 3453-3465
    • Stoykova, A.1    Fritsch, R.2    Walther, C.3    Gruss, P.4
  • 115
    • 0026335927 scopus 로고
    • The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat
    • Thor S, Ericson J, Brannstrom T & Edlund T 1991 The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. Neuron 7 881-889.
    • (1991) Neuron , vol.7 , pp. 881-889
    • Thor, S.1    Ericson, J.2    Brannstrom, T.3    Edlund, T.4
  • 116
    • 33645868980 scopus 로고    scopus 로고
    • Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin
    • Thyssen S, Arany E & Hill DJ 2006 Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin. Endocrinology 147 2346-2356.
    • (2006) Endocrinology , vol.147 , pp. 2346-2356
    • Thyssen, S.1    Arany, E.2    Hill, D.J.3
  • 117
    • 0037312830 scopus 로고    scopus 로고
    • Pax-6 activates endogenous proglucagon gene expression in the rodent gastrointestinal epithelium
    • Trinh DK, Zhang K, Hossain M, Brubaker PL & Drucker DJ 2003 Pax-6 activates endogenous proglucagon gene expression in the rodent gastrointestinal epithelium. Diabetes 52 425-433.
    • (2003) Diabetes , vol.52 , pp. 425-433
    • Trinh, D.K.1    Zhang, K.2    Hossain, M.3    Brubaker, P.L.4    Drucker, D.J.5
  • 119
    • 0026776285 scopus 로고
    • Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB, Isl-1-like, and alpha-CBF-like transcription factors
    • Vallejo M, Penchuk L & Habener JF 1992 Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB, Isl-1-like, and alpha-CBF-like transcription factors. Journal of Biological Chemistry 267 12876-12884.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 12876-12884
    • Vallejo, M.1    Penchuk, L.2    Habener, J.F.3
  • 120
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsboll T, Krarup T, Deacon CF, Madsbad S & Holst JJ 2001 Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 50 609-613.
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsboll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 121
    • 0029047865 scopus 로고
    • The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription
    • Wang M & Drucker DJ 1995 The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription. Journal of Biological Chemistry 270 12646-12652.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 12646-12652
    • Wang, M.1    Drucker, D.J.2
  • 123
    • 0041355491 scopus 로고    scopus 로고
    • Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter
    • Wang J, Cao Y & Steiner DF 2003 Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter. Journal of Biological Chemistry 278 32899-32904.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 32899-32904
    • Wang, J.1    Cao, Y.2    Steiner, D.F.3
  • 124
    • 33645500785 scopus 로고    scopus 로고
    • Redundant and synergistic effect of Cdx-2 and Brn-4 on regulating proglucagon gene expression
    • Wang P, Liu T, Li Z, Ma X &Jin T 2006 Redundant and synergistic effect of Cdx-2 and Brn-4 on regulating proglucagon gene expression. Endocrinology 147 1950-1958.
    • (2006) Endocrinology , vol.147 , pp. 1950-1958
    • Wang, P.1    Liu, T.2    Li, Z.3    Ma, X.4    Jin, T.5
  • 125
    • 33748603481 scopus 로고    scopus 로고
    • Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1)
    • Wideman RD, Yu IL, Webber TD, Verchere CB, Johnson JD, Cheung AT & Kieffer TJ 2006 Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). PNAS 103 13468-13473.
    • (2006) PNAS , vol.103 , pp. 13468-13473
    • Wideman, R.D.1    Yu, I.L.2    Webber, T.D.3    Verchere, C.B.4    Johnson, J.D.5    Cheung, A.T.6    Kieffer, T.J.7
  • 126
    • 35748962950 scopus 로고    scopus 로고
    • A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice
    • Wideman RD, Covey SD, Webb GC, Drucker DJ & Kieffer TJ 2007 A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice. Diabetes 56 2744-2752.
    • (2007) Diabetes , vol.56 , pp. 2744-2752
    • Wideman, R.D.1    Covey, S.D.2    Webb, G.C.3    Drucker, D.J.4    Kieffer, T.J.5
  • 127
    • 0036269003 scopus 로고    scopus 로고
    • Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas
    • Wilson ME, Kalamaras JA & German MS 2002 Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas. Mechanism of Development 115 171-176.
    • (2002) Mechanism of Development , vol.115 , pp. 171-176
    • Wilson, M.E.1    Kalamaras, J.A.2    German, M.S.3
  • 128
    • 0033607763 scopus 로고    scopus 로고
    • Cell type-specific autoregulation of the Caudal-related homeobox gene Cdx-2/3
    • Xu F, Li H & Jin T 1999 Cell type-specific autoregulation of the Caudal-related homeobox gene Cdx-2/3. Journal of Biological Chemistry 274 34310-34316.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 34310-34316
    • Xu, F.1    Li, H.2    Jin, T.3
  • 129
    • 12544254474 scopus 로고    scopus 로고
    • TCF-4 mediates cell type-specific regulation of proglucagon gene expression by β-catenin and glycogen synthase kinase-3beta
    • Yi F, Brubaker PL &Jin T 2005 TCF-4 mediates cell type-specific regulation of proglucagon gene expression by β-catenin and glycogen synthase kinase-3beta. Journal of Biological Chemistry 280 1457-1464.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 1457-1464
    • Yi, F.1    Brubaker, P.L.2    Jin, T.3
  • 130
    • 42449134942 scopus 로고    scopus 로고
    • Crosstalk between the insulin and Wnt signaling pathways: Evidence from intestinal endocrine L cells
    • In Press
    • Yi F, Sun J, Lim GE, Famus IG, Brubaker PL &Jin T 2008. Crosstalk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells. Endocrinology (In Press).
    • (2008) Endocrinology
    • Yi, F.1    Sun, J.2    Lim, G.E.3    Famus, I.G.4    Brubaker, P.L.5    Jin, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.